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Full Answer
What kind of drug is metolazone?
Metolazone Prices, Coupons and Patient Assistance Programs. Metolazone is a member of the thiazide diuretics drug class and is commonly used for Edema and High Blood Pressure. This metolazone price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies.
How much does metolazone cost?
Metolazone is a member of the thiazide diuretics drug class and is commonly used for Edema, and High Blood Pressure. The cost for metolazone oral tablet 5 mg is around $80 for a supply of 100 tablets, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans.
How is metolazone administered in the treatment of edema?
Administration Metolazone is an oral agent, available in 2.5 mg, 5 mg, and 10 mg tablets. A dose of 5-20 mg once daily is recommended as the initial to treat edema associated with congestive heart failure or kidney disease. The dose should be titrated to the patient's response, then continued at the lowest dose needed to maintain diuresis.
How does metolazone affect blood pressure?
These problems may be less likely to occur if blood pressure is controlled . Metolazone is a thiazide diuretic (water pill). It reduces the amount of water in the body by increasing the flow of urine, which helps to lower blood pressure .
How long does it take for metolazone?
It usually takes 3 to 4 days for metolazone to start reducing edema, and 3 to 6 weeks to start reducing blood pressure. This medication may be available under multiple brand names and/or in several different forms.
Is there a generic for metolazone?
Metolazone, Oral Tablet. Metolazone oral tablet is available as both a generic and brand-name drug. Brand name: Zaroxolyn. The most common side effects of metolazone are constipation, dry mouth, diarrhea, headache, stomach pain, and blurred vision.
When should metolazone be administered?
Metolazone is recommended to be taken in the morning due to its prolonged absorption and duration of action. In patients resistant to loop diuretics, metolazone should be given one hour before the regular morning dose of furosemide.
Does metolazone cause weightloss?
No, metolazone (Zaroxolyn) is not approved as a weight loss medication. It helps people who hold extra fluid in their body due to kidney or heart problems. Metolazone (Zaroxolyn) can remove extra fluid to help relieve shortness of breath and to lower blood pressure.
Is there an alternative to metolazone?
Zaroxolyn is the original formulation of metolazone, and Diulo is similar. The absorption of these two drugs is relatively incomplete. Mykrox has more complete absorption and so less Mykrox needs to be given to have the same effects as a larger dose of Zaroxolyn or Diulo.
Is metolazone a strong diuretic?
Even at low doses metolazone significantly potentiates the diuretic effects of furosemide and therefore simplifies the treatment of fluid retention.
Why do you give metolazone 30 minutes before furosemide?
Many physicians dose metolazone 30 minutes prior to dosing the loop diuretic to ensure the distal Na-Cl channel is already blocked when the increased sodium reaches the DCT.
How long do the effects of metolazone last?
This action has been demonstrated in animals by micropuncture studies. When metolazone tablets are given, diuresis and saluresis usually begin within one hour and may persist for 24 hours or more. For most patients, the duration of effect can be varied by adjusting the daily dose. High doses may prolong the effect.
Can metolazone cause confusion?
low levels of sodium in the body--headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady; other signs of an electrolyte imbalance--dry mouth, nausea, vomiting, weakness, drowsiness, lack of energy, muscle pain, little or no urination, or feeling restless; or.
What is the best time of day to take metolazone?
It is best to take this medication at least 4 hours before your bedtime. Use this medication regularly in order to get the most benefit from it. Remember to use it at the same time each day as directed. Keep taking this medication even if you feel well.
Does metolazone make you sleepy?
you should know that metolazone may make you dizzy or drowsy. Do not drive a car or operate machinery until you know how this medication affects you. ask your doctor about the safe use of alcoholic beverages while you are taking metolazone.
Does metolazone affect heart rate?
Check with your doctor right away if you have any of the following symptoms while taking this medicine: convulsions or seizures; decreased urine; drowsiness; dry mouth; excessive thirst; muscle pains or cramps; nausea or vomiting; increased heart rate or pulse; or unusual tiredness or weakness.
What is the generic for Zaroxolyn?
Metolazone is a "water pill" (diuretic) that increases the amount of urine you make, which causes your body to get rid of excess water. This drug is used to treat high blood pressure.
Is metolazone the same as Lasix?
Lasix (furosemide) and Zaroxolyn (metolazone) are diuretics (water pills) used treat excess accumulation of fluid or swelling of the body (edema) and high blood pressure (hypertension). Lasix is a brand name for furosemide. Zaroxolyn is a brand name for metolazone.
Is metolazone stronger than hydrochlorothiazide?
Metolazone is more potent than hydrochlorothiazide and retains its effectiveness even when there is severe glomerular filtration rate (GFR) reduction. Diuretics are used to achieve and maintain euvolaemia (the patient's 'dry weight') with the lowest possible dose.
Why do you give metolazone 30 minutes before furosemide?
Many physicians dose metolazone 30 minutes prior to dosing the loop diuretic to ensure the distal Na-Cl channel is already blocked when the increased sodium reaches the DCT.
Important Note
The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.
Uses
This medication is a "water pill" (diuretic) that decreases the amount of water in the body by increasing urination. It is used to decrease body fluid and swelling of the hands or feet (edema), and for high blood pressure.
How To Use
Because this drug increases urination, it is best taken early in the day. This drug may be taken by mouth with food or milk to reduce stomach upset.
Side Effects
This drug may cause dizziness and lightheadedness especially during the first few days as your body adjusts to it. Rise slowly from a seated or lying position to minimize the dizziness or lightheadedness.
Precautions
Tell your doctor your medical history, especially about: gout, diabetes, liver problems, urinary problems, any allergies (especially to sulfa medications). Thiazide diuretics may increase sensitivity to sunlight. Avoid prolonged sun exposure. If you become sun sensitive, use a sunscreen and wear protective clothing when outdoors.
Drug Interactions
This drug is not recommended for use with: dofetilide. Ask your doctor or pharmacist for more details. Inform your doctor about all the medicines you may use (both prescription and nonprescription), especially if you take: lithium, digoxin, oral drugs used for diabetes, aspirin, NSAIDs (e.g., ibuprofen, naproxen), fluconazole.
Overdose
If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include unconsciousness, nausea/vomiting, weakness, slow or shallow breathing, dizziness, confusion, unusually slow heartbeat, seizures, drowsiness, or fainting.
How to treat edema associated with kidney disease?
Effective treatment of edema associated with both congestive heart failure and kidney disease requires the participation of every member of the healthcare team. For example, urine output should be monitored continuously, and body weight should be recorded daily. If nurses fail to do this, the physician and pharmacist cannot ensure the treatment results in appropriate diuresis and removal of body fluid. The drug's actual effect is unknown and, therefore, cannot be adjusted accordingly. In this way, communication between health care providers is crucial for successful patient outcomes. When used and adjusted correctly, patients with congestive heart failure (CHF) can benefit from metolazone's diuretic effect. In one trial, adding metolazone to a loop diuretic (furosemide) in the treatment of edema associated with CHF showed an increase in diuresis, urinary output, and weight loss when compared to furosemide or metolazone alone. [16]
What is metolazone used for?
The Food and Drug Administration (FDA) has approved metolazone to treat salt and water retention , causing edema accompanying congestive heart failure or chronic kidney disease. It is commonly used as an adjuvant therapy along with loop diuretics for the treatment ...
How does metolazone work?
Metolazone works by inhibiting sodium transport across the epithelium of the renal tubules (mostly in the distal tubules), resulting in a decrease in sodium reabsorption and an increase in sodium, chloride, and water excretion. The shift in water and electrolytes results in hypovolemia, keeping the peripheral vascular resistance low ...
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Does metolazone increase urine output?
Comparing metolazone to chlorothiazide in acutely decompensated heart failure in patients with diuretic resistance, patients had an increase in 72-hour urine output and a shorter hospital duration of stay when using metolazone.[17][ Level 3] Along with treating edema, low-dose metolazone can result in significant changes in both systolic and diastolic blood pressure in the treatment of hypertension.[18] [ Level 1]
Is metolazone safe for breastfeeding?
As metolazone is also excreted in breast milk, the potential for adverse reactions in nursing infants exists. The risk of exposure to the infant should be weighed against the benefit of treatment for the mother. Other safer alternatives are available for diuretic therapy in pregnant individuals, including hydrochlorothiazide and chlorthalidone. [12]
What is metolazone used for?
Uses for metolazone. Metolazone is used to treat fluid retention (edema) and swelling that is caused by congestive heart failure, kidney disease , or other medical conditions . Metolazone is also used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the work load ...
How many milligrams of a sulfate can you take?
Adults—At first, 5 to 20 milligrams (mg) once a day. Your doctor may adjust your dose if needed.
What happens when you get up from a sitting position?
Dizziness, lightheadedness, or fainting may occur, especially when you get up from a lying or sitting position. Getting up slowly may help. If the problem continues or gets worse, check with your doctor .
What to do if you miss a dose of metolazone?
However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
What are the side effects of metolazone?
Check with your doctor right away if you have any of the following symptoms while taking metolazone: convulsions or seizures; decreased urine; drowsiness; dry mouth; excessive thirst; muscle pains or cramps; nausea or vomiting; increased heart rate or pulse; or unusual tiredness or weakness.
Is metolazone safe for children?
Appropriate studies have not been performed on the relationship of age to the effects of metolazone in the pediatric population. Safety and efficacy have not been established .
What is the best treatment for high blood pressure?
Proper use of metolazone. In addition to the use of metolazone, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium or potassium. Your doctor will tell you which of these are most important for you.
Program Details
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How To Use
Simply print this page and bring to your local pharmacy. If you have any issues please have the pharmacist call 1-800-577-6484.
What is metolazone used for?
Metolazone is used to treat high blood pressure. It’s also used to treat the buildup of excess fluid and salt in your body. Metolazone may be taken as part of a combination therapy with other medications.
What happens if you don't take metolazone?
If you don’t take it at all: If you don’t take metolazone at all, your blood pressure or edema, or both, might not be controlled. This may lead to a heart attack, stroke, pain, or infection.
What are the side effects of metolazone?
The most common side effects of metolazone are constipation, dry mouth, diarrhea, headache, stomach pain, and blurred vision.
Is metolazone a tablet?
This dosage information is for metolazone oral tablet. All possible dosages and forms may not be included here. Your doctor will tell you what dosage is right for you. Your dose, form, and how often you take it will depend on:
Can you use metolazone while pregnant?
Speak with your doctor if you’re pregnant or planning to become pregnant. Metolazone should only be used during pregnancy if the potential benefit justifies the potential risk to the fetus.
Can you take metolazone if you have liver failure?
For people with liver failure: You shouldn’t take metolazone if you have advanced stages of liver failure. Metolazone can cause changes to your electrolyte levels, which may bring on a hepatic coma in people with liver disease.
Can metolazone cause allergies?
Metolazone can cause a severe allergic reaction. Symptoms can include:
Important Note
Uses
- This medication is a "water pill" (diuretic) that decreases the amount of water in the body by increasing urination. It is used to decrease body fluid and swelling of the hands or feet (edema), and for high blood pressure.
How to Use
- Because this drug increases urination, it is best taken early in the day. This drug may be taken by mouth with food or milk to reduce stomach upset.
Side Effects
- This drug may cause dizziness and lightheadedness especially during the first few days as your body adjusts to it. Rise slowly from a seated or lying position to minimize the dizziness or lightheadedness. Blurred vision, loss of appetite, itching, stomach upset, headache and weakness may also occur during initial therapy as your body adjusts to the medication. If these effects per…
Precautions
- Tell your doctor your medical history, especially about: gout, diabetes, liver problems, urinary problems, any allergies (especially to sulfa medications). Thiazide diuretics may increase sensitivity to sunlight. Avoid prolonged sun exposure. If you become sun sensitive, use a sunscreen and wear protective clothing when outdoors. This medication sh...
Drug Interactions
- This drug is not recommended for use with: dofetilide. Ask your doctor or pharmacist for more details. Inform your doctor about all the medicines you may use (both prescription and nonprescription), especially if you take: lithium, digoxin, oral drugs used for diabetes, aspirin, NSAIDs (e.g., ibuprofen, naproxen), fluconazole. If you take colestipol or cholestyramine for hig…
Overdose
- If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include unconsciousness, nausea/vomiting, weakness, slow or shallow breathing, dizziness, confusion, unusually slow heartbeat, seizures, drowsiness, or fainting.
Notes
- Do not share this medication with others. This drug may reduce the potassium levels in your blood. Ask your doctor about increasing your dietary potassium. Salt substitutes contain potassium and may be beneficial. Sometimes a potassium supplement medication will be prescribed by your doctor.
Missed Dose
- If you miss a dose, take it as soon as remembered; do not take if it is almost time for the next dose, instead, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up.
Medical Alert
- Your condition can cause complications in a medical emergency. For enrollment information call MedicAlert at 1-800-854-1166 (USA), or 1-800-668-1507 (Canada).