What is actimmune used for?
What is the FDA approved diagnosis?
How much does a free drug card save?
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How much does interferon gamma cost?
Interferon gamma, used in chronic granulomatous disease, costs about $140 for a 100-microg vial; yearly costs average $21840 per patient.
What is interferon gamma used for?
Interferon gamma-1b injection is used to lower the frequency and severity of serious infections caused by chronic granulomatous disease (CGD). It is also used to slow down the progression of severe, malignant osteopetrosis (SMO).
How is interferon gamma administered?
ACTIMMUNE® (Interferon gamma-1b) should be administered subcutaneously 3 times weekly. It can be injected by the patient or caregiver after appropriate training by a healthcare professional.
How long can you take interferon for?
Interferon treatment for hepatitis C would typically last 24–48 weeks (6–12 months). Interferons caused many long-term side effects partly because of this long treatment time.
Is interferon gamma FDA approved?
ACTIMMUNE® (Interferon gamma-1b) is approved by the FDA to delay time to disease progression in patients with severe malignant osteopetrosis (SMO). ACTIMMUNE® is believed to work by changing how some cells in your body work. This includes the cells that help form your bones.
What increases interferon-gamma?
High Interferon-Gamma LPS can be elevated by bacterial infections, a “leaky gut”, or other health conditions. Nitric oxide also increases interferon-gamma levels [4].
What triggers interferon-gamma release?
IFN‐γ is primarily secreted by activated T cells and natural killer (NK) cells, and can promote macrophage activation, mediate antiviral and antibacterial immunity, enhance antigen presentation, orchestrate activation of the innate immune system, coordinate lymphocyte–endothelium interaction, regulate Th1/Th2 balance, ...
Is IFN-gamma inflammatory?
Abstract. IFN-gamma has long been recognized as a signature proinflammatory cytokine that plays a central role in inflammation and autoimmune disease. There is now emerging evidence indicating that IFN-gamma possesses unexpected properties as a master regulator of immune responses and inflammation.
What is the role of an interferon?
Interferons were first described as an antiviral factor that interferes with viral replication in mammalian cells (10). They are secreted from infected cells and activate innate immune response that promotes not only cytokine production but also natural killer cell functions and antigen presentation (11, 12).
What does high interferon gamma mean?
Elevated IFN-gamma levels are commonly associated with: Kidney damage in type 2 diabetic patients, as seen in a study on 100 diabetics [21] Increased severity of heart disease, as seen in a study on 104 people with coronary heart disease and type 2 diabetes [22]
What are the side effects of interferon?
Injection site reactions (pain/swelling/redness), headache, tiredness, diarrhea, upset stomach, loss of appetite, back pain, dizziness, dry mouth, taste changes, nausea, or vomiting may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.
What is human interferon gamma?
Human interferon gamma is a cytokine belonging to a diverse group of interferons which have a crucial immunological function against mycobacteria and a wide variety of viral infections.
What is actimmune used for?
Actimmune (interferon gamma-1b) is a member of the interferons drug class and is commonly used for Chronic Granulomatous Disease, Cutaneous T-cell Lymphoma, Idiopathic Pulmonary Fibrosis, and others.
What is the FDA approved diagnosis?
FDA-approved diagnosis. Must be a US resident and treated by a US licensed healthcare provider. Co-payment assistance, reimbursement support, and patient assistance programs are available for eligible patients. Please visit www.actimmune.com or call 1-877-305-7704 for more information. Applicable drugs:
How much does a free drug card save?
The free Drugs.com Discount Card works like a coupon and can save you up to 80% or more off the cost of prescription medicines, over-the-counter drugs and pet prescriptions.
Contraindications
- In patients who develop or have known hypersensitivity to interferon-gamma, E. coliderived products, or any component of the product
Warnings and Precautions
- ACTIMMUNE should be used with caution in patients with:
- Monitoring:
- Pregnancy, Lactation, and Fertility:
Drug Interactions
- Concomitant use of drugs with neurotoxic, hematotoxic, or cardiotoxic effects may increase the toxicity of interferons
- Avoid simultaneous administration of ACTIMMUNE with other heterologous serum protein or immunological preparations (eg, vaccines)
Adverse Reactions
- The most common adverse experiences occurring with ACTIMMUNE therapy are “flu-like” symptoms such as fever, headache, chills, myalgia, or fatigue, which may decrease in severity as treatment contin...
- Isolated cases of acute serious hypersensitivity reactions have been observed in patients receiving ACTIMMUNE
- The most common adverse experiences occurring with ACTIMMUNE therapy are “flu-like” symptoms such as fever, headache, chills, myalgia, or fatigue, which may decrease in severity as treatment contin...
- Isolated cases of acute serious hypersensitivity reactions have been observed in patients receiving ACTIMMUNE
- Reversible neutropenia, thrombocytopenia, and elevations of AST and/or ALT have been observed during ACTIMMUNE therapy
- At doses 10 times greater than the weekly recommended dose, ACTIMMUNE may exacerbate pre-existing cardiac conditions, or may cause reversible neurological effects such as decreased mental status, g...
