Precautions
Kayexalate is not totally selective for potassium, and small amounts of other cations such as magnesium and calcium can also be lost during treatment. Monitor calcium and magnesium in patients receiving Kayexalate. Each 15 g dose of Kayexalate contains 1500 mg (60 mEq) of sodium.
Does Kayexalate have high potassium?
Monitor serum potassium during therapy because severe hypokalemia may occur. Kayexalate is not totally selective for potassium, and small amounts of other cations such as magnesium and calcium can also be lost during treatment. Monitor calcium and magnesium in patients receiving Kayexalate.
What should I monitor while taking Kayexalate?
Each 15 g dose of Kayexalate contains 1500 mg (60 mEq) of sodium. Monitor patients who are sensitive to sodium intake (heart failure, hypertension, edema) for signs of fluid overload. Adjustment of other sources of sodium may be required.
How much sodium is in Kayexalate 15G?
Indications and Usage for Kayexalate Kayexalate is indicated for the treatment of hyperkalemia.
What is Kayexalate used to treat?
What is kayexalate used for?
Kayexalate (sodium polystyrene sulfonate) is a member of the cation exchange resins drug class and is commonly used for Hyperkalemia.
Is Kayexalate a generic?
A generic version of Kayexalate is available, see sodium polystyrene sulfonate prices.
What is Kayexalate used for?
Kayexalate is indicated for the treatment of hyperkalemia.
How much sodium is in a teaspoon of kayexalate?
One level teaspoon contains approximately 3.5 g of Kayexalate and 15 mEq of sodium.
How many g of kayexalate is in a jar?
Kayexalate is a cream to light brown, finely ground powder and is available in 453.6 g jars.
How long before or after kayexalate?
Administer Kayexalate at least 3 hours before or 3 hours after other oral medications. Patients with gastroparesis may require a 6 hour separation [see Warnings and Precautions (5.5) and Drug Interaction (7)]
Is kayexalate a benzene?
Kayexalate is a benzene, diethenyl-polymer, with ethenylbenzene, sulfonated, sodium salt and has the following structural formula:
Is sorbitol safe to take with kayexalate?
Risk factors for gastrointestinal adverse events were present in many of the cases including prematurity, history of intestinal disease or surgery, hypovolemia, and renal insufficiency and failure. Concomitant administration of sorbitol is not recommended.
Is kayexalate a cation exchange polymer?
Kayexalate is a non-absorbed, cation exchange polymer that contains a sodium counterion.
What is kayexalate used for?from drugs.com
Kayexalate (sodium polystyrene sulfonate) is a member of the cation exchange resins drug class and is commonly used for Hyperkalemia.
What is the donut hole in Medicare?from goodrx.com
In the Donut Hole (also called the Coverage Gap) stage, there is a temporary limit to what Medicare will cover for your drug. Therefore, you may pay more for your drug. In the Post-Donut Hole (also called Catastrophic Coverage) stage, Medicare should cover most of the cost of your drug.
Does Medicare cover post donut holes?from goodrx.com
In the Post-Donut Hole (also called Catastrophic Coverage) stage, Medicare should cover most of the cost of your drug.
Is Kayexalate a generic?from drugs.com
A generic version of Kayexalate is available, see sodium polystyrene sulfonate prices.
How long does it take for potassium to decrease after kayexalate?
Potassium levels will continue to decrease or hold stable for 24 hours after Kayexalate is stopped.
What is the name of the drug that moves extracellular potassium into the intracellular space?
glucose and insulin (to move extracellular potassium into the intracellular space) Beta2-agonists (to move extracellular potassium into the intracellular space) Bicarbonate (to move extracellular potassium into the intracellular space) Exchange resins (such as Kayexalate to remove potassium)
Does sorbitol reduce potassium?
The original non-randomized, likely underpowered, poorly described pilot trial in 1961 suggested that oral sorbitol alone may reduce serum potassium in oliguric patients better than Kayexalate plus sorbitol. Larger trials that control for etiology, severity, and duration of renal dysfunction in ED-relevant patients with hyperkalemia are needed. Such trials would also assess patient-centric outcomes since hyperkalemia is often well-tolerated in chronic renal dysfunction while the side effects, of Kayexalate plus sorbitol (diarrhea) are quite unpleasant. A second non-randomized trial in 1961 suggested that most patients with acute or chronic kidney disease will reduce their serum potassium levels after oral or rectal Kayexalate alone (mean decrease 1 mEq/L). Potassium levels will continue to decrease or hold stable for 24 hours after Kayexalate is stopped. Some patients will experience constipation. Larger trials that control for etiology, severity, and duration of renal dysfunction in ED-relevant patients with hyperkalemia are needed, but since 50 years have passed since these publications and Kayexalate is considered the standard of care in all leading EM textbooks for the acute management of hyperkalemia, insufficient equipoise may exist for Institutional Review Board’s to approve such randomized controlled trials.
Does Kayexalate lower potassium levels?
More recent trials have demonstrated that Kayexalate does not reduce serum potassium significantly within 12 hours in end-stage renal disease patients starting with a mean potassium of 4.4 mEq/L. Additionally, Kayexalate and sorbitol have been associated with colonic necrosis with perforation ( Gerstman 1992, Rashid 1997, Roy-Chaudhury 1997 ). Another therapeutic alternative, phenolphthalein, actually increases serum potassium (4.2 to 4.6 mEq/L at 12 hours). Although this analysis does not recruit or treat ED patients with potassium levels exceeding 6 mEq/L and/or ECG changes, the implication is that Kayexalate may have limited or no role in the management of hyperkalemia given more effective acute alternatives (dialysis, insulin, inhaled B-agonists). If cathartics are used clinicians should remember that small frequent diarrhea stools excrete more potassium than single large stools either with or without Kayexalate.
Overview
In general, Medicare prescription drug plans (Part D) do not cover this drug. Be sure to contact your specific plan to verify coverage information. A limited set of drugs administered in a doctor's office or hospital outpatient setting may be covered under Medical Insurance (Part B).
Ways to Save on Kayexalate
Here are some ways that may lower the cost of your kionex prescription.
How is Kayexalate given?from drugs.com
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
What other drugs will affect Kayexalate?from drugs.com
Kayexalate can make it harder for your body to absorb medicines you take by mouth. Avoid taking other medicines within 3 hours before or 3 hours after you take this medicine.
How long does it take for Kayexalate to lower potassium levels?from drugs.com
The effective lowering of serum potassium with Kayexalate may take hours to days.
How long after taking Kayexalate can you take other medications?from rxlist.com
Administer other oral medications at least 3 hours before or 3 hours after KAYEXALATE. Patients with gastroparesis may require a 6 hour separation. [see DOSAGE AND ADMINISTRATION and DRUG INTERACTIONS ].
How much potassium does Kayexalate bind?from drugs.com
In pediatric patients, as in adults, Kayexalate is expected to bind potassium at the practical exchange ratio of 1mEq potassium per 1 gram of resin.
How much sodium is in a teaspoon of kayexalate?from drugs.com
One level teaspoon contains approximately 3.5 g of Kayexalate and 15 mEq of sodium.
How many g of kayexalate is in a jar?from drugs.com
Kayexalate is a cream to light brown, finely ground powder and is available in 453.6 g jars.
Important Note
This medication is used to treat a high level of potassium in your blood.
Status: Discontinued
May Treat: Hyperkalemia
Alternate Brand Names: Kionex
Drug Class: Electrolyte Depleters - Ion Exchange Resin
Availability: Prescription Required
Status: Discontinued
May Treat: Hyperkalemia
Alternate Brand Names: Kionex
Drug Class: Electrolyte Depleters - Ion Exchange Resin
Availability: Prescription Required
Pregnancy: Consult a doctor before using
Lactation: Consult a doctor before using
Alcohol: Limit intake while taking this medication
Driving: May cause drowsiness or dizziness. Use caution
- Tell pharmacist if you are on a low-sodium diet
- Call Doctor right away if you get constipated
- Tell doctor your complete medical history
- Tell pharmacist if you are on a low-sodium diet
- Call Doctor right away if you get constipated
- Tell doctor your complete medical history
- Lab tests may be ordered to monitor therapy
- For enema products : If available, read the patient package insert. For rectal use only.
- For powder products : Measure dose using a dosing spoon/cup/syringe. Mix with fluid before taking. Take while upright. Do not lie down for 1 hour. Review all drugs you are taking with your doctor.
- For suspension, oral products : Shake well before using.
How to Use
Side Effects
Drug Interactions
Notes
- The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your …
Missed Dose
- To prepare the oral liquid suspension, follow the directions provided by your doctor or pharmacist. Measure out the correct dose of the powder and mix with the correctly measured amount of water or syrup exactly as directed. In some cases, sorbitol liquid may be prescribed to mix with the medication powder instead of water or syrup. Sorbitol acts as a laxative to relieve constipation. …
Storage
- Nausea, stomach pain, loss of appetite, constipation or diarrhea may occur. If these effects persist or worsen, notify your doctor. Unlikely but report promptly: swelling, muscle cramps, dizziness, mental or mood changes. Very unlikely but report promptly: fast/slow/irregular pulse, muscle weakness, muscle spasm. If you notice other effects not listed above, contact your doct…
Medical Alert
- Tell your doctor of all nonprescription and prescription medication you use, especially of: calcium or aluminum or magnesium-containing antacids or laxatives, certain "water pills" (potassium sparing diuretics such as amiloride), digoxin. Do not start or stop any medicine without doctor or pharmacist approval.