Full Answer
What is ibrutinib used to treat?
Imbruvica (ibrutinib) is a member of the multikinase inhibitors drug class and is commonly used for Chronic Lymphocytic Leukemia, Graft-versus-host disease, Lymphoma, and others.
What is the Imbruvica® by Your Side patient support program?
When you have support, such as help understanding your insurance coverage and potential ways to pay for IMBRUVICA®, you may feel more confident during treatment. The IMBRUVICA® By Your Side patient support program is here to help answer some of your questions about the financial aspects of taking IMBRUVICA®.
How should I take Imbruvica® (ibuprofen)?
Take IMBRUVICA® exactly as your healthcare provider tells you to take it. Take IMBRUVICA® 1 time a day at about the same time each day. IMBRUVICA® comes as capsules, tablets, and oral suspension. Swallow IMBRUVICA® capsules or tablets whole with a glass of water. Do not open, break, or chew IMBRUVICA® capsules.
How much does it cost to get Imbruvica®?
If you have commercial insurance, you could get IMBRUVICA ® for as little as *Eligible patients may pay as little as $0 per prescription of IMBRUVICA®. Rules and maximum limits apply. Patients currently using the IMBRUVICA® Copay Card are not eligible for retroactive billing or reimbursement of previous copays.
How long can you survive ibrutinib?
The average duration of Imbruvica therapy in clinical trials has been around 41 months (range, 2–51 months). In people who have stopped Imbruvica, the average survival after treatment discontinuation was 8 months.
What tier is ibrutinib?
Medicare prescription drug plans typically list Imbruvica on Tier 5 of their formulary. Generally, the higher the tier, the more you have to pay for the medication.
How long is a cycle of ibrutinib?
Each study cycle is 28 days. If you are found to be eligible to take part in this study, you will take ibrutinib capsules by mouth every day for 3 cycles. Each dose of ibrutinib should be taken at about the same time, either with or without food.
Can you drink coffee with Imbruvica?
Drink fluids such as water, decaffeinated tea, and clear broth. Eat small meals often, and avoid very hot or spicy foods. Avoid greasy foods, bran, raw fruits and vegetables, and caffeine. Avoid alcohol and drinks with caffeine.
Is there a generic brand for Imbruvica?
No. There is currently no therapeutically equivalent version of Imbruvica available in the United States. Note: Fraudulent online pharmacies may attempt to sell an illegal generic version of Imbruvica. These medications may be counterfeit and potentially unsafe.
What does Tier 3 drug coverage mean?
Level or Tier 1: Low-cost generic and brand-name drugs. Level or Tier 2: Higher-cost generic and brand-name drugs. Level or Tier 3: High-cost, mostly brand-name drugs that may have generic or brand-name alternatives in Levels 1 or 2.
How long can you live with Stage 4 CLL?
Median survivalStaging systemStageMedian survival1 and 27 years3 and 41.5 yearsBinetAMore than 10 yearsB5–7 years2 more rows
What happens when ibrutinib stops working?
Stopping ibrutinib can result in a disease flare-up in patients with chronic lymphocytic leukemia (CLL). A 2020 study in The Oncologist found that approximately 25% of ibrutinib patients with a median interruption period of 8 days experienced a flare or rapid CLL progression.
What are the long term effects of taking Imbruvica?
But certain side effects from Imbruvica may last longer. For example, it's possible to develop cancers as a side effect of Imbruvica, such as skin cancer. And these cancers may require long-term treatment. You may also have heart problems, such as abnormal heart rhythm, after taking Imbruvica.
Can Imbruvica cause memory loss?
It may cause disability or can be deadly. Tell your doctor right away if you have signs like confusion, memory problems, low mood (depression), change in the way you act, change in strength on 1 side is greater than the other, trouble speaking or thinking, change in balance, or change in eyesight.
What is the best time of the day to take Imbruvica?
Imbruvica should be taken at approximately the same time each day with a glass of water. The capsules should be swallowed whole, do not break open, chew, or crush. If you miss a dose of Imbruvica, take the missed dose as soon as possible on the same day.
What is the success rate of Imbruvica?
Imbruvica + Rituxan as Initial Therapy After 4 years of follow up 89% of newly diagnosed CLL patients treated with Imbruvica survived without leukemia progression compared to 71% of FCR treated patients. More importantly, 99% of Imbruvica treated patients were alive compared to 91% of FCR treated patients.
What drug class is ibrutinib?
Ibrutinib is in a class of medications called kinase inhibitors. It works by blocking the action of the abnormal protein that signals cancer cells to multiply.
When is ibrutinib going generic?
In a recent SEC filing, AbbVie said that “no generic entry for any Imbruvica product is expected prior to March 30, 2032,” thanks to prior settlements with generic makers.
How effective is ibrutinib for CLL?
In a phase 1b–2 study of ibrutinib monotherapy, with a median follow-up of 5 years, the overall response rate was 87% among patients with previously untreated CLL and 89% among those with relapsed or refractory disease.
Is ibrutinib a chemotherapy drug?
Ibrutinib is not a chemotherapy drug but one of what are termed "targeted therapies." Targeted therapy is the result of years of research dedicated to understanding the differences between cancer cells and normal cells.
What is JJPAF in healthcare?
The Johnson & Johnson Patient Assistance Foundation, Inc. (JJPAF) is an independent, nonprofit organization that is committed to helping eligible patients without insurance coverage receive prescription products donated by Johnson & Johnson operating companies. To see if you might qualify for assistance, please contact a JJPAF program specialist at 800-652-6227 (Monday – Friday, 9:00 AM to 6:00 PM ET) or visit the foundation website at JJPAF.org.
Does IMBRUVICA have insurance?
You may have insurance coverage through the federal government or the state where you live. Common plans include Medicare, Medicare Part D, Medicaid, VA, and TRICARE. If you have a government insurance plan, potential financial support for IMBRUVICA® may be available through an independent foundation.
How much does Imbruvica cost?
The cost for Imbruvica oral capsule 140 mg is around $15,586 for a supply of 90 capsules, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans. A generic version of Imbruvica has been approved by the FDA.
What is Imbruvica used for?
Imbruvica (ibrutinib) is a member of the BTK inhibitors drug class and is commonly used for Chronic Lymphocytic Leukemia, Graft-versus-host disease, Lymphoma, and others.
How much does it cost to get imbruvia?
If you are eligible and have commercial insurance, you may pay as little as $10 per prescription* for IMBRUVICA®
What is the number to call to stop using imbruvia?
Individuals who become enrolled in a federal or state subsidized healthcare program that covers prescription drugs at any point after enrolling in the IMBRUVICA® Copay Card program must immediately stop using their IMBRUVICA® Copay Card and call 855-332-6210 to inform RxCrossroads of their change in status. Individuals are no longer eligible for the IMBRUVICA® Copay Card program effective as of the date of their enrollment in the federal or state subsidized healthcare program
How old do you have to be to get imbruvia?
This offer is good for eligible patients on IMBRUVICA® who are 18 years of age or older, are residents of the United States, Puerto Rico, US Virgin Islands or Guam, and have a valid prescription for IMBRUVICA®
What to do if you take too much imbruvia?
If you take too much IMBRUVICA® call your healthcare provider or go to the nearest hospital emergency room right away.
What are the symptoms of IMBRUVICA?
Tell your healthcare provider if you get any symptoms of heart problems, such as feeling as if your heart is beating fast and irregular, lightheadedness, dizziness, shortness of breath, swelling of the feet, ankles, or legs, chest discomfort, or you faint. If you develop any of these symptoms, your healthcare provider may do a test to check your heart (ECG) and may change your IMBRUVICA® dose.
What is the NCCN clinical practice guidelines?
The NCCN Clinical Practice Guidelines In Oncology (NCCN Guidelines®) recommend ibrutinib (IMBRUVICA®) as a preferred regimen for the initial treatment of CLL/SLL. The NCCN is a not-for-profit alliance of 28 leading cancer centers devoted to Patient care, research and education. Referenced with permission from the NCCN Clinical Practice Guidelines ...
What is the role of ibrutinib in BTK?from accessdata.fda.gov
BTK is a signaling molecule of the B-cell antigen receptor (BCR) and cytokine receptor pathways. BTK’s role in signaling through the B-cell surface receptors results in activation of pathways necessary for B-cell trafficking, chemotaxis, and adhesion. Nonclinical studies show that ibrutinib inhibits malignant B-cell proliferation and survival in vivo as well as cell migration and substrate adhesion in vitro.
What is the formula for ibrutinib?from accessdata.fda.gov
Ibrutinib is an inhibitor of Bruton’s tyrosine kinase (BTK). It is a white to off-white solid with the empirical formula C25H24N6O2 and a molecular weight 440.50. Ibrutinib is freely soluble in dimethyl sulfoxide, soluble in methanol and practically insoluble in water.
How should I take Imbruvica?from drugs.com
Take Imbruvica exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Imbruvica is usually taken until your body no longer responds to the medication.
What other drugs will affect Imbruvica?from drugs.com
Other drugs may interact with ibrutinib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
How does Imbruvica work? What’s its half-life?from healthline.com
Imbruvica’s mechanism of action (how it works) is to target and block a certain enzyme (type of protein). The enzyme in your body that Imbruvica targets is called Bruton’s tyrosine kinase (BTK).
Can I take Imbruvica if I’m having surgery?from healthline.com
Maybe. Talk with your doctor if you plan on having any type of surgery, including dental procedures, while taking Imbruvica.
What is the study 1118?from imbruvica.com
Study 1118 (NCT01614821), an open-label, multi-center, single-arm trial was conducted in 63 previously treated patients with WM. IMBRUVICA was administered orally at 420 mg once daily until disease progression or unacceptable toxicity. The responses were assessed by investigators and an IRC using criteria adopted from the International Workshop of Waldenström’s Macroglobulinemia.
How much does Imbruvica cost?from drugs.com
The cost for Imbruvica oral capsule 140 mg is around $15,586 for a supply of 90 capsules, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans. A generic version of Imbruvica has been approved by the FDA.
What are the symptoms of IMBRUVICA?from imbruvica.com
Tell your healthcare provider if you get any symptoms of heart problems, such as feeling as if your heart is beating fast and irregular, lightheadedness, dizziness, shortness of breath, swelling of the feet, ankles, or legs, chest discomfort, or you faint. If you develop any of these symptoms, your healthcare provider may do a test to check your heart (ECG) and may change your IMBRUVICA® dose.
What is the NCCN clinical practice guidelines?from imbruvica.com
The NCCN Clinical Practice Guidelines In Oncology (NCCN Guidelines®) recommend ibrutinib (IMBRUVICA®) as a preferred regimen for the initial treatment of CLL/SLL. The NCCN is a not-for-profit alliance of 28 leading cancer centers devoted to Patient care, research and education. Referenced with permission from the NCCN Clinical Practice Guidelines ...
What is JJPAF in healthcare?from imbruvica.com
The Johnson & Johnson Patient Assistance Foundation, Inc. (JJPAF) is an independent, nonprofit organization that is committed to helping eligible patients without insurance coverage receive prescription products donated by Johnson & Johnson operating companies. To see if you might qualify for assistance, please contact a JJPAF program specialist at 800-652-6227 (Monday – Friday, 9:00 AM to 6:00 PM ET) or visit the foundation website at JJPAF.org.
Can you drink grapefruit juice with imbravica?from imbruvica.com
You should not drink grapefruit juice, eat grapefruit, or eat Seville oranges (often used in marmalades) during treatment with IMBRUVICA®. These products may increase the amount of IMBRUVICA® in your blood.
What is Johnson and Johnson Center for Health Worker Innovation?from jnjfoundation.com
This includes the Johnson & Johnson Center for Health Worker Innovation founded in 2019 to catalyze efforts to respond to the human resource crisis in global health and build a thriving health workforce. Leveraging a people-first model, the Center focuses on equipping nurses, midwives and community health workers across the globe with the skills, resources and support they need to improve quality of care and strengthen primary and community-based health systems.
Are you taking other HIV medications that are not covered in this program?from jjpaf.org
If so, please go to the HarborPath website to access the HarborPath Patient Application.
