Pain relief: Benzathine penicillin is sometimes given with a local anaesthetic to relieve discomfort during the injection. If you have allergies to local anaesthetics tell your doctor or nurse. Number of doses: Some people may need 2 doses, which is given as 1 injection into each buttock at the same visit.
Full Answer
How is benzathine penicillin given?
Injection site: Benzathine penicillin is given by injecting it into a large muscle in your buttock (bottom) in adults and older children, or in the thigh (infants and small children). This is called an intramuscular injection. Pain relief: Benzathine penicillin is sometimes given with a local anaesthetic to relieve discomfort during the injection.
What should I know before taking benzylpenicillin benzathine?
Benzylpenicillin benzathine should not be used in tissues with reduced perfusion. Before initiating therapy with benzylpenicillin benzathine, a careful investigation should be made concerning previous hypersensitivity reactions to penicillins, cephalosporins or other beta-lactam agents (see sections 4.3 and 4.8).
What is the composition of benzylpenicillin benzathine?
Benzylpenicillin benzathine 1.2 Million I.U. powder and solvent for suspension for injection 2. Qualitative and quantitative composition 1 vial of powder for suspension for injection contains 1.2 Million I.U., equivalent to approximately 918 mg benzylpenicillin benzathine, or approximately 720 mg benzylpenicillin.
Can lidocaine be used with benzylpenicillin benzathine?
Lidocaine has no effect on the pharmacokinetic profile of benzylpenicillin benzathine following intramuscular administration. Clinical practice guidelines recommend the reconstitution of benzylpenicillin benzathine with local anaesthetics, such as lidocaine, to reduce pain at the injection site.
What is benzathine penicillin?
Where to administer benzathine penicillin?
What is the group A streptococci?
Is benzathine penicillin a bactericidal antimicrobial?
Is benzathine penicillin a gram positive?
What is NCBI bookshelf?
Does penicillin harm the fetus?
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How do you administer benzathine penicillin?
How should this medicine be used? Penicillin G benzathine injection comes as a suspension (liquid) in a prefilled syringe to inject into the muscles of the buttocks or thigh by a doctor or nurse in a medical facility. Penicillin G benzathine injection may be given as a single dose.
How much does benzathine penicillin G cost?
About Bicillin L-A PENICILLIN G BENZATHINE is a penicillin antibiotic. It treats some infections caused by bacteria. It will not work for colds, the flu, or other viruses. The lowest GoodRx price for the most common version of Bicillin L-A is around $1,956.80, 33% off the average retail price of $2,928.20.
How do you use benzyl penicillin injection?
Benzylpenicillin 1000000IU Injection is injected deeply into the muscle, usually into the butt muscle, using a lot of fluid used to inject it.
Is Penicillin G benzathine painful?
Background. Intramuscular (IM) Penicillin G Benzathine (PGB) is the cornerstone of the treatment of primary syphilis [1], but its administration is associated with sharp pain at the site of the injection that sometimes may be of severe intensity.
How much is a penicillin shot without insurance?
The cost for penicillin g potassium injectable powder for injection (5,000,000 units) is around $54 for a supply of 10 powder for injection, depending on the pharmacy you visit....Injectable Powder For Injection.QuantityPer unitPrice1$54.36$54.36
How long does it take for penicillin to cure syphilis?
Syphilis can be treated with penicillin. The penicillin is given as a shot. If you had syphilis for less than one year, you only need to get one shot. If you had syphilis for more than one year, you need three shots—one shot a week for three weeks.
How painful is a penicillin shot?
The penicillin injections (long-acting benzathine penicillin G) are invariably painful because of the large volume that is injected, the viscosity and possibly the irritant nature of the solution. It is difficult to tell what impact this repeated painful procedure has on children.
Where do you inject benzathine penicillin?
It is given as a shot into one of your muscles, usually in the upper buttock or hip area.
How long does benzathine take to work?
Following intramuscular administration, benzylpenicillin benzathine is absorbed slowly and converted by hydrolysis to benzylpenicillin. Peak plasma levels are reached 24 hours (children) or 48 hours (adults) post-injection.
How do you feel after a penicillin shot?
Common side effects may include:nausea, vomiting, diarrhea;itching, sweating, allergic reaction;flushing (sudden warmth, redness, or tingly feeling);feeling anxious or nervous;headache, dizziness, drowsiness; or.pain, swelling, or bruising where an injection was given.
Does penicillin shot make you sleepy?
headache, dizziness, drowsiness; muscle or joint pain; or. pain, swelling, bruising, or a hard lump where an injection was given.
Does penicillin G make you sleepy?
Common side effects of penicillin G benzathine may include: feeling anxious, nervous, weak, or tired; headache, dizziness, drowsiness; muscle or joint pain; or.
How much does penicillin cost in America?
The cost for penicillin v potassium oral tablet 500 mg is around $12 for a supply of 6 tablets, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans.
How much is a unit of penicillin?
Penicillin is one of the few antibiotics that is still measured in terms of units rather than weight in milligrams or micrograms. One unit of penicillin represents the specific activity in 0.6 mcg of sodium penicillin. Thus 1 mg of penicillin sodium represents 1667 units of penicillin.
Can you buy bicillin?
Bicillin L-A is administered as a deep intramuscular injection by a healthcare provider at a hospital or clinic, so it is not purchased by the patient at a pharmacy.
What is a penicillin shot for?
Penicillin G injection is used to treat and prevent certain infections caused by bacteria. Penicillin G injection is in a class of medications called penicillins. It works by killing bacteria that cause infections. Antibiotics such as penicillin G injection will not work for colds, flu, or other viral infections.
Penicillin G benzathine Uses, Side Effects & Warnings - Drugs.com
Penicillin G benzathine side effects. Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).. Some side effects may occur if the medicine has been accidentally injected near a vein or nerve.
Penicillin G Benzathine Intramuscular: Uses, Side Effects ... - WebMD
Find patient medical information for penicillin G benzathine intramuscular on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.
Penicillin G Benzathine Dosage Guide - Drugs.com
Usual Adult Dose for Pharyngitis. 1.2 million units IM as a single dose Uses: For the treatment of mild to moderate upper respiratory tract infections (URTIs) due to susceptible group A streptococci (e.g., pharyngitis); for the treatment of URTIs (pharyngitis) due to group A streptococci (without bacteremia) Infectious Diseases Society of America (IDSA) and American Heart Association (AHA ...
Penicillin G Benzathine (Intramuscular Route) Description and Brand ...
Description and Brand Names. Drug information provided by: IBM Micromedex US Brand Name. Bicillin L-A; Descriptions. Penicillin G benzathine injection is used to treat bacterial infections (eg, mild to moderate infections of the upper respiratory tract, syphilis, yaws, bejel, pinta).
Benzathine Penicillin - Pediatric Oncall
Late (tertiary and neurosyphilis): 50000 IU/kg at 7-day intervals for 3 doses, max: 2.4 million Units/dose.
penicillin G benzathine (Rx) - Medscape
Medscape - Streptococcal infection dosing Bicillin LA, Permapen (penicillin G benzathine), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information.
Important Note
The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.
Uses
Penicillin G benzathine is an antibiotic used to treat a variety of bacterial infections.
How To Use
This drug is administered by a doctor or nurse and is injected into a large muscle. Antibiotics work best when the amount of medicine in your body is kept at a constant level. This is done by scheduling the doses at evenly spaced intervals. If more than one dose is required make sure you do not miss any doses.
Side Effects
This medication may cause mild diarrhea, stomach upset, nausea, vomiting or irritation at injection site during the first few days as your body adjusts to the medication. If these symptoms persist or worsen, inform your doctor.
Precautions
Before using this drug tell your doctor your medical history especially: kidney disease, stomach/intestine diseases, allergies to penicillins or other antibiotics. Tell your doctor if you are pregnant before using this drug. This drug is excreted into breast milk. Consult your doctor before breast-feeding.
Drug Interactions
Tell your doctor of all the medications you take (prescription and nonprescription) especially probenecid, birth control pills, tetracyclines, certain live vaccines or aminoglycosides (e.g., gentamicin). This drug may interfere with the effectiveness of birth control pills. Discuss using other methods of birth control with your doctor.
Overdose
If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include nausea, vomiting, and diarrhea.
What is the best way to reduce pain from benzylpenicillin?
Clinical practice guidelines recommend the reconstitution of benzylpenicillin benzathine with local anaesthetics, such as lidocaine, to reduce pain at the injection site.
How much benzylpenicillin is in a vial?
1 vial of powder for suspension for injection contains 1.2 Million I.U., equivalent to approximately 918 mg benzylpenicillin benzathine, or approximately 720 mg benzylpenicillin.
How many I.U. for streptococcal?
This is generally ensured with a single injection of 0.6 Million I.U., 1.2 Million I.U. or 2.4 Million I.U..
Can you inject a syringe into tissue with reduced perfusion?
The injection must not be administered into tissue with reduced perfusion (see section 4.4).
Can benzylpenicillin be used in tissues with reduced perfusion?
Benzylpenicillin benzathine should not be used in tissues with reduced perfusion.
What is benzathine penicillin?
Benzathine penicillin (also called Bicillin LA) is an antibiotic used to treat bacterial infections such as rheumatic fever and syphilis .
How is benzathine penicillin given?
A doctor or a nurse will give you this medicine. Tell them if you have ever had an allergic reaction to penicillin or any other medicine.
What are the side effects of benzathine penicillin?
Like all medicines, benzathine penicillin can cause side effects, although not everyone gets them. Often side effects improve as your body gets used to the new medicine.
What is benzylpenicillin used for?
Benzathine benzylpenicillin is predominantly used in the treatment and secondary prevention of acute rheumatic fever/rheumatic heart disease and in the treatment of infections susceptible to prolonged, low concentrations of benzylpenicillin (e.g. early or latent syphilis).(1)
Is benzathine benzylpenicillin delayed?
Excretion of benzathine benzylpenicillin is delayed in renal impairment and it should be used with caution in patients requiring repeat dosing. There are no recommendations regarding dose reduction in renal impairment.(2, 5)
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Simply print this page and bring to your local pharmacy. If you have any issues please have the pharmacist call 1-800-577-6484.
What is bicillin L-A?
Bicillin L-A (penicillin G benzathine injectable suspension) is available for deep intramuscular injection. Penicillin G benzathine is prepared by the reaction of dibenzylethylene diamine with two molecules of...
How much sodium is in Bicillin L-A?
Bicillin L-A contains approximately 0.11 mEq of sodium per 600,000 units of penicillin G (approximately 2.59 mg of sodium per 600,000 units of penicillin G). Diarrhea is a common problem caused by antibiotics which usually ends when the antibiotic is discontinued.
How does penicillin G work?
Penicillin G penetrates into all other tissues and the spinal fluid to a lesser degree. With normal kidney function, the drug is excreted rapidly by tubular excretion. In neonates and young infants and in individuals with impaired kidney function, excretion is considerably delayed. Microbiology.
What is Pfizer Rxpathways?
Pfizer RxPathways connects eligible patients to a range of assistance programs that offer insurance support, co-pay help, and medicines for free or at a savings. Patients and physicians can contact RxPathways at (866) 706-2400 or visit the website for more information on these programs www.pfizerrxpathways.com.
Is penicillin G benzathine effective for yaws?
Medical Conditions in which Penicillin G Benzathine Therapy is indicated as Prophylaxis: Rheumatic fever and/or chorea —Prophylaxis with penicillin G benzathine has proven effective in preventing recurrence of these conditions.
Can penicillin be used during pregnancy?
Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Soluble penicillin G is excreted in breast milk. Caution should be exercised when penicillin G benzathine is administered to a nursing woman.
Is penicillin G resistant to Streptococcus pyogenes?
Resistance to penicillin G has not been reported in Streptococcus pyogenes. Antimicrobial Activity. Penicillin has been shown to be active against most isolates of the following bacteria, both in vitro and in clinical infections as described in the INDICATIONS AND USAGE section. Gram-positive bacteria.
What is benzathine penicillin?
Benzathine penicillin is formulated from two penicillin G molecules reacting with diphenylethylene diamine. It is active against Gram-positive bacteria, including beta-hemolytic streptococci (groups A, B, C, G, H, L, and M) as well as Treponema pallidumand T. carateum. There has been no reported resistance to benzathine penicillin in Streptococcus pyogenes. [1][2][3][4][5]
Where to administer benzathine penicillin?
Benzathine penicillin is available as an injectable suspension that is administered intramuscularly, not intravenous, intra-arterial, or subcutaneous. The medication should be warmed to room temperature before administration to lessen the pain associated with the injection, and it should not be given near an artery or nerve. In adults, administer the injection to the upper outer quadrant of the buttocks. In children less than two years old, administer the injection to the mid-lateral muscle of the thigh, not the gluteal region, and rotate the injection site on repeat doses.
What is the group A streptococci?
Upper respiratory infection, group A streptococci that are mild to moderate and are susceptible to low, prolonged concentrations of benzathine penicillin (1.2 million units intramuscularly [IM] x 1)
Is benzathine penicillin a bactericidal antimicrobial?
Benzathine penicillin is in a class of beta-lactam antimicrobials. Beta-lactams are bactericidal antimicrobials. This type of antimicrobial inhibits the biosynthesis of the cell wall peptidoglycan during the stage of active multiplication. It inhibits bacterial peptidoglycan transpeptidase. This results in an osmotically unstable cell wall, leading to cell wall lysis, subsequent destruction of the bacterial cell, and bacterial cellular death.
Is benzathine penicillin a gram positive?
Benzathine penicillin is formulated from two penicillin G molecules reacting with diphenylethylene diamine. It is active against gram-positive bacteria, including beta-hemolytic streptococci (groups A, B, C, G, H, L, and M) as well as Treponema pallidum and T. carateum. There has been no reported resistance to benzathine penicillin in Streptococcus pyogenes. This activity outlines the indications, mechanism of action, administration, adverse effects, and contraindications when using benzathine penicillin.
What is NCBI bookshelf?
NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.
Does penicillin harm the fetus?
Reproduction studies performed in mice, rats, and rabbits have revealed no evidence of harm to the fetus. Human experience with penicillin during pregnancy has not shown to have any adverse effects on the fetus. However, studies with pregnant women are inadequate or not well-controlled and cannot conclusively report harmful effects of penicillin medications on the fetus.
Important Note
- The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug. PENICILLIN G BENZATHINE - INJECTION (pen-ih …
How to Use
- This drug is administered by a doctor or nurse and is injected into a large muscle. Antibiotics work best when the amount of medicine in your body is kept at a constant level. This is done by scheduling the doses at evenly spaced intervals. If more than one dose is required make sure you do not miss any doses. The number of doses depend on the type of infection. Continue to receiv…
Side Effects
- This medication may cause mild diarrhea, stomach upset, nausea, vomiting or irritation at injection site during the first few days as your body adjusts to the medication. If these symptoms persist or worsen, inform your doctor. Notify your doctor immediately if you develop: watery diarrhea, stomach cramps, fever, unusual bleeding or bruising, yello...
Precautions
- Before using this drug tell your doctor your medical history especially: kidney disease, stomach/intestine diseases, allergies to penicillins or other antibiotics. Tell your doctor if you are pregnant before using this drug. This drug is excreted into breast milk. Consult your doctor before breast-feeding.
Drug Interactions
- Tell your doctor of all the medications you take (prescription and nonprescription) especially probenecid, birth control pills, tetracyclines, certain live vaccines or aminoglycosides (e.g., gentamicin). This drug may interfere with the effectiveness of birth control pills. Discuss using other methods of birth control with your doctor. Do not start or stop any medicine without docto…
Overdose
- If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include nausea, vomiting, and diarrhea.