For eligible sickle cell disease (SCD) patients covered by commercial insurance, biopharmaceutical company Emmaus Life Sciences will offer financial assistance to those who need help covering their monthly Endari co-payments. Emmaus is the developer of Endari (L-glutamine oral powder, and called Xyndari in Europe).
Full Answer
What is Emmaus disease?
Emmaus Life Sciences is in clinical development of a patented experimental treatment approach of an orally administered pharmaceutical grade L-glutamine that may be determined to treat some of the symptoms of sickle cell disease (SCD). SCD is an inherited blood disorder that affects red blood cells.
What company makes Endari?
About Emmaus Life Sciences, Inc. Its lead product, Endari, demonstrated positive clinical results in the completed Phase 3 clinical trial for sickle cell anemia and sickle ß0-thalassemia and has received FDA approval.
When was Endari approved?
Endari® was approved by the FDA in July 2017 for the treatment of sickle cell disease in adult and pediatric patients five years of age and older and sales began in 2018.
What is Endari used for?
ENDARI is indicated to reduce the acute complications of sickle cell disease in adults and children 5 years of age and older.
Is Endari a specialty drug?
ENDARI is a specialty medication and may not be available at your usual pharmacy. Your physician will typically send your prescription to a specialty pharmacy that will fill your ENDARI prescription.
What drug class is Endari?
Endari (L-glutamine oral powder) is an amino acid indicated to reduce the acute complications of sickle cell disease in adult and pediatric patients 5 years of age and older.
How is Endari administered?
Administer Endari orally, twice per day at the dose based on body weight according to Table 1. Mix Endari immediately before ingestion with 8 oz. (240 mL) of cold or room temperature beverage, such as water, milk or apple juice, or 4 oz. to 6 oz. of food such as applesauce or yogurt.
What are the side effects of L-glutamine?
L-glutamine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:constipation.nausea.headache.abdominal pain.cough.back, leg, feet, hands, or arm pain.
What drug class is Endari?
Endari (L-glutamine oral powder) is an amino acid indicated to reduce the acute complications of sickle cell disease in adult and pediatric patients 5 years of age and older.
How is Endari administered?
Administer Endari orally, twice per day at the dose based on body weight according to Table 1. Mix Endari immediately before ingestion with 8 oz. (240 mL) of cold or room temperature beverage, such as water, milk or apple juice, or 4 oz. to 6 oz. of food such as applesauce or yogurt.
How does L glutamine help sickle cell?
L-glutamine is a naturally occurring amino acid. Although the mechanism of action for L-glutamine is not fully understood, its use in sickle cell disease is based on its antioxidant activity. It increases NAD redox potential in sickle red blood cells through increasing the availability of reduced glutathione.
How does hydroxyurea treat sickle cell?
Hydroxyurea makes your red blood cells bigger. It helps them stay rounder and more flexible — and makes them less likely to turn into a sickle shape. The medicine does this by increasing a special kind of hemoglobin called hemoglobin F.
INDICATION
ENDARI is indicated to reduce the acute complications of sickle cell disease in adults and children 5 years of age and older.
IMPORTANT SAFETY INFORMATION
The most common side effects in clinical studies were constipation, nausea, headache, pain in the stomach area, cough, pain in hands or feet, back pain, and chest pain.
INDICATION
ENDARI is indicated to reduce the acute complications of sickle cell disease in adults and children 5 years of age and older.
IMPORTANT SAFETY INFORMATION
The most common side effects in clinical studies were constipation, nausea, headache, pain in the stomach area, cough, pain in hands or feet, back pain, and chest pain.
