What is lorlatinib used to treat?
Lorlatinib is a kinase inhibitor for oral administration used to treat cancer. A kinase inhibitor is an enzyme inhibitor that can block the action of protein kinases. Lorlatinib is used to treat a certain type of non-small cell lung cancer that has spread to other parts of the body.
What is the generic name for lorlatinib?
Lorlatinib is the generic name for the trade name drug Lorbrena®. In some cases, health care professionals may use the trade name Lorbrena® when referring to the generic drug name Lorlatinib. Drug Type: Lorlatinib is a targeted therapy (for more detail, see "How Lorlatinib Works" section below).
What are the possible side effects of lorlatinib?
Common lorlatinib side effects may include: 1 swelling in your arms, hands, legs, or feet; 2 numbness, tingling, or burning pain in your hands or feet; 3 mood changes; 4 feeling tired; 5 weight gain; 6 joint pain; or 7 diarrhea. More ...
What is the difference between lorlatinib and a kinase inhibitor?
A kinase inhibitor is an enzyme inhibitor that can block the action of protein kinases. Lorlatinib is used to treat a certain type of non-small cell lung cancer that has spread to other parts of the body. It is used only if your cancer has a specific genetic marker (an abnormal "ALK" gene).
Does Pfizer have a patient assistance program?
Pfizer RxPathways® patients in need get access to their Pfizer medicines. Today, Pfizer RxPathways® connects eligible U.S. patients to a range of Pfizer assistance programs that provide insurance support, co-pay help, and medicines for free or at a savings.
Is Lorlatinib chemo?
Lorlatinib (LOR) or pemetrexed-based chemotherapy (PEM) is the standard treatment after failure of a second-generation ALK tyrosine kinase inhibitor, such as alectinib, in patients with ALK-positive NSCLC. Nevertheless, there have been few data on the clinical outcomes of these treatments after alectinib failure.
What is Lorbrena used for?
LORBRENA® is a prescription medicine that is used to treat adults with non-small cell lung cancer (NSCLC) that is caused by an abnormal anaplastic lymphoma kinase (ALK) gene and that has spread to other parts of your body.
How do you take Lorlatinib?
Lorlatinib comes as a tablet to take by mouth. It is usually taken with or without food once daily. Take lorlatinib at around the same time every day.
How effective is Lorlatinib?
For lorlatinib, the objective response rate was 35.7%, and disease control rate was 64.3%. Their progression-free survival (PFS) was 6.2 months.
Is Lorbrena targeted therapy?
Drug Type: Lorlatinib is a targeted therapy (for more detail, see "How Lorlatinib Works" section below).
Is Lorlatinib better than Alectinib?
Data from the phase 3 CROWN trial (NCT03052608) showed that lorlatinib was superior in terms of efficacy vs crizotinib. Although lorlatinib could have better CNS activity vs alectinib, lorlatinib is associated with neurologic toxicities, such as neurocognitive complications, ataxia, and dizziness.
Is Lorlatinib FDA approved?
On March 3, 2021, the Food and Drug Administration granted regular approval to lorlatinib (Lorbrena, Pfizer Inc.) for patients with metastatic non-small cell lung cancer (NSCLC) whose tumors are anaplastic lymphoma kinase (ALK)-positive, detected by an FDA-approved test.
How do I take Lorbrena?
The recommended dosage of LORBRENA is 100 mg orally once daily, with or without food, until disease progression or unacceptable toxicity [see CLINICAL PHARMACOLOGY]. Swallow tablets whole. Do not chew, crush or split tablets. Do not ingest if tablets are broken, cracked, or otherwise not intact.
What company makes Lorlatinib?
U.S. FDA Approves LORBRENA® (lorlatinib) for Previously-Treated ALK-Positive Metastatic NSCLC. NEW YORK--(BUSINESS WIRE )--Pfizer Inc.
Can you crush Lorlatinib?
Lorlatinib is taken by mouth, in tablet form. Lorlatinib can be taken with or without food. The tablet should be swallowed whole. You should not chew, crush or split tablets.
Who discovered Lorlatinib?
Therefore, next-generation ALK inhibitors, such as brigatinib (AP26113) and lorlatinib (PF-06463922), were designed to inhibit resistant ALK mutants and to penetrate the BBB. Lorlatinib, was developed by Pfizer to specifically inhibit TKI-resistant ALK mutants with optimal brain penetration.
What type of drug is lorlatinib?
Lorlatinib is an antineoplastic (cancer) agent. It interferes with the growth of cancer cells, which are eventually destroyed by the body. This medicine is available only with your doctor's prescription.
Is lorlatinib better than Alectinib?
Data from the phase 3 CROWN trial (NCT03052608) showed that lorlatinib was superior in terms of efficacy vs crizotinib. Although lorlatinib could have better CNS activity vs alectinib, lorlatinib is associated with neurologic toxicities, such as neurocognitive complications, ataxia, and dizziness.
Is lorlatinib FDA approved?
On March 3, 2021, the Food and Drug Administration granted regular approval to lorlatinib (Lorbrena, Pfizer Inc.) for patients with metastatic non-small cell lung cancer (NSCLC) whose tumors are anaplastic lymphoma kinase (ALK)-positive, detected by an FDA-approved test.
How do ALK inhibitors work?
They fall under the category of tyrosine kinase inhibitors, which work by inhibiting proteins involved in the abnormal growth of tumour cells. All the current approved ALK inhibitors function by binding to the ATP pocket of the abnormal ALK protein, blocking its access to energy and deactivating it.
What to tell your doctor before taking Lorbrena?
Before taking LORBRENA, tell your healthcare provider about all of your medical conditions, including if you: have kidney problems. have had episodes of depression or seizures. have high levels of cholesterol or triglycerides in your blood. have problems with your heartbeat. have lung or breathing problems.
What is Lorbrena used for?
LORBRENA ® is a prescription medicine that is used to treat adults with non-small cell lung cancer (NSCLC) that is caused by an abnormal anaplastic lymphoma kinase (ALK) gene and that has spread to other parts of your body.
How long after Lorbrena can you breastfeed?
are breastfeeding or plan to breastfeed. It is not known if LORBRENA passes into your breast milk. Do not breastfeed during treatment with LORBRENA and for 7 days after the final dose. Talk to your healthcare provider about the best way to feed your baby during this time.
How long after Lorbrena can you use birth control?
–Males who have female partners who are able to become pregnant should use effective birth control during treatment with LORBRENA and for at least 3 months after the final dose of LORBRENA.
How long does it take for a lipid to be checked before taking Lorbrena?
Your healthcare provider should do blood tests to check the lipid levels in your blood before starting treatment, 1 to 2 months after starting treatment, and during treatment with LORBRENA. Heart problems. LORBRENA may cause very slow or abnormal heartbeats.
Does Lorbrena affect fertility?
LORBRENA may cause decreased fertility in males. In males, this could affect your ability to father a child. Talk to your healthcare provider if you have concerns about fertility.
Does Lorbrena affect the nervous system?
LORBRENA may cause CNS effects, including problems with thinking (such as forgetfulness or confusion), changes in mood (such as depression and thoughts about suicide or dying), psychotic effects such as seeing or hearing things that are not real (hallucinations), seizures, changes in speech and changes in sleep. Tell your healthcare provider if you experience new or worsening symptoms of CNS effects.
What is lorlatinib?
Lorlatinib is a kinase inhibitor for oral administration used to treat cancer. A kinase inhibitor is an enzyme inhibitor that can block the action of protein kinases.
When is Lorlatinib given?
Lorlatinib is given after other cancer treatments did not work or have stopped working.
What is the ALK inhibitor used for?
Use: For the treatment of patients with anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer ( NSCLC) whose disease has progressed on crizotinib and at least one other ALK inhibitor for metastatic disease OR alectinib as the first ALK inhibitor therapy for metastatic disease.
What happens if you are allergic to Lorlatinib?
Get emergency medical help if you have signs of an allergic reaction to lorlatinib: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Can Lorlatinib cause birth defects?
high cholesterol or triglycerides (a type of fat in the blood). Lorlatinib can harm an unborn baby or cause birth defects if the mother or the father is using this medicine. If you are a woman, do not use lorlatinib if you are pregnant. You may need to have a negative pregnancy test before starting this treatment.
Does Lorlatinib affect fertility?
This medicine may affect fertility (ability to have children) in men. However, it is important to use birth control to prevent pregnancy because lorlatinib can harm an unborn baby. Lorlatinib can make hormonal birth control less effective ( birth control pills, injections, implants, skin patches, vaginal rings).
Is Lorlatinib safe for you?
Tell your doctor about all your current medicines and any you start or stop using. To make sure lorlatinib is safe for you, tell your doctor if you have: heart problems, such as "AV block" (unless you have a pacemaker); lung disease, breathing problems; liver disease; depression; seizures; or.
What is lorlatinib drug?
Drug Type: Lorlatinib is a targeted therapy (for more detail, see "How Lorlatinib Works" section below).
What are the side effects of Lorlatinib?
The following side effects are common (occurring in greater than 30%) for patients taking lorlatinib: Anemia (low red blood cell count) High blood sugar or hyperglycemia. High cholesterol or hypercholesterolemia.
How long after lorlatinib is breast feeding recommended?
Do not breast feed while taking lorlatinib and for at least 7 days after the last dose of lorlatinib.
What to tell your doctor before taking Lorlatinib?
Before starting lorlatinib treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.).
What is the generic name for Lorlatinib?
Lorlatinib. Lorlatinib is the generic name for the trade name drug Lorbrena ®. In some cases, health care professionals may use the trade name Lorbrena® when referring to the generic drug name Lorlatinib. Drug Type: Lorlatinib is a targeted therapy (for more detail, see "How Lorlatinib Works" section below).
What to do if you miss a Lorlatinib?
Do not take an extra dose to make up for a missed dose. If you take too much lorlatinib, call your health care provider right away and go to the emergency room.
Can you take Lorlatinib with food?
Take this medication with or without food. Swallow lorlatinib tablets whole. Do not open, crush or split the tablets. Do not take tablets that are broken or cracked. Do not change your dose or stop lorlatinib unless your health care provider tells you to. Take lorlatinib at the same time each day.
What is lungevity foundation?
LUNGevity Foundation is committed to making an immediate impact on increasing quality of life and survivorship of people with lung cancer, as well as providing community, support, and education for all those affected by the disease.
What is Pfizer Oncology Together?
By checking this box, I also agree to receive communications from Pfizer Oncology Together, a support program that offers financial assistance and personalized resources for patients prescribed Pfizer Oncology medicines.
What is an alk positive?
ALK Positive is a worldwide community of patients, caregivers, and supporters that provides information, empathy, support, and research for those affected by ALK-positive lung cancer. American Cancer Society. www.cancer.org.
How old do you have to be to fill out a symlink?
By filling out this form, you acknowledge you are over 18 years of age.
Can you use a medicaid card in Puerto Rico?
Patients are not eligible to use this card if they are enrolled in a state or federally funded insurance program, including but not limited to Medicare, Medicaid, TRICARE, Veterans Affairs health care, a state prescription drug assistance program, or the Government Health Insurance Plan available in Puerto Rico (formerly known as “La Reforma de Salud”).
Is Pfizer Savings Program a health insurance program?
with distinct legal restrictions. § The Pfizer Savings Program is not health insurance. For more information, call the toll-free number: 1-877-744-5675 . There are no membership fees to participate in this program.
What is lungevity foundation?
LUNGevity Foundation is committed to making an immediate impact on increasing quality of life and survivorship of people with lung cancer, as well as providing community, support, and education for all those affected by the disease.
What is Pfizer Oncology Together?
By checking this box, I also agree to receive communications from Pfizer Oncology Together, a support program that offers financial assistance and personalized resources for patients prescribed Pfizer Oncology medicines.
What is an alk positive?
ALK Positive is a worldwide community of patients, caregivers, and supporters that provides information, empathy, support, and research for those affected by ALK-positive lung cancer. American Cancer Society.
How old do you have to be to fill out a symlink?
By filling out this form, you acknowledge you are over 18 years of age.
Can you use a medicaid card in Puerto Rico?
Patients are not eligible to use this card if they are enrolled in a state or federally funded insurance program, including but not limited to Medicare, Medicaid, TRICARE, Veterans Affairs health care, a state prescription drug assistance program, or the Government Health Insurance Plan available in Puerto Rico (formerly known as “La Reforma de Salud”).
Is Pfizer Savings Program a health insurance program?
with distinct legal restrictions. § The Pfizer Savings Program is not health insurance. For more information, call the toll-free number: 1-877-744-5675 . There are no membership fees to participate in this program.
What is lungevity foundation?
LUNGevity Foundation is committed to making an immediate impact on increasing quality of life and survivorship of people with lung cancer, as well as providing community, support, and education for all those affected by the disease.
What is Pfizer Oncology Together?
By checking this box, I also agree to receive communications from Pfizer Oncology Together, a support program that offers financial assistance and personalized resources for patients prescribed Pfizer Oncology medicines.
What is an alk positive?
ALK Positive is a worldwide community of patients, caregivers, and supporters that provides information, empathy, support, and research for those affected by ALK-positive lung cancer. American Cancer Society. www.cancer.org.
How old do you have to be to fill out a symlink?
By filling out this form, you acknowledge you are over 18 years of age.
Is the offer valid for cash paying patients?
Patient must have private insurance. Offer is not valid for cash-paying patients.
Can you use a medicaid card in Puerto Rico?
Patients are not eligible to use this card if they are enrolled in a state or federally funded insurance program, including but not limited to Medicare, Medicaid, TRICARE, Veterans Affairs health care, a state prescription drug assistance program, or the Government Health Insurance Plan available in Puerto Rico (formerly known as “La Reforma de Salud”).
When does Lorbrena Pfizer Oncology rebate expire?
Expires. December 31, 2022. Form more information phone: 877-744-5675 or Visit website. Lorbrena Pfizer Oncology Together Mail-In Rebate: If a pharmacy does not accept the Savings Card the patient may submit a request for a rebate in connection with the offer; for additional information contact the program at 877-744-5675.
How much does Lorbrena Pfizer pay per year?
Lorbrena Pfizer Oncology Together Co-Pay Savings Program: Eligible commercially insured patients may pay $0 per prescription with a maximum savings of up to $25,000 per calendar year; for additional information contact the program at 877-744-5675.
What is Lorbrena used for?
Lorbrena (lorlatinib) is a member of the multikinase inhibitors drug class and is commonly used for Non-Small Cell Lung Cancer.
Why is oral tablet important?
Oral Tablet. Important: When there is a range of pricing, consumers should normally expect to pay the lower price. However, due to stock shortages and other unknown variables we cannot provide any guarantee. Important: When there is a range of pricing, consumers should normally expect to pay the lower price.
Is Lorbrena a generic?
Lorbrena is available as a brand name drug only, a generic version is not yet available. For more information, read about generic Lorbrena availability . This Lorbrena price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies.
