What is Jakafi used to treat?
INDICATIONS AND USAGE Jakafi is a prescription medicine used to treat adults with polycythemia vera who have already taken a medicine called hydroxyurea and it did not work well enough or they could not tolerate it. Jakafi is used to treat adults with certain types of myelofibrosis.
Who is not eligible for Jakafi?
Uninsured, cash-paying patients are not eligible. Not valid for patients insured through Medicare Part D, Medicare Advantage, Medicaid, and TRICARE or any state medical or pharmaceutical assistance program. Valid prescription for Jakafi for an FDA-approved indication is required.
How much does Jakafi cost?
We can arrange to have the patient’s prescription for Jakafi filled by an approved specialty pharmacy and delivered directly to either the patient’s home or Healthcare Professional’s office. For patients with commercial or private prescription drug coverage—eligible patients pay as little as $0 per month, subject to certain limits.*
How do I check my blood count before taking Jakafi?
Your healthcare provider will do a blood test to check your blood counts before you start Jakafi and regularly during your treatment. Your healthcare provider may change your dose of Jakafi or stop your treatment based on the results of your blood tests.
Is Jakafi covered by Medicaid?
Be confirmed as eligible for and enrolled in IncyteCARES for Jakafi. Have commercial prescription drug coverage or a healthcare exchange plan. Patients insured under federal or state government prescription drug programs—including Medicare Part D, Medicare Advantage, Medicaid, or TRICARE—are not eligible.
When will there be a generic for Jakafi?
Jakafi was eligible for patent challenges on November 16, 2015. By analyzing the patents and regulatory protections it appears that the earliest date for generic entry will be September 22, 2028.
Is Jakafi better than hydroxyurea?
The researchers concluded that Jakafi provides superior results compared to BAT among patients with PV who have stopped responding to, or are intolerant to hydroxyurea. These results are promising, and provide an effective and well-tolerated treatment option among patients with uncontrolled PV.
What tier drug is Jakafi?
Medicare prescription drug plans typically list Jakafi on Tier 5 of their formulary.
What is the monthly cost of Jakafi?
As a guide, Jakafi tablets 5 mg usually cost $15,400 for 60 tablets. With NiceRx you will pay a flat monthly fee of $49, regardless of the retail price of your medication.
How long can you take Jakafi?
Jakafi is a long-term treatment. Your Healthcare Professional may allow up to 6 months to see if Jakafi is working for you. If you do not see an improvement after 6 months of treatment, your Healthcare Professional may have you stop taking Jakafi.
Does Jakafi make tired?
Jakafi can cause anemia (low red blood cell counts). When you start taking Jakafi, you should watch for the symptoms of anemia and discuss them with your Healthcare Professional. They include: Fatigue (extreme tiredness) or a lack of energy.
Does Jakafi weaken your immune system?
It works by weakening your body's defense system (immune system).
Does Jakafi raise platelets?
Within the first 24 weeks, 45.7% and 67.4% of patients had a significant improvement in anemia and a platelet count increase in the combination therapy arm compared to those who did not receive the therapy.
When does Jakafi patent expire?
In the United States, "Jakafi is covered by eight patents, which range in expiration from December 12, 2026 (the earliest expiration date) to June 12, 2028 (the latest expiration date)." Compl.
What does Tier 3 drug coverage mean?
Level or Tier 1: Low-cost generic and brand-name drugs. Level or Tier 2: Higher-cost generic and brand-name drugs. Level or Tier 3: High-cost, mostly brand-name drugs that may have generic or brand-name alternatives in Levels 1 or 2.
How often do you take Jakafi?
For most patients, the starting dose of Jakafi is 1 tablet taken twice a day by mouth. In certain cases, a Healthcare Professional may start a patient at a lower dose or temporarily reduce the dose of Jakafi to once a day. It is important to take each dose of Jakafi as prescribed.
When does Jakafi go off patent?
In the United States, "Jakafi is covered by eight patents, which range in expiration from December 12, 2026 (the earliest expiration date) to June 12, 2028 (the latest expiration date)." Compl.
When does ruxolitinib patent expire?
Ruxolitinib was authorized likewise by FDA in November 2011 and the US patent is expected to expire in December 2027.
When can drugs become generic?
When patent protection for a brand-name drug expires, the U.S. Food and Drug Administration can approve a generic version of it for sale. The patent protection for a brand-name drug is usually 20 years from the date of the submission of the patent.
Who manufactures Jakafi?
Jakafi (ruxolitinib) is an oral janus kinase (JAK) inhibitor indicated for the treatment of myelofibrosis. It was developed by Incyte Corp in collaboration with Novartis.
Can I get free Jakafi?
For insurance coverage delays, eligible patients can receive a free short-term supply of Jakafi. †
Is Jakafi compendia approved?
Valid prescription for Jakafi for an FDA-approved indication or compendia-recognized use is required. Patients insured through Medicare Part D, Medicare Advantage, Medicaid, TRICARE, or a state medical assistance program are not eligible. Free product is offered to eligible patients without any purchase contingency or other obligation.
What is Jakafi treatment?
Resources include support info for patients taking Jakafi (ruxolitinib), a treatment for adults with polycythemia vera who did not benefit from or could not tolerate hydroxyurea.
What to tell your healthcare provider before taking Jakafi?
Before taking Jakafi, tell your healthcare provider about:all the medications, vitamins, and herbal supplements you are taking and all your medical conditions, including if you have an infection, have or had low white or red blood cell counts, have or had tuberculosis (TB) or have been in close contact with someone who has TB, had shingles (herpes zoster), have or had hepatitis B, have or had liver or kidney problems, are on dialysis, have high cholesterol or triglycerides, had cancer, are a current or past smoker, had a blood clot, heart attack, other heart problems or stroke, or have any other medical condition. Take Jakafi exactly as your healthcare provider tells you. Do not change your dose or stop taking Jakafi without first talking to your healthcare provider.
What is Jakafi used for?
Jakafi is a prescription medicine used to treat adults with polycythemia vera who have already taken a medicine called hydroxyurea and it did not work well enough or they could not tolerate it.
Can I take jakafi while pregnant?
Women should not take Jakafi while pregnant or planning to become pregnant. Do not breastfeed during treatment with Jakafi and for 2 weeks after the final dose.
Does Jakafi cause bruising?
The most common side effects of Jakafi include :for certain types of myelofibrosis ( MF) and polycythemia vera ( PV) – low platelet or red blood cell counts , bruising, dizziness, headache, and diarrhea; for acute GVHD – low platelet counts, low red or white blood cell counts, infections, and swelling; and for chronic GVHD – low red blood cell or platelet counts and infections including viral infections.
How often should I check my cholesterol after taking Jakafi?
Your healthcare provider will do blood tests to check your cholesterol levels about every 8 to 12 weeks after you start taking Jakafi, and as needed.
Can Jakafi cause low platelet count?
Low blood counts: Jakafi®(ruxolitinib) may cause low platelet, red blood cell, and white blood cell counts. If you develop bleeding, stop taking Jakafi and call your healthcare provider. Your healthcare provider will do a blood test to check your blood counts before you start Jakafi and regularly during your treatment. Your healthcare provider may change your dose of Jakafi or stop your treatment based on the results of your blood tests. Tell your healthcare provider right away if you develop or have worsening symptoms such as unusual bleeding, bruising, tiredness, shortness of breath, or a fever.
What to tell your healthcare provider before taking Jakafi?
Before taking Jakafi, tell your healthcare provider about: all the medications, vitamins, and herbal supplements you are taking and all your medical conditions, including if you have an infection, have or had low white or red blood cell counts, have or had tuberculosis (TB) or have been in close contact with someone who has TB, had shingles (herpes zoster), have or had hepatitis B, have or had liver or kidney problems, are on dialysis, have high cholesterol or triglycerides, had cancer, are a current or past smoker, had a blood clot, heart attack, other heart problems or stroke, or have any other medical condition. Take Jakafi exactly as your healthcare provider tells you. Do not change your dose or stop taking Jakafi without first talking to your healthcare provider.
What is jakafi used for?
Jakafi is used to treat adults with certain types of myelofibrosis.
How often should I check my cholesterol after taking Jakafi?
Your healthcare provider will do blood tests to check your cholesterol levels about every 8 to 12 weeks after you start taking Jakafi, and as needed.
Can Jakafi cause blood clots?
Increased risk of blood clots: Blood clots in the veins of your legs (deep vein thrombosis, DVT) or lungs (pulmonary embolism, PE) have happened in people taking another JAK inhibitor for rheumatoid arthritis and may be life-threatening. Tell your healthcare provider right away if you have any signs and symptoms of blood clots during treatment with Jakafi, including: swelling, pain, or tenderness in one or both legs, sudden, unexplained chest or upper back pain, shortness of breath or difficulty breathing
Can Jakafi cause heart attacks?
Increased risk of major cardiovascular events such as heart attack, stroke or death in people who have cardiovascular risk factors and who are current or past smokers while using another JAK inhibitor to treat rheumatoid arthritis: Get emergency help right away if you have any symptoms of a heart attack or stroke while taking Jakafi, including: discomfort in the center of your chest that lasts for more than a few minutes, or that goes away and comes back, severe tightness, pain, pressure, or heaviness in your chest, throat, neck, or jaw, pain or discomfort in your arms, back, neck, jaw, or stomach, shortness of breath with or without chest discomfort, breaking out in a cold sweat, nausea or vomiting, feeling lightheaded, weakness in one part or on one side of your body, slurred speech
Does Jakafi help with cancer?
Cancer: Some people have had certain types of non-melanoma skin cancers during treatment with Jakafi. Your healthcare provider will regularly check your skin during your treatment with Jakafi. Tell your healthcare provider if you develop any new or changing skin lesions during treatment with Jakafi.
Can Jakafi cause a fever?
Infection: You may be at risk for developing a serious infection during treatment with Jakafi. Tell your healthcare provider if you develop any of the following symptoms of infection: chills, nausea, vomiting, aches, weakness, fever, painful skin rash or blisters.
What is Jakafi treatment?from jakafi.com
It is a targeted treatment that works to help keep the production of blood cells under control. Discover what may be possible with Jakafi for the treatment of polycythemia vera in patients who did not benefit from HU.
What to tell your healthcare provider before taking Jakafi?from jakafi.com
Before taking Jakafi, tell your healthcare provider about: all the medications, vitamins, and herbal supplements you are taking and all your medical conditions, including if you have an infection, have or had tuberculosis (TB) or have been in close contact with someone who has TB, have or had hepatitis B, have or had liver or kidney problems, are on dialysis, have high cholesterol or triglycerides, had skin cancer, or have any other medical condition. Take Jakafi exactly as your healthcare provider tells you. Do not change your dose or stop taking Jakafi without first talking to your healthcare provider.
How does Jakafi work?from jakafi.com
JAK proteins send signals that affect the production of blood cells in the bone marrow (A). When JAKs send too many signals , they cause the body to make the wrong number of blood cells. This chain of events is called overactive JAK signaling (B) .
What are possible side effects of Jakafi?from jakafi.com
Your healthcare provider will perform blood tests to check your blood counts before you start Jakafi and regularly during your treatment. Your healthcare provider may change your dose of Jakafi or stop your treatment based on the results of your blood tests. Tell your healthcare provider right away if you develop or have worsening symptoms such as unusual bleeding, bruising, tiredness, shortness of breath, or a fever.
What is a JAK mutation?from jakafi.com
One way is by a JAK mutation. A mutation is a small change in the DNA that causes proteins to act differently than normally intended. All people with PV are believed to have overactive JAK signaling even if they do not have a JAK mutation.
Can you change your dose of Jakafi?from jakafi.com
Your healthcare provider will perform blood tests to check your blood counts before you start Jakafi and regularly during your treatment. Your healthcare provider may change your dose of Jakafi or stop your treatment based on the results of your blood tests.
Does Jakafi cause cancer?from jakafi.com
Skin cancers: Some people who take Jakafi have developed certain types of non-melanoma skin cancers. Tell your healthcare provider if you develop any new or changing skin lesions. Increases in cholesterol: You may have changes in your blood cholesterol levels.
What to tell your healthcare provider before taking Jakafi?
Before taking Jakafi, tell your healthcare provider about: all the medications, vitamins, and herbal supplements you are taking and all your medical conditions, including if you have an infection, have or had low white or red blood cell counts, have or had tuberculosis (TB) or have been in close contact with someone who has TB, had shingles (herpes zoster), have or had hepatitis B, have or had liver or kidney problems, are on dialysis, have high cholesterol or triglycerides, had cancer, are a current or past smoker, had a blood clot, heart attack, other heart problems or stroke, or have any other medical condition. Take Jakafi exactly as your healthcare provider tells you. Do not change your dose or stop taking Jakafi without first talking to your healthcare provider.
What is Jakafi used for?
Jakafi is a prescription medicine used to treat adults with polycythemia vera who have already taken a medicine called hydroxyurea and it did not work well enough or they could not tolerate it.
Does Jakafi cause bruising?
The most common side effects of Jakafi include: for certain types of myelofibrosis (MF) and polycythemia vera (PV) – low platelet or red blood cell counts , bruising, dizziness, headache, and diarrhea; for acute GVHD – low platelet counts, low red or white blood cell counts, infections, and swelling; and for chronic GVHD – low red blood cell or platelet counts and infections including viral infections.
Can Jakafi cause low platelet count?
Low blood counts: Jakafi® (ruxolitinib) may cause low platelet, red blood cell, or white blood cell counts. If you develop bleeding, stop taking Jakafi and call your healthcare provider. Your healthcare provider will do a blood test to check your blood counts before you start Jakafi and regularly during your treatment. Your healthcare provider may change your dose of Jakafi or stop your treatment based on the results of your blood tests. Tell your healthcare provider right away if you develop or have worsening symptoms such as unusual bleeding, bruising, tiredness, shortness of breath, or a fever.
How often should I check my cholesterol after taking Jakafi?
Your healthcare provider will do blood tests to check your cholesterol levels about every 8 to 12 weeks after you start taking Jakafi, and as needed.
Can Jakafi cause blood clots?
Increased risk of blood clots: Blood clots in the veins of your legs (deep vein thrombosis, DVT) or lungs (pulmonary embolism, PE) have happened in people taking another JAK inhibitor for rheumatoid arthritis and may be life-threatening. Tell your healthcare provider right away if you have any signs and symptoms of blood clots during treatment with Jakafi, including: swelling, pain, or tenderness in one or both legs, sudden, unexplained chest or upper back pain, shortness of breath or difficulty breathing
Can Jakafi cause heart attacks?
Increased risk of major cardiovascular events such as heart attack, stroke or death in people who have cardiovascular risk factors and who are current or past smokers while using another JAK inhibitor to treat rheumatoid arthritis: Get emergency help right away if you have any symptoms of a heart attack or stroke while taking Jakafi, including: discomfort in the center of your chest that lasts for more than a few minutes, or that goes away and comes back, severe tightness, pain, pressure, or heaviness in your chest, throat, neck, or jaw, pain or discomfort in your arms, back, neck, jaw, or stomach, shortness of breath with or without chest discomfort, breaking out in a cold sweat, nausea or vomiting, feeling lightheaded, weakness in one part or on one side of your body, slurred speech
What is Jakafi used for?
Jakafi is indicated for treatment of steroid-refractory acute graft-versus-host disease (aGVHD) in adult and pediatric patients 12 years and older .
What is the PAP number for Jakafi?
For more information, call IncyteCARES at 1-855-452-5234, Monday through Friday, 8 am –8 pm ET. The IncyteCARES Patient Assistance Program (PAP) helps eligible patients who do not have prescription drug insurance or who have trouble affording their copay for Jakafi. No purchase contingencies or other obligations apply.
How long does it take for myelofibrosis to return after Jakafi?
When discontinuing Jakafi, myeloproliferative neoplasm-related symptoms may return within one week. After discontinuation, some patients with myelofibrosis have experienced fever, respiratory distress, hypotension, DIC, or multi-organ failure. If any of these occur after discontinuation or while tapering Jakafi, evaluate and treat any intercurrent illness and consider restarting or increasing the dose of Jakafi. Instruct patients not to interrupt or discontinue Jakafi without consulting their physician. When discontinuing or interrupting Jakafi for reasons other than thrombocytopenia or neutropenia, consider gradual tapering rather than abrupt discontinuation
What are the most common nonhematologic adverse reactions in myelofibrosis?
In myelofibrosis and polycythemia vera, the most common nonhematologic adverse reactions (incidence ≥15%) were bruising, dizziness, headache, and diarrhea. In acute graft-versus-host disease, the most common nonhematologic adverse reactions (incidence >50%) were infections (pathogen not specified) and edema. In chronic graft-versus-host disease, the most common nonhematologic adverse reactions (incidence ≥20%) were infections (pathogen not specified) and viral infections
How to manage thrombocytopenia?
Manage thrombocytopenia by reducing the dose or temporarily interrupting Jakafi. Platelet transfusions may be necessary
Can you take jakafi for TB?
Tuberculosis (TB) infection has been reported. Observe patients taking Jakafi for signs and symptoms of active TB and manage promptly. Prior to initiating Jakafi, evaluate patients for TB risk factors and test those at higher risk for latent infection. Consult a physician with expertise in the treatment of TB before starting Jakafi in patients with evidence of active or latent TB. Continuation of Jakafi during treatment of active TB should be based on the overall risk-benefit determination
Can Jakafi be taken with fluconazole?
Avoid concomitant use with fluconazole doses greater than 200 mg. Dose modifications may be required when administering Jakafi with fluconazole doses of 200 mg or less , or with strong CYP3A4 inhibitors, or in patients with renal or hepatic impairment. Patients should be closely monitored and the dose titrated based on safety and efficacy
What is Jakafi used for?
Jakafi is indicated for treatment of polycythemia vera (PV) in adults who have had an inadequate response to or are intolerant of hydroxyurea. Jakafi is indicated for treatment of intermediate or high-risk myelofibrosis (MF), including primary MF, post–polycythemia vera MF and post–essential thrombocythemia MF in adults.
How long does it take for myelofibrosis to return after Jakafi?
When discontinuing Jakafi, myeloproliferative neoplasm-related symptoms may return within one week. After discontinuation, some patients with myelofibrosis have experienced fever, respiratory distress, hypotension, DIC, or multi-organ failure. If any of these occur after discontinuation or while tapering Jakafi, evaluate and treat any intercurrent illness and consider restarting or increasing the dose of Jakafi. Instruct patients not to interrupt or discontinue Jakafi without consulting their physician. When discontinuing or interrupting Jakafi for reasons other than thrombocytopenia or neutropenia, consider gradual tapering rather than abrupt discontinuation
What are the most common nonhematologic adverse reactions in myelofibrosis?
In myelofibrosis and polycythemia vera, the most common nonhematologic adverse reactions (incidence ≥15%) were bruising, dizziness, headache, and diarrhea. In acute graft-versus-host disease, the most common nonhematologic adverse reactions (incidence >50%) were infections (pathogen not specified) and edema. In chronic graft-versus-host disease, the most common nonhematologic adverse reactions (incidence ≥20%) were infections (pathogen not specified) and viral infections
How long does it take to assess lipid parameters after Jakafi?
Assess lipid parameters 8-12 weeks after initiating Jakafi. Monitor and treat according to clinical guidelines for the management of hyperlipidemia.
How to manage thrombocytopenia?
Manage thrombocytopenia by reducing the dose or temporarily interrupting Jakafi. Platelet transfusions may be necessary
Does Jakafi cause pulmonary embolism?
Another JAK-inhibitor has increased the risk of thrombosis, including deep venous thrombosis (DVT), pulmonary embolism (PE), and arterial thrombosis (compared to those treated with TNF blockers) in patients with rheumatoid arthritis, a condition for which Jakafi is not indicated. In patients with myelofibrosis (MF) and polycythemia vera (PV) treated with Jakafi in clinical trials, the rates of thromboembolic events were similar in Jakafi and control treated patients. Patients with symptoms of thrombosis should be promptly evaluated and treated appropriately
Can you take jakafi for TB?
Tuberculosis (TB) infection has been reported. Observe patients taking Jakafi for signs and symptoms of active TB and manage promptly. Prior to initiating Jakafi, evaluate patients for TB risk factors and test those at higher risk for latent infection. Consult a physician with expertise in the treatment of TB before starting Jakafi in patients with evidence of active or latent TB. Continuation of Jakafi during treatment of active TB should be based on the overall risk-benefit determination
What is Jakafi used for?
Jakafi (ruxolitinib) is a member of the multikinase inhibitors drug class and is commonly used for Graft-versus-host disease, Myelofibrosis, Myeloproliferative Disorders, and others.
How much does Jakafi cost?
The cost for Jakafi oral tablet 5 mg is around $15,413 for a supply of 60 tablets, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans.
Is Jakafi covered by insurance?
Jakafi Temporary Coverage: Eligible commercially insured patients may receive a supply of medication for FREE if they are experiencing a delay in their insurance coverage; for additional information contact the program at 855-452-5234.
Is Jakafi a brand name?
Jakafi is available as a brand name drug only, a generic version is not yet available. For more information, read about generic Jakafi availability .
