Patient Assistance Programs for Activase. Patient assistance programs (PAPs) are usually sponsored by pharmaceutical companies and provide free or discounted medicines to low income or uninsured and under-insured people who meet specific guidelines. Eligibility requirements vary for each program.
Full Answer
Can activase be used to treat a stroke?
Patients can receive Activase only if they begin treatment within 3 hours after their stroke symptoms start and only after bleeding in the brain has been ruled out. Activase (alteplase) is approved for treating an acute myocardial infarction, also known as a sudden heart attack.
What is the prognosis of angioedema caused by activase infusion?
Angioedema has been observed during and up to 2 hours after Activase infusion in patients treated for acute ischemic stroke and acute myocardial infarction. In many cases, patients received concomitant angiotensin-converting enzyme inhibitors. Monitor patients treated with Activase during and for several hours after infusion for hypersensitivity.
What are the possible adverse effects of activase?
Hypersensitivity, including urticarial / anaphylactic reactions, have been reported after administration of Activase. Rare fatal outcome for hypersensitivity was reported. Angioedema has been observed during and up to 2 hours after Activase infusion in patients treated for acute ischemic stroke and acute myocardial infarction.
What should be monitored during and after activase® administration?
Patients should be monitored and managed during and after Activase® administration. When Activase is administered, the first 24 hours are critical. Observe and frequently monitor patients for neurologic changes, as well as any signs and symptoms of intracranial hemorrhage and adverse drug reactions, during patient recovery.
What is activase used for?
What is Genentech Access to Care Foundation?
How much does a free drug card save?
Is activase valid with insurance?
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What is activase used for?
Activase (alteplase) is a member of the thrombolytics drug class and is commonly used for Heart Attack, Ischemic Stroke, Pulmonary Embolism, and others.
What is Genentech Access to Care Foundation?
The Genentech Access to Care Foundation is now the Genentech Patient Foundation. Eligibility determined on a case-by-case basis. Call for most recent medications as the list is subject to change.
How much does a free drug card save?
The free Drugs.com Discount Card works like a coupon and can save you up to 80% or more off the cost of prescription medicines, over-the-counter drugs and pet prescriptions.
Is activase valid with insurance?
Prices are for cash paying customers only and are not valid with insurance plans. This Activase price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies.
What is the most common adverse reaction associated with activase therapy?
The most frequent adverse reaction associated with Activase therapy is bleeding.
What are the risks of activase?
In the following conditions, the risks of bleeding with Activase are increased and should be weighed against the anticipated benefits: recent major surgery or procedure; cerebrovascular disease; recent intracranial hemorrhage; recent gastrointestinal or genitourinary bleeding; recent trauma; hypertension; acute pericarditis; subacute bacterial endocarditis; hemostatic defects including those secondary to severe hepatic or renal disease; significant hepatic dysfunction; pregnancy; diabetic hemorrhagic retinopathy or other hemorrhagic ophthalmic conditions; septic thrombophlebitis or occluded AV cannula at seriously infected site; advanced age; and patients currently receiving oral anticoagulants, or any other condition in which bleeding constitutes a significant hazard or would be particularly difficult to manage because of its location.
How long after activase infusion can you get angioedema?
Angioedema has been observed during and up to 2 hours after Activase infusion in patients treated for acute ischemic stroke and acute myocardial infarction. In many cases, patients received concomitant angiotensin-converting enzyme inhibitors.
Can activase be used for pulmonary embolism?
Do not administer Activase to treat acute myocardial infarction or pulmonary embolism in the following situations in which the risk of bleeding is greater than the potential benefit: active internal bleeding; history of recent stroke; recent (within 3 months) intracranial or intraspinal surgery or serious head trauma; presence of intracranial conditions that may increase the risk of bleeding; bleeding diathesis; and current severe uncontrolled hypertension.
Can activase be used for ischemic stroke?
Do not administer Activase to treat acute ischemic stroke in the following situations in which the risk of bleeding is greater than the potential benefit: current intracranial hemorrhage (ICH); subarachnoid hemorrhage; active internal bleeding; recent (within 3 months) intracranial or intraspinal surgery or serious head trauma; presence of intracranial conditions that may increase the risk of bleeding (e.g., some neoplasms, arteriovenous malformations, or aneurysms); bleeding diathesis; and current severe uncontrolled hypertension.
Does activase help with thromboembolism?
Thromboembolism. The use of thrombolytics can increase the risk of thrombo-embolic events in patients with high likelihood of left heart thrombus, such as patients with mitral stenosis or atrial fibrillation. Activase has not been shown to treat adequately underlying deep vein thrombosis in patients with PE.
Can activase cause bleeding?
Activase can cause significant, sometimes fatal internal or external bleeding, especially at arterial and venous puncture sites . Avoid intramuscular injections and trauma to the patient. Perform venipunctures carefully and only as required.
What is activase.com?
Activase.com. Provides additional resources and information. Get answers to your questions about your Activase prescription. SUPPORT. Medicine Information Support. Ask about possible side effects and any other medical questions related to your prescribed Genentech medicine. Call us at (800) 821-8590, Monday-Friday, 5am-5pm PT.
What are the side effects of activase?
The most common side effect with Activase is bleeding.
How to report activase side effects?
Report side effects for your Activase prescription. Report side effects to the FDA at (800) FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Genentech at (888) 835-2555. Get help paying for your Activase prescription. SUPPORT.
How long after stroke can you take activase?
Patients can receive Activase only if they begin treatment within 3 hours after their stroke symptoms start and only after bleeding in the brain has been ruled out.
How to contact Genentech?
Patients and their caregivers are encouraged to report side effects to Genentech and the FDA. They may contact Genentech by calling 1-888- 835- 2555. They may contact the FDA by visiting www.fda.gov/medwatch or calling 1-800-FDA-1088.
Does activase help with stroke?
In patients whose heart attack puts them at low risk for death or heart failure, the benefit that comes from the use of Activase may be outweighed by the risk of stroke that Activase presents. Activase (alteplase) is indicated to break apart an acute massive pulmonary embolism, which is a large blood clot lodged in the blood vessels of the lung.
Can activase be used for brain tumors?
Activase should not be used in patients who have: active internal bleeding; history of recent stroke; recent (within 3 months) brain or spinal surgery or major head trauma; some brain tumor, an abnormal connection between veins and arteries in the brain, or an abnormal bulge in the wall of an artery that supplies blood to the brain; problems with blood clotting; or current severe uncontrolled high blood pressure (hypertension).
How soon after stroke can you start activase?
Initiate treatment as soon as possible, but within 3 hours after symptom onset.
Can angiotensin converting enzyme inhibitors cause angioedema?
In the post-marketing setting, there have been reports of angioedema in patients (primarily patients with AIS) receiving concomitant angiotensin-converting enzyme inhibitors.
Can you use activase for AIS?
Do not administer Activase to treat AIS in the following situations in which the risk of bleeding is greater than the potential benefit
Does activase cause bleeding?
The interaction of Activase with other cardioactive or cerebroactive drugs has not been studied. Anticoagulants and antiplatelet drugs increase the risk of bleeding if administered prior to, during, or after Activase therapy.
What is activase N#?
Activase#N#®#N#(alteplase) is indicated for the treatment of acute ischemic stroke (AIS). Exclude intracranial hemorrhage as the primary cause of stroke signs and symptoms prior to initiation of treatment. Initiate treatment as soon as possible but within 3 hours after symptom onset.
What is the most common adverse reaction associated with activase therapy?
The most frequent adverse reaction associated with Activase therapy is bleeding.
What are the risks of activase?
In the following conditions, the risks of bleeding with Activase are increased and should be weighed against the anticipated benefits: recent major surgery or procedure; cerebrovascular disease; recent intracranial hemorrhage; recent gastrointestinal or genitourinary bleeding; recent trauma; hypertension; acute pericarditis; subacute bacterial endocarditis; hemostatic defects including those secondary to severe hepatic or renal disease; significant hepatic dysfunction; pregnancy; diabetic hemorrhagic retinopathy or other hemorrhagic ophthalmic conditions; septic thrombophlebitis or occluded AV cannula at seriously infected site; advanced age; and patients currently receiving oral anticoagulants, or any other condition in which bleeding constitutes a significant hazard or would be particularly difficult to manage because of its location.
How long after activase infusion can you get angioedema?
Angioedema has been observed during and up to 2 hours after Activase infusion in patients treated for acute ischemic stroke and acute myocardial infarction. In many cases, patients received concomitant angiotensin-converting enzyme inhibitors. Monitor patients treated with Activase during and for several hours after infusion for hypersensitivity.
Can activase cause bleeding?
Activase can cause significant, sometimes fatal internal or external bleeding, especially at arterial and venous puncture sites. Avoid intramuscular injections and trauma to the patient. Perform venipunctures carefully and only as required. Fatal cases of hemorrhage associated with traumatic intubation in patients administered Activase have been reported. Aspirin and heparin have been administered concomitantly with and following infusion with Activase in the management of acute myocardial infarction and pulmonary embolism. The concomitant administration of heparin and aspirin with and following infusions of Activase for the treatment of acute ischemic stroke during the first 24 hours after symptom onset has not been investigated. Because heparin, aspirin, or Activase may cause bleeding complications, carefully monitor for bleeding, especially at arterial puncture sites. Hemorrhage can occur 1 or more days after administration of Activase, while patients are still receiving anticoagulant therapy. If serious bleeding occurs, terminate the Activase infusion, and treat appropriately.
Does activase help with PE?
Activase has not been shown to treat adequately underlying deep vein thrombosis in patients with PE. Consider the possible risk of re-embolization due to the lysis of underlying deep venous thrombi in this setting.
Does activase help with thromboembolism?
Thromboembolism. The use of thrombolytics can increase the risk of thrombo-embolic events in patients with high likelihood of left heart thrombus, such as patients with mitral stenosis or atrial fibrillation. Activase has not been shown to treat adequately underlying deep vein thrombosis in patients with PE.
Important Note
The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.
Uses
This medication is an enzyme used to dissolve blood clots that may sometimes form within patient's IV lines (central venous access devices - CVADs). Blood clots can block the IV line and prevent other injectable drugs from being given.
How To Use
Mix this product by injecting 2.2 ml of Sterile Water for Injection into the vial. Do not use a mixing solution containing a preservative (e.g., Bacteriostatic Water for Injection). Gently swirl the vial until the drug is completely dissolved. Do not shake the vial. Slight foaming or bubbles may be present.
Side Effects
No side effects are expected to occur. If side effects occur, notify your doctor immediately. Tell your doctor immediately if any of these unlikely but serious side effects occur: dizziness, lightheadedness, persistent sore throat or fever.
Precautions
Tell your doctor your medical history, especially of: recent surgery or medical procedures (e.g., biopsies, blood tests), recent childbirth, liver problems, kidney problems, blood disorders (e.g., low platelets) any allergies. This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor.
Drug Interactions
Tell your doctor of all prescription and nonprescription medication you may use, especially: "blood thinners" (e.g., warfarin), aspirin. Do not start or stop any medicine without doctor or pharmacist approval.
Overdose
If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include: unusual bleeding.
What is activase used for?
Activase is indicated for use in acute myocardial infarction (AMI) for the reduction of mortality and reduction of the incidence of heart failure. Limitation of Use: The risk of stroke may outweigh the benefit produced by thrombolytic therapy in patients whose AMI puts them at low risk for death or heart failure.
What is the most common adverse reaction associated with activase therapy?
The most frequent adverse reaction associated with Activase therapy is bleeding.
What are the risks of activase?
In the following conditions, the risks of bleeding with Activase are increased and should be weighed against the anticipated benefits: recent major surgery or procedure; cerebrovascular disease; recent intracranial hemorrhage; recent gastrointestinal or genitourinary bleeding; recent trauma; hypertension; acute pericarditis; subacute bacterial endocarditis; hemostatic defects including those secondary to severe hepatic or renal disease; significant hepatic dysfunction; pregnancy; diabetic hemorrhagic retinopathy or other hemorrhagic ophthalmic conditions; septic thrombophlebitis or occluded AV cannula at seriously infected site; advanced age; and patients currently receiving oral anticoagulants, or any other condition in which bleeding constitutes a significant hazard or would be particularly difficult to manage because of its location.
Can activase cause bleeding?
Activase can cause significant, sometimes fatal internal or external bleeding, especially at arterial and venous puncture sites. Avoid intramuscular injections and trauma to the patient. Perform venipunctures carefully and only as required. Fatal cases of hemorrhage associated with traumatic intubation in patients administered Activase have been reported. Aspirin and heparin have been administered concomitantly with and following infusion with Activase in the management of acute myocardial infarction and pulmonary embolism. The concomitant administration of heparin and aspirin with and following infusions of Activase for the treatment of acute ischemic stroke during the first 24 hours after symptom onset has not been investigated. Because heparin, aspirin, or Activase may cause bleeding complications, carefully monitor for bleeding, especially at arterial puncture sites. Hemorrhage can occur 1 or more days after administration of Activase, while patients are still receiving anticoagulant therapy. If serious bleeding occurs, terminate the Activase infusion, and treat appropriately.
Can activase be used for pulmonary embolism?
Do not administer Activase to treat acute myocardial infarction or pulmonary embolism in the following situations in which the risk of bleeding is greater than the potential benefit: active internal bleeding; history of recent stroke; recent (within 3 months) intracranial or intraspinal surgery or serious head trauma; presence of intracranial conditions that may increase the risk of bleeding; bleeding diathesis; and current severe uncontrolled hypertension.
Can activase be used for ischemic stroke?
Do not administer Activase to treat acute ischemic stroke in the following situations in which the risk of bleeding is greater than the potential benefit: current intracranial hemorrhage (ICH); subarachnoid hemorrhage; active internal bleeding; recent (within 3 months) intracranial or intraspinal surgery or serious head trauma; presence of intracranial conditions that may increase the risk of bleeding (e.g., some neoplasms, arteriovenous malformations, or aneurysms); bleeding diathesis; and current severe uncontrolled hypertension.
Does activase help with thromboembolism?
Thromboembolism. The use of thrombolytics can increase the risk of thrombo-embolic events in patients with high likelihood of left heart thrombus, such as patients with mitral stenosis or atrial fibrillation. Activase has not been shown to treat adequately underlying deep vein thrombosis in patients with PE.
What is activase used for?
Activase (alteplase) is a member of the thrombolytics drug class and is commonly used for Heart Attack, Ischemic Stroke, Pulmonary Embolism, and others.
What is Genentech Access to Care Foundation?
The Genentech Access to Care Foundation is now the Genentech Patient Foundation. Eligibility determined on a case-by-case basis. Call for most recent medications as the list is subject to change.
How much does a free drug card save?
The free Drugs.com Discount Card works like a coupon and can save you up to 80% or more off the cost of prescription medicines, over-the-counter drugs and pet prescriptions.
Is activase valid with insurance?
Prices are for cash paying customers only and are not valid with insurance plans. This Activase price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies.
Important Note
- The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your …
Uses
- This medication is an enzyme which works to break up and dissolve blood clots which can block arteries. It is used in the treatment of an acute heart attack or pulmonary embolism.
Side Effects
- Nausea, vomiting, dizziness or mild fever may occur. If any of these effects continue or become bothersome, inform your doctor. Notify your doctor if you experience: easy bruising or bleeding, skin rash, trouble breathing, rapid or abnormal heartbeat, chest pain. Immediately report any signs of bleeding to your doctor. If you notice other effects not listed above, contact your doctor or ph…
Precautions
- Tell your doctor your medical history, especially of: bleeding disorders, high blood pressure, recent injury or surgery, liver disease, endocarditis, any allergies. Use extra caution to avoid injury and trauma while using this medication due to the increased risk of bleeding. This medication should be used only if clearly needed during pregnancy. Discuss the risks and benefits with your doctor…
Drug Interactions
- Tell your doctor of any over-the-counter or prescription medication you may take including: "blood thinners" (e.g., warfarin), aspirin. Do not start or stop any medicine without doctor or pharmacist approval.
Overdose
- If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include fainting, vision changes, one-sided weakness, slurred speech, black stools, coughing up or vomiting blood, dizziness upon standing.
Notes
- Laboratory tests will be done frequently while using this medication to monitor its effects and to prevent side effects.
Storage
- Store in a cool area as directed and protect from light. Discard any unused medication after the expiration date on the label.
Support & Resources
- Report side effects for your Activase prescriptionReport side effects to the FDA at (800) FDA-1088 or www.fda.gov/medwatch.You may also report side effects to Genentech at (888) 835-2555.Get help p...
What It Treats
- Acute Ischemic Stroke Activase ® (alteplase) is indicated for treating patients with acute ischemic stroke (sudden stroke), which is caused by a blood clot in the brain’s blood vessels. Patients can receive Activase only if they begin treatment within 3 hours after their stroke symptoms start and only after bleeding in the brain has been ruled out.
Important Safety Information
- Who should not be given Activase? Activase should not be used in patients who have: current bleeding in the brain; bleeding in the area between the brain and the thin tissues that cover the brain; active internal bleeding; recent (within 3 months) brain or spinal surgery or major head trauma; some brain tumor, an abnormal connection between veins and arteries in the brain, or a…
What It Treats
- Acute Myocardial Infarction & Pulmonary Embolism Activase ® (alteplase) is approved for treating an acute myocardial infarction, also known as a sudden heart attack. In patients whose heart attack puts them at low risk for death or heart failure, the benefit that comes from the use of Activase may be outweighed by the risk of stroke that Activase presents. Activase (alteplase) is …