To request a LONSURF Starter Kit, you can: Call 1‑844‑TAIHO‑4U (1‑844‑824‑4648) or visit TaihoPatientSupport.com
Full Answer
What is the clinical effectiveness of Lonsurf?
Clinical effectiveness of Lonsurf is based on benefit observed in a pivotal study in patients who had been previously treated with all of the above available therapies. 1.1 Pediatrics Pediatrics(0 – 18 years): No pediatric data have been made available to Health Canada; therefore, Health Canada has not approved an indication for pediatric use.
Is Lonsurf safe for patients with hepatic impairment?
(See DOSAGE AND ADMINISTRATION, ADVERSE REACTIONS) Hepatic/Biliary/Pancreatic Lonsurf is not recommended for use in patients with moderate or severe hepatic impairment (National Cancer Institute [NCI] Criteria Group C and D defined by total bilirubin > 1.5 X ULN).
Is Lonsurf safe for geriatric colorectal cancer patients?
1.2 Geriatrics Geriatrics (≥65years of age): The effect of Lonsurf (trifluridine and tipiracil tablets), on overall survival in metastatic colorectal cancer was similar in patients <65 years and ≥65 years of age. Efficacy and safety data in patients ≥ 75 years old is limited. 2 CONTRAINDICATIONS
What blood tests do I need before taking Lonsurf?
Your healthcare provider should do blood tests before you receive LONSURF, at day 15 during treatment with LONSURF, and as needed to check your blood cell counts. Your healthcare provider may lower your dose of LONSURF or stop LONSURF if you have low white blood cell or platelet counts
What is a lonsurf?
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Is Lonsurf a generic?
About this website
Is LONSURF available in Canada?
We are pleased to announce that PrLONSURF® (trifluridine and tipiracil) is now available in Canada as of January 23, 2018.
Is LONSURF a new drug?
Lonsurf (Trifluridine plus Tipiracil): A New Oral Treatment Approved for Patients with Metastatic Colorectal Cancer - PMC. The . gov means it's official.
Is LONSURF chemotherapy?
Lonsurf is a type of chemotherapy drug. You might have Lonsurf as a treatment for bowel cancer that has spread to other parts of the body. Bowel cancer is cancer that started in the large bowel (colon) or back passage (rectum). Find out about how you have it, possible side effects and other important information.
What are the side effects of LONSURF?
The most common side effects with LONSURF include tiredness (fatigue, weakness), nausea, decreased appetite, diarrhea, vomiting, abdominal pain, and fever. Tell your doctor if you have nausea, vomiting, or diarrhea that is severe or that does not go away. These are not all of the possible side effects of LONSURF.
How long can you take LONSURF?
Your doctor will usually prescribe LONSURF for 10 days during the first two weeks and then stop for two weeks.
Does LONSURF shrink tumors?
Tipiracil slows down the body's ability to break down trifluridine, which allows it to stay in the body longer and affect more colon cancer cells. Goals of therapy: Trifluridine and tipiracil is taken to shrink colon tumors or decrease symptoms of colon cancer and is not commonly given with the goal of cure.
What is the success rate of LONSURF?
At 12 months, treatment with Lonsurf and Avastin induced a progression-free survival rate of 40% versus 30% with the Xeloda-based treatment.
How successful is LONSURF?
On average, the time to cancer progression was 2 months for patients on Lonsurf compared to 1.7 months for patients receiving a placebo. Worsening of the disease or death occurred in 88% of patients treated with Lonsurf and 94% of patients who received placebo.
Is LONSURF better than stivarga?
These agents were tested in very similar settings, but they have never been compared head-to-head. Stivarga was compared with placebo in a large study and it showed superiority to placebo in all parameters. Lonsurf was also compared with placebo and also showed an improvement in all efficacy parameters.
What is the half life of LONSURF?
After the administration of TFD/TPI 35 mg/m2 twice daily, the mean elimination half-lives of TFD and TPI were 1.4 hours and 2.1 hours, respectively, after a single dose.
What class of drug is LONSURF?
Drug Type: Trifluridine/tipiricil is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug. This medication is classified as an antimetabolite/pyrimidine analog; antimetabolite/thymidine phosphorylase inhibitor (for more detail, see "How Trifluidine/tipiricil Works" below).
Does LONSURF cause shortness of breath?
Lonsurf side effects low red blood cells (anemia) - pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet; or.
What company makes LONSURF?
LONSURF (trifluridine/tipiracil), discovered and developed by Taiho Pharmaceutical Co., Ltd., is an oral anticancer drug, which utilizes the combination of trifluridine (FTD) and tipiracil (TPI), whose dual mechanism of action is designed to maintain clinical activity and differs from conventional fluoropyrimidines.
Is LONSURF FDA approved?
FDA approves Lonsurf for recurrent, metastatic gastric and gastroesophageal junction adenocarcinoma. On February 22, 2019, the Food and Drug Administration approved trifluridine/ tipiracil tablets (LONSURF, Taiho Pharmaceutical Co., Ltd.)
Is LONSURF generic?
Trifluridine/tipiricil is the generic name for the trade name drug, Lonsurf. In some cases, health care professionals may use the trade name, Lonsurf, when referring to the generic drug name, trifluridine/tipiricil. Drug Type: Trifluridine/tipiricil is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug.
When is LONSURF used?
LONSURF is a prescription medicine used to treat people with colon, rectal, or stomach cancer that has spread to other parts of the body and who have been previously treated with or cannot receive certain chemotherapy medicines.
Lonsurf Medicare Coverage and Co-Pay Details - GoodRx
Medicare coverage and pricing details for Lonsurf. Learn more about Medicare prescription drug plans and savings with GoodRx.
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Cost Help and $0 Co-pay - LONSURF® (trifluridine and tipiracil) tablets
See how the Taiho Oncology Patient Support™ Program can help with insurance coverage, reimbursement support, co-pay savings, and patient assistance programs. Please see Important Safety Information and full Prescribing Information.
What is a lonsurf?
LONSURF is a prescription medicine used to treat adults with
What are the symptoms of a lonsuf?
Tell your healthcare provider right away if you get any of the following signs and symptoms of infection during treatment with LONSURF: fever, chills, or body aches.
What happens if you take lonsuf?
LONSURF can cause a decrease in your white blood cells, red blood cells, and platelets. Low white blood cells can make you more likely to get serious infections that could lead to death. Your healthcare provider should do blood tests before you receive LONSURF, at day 15 during treatment with LONSURF, and as needed to check your blood cell counts. Your healthcare provider may lower your dose of LONSURF or stop LONSURF if you have low white blood cell or platelet counts
Where to fill out patient enrollment form?
Fill out a Patient Enrollment Form at your doctor's office with your doctor, nurse, or support staff. The office can then fax the form to 1‑844‑287‑2559
Does lonsufr cause nausea?
Tell your doctor if you have nausea, vomiting, or diarrhea that is severe or that does not go away. These are not all of the possible side effects of LONSURF.
Can a lonsufr hurt a baby?
Are pregnant or plan to become pregnant. LONSURF can harm your unborn baby.
Is lonsurf safe for children?
a kind of stomach cancer called gastric cancer including cancer of the gastroesophageal junction that has spread to other parts of the body and who have been previously treated or cannot receive certain chemotherapy medications. It is not known if LONSURF is safe and effective in children. IMPORTANT SAFETY INFORMATION.
What is a lonsuf?
LONSURF is indicated for the treatment of adult patients with metastatic gastric or gastroesophageal junction adenocarcinoma previously treated with at least two prior lines of chemotherapy that included a fluoropyrimidine, a platinum, either a taxane or irinotecan, and if appropriate, HER2/neu‑targetedtherapy.
What is the molar ratio of Lonsurf?
LONSURF®(trifluridine and tipiracil) tablets consist of a thymidine‑based nucleoside analog, trifluridine, and the thymidine phosphorylase inhibitor, tipiracil, at a molar ratio 1:0.5 (weight ratio, 1:0.471). Inclusion of tipiracil increases trifluridine exposure by inhibiting its metabolism by thymidine phosphorylase.
Can lonsurf harm the fetus?
Embryo‑Fetal Toxicity:LONSURF can cause fetal harm when administered to a pregnant woman. Advise pregnant women of the potential risk to the fetus. Advise females of reproductive potential to use effective contraception during treatment and for at least 6 months after the final dose.
Can you breastfeed with lonsufrf?
Because of the potential for serious adverse reactions in breast‑fed infants, advise women not to breastfeed during treatment with LONSURF and for 1 day following the final dose.
What is a lonsurf?
Lonsurf (tipiracil/trifluridine) is a member of the antineoplastic combinations drug class and is commonly used for Colorectal Cancer, and Gastric Cancer.
How much does a free drug card save?
The free Drugs.com Discount Card works like a coupon and can save you up to 80% or more off the cost of prescription medicines, over-the-counter drugs and pet prescriptions.
Is Lonsurf a generic?
Lonsurf is available as a brand name drug only, a generic version is not yet available. For more information, read about generic Lonsurf availability . This Lonsurf price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies.
What is a lonsuf?
LONSURF is indicated for the treatment of adult patients with metastatic gastric or gastroesophageal junction adenocarcinoma previously treated with at least two prior lines of chemotherapy that included a fluoropyrimidine, a platinum, either a taxane or irinotecan, and if appropriate, HER2/neu‑targeted therapy.
Can you breastfeed with lonsufrf?
There are no data to assess the effects of LONSURF or its metabolites on the breast‑fed infant or the effects on milk production. Because of the potential for serious adverse reactions in breast‑fed infants, advise women not to breastfeed during treatment with LONSURF and for 1 day following the final dose.
What is a lonsurf?
Lonsurf® (trifluridine and tipiracil [as tipiracil hydrochloride] tablets) is indicated for the treatment of adult patients with metastatic colorectal cancer who have been previously treated with, or are not candidates for, available therapies including fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapies, anti-VEGF biological agents, and, if RAS wild-type, anti-EGFR agents.
How many patients were exposed to Lonsurf?
A total of 761 colorectal cancer patients were exposed to Lonsurf (trifluridine and tipiracil tablets) at a dose of 35mg/m2.BID. The most serious observed adverse drug reactions in patients receiving Lonsurf (trifluridine/tipiracil) were bone marrow suppression and gastrointestinal toxicity.
How much of the 14C trifluridine is absorbed?
After oral administration of Lonsurf with [14C]-trifluridine, at least 57% of the administered trifluridine was absorbed and only 3% of the dose was excreted into faeces. After oral administration of Lonsurf with [14C]-tipiracil, at least 27% of the administered tipiracil was absorbed and 50% of the total radioactivity dose measured into faeces, suggestive of moderate gastrointestinal absorption of tipiracil.
What to do if you take too much Lonsurf?
If you think you have taken too much Lonsurf, contact your healthcare professional, hospital emergency department or regional poison control centre immediately, even if there are no symptoms.
How long after Lonsurf can you use contraception?
Contraception Because of the potential for genotoxicity, males with female partners of reproductive potential should be advised to use an adequate form of contraception during treatment with Lonsurf and for up to 6 months after the final dose. (See NON-CLINICAL TOXICOLOGY).
What is the dose of trifluridine/tipiracil?
Dental toxicity including whitening, breakage, and malocclusion (degeneration and disarrangement in the ameloblasts, papillary layer cells and odontoblasts) were observed in rats treated with trifluridine/tipiracil at doses greater than or equal to 50 mg/kg (approximately 0.33 times the exposure at the clinical dose of 35 mg/m twice daily).
How long after taking lonsurf can you drink water?
Lonsurf (trifluridine and tipiracil tablets) is for oral use. Lonsurf must be taken with a glass of water within 1 hour after completion of the morning and evening meals. (See ACTION AND CLINICAL PHARMACOLOGY, PHARMACOKINETICS, ABSORPTION).
What is a lonsurf?
Lonsurf (tipiracil/trifluridine) is a member of the antineoplastic combinations drug class and is commonly used for Colorectal Cancer, and Gastric Cancer.
How much does a free drug card save?
The free Drugs.com Discount Card works like a coupon and can save you up to 80% or more off the cost of prescription medicines, over-the-counter drugs and pet prescriptions.
Is Lonsurf a generic?
Lonsurf is available as a brand name drug only, a generic version is not yet available. For more information, read about generic Lonsurf availability . This Lonsurf price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies.
Warnings and Precautions
- Severe Myelosuppression: LONSURF caused severe and life‑threatening myelosuppression (Grade 3‑4) consisting of neutropenia (38%), anemia (18%), thrombocytopenia (5%), and febrile neutropenia (3%). Two patients (0.2%) died due to neutropenic infection. A total of 12% of LONSURF‑treated patients received granulocyte‑colony stimulating factors. Obtain complete blo…
Use in Specific Populations
- Lactation:It is not known whether LONSURF or its metabolites are present in human milk. There are no data to assess the effects of LONSURF or its metabolites on the breast‑fed infant or the effects on milk production. Because of the potential for serious adverse reactions in breast‑fed infants, advise women not to breastfeed during treatment with LONSURF and for 1 day followin…
Adverse Reactions
- Most Common Adverse Drug Reactions in Patients Treated With LONSURF (≥5%):The most common adverse drug reactions in LONSURF‑treated patients vs placebo‑treated patients with mCRC, respectively, were asthenia/fatigue (52% vs 35%), nausea (48% vs 24%), decreased appetite (39% vs 29%), diarrhea (32% vs 12%), vomiting (28% vs 14%), infections (27% vs 1...
Warnings and Precautions
Use in Specific Populations
- Lactation:It is not known whether LONSURF or its metabolites are present in human milk. There are no data to assess the effects of LONSURF or its metabolites on the breast‑fed infant or the effects on milk production. Because of the potential for serious adverse reactions in breast‑fed infants, advise women not to breastfeed during treatment with LONSURF and for 1 day followin…
Adverse Reactions
- Most Common Adverse Drug Reactions in Patients Treated With LONSURF (≥5%):The most common adverse drug reactions in LONSURF‑treated patients vs placebo‑treated patients with mCRC, respectively, were asthenia/fatigue (52% vs 35%), nausea (48% vs 24%), decreased appetite (39% vs 29%), diarrhea (32% vs 12%), vomiting (28% vs 14%), infections (27% vs 1...