What is dabrafenib?
Skip to Dabrafenib price list. DABRAFENIB is a medicine that targets proteins in cancer cells and stops the cancer cells from growing. It is used to treat melanoma, non- small cell lung cancer, and thyroid cancer. The lowest GoodRx price for the most common version of Tafinlar is around $11,909.46, 39% off the average retail price of $19,596.34.
What are the recommended doses for dabrafenib and trametinib?
The recommended dabrafenib dose in adult patients is 150 mg (two 75 mg capsules) orally twice daily in combination with trametinib 2 mg orally once daily. The recommended doses for dabrafenib and trametinib in pediatric patients are based on body weight.
Does dabrafenib work in advanced non-small-cell lung cancer?
Dabrafenib is an oral selective inhibitor of BRAF kinase. We did a trial to assess the clinical activity of dabrafenib in patients with advanced non-small-cell lung cancer (NSCLC) positive for the BRAF(V600E) mutation.
Are there any patient assistance programs for Tafinlar?
Patient Assistance Programs for Tafinlar. Patient assistance programs (PAPs) are usually sponsored by pharmaceutical companies and provide free or discounted medicines to low income or uninsured and under-insured people who meet specific guidelines. Eligibility requirements vary for each program.
What is the income requirements for Novartis patient assistance?
To be eligible for NPAF assistance, you must:Household SizeAnnual Household Income Threshold2 People< USD 100 0003 People< USD 125 0004 People< USD 150 000> 5 PeopleAdd USD 25 000 for each additional person1 more row
What is dabrafenib used for?
Dabrafenib is a type of targeted cancer drug called a cancer growth blocker. You might have it as a treatment for: melanoma skin cancer that can't be removed with surgery (unresectable) or has spread to another area of the body (metastatic or advanced melanoma)
What is the cost of Tafinlar?
Learn more about this drug here . This is a brand name drug and a generic may be available. The average cost for 120 Capsule(s), 75mg each, is $14,986.80. You can buy Tafinlar at the discounted price of $12,299.26 by using the WebMDRx coupon, a savings of 18%.
Can dabrafenib cure melanoma?
Through clinical trials, cancer researchers have found that combining dabrafenib and trametinib can treat advanced melanoma more effectively than either medication on its own. The combination also produces less serious side effects than the single drugs used alone.
Is dabrafenib immunotherapy or chemotherapy?
Dabrafenib is the generic name for the trade name chemotherapy drug Tafinlar. In some cases, health care professionals may use the trade name Tafinlar when referring to the generic drug dabrafenib.
How do you take dabrafenib?
You usually take dabrafenib twice a day, with about 12 hours between each dose. If you forget to take it and there are more than 6 hours until your next dose, take it as soon as you remember. If there are fewer than 6 hours until the next dose, do not take it. Just take the next dose at the usual time.
How long does Tafinlar stay in your system?
Your health care provider should continue to check your skin for 6 months after you stop taking TAFINLAR and MEKINIST.
What does Tafinlar treat?
TAFINLAR and MEKINIST are prescription medicines that can be used in combination to treat a type of lung cancer called non-small cell lung cancer (NSCLC) that has spread to other parts of the body (metastatic NSCLC), and that has a certain type of abnormal “BRAF V600E” gene.
Is Tafinlar chemotherapy?
Generic name: Dabrafenib Tafinlar is the trade name for the generic chemotherapy drug dabrafenib. In some cases, health care professionals may use the generic name dabrafenib when referring to the trade name Tafinlar. Drug type: Tafinlar is a targeted therapy.
Is BRAF positive melanoma more aggressive?
Even though BRAF-positive melanomas can be more aggressive, many factors can affect the risk of your melanoma coming back.
How long does BRAF treatment last?
In the BRAF-mutated subgroup, a 5-year landmark OS and PFS rate of 46% and 22%, respectively, was observed. The median OS was 45.5 months (95% CI 26.4–not reached) and the median PFS was 5.6 months (95% CI 2.8–9.5). A possible explanation for the better median OS could be due to subsequent therapies, e.g. cTT.
How successful is immunotherapy for melanoma?
In a small study published in the Journal of Clinical Oncology, scientists reported a 3-year overall survival rate of 63 percent among 94 patients treated with this combination of drugs. All of the patients had stage 3 or stage 4 melanoma that couldn't be removed with surgery.
Is dabrafenib a targeted therapy?
Dabrafenib and trametinib are targeted therapies: treatments that attack cancer cells with a specific gene or protein change. Dabrafenib targets cells with certain BRAF mutations and prevents the altered BRAF protein from sending growth signals.
What is dabrafenib and trametinib used for?
Dabrafenib and trametinib are types of targeted cancer drugs called cancer growth blockers. They are used together to treat: melanoma skin cancer that can't be removed with surgery (unresectable) or has spread to other areas of the body (metastatic or advanced melanoma)
Is it best to take Tafinlar before or after meal?
Since TAFINLAR + MEKINIST is an oral melanoma treatment, you'll take it by mouth—at least 1 hour before or at least 2 hours after eating. Do not open, crush, or break TAFINLAR capsules.
Can dabrafenib cause bleeding?
This medicine may cause hemorrhage (severe bleeding) in the stomach and bowel areas or in the brain. Call your doctor right away if you have any unusual or unexplained bleeding. Dabrafenib may cause heart problems.
What is Tafinlar used for?
Tafinlar (dabrafenib) is a member of the multikinase inhibitors drug class and is commonly used for Melanoma - Metastatic, Non-Small Cell Lung Cancer, and Thyroid Cancer.
How much does a free drug card save?
The free Drugs.com Discount Card works like a coupon and can save you up to 80% or more off the cost of prescription medicines, over-the-counter drugs and pet prescriptions.
Is Tafinlar a generic?
Tafinlar is available as a brand name drug only, a generic version is not yet available. For more information, read about generic Tafinlar availability . This Tafinlar price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies.
What is a tafenar?
TAFINLAR ® (dabrafenib) capsules, in combination with MEKINIST ® (trametinib) tablets , is indicated for the treatment of patients with metastatic non-small cell lung cancer (NSCLC) with BRAF V600E mutation as detected by an FDA-approved test.
What is TAFINLAR used for?
Indication TAFINLAR, in combination with MEKINIST, is indicated for the treatment of patients with metastatic non-small cell lung cancer (NSCLC) with BRAF V600E mutation as detected by an FDA-approved test.
How to assess LVEF?
Assess LVEF by echocardiogram or multigated acquisition (MUGA) scan before initiation of the combination, 1 month after initiation, and then at 2- to 3-month intervals while on treatment. Withhold TAFINLAR for symptomatic cardiomyopathy or asymptomatic left ventricular dysfunction of >20% from baseline that is below institutional LLN. Resume TAFINLAR at the same dose level upon recovery of cardiac function to at least the institutional LLN for LVEF and absolute decrease ≤10% compared to baseline. For an asymptomatic absolute decrease in LVEF of 10% or greater from baseline that is below the LLN, withhold MEKINIST for up to 4 weeks. If improved to normal LVEF value, resume at a lower dose. If no improvement to normal LVEF value within 4 weeks, permanently discontinue MEKINIST. For symptomatic cardiomyopathy or an absolute decrease in LVEF of >20% from baseline that is below LLN, permanently discontinue MEKINIST.
How long is the TAFINLAR trial?
The TAFINLAR + MEKINIST 30-Day Free Trial helps eligible patients start therapy quickly. A 30-day supply is shipped directly to a patient’s home or another convenient location.
How to contact Novartis oncology?
Encourage your patients to find out if they are eligible to enroll in the Novartis Oncology Universal Co-pay Program by visiting CoPay.NovartisOncology.com or calling 1-877-577-7756.
Does BRAF promote tumors?
Tumor Promotion in BRAF Wild-type Tumors. In vitro experiments have demonstrated paradoxical activation of mitogen-activated protein kinase (MAPK) signaling and increased cell proliferation in BRAF wild-type cells that are exposed to BRAF inhibitors. Confirm evidence of BRAF V600E or V600K mutation status prior to initiation of therapy.
Is tafinar safe for wild type BRAF?
Limitation of Use: TAFINLAR is not indicated for the treatment of patients with wild-type BRAF N SCLC.
Patient Website
Our patient website is a helpful resource for patients taking TAFINLAR ® (dabrafenib) capsules + MEKINIST ® (trametinib) tablets, providing the Medication Guide, information on co-pay assistance, and downloadable support materials. Visit the site at us.tafinlarmekinist.com.
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TAFINLAR ® (dabrafenib) capsules, in combination with MEKINIST ® (trametinib) tablets, is indicated for the treatment of patients with unresectable or metastatic melanoma with BRAF V600E or V600K mutations as detected by an FDA-approved test.
