Patient Assistance & Copay Programs for Mitomycin Patient assistance programs (PAPs) are usually sponsored by pharmaceutical companies and provide free or discounted medicines and copay programs to low income or uninsured and under-insured people who meet specific guidelines. Eligibility requirements vary for each program.
Full Answer
How long does it take for mitomycin to work?
The medication is left in for about 2 hours, after which the patient then empties the bladder (urinates). There is no pill form of mitomycin. The amount of mitomycin that you will receive depends on many factors, including your height and weight, your general health or other health problems, and the type of cancer or condition being treated.
What is mitomycin used for?
Mitomycin is a member of the antibiotics/antineoplastics drug class and is commonly used for Anal Cancer, Bladder Cancer, Pancreatic Cancer and others. Brand names for mitomycin include Mutamycin.
How do I get mitomycin offers?
Mitomycin offers may be in the form of a printable coupon, rebate, savings card, trial offer, or free samples. Some offers may be printed right from a website, others require registration, completing a questionnaire, or obtaining a sample from the doctor's office.
How is mitomycin used to treat bladder cancer?
The mitomycin solution is injected into the catheter, which is then removed. Normal walking around helps to disperse the medication throughout the bladder. The medication is left in for about 2 hours, after which the patient then empties the bladder (urinates).
Important Note
The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.
How To Use
This is a potent medication. Take it exactly as prescribed. Tell your doctor or nurse immediately if you experience pain, burning or redness at the place where injected.
Drug Interactions
Tell your doctor of all the medications you may use (both prescription and nonprescription), especially of: "blood thinners" such as warfarin.
Overdose
If overdose is suspected, contact your local poison control center or emergency room immediately.
Notes
Regular doctor visits are important. Keep all medical appointments. Blood tests will be done to monitor your progress.
Missed Dose
It is important to take each scheduled dose of this medication. If you miss a dose, contact your doctor.
Storage
Prior to reconstitution, store at room temperature between 59 and 86 degree F (between 15 and 30 degrees C). Reconstituted solution may be stored at room temperature or refrigerated. Check expiration dates and discard any unused medication after that date. Protect from light.
How is mitomycin given?
The urinary catheter is inserted through the urethra (the tube which carries urine from the bladder to the outside the body). The mitomycin solution is injected into the catheter , which is then removed. Normal walking around helps to disperse the medication throughout the bladder. The medication is left in for about 2 hours, after which the patient then empties the bladder (urinates).
What is mitomycin used for?
What Mitomycin Is Used For: Treatment of adenocarcinoma of the stomach or pancreas. Also used in treatment of anal, bladder, breast, cervical, colorectal, head and neck, and non-small cell lung cancer.
What is the trade name for mitomycin?
Mutamycin is the trade name for mitomycin. MTC and Mitomycin-C are other names for mitomycin. In some cases, health care professionals may use the trade name mutamycin or other names MTC or Mitomycin-C when referring to the generic drug name mitomycin. Drug type: Mitomycin is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug.
What to do if you notice redness on mitomycin IV?
If you notice redness or swelling at the IV site while you are receiving mitomycin, alert your health care professional immediately . As an intravesicle infusion to treat superficial bladder cancer (cancer on the surface of the bladder wall).
How long does mitomycin stay in the bladder?
Normal walking around helps to disperse the medication throughout the bladder. The medication is left in for about 2 hours, after which the patient then empties the bladder (urinates). There is no pill form of mitomycin.
What is chemocare.com?
Chemocare.com is designed to provide the latest information about chemotherapy to patients and their families, caregivers and friends. For information about the 4th Angel Mentoring Program visit www.4thangel.org
What is the term for a drug that affects cells only when they are dividing?
They also induce cell suicide (self-death or apoptosis). Chemotherapy drugs that affect cells only when they are dividing are called cell-cycle specific. Chemotherapy drugs that affect cells when they are at rest are called cell-cycle non-specific.
How long does it take to get rid of mitomycin?
Time required to reduce the serum concentration by 50% after a 30 mg bolus injection is 17 minutes.
What are the complications of a chemo patient with mitomycin?
This serious complication of chemotherapy, consisting primarily of microangiopathic hemolytic anemia (hematocrit ≤25%), thrombocytopenia (≤100,000/mm 3 ), and irreversible renal failure (serum creatinine ≥1.6 mg/dL) has been reported in patients receiving systemic Mitomycin. Microangiopathic hemolysis with fragmented red blood cells on peripheral blood smears has occurred in 98% of patients with the syndrome. Other less frequent complications of the syndrome may include pulmonary edema (65%), neurologic abnormalities (16%), and hypertension. Exacerbation of the symptoms associated with HUS has been reported in some patients receiving blood product transfusions. A high mortality rate (52%) has been associated with this syndrome.
How long does it take for thrombocytopenia to go away after mitomycin?
Thrombocytopenia and/or leukopenia may occur anytime within 8 weeks after onset of therapy with an average time of 4 weeks. Recovery after cessation of therapy was within 10 weeks. About 25% of the leukopenic or thrombocytopenic episodes did not recover. Mitomycin produces cumulative myelosuppression.
What is a HUS in chemo?
Hemolytic Uremic Syndrome (HUS) a serious complication of chemotherapy, consisting primarily of microangiopathic hemolytic anemia, thrombocytopenia, and irreversible renal failure has been reported in patients receiving systemic Mitomycin. The syndrome may occur at any time during systemic therapy with Mitomycin as a single agent or in combination with other cytotoxic drugs, however, most cases occur at doses ≥60 mg of Mitomycin. Blood product transfusion may exacerbate the symptoms associated with this syndrome.
How long is mitomycin stable?
Reconstituted with Sterile Water for Injection to a concentration of 0.5 mg per mL, Mitomycin is stable for 14 days refrigerated or 7 days at room temperature.
How much mitomycin is excreted in urine?
Approximately 10% of a dose of Mitomycin is excreted unchanged in the urine. Since metabolic pathways are saturated at relatively low doses, the percent of a dose excreted in urine increases with increasing dose. In children, excretion of intravenously administered Mitomycin is similar.
What is the molecular weight of mitomycin?
Mitomycin is a blue-violet crystalline powder with the molecular formula of C 15 H 18 N 4 O 5, and a molecular weight of 334.33. Its chemical name is 7-amino-9α-methoxymitosane and it has the following structural formula;
Important Note
The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.
How To Use
This is a potent medication. Take it exactly as prescribed. Tell your doctor or nurse immediately if you experience pain, burning or redness at the place where injected.
Side Effects
Nausea, vomiting, loss of appetite, skin rash, numbness or tingling in the fingers or toes, purple-colored bands on nails, or unusual tiredness or weakness are common side effects. Not eating before treatment may help relieve vomiting. Changes in diet such as eating several small meals or limiting activity may help lessen some of these effects.
Precautions
Tell your doctor your medical history, especially of: kidney disease, any infections, previous anti-cancer treatment, blood disorders, recent exposure to chickenpox, allergies. This medication can lower your body's ability to fight an infection. Notify your doctor if you develop any signs of an infection such as fever, sore throat, rash, or chills.
Drug Interactions
Tell your doctor of all the medications you may use (both prescription and nonprescription), especially of: "blood thinners" such as warfarin.
Overdose
If overdose is suspected, contact your local poison control center or emergency room immediately.
Notes
Regular doctor visits are important. Keep all medical appointments. Blood tests will be done to monitor your progress.
How long does it take for Mitomycin to work?
How long it takes. 1. Mitomycin (my-tow-my-sin) Through a tube (urinary catheter) into your bladder. About 2 to 3 hours. Mitomycin is a chemotherapy drug that aims to kill any cancer cells that may have remained in your bladder after surgery.
How many cycles of mitomycin?
The treatment schedule below explains how the drug for this treatment is given. This treatment cycle is repeated every 7 days. You will have 6 cycles. Mitomycin is a chemotherapy drug that aims to kill any cancer cells that may have remained in your bladder after surgery.
What to tell your doctor before starting a med?
Before you start treatment, tell your doctor about any medications you are taking, including vitamins or herbal supplements.
How to improve chances of quitting smoking?
There are many effective tools to improve your chances of quitting. Talk to your treating team for more information and referral to a smoking cessation support service. Staying active. Research shows that exercise, no matter how small, has many benefits for people during and after cancer treatment.
Important Note
- The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug. MITOMYCIN - INJECTION (mitt-oh-MY-sin) COM…
How to Use
- This is a potent medication. Take it exactly as prescribed. Tell your doctor or nurse immediately if you experience pain, burning or redness at the place where injected.
Side Effects
- Nausea, vomiting, loss of appetite, skin rash, numbness or tingling in the fingers or toes, purple-colored bands on nails, or unusual tiredness or weakness are common side effects. Not eating before treatment may help relieve vomiting. Changes in diet such as eating several small meals or limiting activity may help lessen some of these effects. In some cases, drug therapy may be nec…
Precautions
- Tell your doctor your medical history, especially of: kidney disease, any infections, previous anti-cancer treatment, blood disorders, recent exposure to chickenpox, allergies. This medication can lower your body's ability to fight an infection. Notify your doctor if you develop any signs of an infection such as fever, sore throat, rash, or chills....
Drug Interactions
- Tell your doctor of all the medications you may use (both prescription and nonprescription), especially of: "blood thinners" such as warfarin.
Notes
- Regular doctor visits are important. Keep all medical appointments. Blood tests will be done to monitor your progress.
Missed Dose
- It is important to take each scheduled dose of this medication. If you miss a dose, contact your doctor.
Storage
- Prior to reconstitution, store at room temperature between 59 and 86 degree F (between 15 and 30 degrees C). Reconstituted solution may be stored at room temperature or refrigerated. Check expiration dates and discard any unused medication after that date. Protect from light.
Medical Alert
- Your condition can cause complications in a medical emergency. For enrollment information call MedicAlert at 1-800-854-1166 (USA), or 1-800-668-1507 (Canada).
Mitomycin Description
Mitomycin - Clinical Pharmacology
- Mitomycin selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of Mitomycin-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed. In humans, Mitomycin is rapidly cleared from the serum after intravenous administration. Time required to r…
Indications and Usage For Mitomycin
- Mitomycin for Injection, USP is not recommended as single-agent, primary therapy. It has been shown to be useful in the therapy of disseminated adenocarcinoma of the stomach or pancreas in proven combinations with other approved chemotherapeutic agents and as palliative treatment when other modalities have failed. Mitomycin is not recommended to replace appropriate surger…
Contraindications
- Mitomycin is contraindicated in patients who have demonstrated a hypersensitive or idiosyncratic reaction to it in the past. Mitomycin is contraindicated in patients with thrombocytopenia, coagulation disorder, or an increase in bleeding tendency due to other causes.
Warnings
- Patients being treated with Mitomycin must be observed carefully and frequently during and after therapy. The use of Mitomycin results in a high incidence of bone marrow suppression, particularly thrombocytopenia and leukopenia. Therefore, the following studies should be obtained repeatedly during therapy and for at least eight weeks following therapy: platelet count…
Precautions
- Acute shortness of breath and severe bronchospasm have been reported following the administration of vinca alkaloids in patients who had previously or simultaneously received Mitomycin. The onset of this acute respiratory distress occurred within minutes to hours after the vinca alkaloid injection. The total number of doses for each drug has varied considerably. Bronc…
Geriatric Use
- Insufficient data from clinical studies of Mitomycin are available for patients 65 years of age and older to determine whether they respond differently than younger patients. Postmarketing surveillance suggests that elderly patients may be more susceptible than younger patients to injection site reactions (see ADVERSE REACTIONS: Integument and Mucous Membrane Toxicity…
Adverse Reactions
- Bone Marrow Toxicity
This was the most common and most serious toxicity, occurring in 605 of 937 patients (64.4%). Thrombocytopenia and/or leukopenia may occur anytime within 8 weeks after onset of therapy with an average time of 4 weeks. Recovery after cessation of therapy was within 10 weeks. Abo… - Integument and Mucous Membrane Toxicity
This has occurred in approximately 4% of patients treated with Mitomycin. Cellulitis at the injection site has been reported and is occasionally severe. Stomatitis and alopecia also occur frequently. Rashes are rarely reported. The most important dermatological problem with this dru…
Mitomycin Dosage and Administration
- Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration whenever solution and container permit. Mitomycin should be given intravenously only, using care to avoid extravasation of the compound. If extravasation occurs, cellulitis, ulceration, and slough may result. Each vial contains Mitomycin, USP 5 mg and mannit…
How Is Mitomycin Supplied
- Mitomycin for Injection USP NDC 72819-152-95 5 mg; individually-boxed amber vial. Storage:Store dry powder at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature.], protected from light. Avoid excessive heat, over 40 °C (104° F). Protect reconstituted solution from light. Store solution under refrigeration 2° to 8 °C (36° to 46°F), discard after 14 days. If unrefrigerated, disca…