What is KYPROLIS used to treat?
Relapsed Multiple Myeloma Treatment | KYPROLIS® (carfilzomib)
Is KYPROLIS a chemo or immunotherapy?
Kyprolis (carfilzomib) is a type of chemotherapy drug and a second-generation proteasome inhibitor. Kyprolis is used to treat multiple myeloma, which is a type of hematological malignancy, or blood cancer, that affects plasma cells.
Do you lose your hair with KYPROLIS?
Hair loss hasn't been reported as a side effect of Kyprolis. With other cancer treatments, such as chemotherapy (traditional drugs used to treat cancer), hair loss is often a side effect.
Is KYPROLIS better than Velcade?
"These results confirm the superiority of KYPROLIS over Velcade in relapsed or refractory multiple myeloma patients," said Sean E. Harper , M.D., executive vice president of Research and Development at Amgen . "A survival benefit has rarely been demonstrated in relapsed or refractory multiple myeloma.
How long can you take kyprolis?
You'll likely receive Kyprolis for 3 weeks, followed by 1 week without any infusions. But depending on how long you've been using Kyprolis, you may receive infusions every other week. Your doctor will explain how often you'll receive Kyprolis infusions and how long your treatment may last.
How long can you take carfilzomib?
of treatment. Each cycle is 28 days (4 weeks). You have both drugs two days in a row every week for 3 weeks, followed by a week with two days of dexamethasone on its own. You usually have this treatment for as long as it is working and your side effects aren't too bad.
What are the side effects of kyprolis?
Common side effects of Kyprolis are:fatigue.low blood cell count and blood platelet levels.shortness of breath.diarrhea.constipation.nausea.fever.swelling of the extremities.More items...
How effective is kyprolis?
Results from an early study in newly diagnosed patients suggest that the combination of Kyprolis, Revlimid, and low-dose dexamethasone is highly effective, with 98% of patients responding to treatment and 42% achieving a stringent complete response.
Does carfilzomib cause joint pain?
This medicine may cause a serious reaction called tumor lysis syndrome (TLS). Call your doctor right away if you have a change in how much or how often you urinate, rapid weight gain, muscle or joint pain, swelling of the feet or lower legs, or feel tired.
Which is better bortezomib or carfilzomib?
The first pre-specified interim analysis showed that patients in the carfilzomib group had higher rates of deeper responses, which translated into significantly longer progression-free survival than those who received bortezomib (median progression-free survival 18·7 months [95% CI 15·6–not estimable] vs 9·4 months [8· ...
Is carfilzomib better than bortezomib?
In the phase 3 ENDEAVOR trial, carfilzomib (56 mg/m2) and dexamethasone (Kd56) demonstrated a clinically and statistically significant improvement compared with bortezomib and dexamethasone (Vd) in progression-free survival (PFS; primary end point; median, 18.7 vs 9.4 months; hazard ratio [HR], 0.53; 95% confidence ...
How effective is kyprolis?
Results from an early study in newly diagnosed patients suggest that the combination of Kyprolis, Revlimid, and low-dose dexamethasone is highly effective, with 98% of patients responding to treatment and 42% achieving a stringent complete response.
What are the side effects of kyprolis?
Common side effects of Kyprolis are:fatigue.low blood cell count and blood platelet levels.shortness of breath.diarrhea.constipation.nausea.fever.swelling of the extremities.More items...
Is lenalidomide a chemotherapy?
It is a treatment for myeloma and blood disorders called myelodysplastic syndromes. You may also have it as part of clinical trials for other types of cancer. For myeloma, you might have lenalidomide with a steroid drug called dexamethasone. Or with a chemotherapy drug called melphalan and dexamethasone.
What is carfilzomib used for?
Carfilzomib injection is used alone to treat relapsed (cancer that has come back) or refractory (cancer that did not respond to treatment) multiple myeloma (a type of bone marrow cancer) in patients who have received 1 or more previous treatments.
Who is the rebate number for Kyprolis Amgen?
Kyprolis Amgen First Step Program Rebate: Eligible commercially insured patients who have already paid for treatment may request a rebate check; for additional information contact the program at 888-657-8371.
What is the Kyprolis Amgen first step program?
Kyprolis Amgen First Step Program: Eligible commercially insured patients may save on their out-of-pocket medication costs; for additional information contact the program at 888-427-7478.
Does Kyprolis offer coupons?
Kyprolis Coupons and Rebates. Kyprolis offers may be in the form of a printable coupon, rebate, savings card, trial offer, or free samples. Some offers may be printed right from a website, others require registration, completing a questionnaire, or obtaining a sample from the doctor's office.
Do you have to be a US citizen to be a patient?
The patient must also be a US citizen.
Is Kyprolis a generic?
A generic version of Kyprolis has been approved by the FDA . However we either do not have pricing information for it, or it is not commercially available. More info: generic Kyprolis availability. This Kyprolis price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies.
How to contact KYPROLIS?
KYPROLIS ® Field Representatives are here to answer any questions you may have or to schedule a visit. To report an adverse event, please call 1-800-77-AMGEN (1-800-772-6436). By clicking "Submit,” you agree to disclose your personal information to Amgen and to be contacted by Amgen and their agents in the future regarding products, services, ...
What is the best combination for kyprolis?
KYPROLIS ® (carfilzomib) is indicated in combination with dexamethasone or with lenalidomide plus dexamethasone or with daratumumab and dexamethasone for the treatment of adult patients with relapsed or refractory multiple myeloma who have received one to three lines of therapy.
What is TTP/HUS?
Cases of thrombotic microangiopathy, including thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS), including fatal outcome, have occurred. Monitor for signs and symptoms of TTP/HUS. Discontinue if diagnosis is suspected. If the diagnosis of TTP/HUS is excluded, KYPROLIS may be restarted. The safety of reinitiating KYPROLIS is not known.
Is Kyprolis a single agent?
KYPROLIS ® is indicated as a single agent for the treatment of adult patients with relapsed or refractory multiple myeloma who have received one or more lines of therapy.
What are the most common adverse reactions to combination therapy?
The most common adverse reactions in the combination therapy trials: anemia, diarrhea, fatigue, hypertension, pyrexia, upper respiratory tract infection, thrombocytopenia, cough, dyspnea, and insomnia.
Does Kyprolis cause liver failure?
Cases of hepatic failure, including fatal cases, have occurred. KYPROLIS can cause increased serum transaminases. Monitor liver enzymes regularly regardless of baseline values. Reduce or withhold dose as appropriate.
Can you restart Kyprolis if you have hypertension?
Control hypertension prior to starting KYPROLIS. Monitor blood pressure regularly in all patients. If hypertension cannot be adequately controlled, with hold KYPROLIS and evaluate. Consider whether to restart based on a benefit/risk assessment.
Billing Professionals Resource Center
From access and reimbursement to webinars and useful links, our Billing Professionals Resource Center has the tools to help you stay informed.
For patients with government insurance like Medicare
We provide referrals to independent nonprofit patient assistance programs that may be able to help them afford the co-pay cost of their medicine.**
For uninsured patients
Amgen Safety Net Foundation is a nonprofit patient assistance program sponsored by Amgen that helps qualifying patients access Amgen medicines at no cost.
What is a kyprolis?
KYPROLIS ® (carfilzomib) is a prescription medication used to treat adult patients with relapsed or refractory multiple myeloma who have received one to three previous treatments for multiple myeloma.
How long does it take to live with Kyprolis?
KYPROLIS® given twice a week with DARZALEX ® (daratumumab) and dexamethasone kept the disease from getting worse longer than KYPROLIS ® and dexamethasone alone. With a median follow-up of nearly 28 months, the median progression-free survival (the length of time from the start of treatment until half of the patients have experienced worsening disease or death) for patients who received KYPROLIS ®, DARZALEX ®, and dexamethasone was 28.6 months vs 15.2 months for KYPROLIS ® and dexamethasone alone. In an earlier analysis with a median follow-up of ~17 months, more patients reached a complete response when they received KYPROLIS ® given with DARZALEX ® and dexamethasone vs KYPROLIS ® and dexamethasone alone (28% vs 10%).
What is the name of the medication used to treat multiple myeloma?
KYPROLIS. ®. (carfilzomib) is a prescription medication used to treat adult patients with relapsed or refractory multiple myeloma who have received one to three previous treatments for multiple myeloma. KYPROLIS is approved for use in combination with daratumumab plus dexamethasone, dexamethasone or with lenalidomide plus dexamethasone, ...
How long does it take for a kyprolis to cause chest pain?
These symptoms can occur immediately following infusion or up to 24 hours after administration of KYPROLIS. If you experience any of these symptoms, contact your doctor immediately.
Can you take Kyprolis with Daratumumab?
KYPROLIS is approved for use in combination with daratumumab plus dexamethasone, dexamethasone or with lenalidomide plus dexamethasone, which are other medicines used to treat multiple myeloma. See More.
Can you take melphalan with kyprolis?
KYPROLIS should not be combined with melphalan and prednisone: Newly diagnosed transplant ineligible multiple myeloma patients have shown an increased risk of serious and fatal side effects when using KYPROLIS in combination with melphalan and prednisone.
Where to report side effects of prescription drugs?
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call
What Are the Indications for Treatment with Kyprolis?
Kyprolis is currently approved by the US Food and Drug Administration (FDA) in the following settings:
What Are the Dose and Schedule of Kyprolis?
There are different dosing regimens for Kyprolis. Hydrate prior to and following Kyprolis as needed. Pre-medicate prior to all Cycle 1 doses and if infusion-related reactions develop or reappear. You and your doctor will determine which one of the following dosing regimens is best for you:
How much Kyprolis is given in cycle 1?
For Cycle 1 only, patients receive a 20-mg/m2 loading dose of Kyprolis on days 1 and 2. For all subsequent treatments thereafter, Kyprolis is administered at a dose of 56 mg/m 2. Darzalex is given. at a dose of 16 mg/kg on days 1, 8, 15, and 22, of Cycles 1 and 2. It is given at every 2 weeks during Cycles 3 to 6,
How often is Kyprolis given?
Kyprolis is given at 20 mg/m 2 for the first dose (Cycle 1, day 1), then 70mg/m 2 is given once weekly on days 8 and 15. From Cycle 2 onward, Kyprolis is given at 70 mg/m 2 on days 1, 8, and 15 of each 28-day Cycle. No Kyprolis is given on days 16–28 of any Cycle.
How many days does Kyprolis last?
Kyprolis is given on days 1, 2, 8, 9, 15, and 16 of each 28-day treatment Cycle.
What are the side effects of Kyprolis?
These side effects include heart problems, tumor lysis syndrome (TLS), lung disorders, and liver problems. You will be monitored carefully during treatment for any signs of these problems.
Is Kyprolis a freeze dried powder?
Kyprolis is a freeze-dried powder, which must be reconstituted (dissolved) before it is administered. Kyprolis is administered intravenously (into the vein - IV) at a doctor’s office, hospital, or clinic. Hydration may be given before and after each dose of Kyprolis, based upon the patient’s tolerance of Kyprolis, the dose of Kyprolis, and the duration of infusion time.
What is Kyprolis used for?
Kyprolis is a proteasome inhibitor that is used to treat people with relapsed or refractory multiple myeloma. It works by blocking a cell’s proteasomes, which causes a build-up of proteins inside the cells resulting in the death of myeloma cells.
Can Prescription Hope Help Me Obtain My Other Medications?
Prescription Hope works directly with over 180 U.S. based pharmaceutical manufacturers patient assistance programs to obtain over 1,500 FDA-approved prescription medications. Visit our website to see our full list of medications and fill out an application.
Is Prescription Hope A Kyprolis Coupon Card, Generic, Or Insurance Product?
Prescription Hope is not a Kyprolis coupon card or insurance policy. Our program is also not a Kyprolis Generic. Prescription Hope is a national advocacy program that works with any coverage you may already have. Although Prescription Hope is not a Kyprolis coupon, individuals looking for a Kyprolis coupon can find more savings through Prescription Hope!
Can Prescription Hope Get My Kyprolis If I Have Health Insurance Coverage?
Because Prescription Hope is not a health insurance plan, our program works alongside any coverage you may currently have to obtain your Kyprolis medication at an affordable price. Our national advocacy program does not have medication tiers, copays, or deductibles.
Do I Qualify For Kyprolis Patient Assistance With Prescription Hope?
Prescription Hope works with thousands of Americans every month, obtaining prescription medications on their behalf for the set price of $50.00 per month per medication.
If you have commercial insurance
The Amgen FIRST STEP™ Program can help eligible commercially insured patients meet their deductible, co-insurance, or co-payment. ‡
If you have government insurance like Medicare
Amgen Assist 360™ can refer patients to independent nonprofit patient assistance programs that may be able to help them afford the co-pay costs for their prescribed medicine. †
For uninsured patients
Amgen Safety Net Foundation is a nonprofit patient assistance program sponsored by Amgen that helps qualifying patients access Amgen medicines at no cost.
Where to speak with a patient assistance technician?
Ask to speak with a patient assistance technician or financial counselor at the clinic or hospital administering this therapy.
How is Carfilzomib given?
Carfilzomib is given by intravenous infusion to decrease myeloma symptoms and possibly prolong life. Carfilzomib is not commonly given with the goal of cure. listen. Tap along the timeline to move to different parts of the audio file.
What is clinical trial?
A clinical trial is a type of study in which people are assigned to groups that either receive a new treatment intervention or standard treatment. In clinical trials with patients with cancer, it is sometimes unethical to give no treatment or a placebo. The type of treatment received by the patient is determined by the study protocol. Ask your doctor if they have any clinical trials that are enrolling patients or know if any at treatment centers nearby. You may also visit the website clinicaltrials.gov to see what clinical trials might be available for all cancer types and where these clinical trial medications are being offered.
When to give dexamethasone before carfilzomib?
Oral or intravenous dexamethasone is given before carfilzomib in Cycle 1 to prevent infusion related reactions, and may also be given if infusion reactions develop or reappear
Can you continue carfilzomib treatment?
Treatment with carfilzomib is continued until unacceptable side effects appear or until the multiple myeloma stops responding to treatment. Click here for common carfilzomib (Kyprolis®) starting doses. listen. Tap along the timeline to move to different parts of the audio file.
Can you travel to a clinical trial?
It is possible, but it will depend upon the clinical trial requirements and whether you are willing to travel periodically for monitoring. Some, but not all, clinical trials require daily laboratory work as part of the monitoring requirements. Usually monitoring is more frequent at the start of the trial and decreases as time goes on. Most clinical trials cover the cost of the experimental medication and some help to cover travel costs as well as scans when needed. If you cannot afford a standard treatment, a clinical trial may be a way to receive treatment while minimizing out-of-pocket costs.
Can you give Carfilzomib in an outpatient infusion?
Pre-medications and intravenous (I.V.) fluids, such as hydration, may add more time. Carfilzomib is usually given in an outpatient infusion center allowing the person to go home afterwards.
