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Full Answer
What type of cancer is mitotane used to treat?
Lysodren ® (mitotane) is indicated to treat inoperable, functional or nonfunctional, adrenocortical carcinoma (ACC). WARNINGS: ADRENAL CRISIS IN THE SETTING OF SHOCK OR SEVERE TRAUMA: In patients taking LYSODREN, adrenal crisis occurs in the setting of shock or severe trauma and response to shock is impaired.
How does mitotane work in the body?
Mitotane acts on a part of the body called the adrenal cortex. Mitotane reduces the amount of steroids (cortisone-like hormones) that are produced by the adrenal cortex. These hormones are important for various functions of the body, including growth.
When to discontinue mitotane for adrenal crisis?
Last updated on Mar 7, 2021. In patients taking mitotane, adrenal crisis occurs in the setting of shock or severe trauma and response to shock is impaired. Administer hydrocortisone, monitor for escalating signs of shock and discontinue mitotane until recovery .
How should I take mitotane?
Mitotane comes as a tablet to take by mouth. It is usually taken three to four times a day. Take mitotane at around the same times every day. The pill should be swallowed whole with a glass of water; do not crush, chew or break. Mitotane should be taken with meals containing fat-rich foods such as milk, chocolate and oil.
What is the cost of mitotane?
Mitotane is an FDA-approved, prescription medicine used to treat cancer of the adrenal gland that cannot be treated by surgery. It comes in the form of a 500 mg oral tablet. Mitotane is currently only available as a brand-name drug called Lysodren. The average retail price of Mitotane is $3,983.04.
Is mitotane a chemotherapy?
Mitotane is a chemotherapy drug. It's pronounced my-toe-tane. It is also known as Lysodren. You might have it as a treatment for a rare type of adrenal gland cancer called adrenal cortical cancer (ACC).
What is mitotane used to treat?
Mitotane is used to treat some types of cancer in the adrenal glands. This medicine acts on a part of the body called the adrenal cortex. Mitotane reduces the amount of steroids (cortisone-like hormones) that are produced by the adrenal cortex.
Is Lysodren available in the US?
No. There is currently no therapeutically equivalent version of Lysodren available in the United States. Note: Fraudulent online pharmacies may attempt to sell an illegal generic version of Lysodren.
How long can you take mitotane?
Mitotane may cause brain or nervous system damage when taken at high doses for longer than 2 years. Talk to your doctor about the risks of taking this medication.
How long does it take for mitotane to work?
At daily low dose of mitotane, the target plasma concentration is usually reached within a period of 3–5 months (total mitotane dose of 283–387 g). Mitotane plasma levels should be monitored at frequent intervals (approximately every 2 weeks) until the therapeutic window has been reached.
Can you drink alcohol while taking mitotane?
Mitotane may cause drowsiness and dizziness which can affect your ability to drive a car or operate machinery. Use care with activities that require mental alertness. Alcohol may increase the risk of drowsiness and other side effects. Avoid drinking alcohol while being treated with mitotane.
What drugs interact with mitotane?
Most frequently checked interactionsActivated Charcoal (charcoal)Adderall (amphetamine / dextroamphetamine)Aldactone (spironolactone)Aleve (naproxen)Allegra-D 24 Hour (fexofenadine / pseudoephedrine)Astelin (azelastine nasal)Atarax (hydroxyzine)Celebrex (celecoxib)More items...
Is mitotane cytotoxic?
Mitotane is directly cytotoxic to adrenal tissue and appears to act by inhibition of sterol-O-acyl-transferase (SOAT) activity which blocks the esterification of cholesterol.
Is LYSODREN a prescription?
LYSODREN is a prescription medication used to treat the symptoms of adrenal cortical carcinoma (cancer of the outer layer of the adrenal gland). LYSODREN is used when the cancer cannot be removed by surgery.
Who manufactures LYSODREN?
See full prescribing information for LYSODREN. See full prescribing information for complete boxed warning. To report SUSPECTED ADVERSE REACTIONS, contact Bristol-Myers Squibb at 1-800-721-5072 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
How is mitotane administered?
Mitotane is given by mouth in the form of a tablet.
What are the side effects of mitotane?
More commonDarkening of the skin.dizziness or lightheadedness.drowsiness.mental depression.nausea or vomiting.skin rash.unusual tiredness or weakness.
What is Lysodren used for?
Lysodren (mitotane) is an antineoplastic (anticancer) medication used to treat cancer of the adrenal gland (adrenal cortical carcinoma).
How does mitotane work for Cushing's?
Mitotane is a cytotoxic agent used for the treatment of adrenocortical carcinoma, but it is also of value in controlling hypercortisolemia in benign causes of Cushing's syndrome. Mitotane reduces cortisol production by blocking cholesterol side-chain cleavage and 11 β-hydroxylase.
What is adrenocortical carcinoma?
Adrenocortical carcinoma is a rare disease in which malignant (cancer) cells form in the outer layer of the adrenal gland. Having certain genetic conditions increases the risk of adrenocortical carcinoma. Symptoms of adrenocortical carcinoma include pain in the abdomen.
What to do if you miss a dose of mitotane?
If you miss a dose of mitotane, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
What is mitotane used for?
Uses for mitotane. Mitotane is used to treat some types of cancer in the adrenal glands. Mitotane acts on a part of the body called the adrenal cortex. Mitotane reduces the amount of steroids (cortisone-like hormones) that are produced by the adrenal cortex. These hormones are important for various functions of the body, including growth.
Does mitotane cause side effects?
Mitotane side effects. Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: More common. Darkening of the skin.
Can mitotane cause ovaries to bleed?
Mitotane may cause cysts in the ovaries in premenopausal women (have menstrual cycles). Tell your doctor if you have bloating, sudden or severe pelvic pain, or vaginal bleeding. Do not take other medicines unless they have been discussed with your doctor.
Can mitotane cause a rash?
Adrenal insufficiency may develop in patients using mitotane. Check with your doctor right away if you have more than one of the following symptoms: darkening of the skin, diarrhea, dizziness, fainting, loss of appetite, mental depression, nausea, skin rash, unusual tiredness or weakness, or vomiting.
Can you change the dose of mitotane?
Follow your doctor's orders or the directions on the label. The following information includes only the average doses of mitotane. If your dose is different, do not change it unless your doctor tells you to do so.
Can you take mitotane with cancer?
It is important for you to work closely with your doctor during your treatment. Take mitotane only as directed by your doctor.
Where do I get this medication?
Mitotane is available through retail and mail order pharmacies. Your oncology team will work with your prescription drug plan to identify an in-network pharmacy for distribution of this medication.
What to do if you have a rash on your lips?
Rash. Some patients may develop a rash, scaly skin, or red itchy bumps. Use an alcohol free moisturizer on your skin and lips; avoid moisturizers with perfumes or scents. Your oncology care team can recommend a topical medication if itching is bothersome.
How to get rid of a bad smell in your body?
Sometimes cold food has less of an odor. Add extra flavor to meat or fish by marinating it in sweet juices, sweet and sour sauce or dressings.
What foods help with diarrhea?
Foods high in soluble fiber include: applesauce, bananas (ripe), canned fruit, orange sections, boiled potatoes, white rice, products made with white flour, oatmeal, cream of rice, cream of wheat, and farina.
How to get rid of metallic taste in cancer?
Try to eat five or six small meals or snacks throughout the day, instead of 3 larger meals. If you are not eating enough, nutritional supplements may help. You may experience a metallic taste or find that food has no taste at all. You may dislike foods or beverages that you liked before receiving cancer treatment.
What to eat to help with a swollen thigh?
Avoid things that may worsen the symptoms, such as heavy or greasy/fatty, spicy or acidic foods (lemons, tomatoes, oranges). Try saltines, or ginger ale to lessen symptoms.
What are the side effects of mitotane?
Less common, but important side effects can include: 1 Central Nervous System Toxicity: Prolonged use (greater than 2 years) of mitotane can lead to neurotoxic side effects including brain damage and functional impairment. The levels of mitotane in your blood will be closely monitored to prevent these problems and your neurological status will be closely monitored. 2 Ovarian Marcocysts: These cysts have been reports in premenopauasal women taking mitotoane. Report any gynecologic symptoms including vaginal bleeding and/or pelvic pain to your healthcare team.
What is lysodren used for?
Lysodren (mitotane) is a member of the miscellaneous antineoplastics drug class and is commonly used for Adrenal Cortical Carcinoma.
How much does a free drug card save?
The free Drugs.com Discount Card works like a coupon and can save you up to 80% or more off the cost of prescription medicines, over-the-counter drugs and pet prescriptions.
Is Lysodren a generic?
Lysodren is available as a brand name drug only, a generic version is not yet available. For more information, read about generic Lysodren availability . This Lysodren price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies.
Does Lysodren offer coupons?
Lysodren Coupons and Rebates. Lysodren offers may be in the form of a printable coupon, rebate, savings card, trial offer, or free samples. Some offers may be printed right from a website, others require registration, completing a questionnaire, or obtaining a sample from the doctor's office.
How long does mitotane stay in your system?
Because mitotane remains in your body for several days after it is taken , some of the drug may be present in urine, stool, sweat, or vomit. Once you have started to take mitotane, it is important to follow the instructions below every day for as long as your treatment lasts. This will keep yourself, loved ones, and the environment as safe as possible.
Can you get pregnant while taking mitotane?
Women should not become pregnant and men should not get a partner pregnant while taking mitotane. Men and women of childbearing age and potential should use effective contraception during therapy and for as long as mitotane levels are detectable.
Does mitotane lower steroid levels?
Mitotane lowers how much natural steroid is made by your adrenal gland. If you have a fever, an infection, surgery, or you are hurt, talk with your provider.
How should I take Lysodren?from drugs.com
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
What happens if I overdose?from drugs.com
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What other drugs will affect Lysodren?from drugs.com
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
What is lysodren used for?from drugs.com
Lysodren is indicated for the treatment of patients with inoperable, functional or nonfunctional, adrenal cortical carcinoma.
What is the mechanism of action of mitotane?from drugs.com
Mitotane is an adrenal cytotoxic agent with an unknown mechanism of action. Mitotane modifies the peripheral metabolism of steroids and directly suppresses the adrenal cortex. A reduction in 17-hydroxycorticosteroids in the absence of decreased corticosteroid concentrations and increased formation of 6-β-hydroxycortisol have been reported.
How long does mitotane last?from drugs.com
Following discontinuation of mitotane, the plasma terminal half-life ranges from 18 to 159 days (median 53 days).
What are the ingredients in Lysodren?from drugs.com
Inactive ingredients in Lysodren are: microcrystalline cellulose, polyethylene glycol 3350, silicon dioxide, and starch.
What is mitotane used for?
Mitotane is a type of chemotherapy used to treat cancer of the adrenal gland. It works by slowing or stopping the growth of adrenocortical cells. It also lowers production of steroid hormones made in the adrenal gland. These hormones help to regulate important body functions. Patients will need steroid replacement therapy with fludrocortisone and hydrocortisone.
How to give mitotane?
Mitotane can be given by feeding tube. Follow the instructions given by your doctor or pharmacist.
What to wear when handling medicine?
Wear gloves when handling the medicine. Wear a mask if there is potential for exposure to crushed or broken tablets.
Does mitotane affect adrenal glands?
Mitotane decreases hormones made by the adrenal gland and can affect the body’s response to stress or illness . Patients may need extra steroid medications during illness, injury, or stress. This is referred to as an adrenal crisis.
Do you have to check the label on a prescription?
Always check the medication label. Many medicines look the same. Do not take any new medicine, including over-the-counter medicines or supplements, without checking with your doctor or pharmacist. Talk to your doctor or pharmacist about what to do in the case of a missed dose, allergic reaction, or medical emergency. This information is not intended to be a complete guide and is not a substitute for talking with your provider.
Can you crush a tablet?
Swallow tablets whole. Do not crush, chew, or break unless otherwise instructed by a doctor or pharmacist. If tablets are crushed, wear a mask and gloves during preparation and place in food for administration.
Should you tell your doctor if you are pregnant?
Patients should tell their doctor if they are pregnant or breastfeeding.
Commonly Used Brand Name
Uses For Mitotane
- Mitotane is used to treat some types of cancer in the adrenal glands. Mitotane acts on a part of the body called the adrenal cortex. Mitotane reduces the amount of steroids (cortisone-like hormones) that are produced by the adrenal cortex. These hormones are important for various functions of the body, including growth. However, too much of these h...
Before Using Mitotane
- In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For mitotane, the following should be considered:
Proper Use of Mitotane
- Medicines used to treat cancer are very strong and can have many side effects. Before receiving mitotane, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment. Take mitotane only as directed by your doctor. Do not take more or less of it, do not take it more often, and do not take it for a longer time than you…
Precautions While Using Mitotane
- It is very important that your doctor check you at regular visits for any problems or unwanted effects that may be caused by mitotane. Using mitotane while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant during treatment and for as long as mitotane is detected in your blood. If you think you have become pr…
Mitotane Side Effects
- Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediatelyif any of the following side effects occur: More common 1. Darkening of the skin 2. diarrhea 3. dizziness or lightheadedness 4. drowsiness 5. loss of appetite 6. mental depr…
Further Information
- Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Medical Disclaimer
How to Take Mitotane
- Mitotane comes as a tablet to take by mouth. It is usually taken three to four times a day. Take mitotane at around the same times every day. The pill should be swallowed whole with a glass of water; do not crush, chew or break. Mitotane should be taken with meals containing fat-rich foods such as milk, chocolate and oil. Your care provider will de...
Storage and Handling
- Store your medication in the original, labeled container at room temperature and in a dry location (unless otherwise directed by your healthcare provider or pharmacist). This medication should not be stored in a pillbox. Keep containers out of reach of children and pets. If a caregiver prepares your dose for you, they should consider wearing gloves or pour the pills directly from their contai…
Where Do I Get This medication?
- Mitotane is available through retail and mail order pharmacies. Your oncology team will work with your prescription drug plan to identify an in-network pharmacy for distribution of this medication.
Insurance Information
- This medication may be covered under your prescription drug plan. Patient assistance may be available to qualifying individuals without prescription drug coverage. Co-pay cards, which reduce the patient co-pay responsibility for eligible commercially (non-government sponsored) insured patients, may also be available. Your care team can help you find these resources, if they are av…
Possible Side Effects of Mitotane
- There are a number of things you can do to manage the side effects of mitotane. Talk to your care team about these recommendations. They can help you decide what will work best for you. These are some of the most common or important side effects: