Patient Assistance Programs for Advate Patient assistance programs (PAPs) are usually sponsored by pharmaceutical companies and provide free or discounted medicines to low income or uninsured and under-insured people who meet specific guidelines. Eligibility requirements vary for each program. Provider: Patient Access Network Foundation (PAN)
Full Answer
What does Advate stand for?
ADVATE [Antihemophilic Factor (Recombinant)] Important Information. Indications. ADVATE is a medicine used to replace clotting factor (factor VIII or antihemophilic factor) that is missing in people with hemophilia A (also called "classic" hemophilia).
What does Advate stand for in hemophilia A?
Hemophilia A Treatment - ADVATE® [Antihemophilic Factor (Recombinant)] Official Site. What is ADVATE? ADVATE is a medicine used to replace clotting factor (factor VIII or antihemophilic factor) that is missing in people with hemophilia A (also called “classic” hemophilia).
Is Advate a coagulation modifier?
Advate Prices, Coupons and Patient Assistance Programs. Advate (antihemophilic factor) is a member of the miscellaneous coagulation modifiers drug class and is commonly used for Hemophilia A.
What is a patient assistance program?
Patient Assistance Programs for Advate. Patient assistance programs (PAPs) are usually sponsored by pharmaceutical companies and provide free or discounted medicines to low income or uninsured and under-insured people who meet specific guidelines.
How often is ADVATE given?
ADVATE dosing for routine prophylaxis Use dose of 20 to 40 international units of factor VIII per kg of body weight every other day (3 to 4 times weekly). Alternatively, use every third day dosing regimen targeted to maintain factor VIII trough levels ≥1%. Adjust dose based on the patient's clinical response.
What is the difference between ADVATE and Adynovate?
ADYNOVATE is built on the ADVATE® molecule, a proven treatment in hemophilia A patients. ADYNOVATE was designed to have a longer half-life than ADVATE. This means ADYNOVATE will remain in your body longer to help prevent bleeds. Talk to your healthcare provider to find out what treatment is right for you.
Who manufactures ADVATE?
Takeda has a variety of resources to help you and your patient navigate access to ADVATE.
Who makes Adynovate?
Manufacturer: Baxalta US Inc.
What is the half-life of ADVATE?
Product nameHalf-life (hours)*CharacteristicsAdvate9 to 12RecombinantHemofil M15Plasma-derived; mAb-purifiedKogenate FS11 to 15RecombinantKoate (previously called Koate DVI)16Plasma-derived; chromatography purified12 more rows
How is Adynovate given?
Administer ADYNOVATE intravenously over a period of less than or equal to 5 minutes (maximum infusion rate 10 mL per min).
Is ADVATE the same as Hemlibra?
While Advate requires at least three IV bolus administrations a week, Hemlibra can be given as a weekly subcutaneous injection with better outcomes in annualized bleeding rate and in the proportion of patients experiencing zero bleeds per year.
Where is ADVATE manufactured?
1 is produced at the Baxter facility in Hayward, CA, USA and is also used for the purification of the already licensed rFVIII product Recombinate as well as the plasma-derived FVIII product Hemofil.
Is ADVATE a blood product?
In 2003, ADVATE became the first recombinant factor VIII treatment free of blood-based additives. Since then, TAKEDA has made advancements with flexible dosing options, reconstitution with BAXJECT® system, and the introduction of myPKFiT® for PK-guided personalized dosing.
What causes hemophilia type A?
Hemophilia A is the result of the body not making enough factor VIII. Hemophilia A is caused by an inherited X-linked recessive trait, with the defective gene located on the X chromosome. Females have two copies of the X chromosome.
What is Adynovi?
Adynovi is a medicine used to treat and prevent bleeding in patients with haemophilia A, an inherited bleeding disorder caused by lack of a clotting protein called factor VIII. It can be used in adults and children from 12 years of age. Adynovi contains the active substance rurioctocog alfa pegol.
Who makes Kovaltry?
Bayer, the Bayer Cross, and KOVALTRY are registered trademarks of Bayer. Access Services by Bayer is a trademark of Bayer. Advate is a registered trademark of Baxalta Incorporated, a wholly owned, indirect subsidiary of Shire plc.
Is ADVATE the same as Hemlibra?
While Advate requires at least three IV bolus administrations a week, Hemlibra can be given as a weekly subcutaneous injection with better outcomes in annualized bleeding rate and in the proportion of patients experiencing zero bleeds per year.
Is ADVATE a blood product?
In 2003, ADVATE became the first recombinant factor VIII treatment free of blood-based additives. Since then, TAKEDA has made advancements with flexible dosing options, reconstitution with BAXJECT® system, and the introduction of myPKFiT® for PK-guided personalized dosing.
Is ADVATE an injection?
Powder for injection with diluent. Advate is formulated as a sterile, non-pyogenic, white to off-white, lyophilised powder for injection after reconstitution with water for injections.
How is ADVATE administered?
Administer ADVATE by intravenous (IV) injection after reconstitution. Ask patients to follow the specific preparation and administration procedures provided by their physicians.
What is myPKFiT used for?
myPKFiT should only be used to evaluate prophylactic dosing regimens for hemophilia A patients treated with ADVATE, as per the ADVATE Prescribing Information (PI).
What is myPKfit software?
The myPKFiT software can be used to generate ADVATE dosage amount and frequency recommendations for routine prophylaxis for an individual patient 16 years of age and older and body weight of 45 kg or greater, using that patient’s age and body weight information and local laboratory FVIII one-stage clotting activity measurements of sparse samples collected from that patient.
What is the phone number for Takeda hematology?
HSC offers help with treatment access, as well as educational resources and information for financial assistance programs. Call 1-888-229-8379 Monday–Friday 8:30AM–8:00PM (ET).
What is routine prophylaxis?
Routine prophylaxis to prevent or reduce the frequency of bleeding episodes.
Is myPKfit for advice indicated for von Willebrand disease?
myPKFiT for ADVATE is not indicated for the treatment of von Willebrand disease. MyPKFiT for ADVATE should not be used for patients who have developed neutralizing antibody (inhibitor) to FVIII products.
What is a patient access manager?
A Patient Access Manager is available and can provide one-on-one, personalized insurance education and access information
Is myPKfit for advance RX?
myPKFiT for ADVATE is Rx only. For safe and proper use of the myPKFiT software, please refer to the complete instructions for use in the User Manual.
What is ADVATE?
ADVATE is a medicine used to replace clotting factor (factor VIII or antihemophilic factor) that is missing in people with hemophilia A (also called “classic” hemophilia).
What important information do I need to know about ADVATE?
You can have an allergic reaction to ADVATE. Call your HCP right away and stop treatment if you get a rash or hives, itching, tightness of the throat, chest pain or tightness, difficulty breathing, lightheadedness, dizziness, nausea or fainting.
What are possible side effects of ADVATE?
Side effects that have been reported with ADVATE include: cough, headache, joint swelling/aching, sore throat, fever, itching, unusual taste, dizziness, hematoma, abdominal pain, hot flashes, swelling of legs, diarrhea, chills, runny nose/congestion, nausea/vomiting, sweating, and rash. Tell your HCP about any side effects that bother you or do not go away or if your bleeding does not stop after taking ADVATE.
What is myPKFit software?
Your HCP can use the myPKFiT software to generate ADVATE dosage amount and frequency recommendations for routine prophylaxis using your age, body weight information, and laboratory tests that measure your Factor VIII clotting activity . Using myPKFiT software, HCPs can evaluate various prophylaxis dose regimens tailored to your individual needs and treatment plan.
What is mypkfit for patients?
The myPKFiT for Patients Mobile Application (“myPKFiT Mobile App”) is intended for use by patients with hemophilia A being treated with ADVATE [Antihemophilic Factor (Recombinant)] who are 16 years of age or older with a body weight of 45 kg or higher, and their caregivers.
What happens if you take inhibitors to factor VIII?
An inhibitor is part of the body’s normal defense system. If you form inhibitors, it may stop ADVATE from working properly. Talk with your HCP to make sure you are carefully monitored with blood tests for the development of inhibitors to factor VIII.
What is the MyPKFit app?
The myPKFiT Mobile App is designed to make it convenient for you to record your infusion and bleed events, track your estimated Factor VIII levels following a prophylactic infusion, and export the data for review by your health care provider (“HCP”).
What else should I know about ADVATE and Hemophilia A?
Your body may form inhibitors to factor VIII. An inhibitor is part of the body’s normal defense system. If you form inhibitors, it may stop ADVATE from working properly. Talk with your HCP to make sure you are carefully monitored with blood tests for the development of inhibitors to factor VIII.
What is ADVATE?
ADVATE is a medicine used to replace clotting factor (factor VIII or antihemophilic factor) that is missing in people with hemophilia A (also called “classic” hemophilia).
What are possible side effects of ADVATE?
Side effects that have been reported with ADVATE include: cough, headache, joint swelling/aching, sore throat, fever, itching, unusual taste, dizziness, hematoma, abdominal pain, hot flashes, swelling of legs, diarrhea, chills, runny nose/congestion, nausea/vomiting, sweating, and rash. Tell your HCP about any side effects that bother you or do not go away or if your bleeding does not stop after taking ADVATE.
What is myPKFit software?
Your HCP can use the myPKFiT software to generate ADVATE dosage amount and frequency recommendations for routine prophylaxis using your age, body weight information, and laboratory tests that measure your Factor VIII clotting activity . Using myPKFiT software, HCPs can evaluate various prophylaxis dose regimens tailored to your individual needs and treatment plan.
What is mypkfit for patients?
The myPKFiT for Patients Mobile Application (“myPKFiT Mobile App”) is intended for use by patients with hemophilia A being treated with ADVATE [Antihemophilic Factor (Recombinant)] who are 16 years of age or older with a body weight of 45 kg or higher, and their caregivers.
What to do if you have a rash and hives?
Call your HCP right away and stop treatment if you get a rash or hives, itching, tightness of the throat, chest pain or tightness, difficulty breathing, lightheadedness, dizziness, nausea or fainting. Do not attempt to infuse yourself with ADVATE unless you have been taught by your HCP or hemophilia center.
What is the MyPKFit app?
The myPKFiT Mobile App is designed to make it convenient for you to record your infusion and bleed events, track your estimated Factor VIII levels following a prophylactic infusion, and export the data for review by your health care provider (“HCP”).
Important Note
The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.
Uses
Antihemophilic factor is a protein in the blood necessary in forming clots to stop bleeding. Persons with hemophilia A have low levels of this protein leaving them susceptible to bleeding episodes. This medication is used to temporarily prevent or control bleeding episodes in patients with hemophilia A.
How To Use
This medication is given by injection into a vein. The rate of injection depends upon patient response but is generally injected over 5 to 10 minutes. The powder and dissolving fluid should be warmed to room temperature before combining if they were refrigerated.
Side Effects
This medication is generally well tolerated. Mild chills, nausea and irritation at the injection site may occur. In the unlikely event you have an allergic reaction to this drug, seek immediate medical attention. Symptoms of an allergic reaction include: rash, itching, swelling, dizziness, trouble breathing.
Precautions
Tell your doctor your medical history, especially of: other illnesses, allergies (especially to animal proteins). You should check your heart rate before and during injection. The dose or rate of infusion may need to be changed if your heart rate is too fast. This drug should be used only when clearly needed during pregnancy.
Drug Interactions
Tell your doctor of all over-the-counter and prescription medications you may use. Do not start or stop any medicine without doctor or pharmacist approval.
Overdose
If overdose is suspected, contact your local poison control center or emergency room immediately.
What is the Advate Takeda HSC Copay Assistance Program?
Advate Takeda HSC CoPay Assistance Program: Eligible commercially insured patients' eligible out-of-pocket costs to be covered 100% by the program; for additional information contact the program at 888-229-8379.
What is Advate used for?
Advate (antihemophilic factor) is a member of the miscellaneous coagulation modifiers drug class and is commonly used for Hemophilia A.
What is an advance offer?
Advate offers may be in the form of a printable coupon, rebate, savings card, trial offer, or free samples. Some offers may be printed right from a website, others require registration, completing a questionnaire, or obtaining a sample from the doctor's office.
How much does a free drug card save?
The free Drugs.com Discount Card works like a coupon and can save you up to 80% or more off the cost of prescription medicines, over-the-counter drugs and pet prescriptions.
When there is a range of pricing, should consumers expect to pay the lower price?
Important: When there is a range of pricing, consumers should normally expect to pay the lower price. However, due to stock shortages and other unknown variables we cannot provide any guarantee.
What is myPKfit software?
The myPKFiT software is intended for use by licensed healthcare professionals (HCPs) who are familiar with hemophilia care. The myPKFiT software can be used to generate ADVATE dosage amount and frequency recommendations for routine prophylaxis for an individual patient 16 years of age and older and body weight of 45 kg or greater, using that patient’s age and body weight information and local laboratory FVIII one-stage clotting activity measurements of sparse samples collected from that patient.
What is the phone number for Takeda hematology?
HSC offers help with treatment access, as well as educational resources and information for financial assistance programs. Call 1-888-229-8379 Monday–Friday 8:30AM–8:00PM (ET).
What is routine prophylaxis?
Routine prophylaxis to prevent or reduce the frequency of bleeding episodes.
What is a prophylactic injection?
Therapeutic, prophylactic, or diagnostic injection (specify substance or drug ); each additional sequential intravenous push of the same substance/drug provided in a facility (List separately in addition to code for primary procedure.
What is the phone number for HSC?
HSC offers help with treatment access, as well as educational resources and information for financial assistance programs. Call 1-888-229-8379 Monday–Friday 8:30AM–8:00PM (ET). Visit HEMATOLOGYSUPPORTPRO.COM.
Is myPKfit for advice indicated for von Willebrand disease?
myPKFiT for ADVATE is not indicated for the treatment of von Willebrand disease. MyPKFiT for ADVATE should not be used for patients who have developed neutralizing antibody (inhibitor) to FVIII products.
Is myPKfit for advance RX?
myPKFiT for ADVATE is Rx only. For safe and proper use of the myPKFiT software, please refer to the complete instructions for use in the User Manual.
What is Advocate Health Care?
Consistent with Advocate Health Care's values of compassion and stewardship, it is Advocate's policy to provide financial assistance to patients in need. Advocate prides itself on assisting those individuals.
How to contact Advocate Medical Group?
For information about financial assistance for care received in an Advocate Medical Group provider office, call the Advocate Medical Group customer service department at 847-390-5900.
How to contact a financial advocate at a hospital?
Patients can locate a financial advocate by visiting the concierge desk at the hospital and requesting to speak with a financial advocate. For questions about the application process or to check the status of an application submitted, financial advocates are available to assist in person at the hospital or call 630-645-2400.
How to get a free paper copy of the Advocate application?
Additionally, if you would like to request a free paper copy of the application by mail , call 630-645-2400.
What is the phone number for Takeda?
To connect with a PAM, you can call HSC Monday through Friday, 8:30 AM to 8:00 PM ET, at 1-888-229-8379.
What is a PAM in Takeda?
Patient Access Managers (PAMs)* can help address complex coverage issues. They can also help you address potential access challenges with your prescribed Takeda treatment. To connect with a PAM, you can call HSC Monday through Friday, 8:30 AM to 8:00 PM ET, at 1-888-229-8379. 1-888-229-8379.
How to contact HSC?
HSC will let you know if you qualify. If you have questions, call us Monday through Friday, 8:30 AM to 8:00 PM ET, at 1-888-229-8379. 1-888-229-8379. You can also find out how to self-enroll in HSC here. *IMPORTANT NOTICE: The Hematology Support Center Copay Assistance Program (the Program) is not valid for prescriptions eligible to be reimbursed, ...
What is the phone number for a void insurance?
Void where use is prohibited by your insurance provider. If your insurance situation changes you must notify the Program immediately at 1-888-229-8379. 1- 888-229-8379. Coverage of certain administration charges will not apply for patients residing in states where it is prohibited by law.
Can I pay less for Takeda treatment?
How can I pay less for my prescribed Takeda treatment? If you have commercial insurance, you may be eligible for Takeda's HSC CoPay Assistance. If you are commercially insured and eligible, Takeda's HSC CoPay Assistance Program may cover 100% of eligible out-of-pocket costs related to your prescribed Take da hematology treatment for which there is ...
Does HSC offer copay assistance?
HSC offers copay assistance for eligible patients with commercial insurance.
Is Copayment Assistance transferable?
Copayment assistance under the Program is not transferable. The Program only applies in the United States, including Puerto Rico and other U.S. territories, and does not apply where prohibited by law, taxed, or restricted. This does not constitute health insurance.
Important Note
- The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug. ANTIHEMOPHILIC FACTOR, RECOMBINANT - IN…
Uses
- Antihemophilic factor is a protein in the blood necessary in forming clots to stop bleeding. Persons with hemophilia A have low levels of this protein leaving them susceptible to bleeding episodes. This medication is used to temporarily prevent or control bleeding episodes in patients with hemophilia A.
How to Use
- This medication is given by injection into a vein. The rate of injection depends upon patient response but is generally injected over 5 to 10 minutes. The powder and dissolving fluid should be warmed to room temperature before combining if they were refrigerated. After adding the dissolving fluid, swirl the vial gently to completely dissolve the powder. Do not use the mixed sol…
Side Effects
- This medication is generally well tolerated. Mild chills, nausea and irritation at the injection site may occur. In the unlikely event you have an allergic reaction to this drug, seek immediate medical attention. Symptoms of an allergic reaction include: rash, itching, swelling, dizziness, trouble breathing. If you notice other effects not listed a...
Precautions
- Tell your doctor your medical history, especially of: other illnesses, allergies (especially to animal proteins). You should check your heart rate before and during injection. The dose or rate of infusion may need to be changed if your heart rate is too fast. This drug should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. It is not know…
Drug Interactions
- Tell your doctor of all over-the-counter and prescription medications you may use. Do not start or stop any medicine without doctor or pharmacist approval.
Notes
- Blood tests will be done frequently to determine dosing and evaluate the effectiveness of this medication.
Missed Dose
- It is important that each dose be used as directed. If you miss a dose, contact your doctor to establish a new dosing schedule. Do not "double-up" the dose to catch up.
Storage
- Store the medication according to manufacturer's instructions. Check the expiration date on the label and properly discard any unused medication after that time.
Medical Alert
- Your condition can cause complications in a medical emergency. For enrollment information call MedicAlert at 1-800-854-1166 (USA), or 1-800-668-1507 (Canada).