What is Eribulin used for?
Eribulin is a chemotherapy drug given to alleviate symptoms of metastatic breast cancer and extend life. It is not commonly given with the goal of cure. Eribulin intravenous (I.V.) push over 2 to 5 minutes on Day 1 and Day 8 of each treatment cycle
What is the efficacy of eribulin in metastatic breast cancer?
A study completed in 2016 that was sponsored by Eisai, the manufacturer of Halaven (the brand name of eribulin), reported that patients with metastatic breast cancer treated with eribulin had significantly improved overall survival (median 13.1 months) compared with patients given other standard treatments (median 10.6 months).
What is Eribulin (Halaven)?
On January 28, 2016, the U. S. Food and Drug Administration approved eribulin (HALAVEN injection, Eisai Co., Ltd.) for the treatment of patients with unresectable or metastatic liposarcoma who have received a prior anthracycline-containing regimen.
What is the recommended dose and schedule for Eribulin?
The recommended dose and schedule for eribulin is 1.4 mg/m2 on Days 1 and 8 of a 21-day cycle. The application was granted a Priority Review. The development program for eribulin for this indication received orphan drug designation.
How long can you stay on HALAVEN?
Although some women lived longer and some women did not live as long, women who were treated with HALAVEN lived an average of 13.2 months compared with women treated with other chemotherapy or hormone therapy, who lived an average of 10.6 months.
Will I lose my hair on Eribulin?
Some or all of your hair may fall out around 3 to 4 weeks after treatment starts. You may lose hair on your head, as well as facial and body hair. You may want to buy a wig before hair loss begins. Hair may grow back during treatment.
Does Eribulin cause neuropathy?
Among patients in the eribulin group, a performance status (ECOG PS) of 2 was correlated with peripheral sensory neuropathy (p = 0.015), and accumulated eribulin dose (≥ 10 mg/m2) was associated with all neuropathy and peripheral sensory neuropathy (p = 0.003 and p = 0.007, respectively).
How often is Eribulin given?
This medicine is given through a needle placed in one of your veins. This medicine is usually given on Day 1 and Day 8 of a 21-day cycle of treatment. This 2-day treatment is given again every 21 days until your body responds to the medicine or you and your doctor decide to stop the treatment.
How long does eribulin work for?
A cycle of eribulin lasts 21 days, with treatment given on days one and eight of the cycle.
How effective is eribulin?
Eribulin was third-line therapy for 78.0% of patients, and fourth-line or later for the remainder. ORR was 54.4%, median PFS was 6.1 months (95% CI: 5.8, 6.6), and median OS was 10.6 months (95% CI 9.9, 11.7) in all patients.
Can eribulin cause chest pain?
chest pain, severe dizziness, fast or pounding heartbeats; numbness, tingling, or burning pain in your hands or feet; pain or burning when you urinate; low calcium level--muscle spasms or contractions, numbness or tingly feeling (around your mouth, or in your fingers and toes);
What drug class is eribulin?
Eribulin is in a class of anticancer medications called microtubule dynamics inhibitors. It works by stopping the growth and spread of cancer cells.
Does eribulin cause stomach pain?
What safety information do I need to know about HALAVEN? The most common side effects of HALAVEN in adults with liposarcoma include tiredness, nausea, hair loss (alopecia), constipation, stomach pain, and fever.
What type of chemotherapy is eribulin?
Eribulin works by stopping the cancer cells from separating into 2 new cells. So it blocks the growth of the cancer. It is a type of drug called a microtubule inhibitor.
Is eribulin an immunotherapy?
As monotherapies, eribulin (chemotherapy) and pembrolizumab (immunotherapy) have shown promise for patients with metastatic triple-negative breast cancer (mTNBC).
Does eribulin cross the blood brain barrier?
Eribulin does not cross the healthy blood–brain barrier (BBB), but could have the potential to do so after cranial radiation therapy. Capecitabine may cross the BBB and has demonstrated activity in BCBM.
Will I lose my hair on halaven?
The most common side effects of HALAVEN in adults with breast cancer include low white blood cell count (neutropenia), low red blood cell count (anemia), weakness or tiredness, hair loss (alopecia), nausea, and constipation.
What do the Chinese do for hair loss?
Regular acupuncture can stimulate hair regrowth by encouraging the flow of qi and blood to the scalp. Chinese herbs have been used for hundreds of years to stop hair loss. One herb in particular is known for its ability to treat alopecia.
What causes hair loss Chinese medicine?
Our spleen is responsible for digestion and nutrient absorption, while the liver is responsible for storing and circulating blood. A compromised liver and/or spleen system often results in blood deficiency or blood stagnation. This affects the nutrient supply to our hair and can eventually result in hair loss.
What is the best herb for hair growth?
Herbs for Natural Hair: 10 of the Best Herbs for Hair GrowthAloe Vera. ... Lavender. ... Hibiscus. ... Rose Petals. ... Ginseng.The popular Chinese herb is a natural herbal remedy for a lot of health problems including hair loss. ... Green Tea is very popular natural herb as it has many health benefits. ... Rosemary.More items...•
How long does Halaven last?
Advise males with female partners of reproductive potential to use effective contraception during treatment with HALAVEN ® and for 3.5 months following the final dose.
What is the HALAVEN patient assistance number?
Healthcare providers can call the HALAVEN ® Patient Assistance Program at 1-866-61-EISAI (1-866-613-4724) to determine eligibility.
Can Halaven cause fetal harm?
Withhold HALAVEN ® in patients who experience Grade 3 or 4 peripheral neuropathy until resolution to Grade 2 or less. Embryo-Fetal Toxicity: HALAVEN ® can cause fetal harm when administered to a pregnant woman.
Does Eis Ai cover claims?
Eis ai cannot guarantee payment of any claim. Coding, coverage, and reimbursement may vary significantly by payor, plan, patient, and setting of care. Actual coverage and reimbursement decisions are made by individual payors following the receipt of claims.
Who is responsible for disclosing the value of a prescription card?
Patients and pharmacies are responsible for disclosing to insurance carriers the redemption and value of the card and complying with any other conditions imposed by insurance carriers on third-party payors. The value of this card is not contingent on any prior or future purchases.
Where is eribulin given?
Eribulin is usually given in an outpatient infusion center, allowing the person to go home afterwards.
How to minimize the cost of cancer treatment?
One way to minimize costs associated with cancer treatment is to ask your doctor what types of tests they are ordering. If they are expensive, ask if they are covered by insurance before getting the test. If you are concerned about costs, you can also ask your doctor to only order tests that are absolutely necessary and to minimize the ones that are unlikely to change the plan. Some anti-cancer and supportive care medications are now available as generic formulations and preferred by insurance companies. If these medications are still expensive, ask your doctor to work with your pharmacist to find cheaper alternatives. Some drugs have co-pay cards or patient assistance programs that can help reduce the cost.
How long does it take to push eribulin?
Eribulin intravenous (I.V.) push over 2 to 5 minutes on Day 1 and Day 8 of each treatment cycle
What is the purpose of eribulin?
Eribulin is designed to stop cancer cells from dividing and cause them to die. Eribulin is a chemotherapy drug given to alleviate symptoms of metastatic breast cancer and extend life. It is not commonly given with the goal of cure.
Why did 10% of patients discontinue eribulin?
In this study, 10% of patients discontinued eribulin due to unacceptable side effects.
What is clinical trial?
A clinical trial is a type of study in which people are assigned to groups that either receive a new treatment intervention or standard treatment. In clinical trials with patients with cancer, it is sometimes unethical to give no treatment or a placebo. The type of treatment received by the patient is determined by the study protocol. Ask your doctor if they have any clinical trials that are enrolling patients or know if any at treatment centers nearby. You may also visit the website clinicaltrials.gov to see what clinical trials might be available for all cancer types and where these clinical trial medications are being offered.
What are some resources to learn about cancer?
There are many reputable online resources to learn more about specific types of cancer, such as the American Cancer Society. Once a final diagnosis is made by your doctor, they can share this information with you and point you to other resources they know as well.
When was eribulin approved?
Eribulin. On January 28, 2016, the U. S. Food and Drug Administration approved eribulin (HALAVEN injection, Eisai Co., Ltd.) for the treatment of patients with unresectable or metastatic liposarcoma who have received a prior anthracycline-containing regimen.
How to report adverse events to FDA?
Healthcare professionals should report all serious adverse events suspected to be associated with the use of any medicine and device to FDA’s MedWatch Reporting System by completing a form online at http://www.fda.gov/medwatch/report.htm, by faxing (1-800-FDA-0178) or mailing the postage-paid address form provided online, or by telephone (1-800-FDA-1088).
Is eribulin an orphan drug?
The application was granted a Priority Review. The development program for eribulin for this indication received orphan drug designation. A description of the expedited programs is in the Guidance for Industry: Expedited Programs for Serious Conditions-Drugs and Biologics, available at: http://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm358301.pdf
What is eribulin?
Eribulin mesylate is an anticancer chemotherapy drug used to treat metastatic breast cancer (breast cancer that has spread to other parts of the body) that has already been treated with at least two other forms of chemotherapy, including an anthracycline and a taxane.
How much does eribulin cost?
As of February 2020, the average eribulin cost for six vials of 1 mg2/mL ranged from $6,973.72 to $7,230.10.
How many days does eribulin take?
Eribulin is normally given on days 1 and 8 of a 21-day cycle. The amount of eribulin administered and the number of cycles a patient receives is dependent on individual factors, including overall health status and medical history, height and weight, and type of cancer.
How to report eribulin side effects?
Consult a doctor for medical advice about side effects. To report eribulin side effects to the FDA, visit www.fda.gov/medwatch.
What is the role of eribulin in cancer?
Eribulin disrupts the activity of microtubules within cells. Microtubules are essential for cell growth and division and by interfering with their activity, eribulin stops the reproduction cycle of cells, inhibiting the growth and spread of the cancer cells. (1, 2, 3)
What causes numbness in the arms and legs?
peripheral neuropathy (damage to peripheral nerves that can cause numbness, burning, or tingling in the arms, legs, hands, or feet) pale skin. shortness of breath. irregular heartbeat. View the eribulin side effects section for a more complete list of possible eribulin side effects.
How long did Halaven work on my liver?
From the community: “Halaven worked on my bone and liver mets for 14 months before we noted a slight bone progression…” - Inspire member
Overview
In general, Medicare prescription drug plans (Part D) do not cover this drug. Be sure to contact your specific plan to verify coverage information. A limited set of drugs administered in a doctor's office or hospital outpatient setting may be covered under Medical Insurance (Part B).
Ways to Save on Eribulin
Here are some ways that may lower the cost of your Halaven prescription.
