Full Answer
What is Nexavar used to treat?
NEXAVAR is a prescription medicine used to treat: a type of liver cancer called hepatocellular carcinoma (HCC) that cannot be removed by surgery. a type of kidney cancer called renal cell carcinoma (RCC)
Can I take Nexavar If I am pregnant?
Your healthcare provider should do a pregnancy test before you start treatment with NEXAVAR. Use effective birth control (contraception) during your treatment with NEXAVAR and for 6 months after the last dose of NEXAVAR. For males with female partners who are able to become pregnant:
When should I stop taking Nexavar before surgery?
You should stop taking NEXAVAR at least 10 days before planned surgery. Your healthcare provider should tell you when you may start taking NEXAVAR again after surgery. changes in the electrical activity of your heart called QT prolongation. QT prolongation can cause irregular heartbeats that can be life threatening.
How do I submit my application to the Bayer Patient Assistance Foundation?
The completed and signed application can be submitted by fax or mail: Fax: 1-866-575-6568 Mail: Bayer US Patient Assistance Foundation P.O. Box 5670, Louisville, KY 40255
What is the cost of Nexavar?
The cost for Nexavar oral tablet 200 mg is around $24,033 for a supply of 120 tablets, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans. This Nexavar price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies.
When should I stop taking Nexavar?
risk of wound healing problems. Tell your healthcare provider if you plan to have any surgery before starting or during treatment with NEXAVAR. You should stop taking NEXAVAR at least 10 days before planned surgery. Your healthcare provider should tell you when you may start taking NEXAVAR again after surgery.
Is there a generic for Nexavar?
Currently, no generic version of Nexavar is available in the U.S. The FDA has approved Nexavar, or sorafenib, to treat thyroid, liver and kidney cancer.
Where can I get sorafenib?
NEXAVAR tablets are available by prescription only and distributed through your healthcare professional (HCP), as well as different types of pharmacies: a network of specialty pharmacy providers (SPPs) and dispensing pharmacies. Your insurance company may require you to fill your prescription through an SPP.
How long can you live with sorafenib?
Median overall survival was 26.1 months with overall 6- and 12-month survival rates of 92.1 and 85%, respectively. Median time to radiological progression was 8 months. The progression-free rate was 64.3%. Fatigue, skin disorders and diarrhea were the most frequent grade 3-4 side effects.
Can you have chemo for the rest of your life?
Some people have cancer that can be controlled with treatment and they can live for a long time. If treatment stops working, the hope may change again.
Is Nexavar a chemotherapy?
What Is Nexavar? Nexavar (sorafenib) is a cancer (chemotherapeutic) medication used to treat a type of kidney cancer called advanced renal cell carcinoma. Nexavar is also used to treat liver cancer.
How effective is Nexavar?
The patients administered with Nexavar showed a 41% reduction in the risk of progression or death when compared to placebo-treated patients. The median PFS was 10.8 months in patients treated with Nexavar, compared to 5.8 months in patients receiving placebo.
Can you eat after taking Nexavar?
Dosage for thyroid cancer You shouldn't take Nexavar with food. Take your dose at least 1 hour before or 2 hours after eating.
Can cancers be fully cured?
Treatment. There are no cures for any kinds of cancer, but there are treatments that may cure you. Many people are treated for cancer, live out the rest of their life, and die of other causes. Many others are treated for cancer and still die from it, although treatment may give them more time: even years or decades.
Does Nexavar cause hair loss?
These are less common side effects for patients receiving Nexavar, when compared with those receiving placebo: High blood pressure (particularly in first 6 weeks of treatment) Hair loss (thinning or patchy hair loss) Nausea.
Can sorafenib shrink tumors?
These findings are supported by previous works. Not only that, MRI scans showed rapid shrinkage of the tumor size during early sorafenib treatment (39.8% in week 5 and by 96.9% in week 15), which indicated that rapid tumor shrinking on the imaging may be another indicator of the therapeutic effects of sorafenib.
How do you know when to stop chemo?
You may reach a point when there are no more effective cancer treatments for you. This is when you should seek hospice care, according to the American Society of Clinical Oncology (ASCO). You may have reached that point if: Your doctor does not think you will live for more than six months.
What happens when you stop taking sorafenib?
Our results showed that the side effects of sorafenib, such as HFSR, diarrhea and hypertension, resolved after the discontinuation of sorafenib. Weight loss and alopecia also improved gradually.
When can you stop taking chemo pills?
Cancer treatment is at its most effective the first time that it's used. If you've undergone three or more chemotherapy treatments for your cancer and the tumors continue to grow or spread, it may be time for you to consider stopping chemotherapy.
How long can you stay on chemotherapy tablets for?
Chemotherapy treatment typically lasts 3–6 months. However, it may be shorter or longer.
Where to report a negative side effect of Nexavar?
You are encouraged to report negative side effects or quality complaints of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088. For important risk and use information about NEXAVAR, please see the full Prescribing Information.
How to know if Nexavar is working?
Your healthcare provider will do blood tests to check your liver function regularly during your treatment with NEXAVAR. Tell your healthcare provider right away if you develop any of the following symptoms: yellowing of your skin or the whites of your eyes. dark “tea-colored” urine.
How long after nexavar is used?
Use effective birth control (contraception) during your treatment with NEXAVAR and for 6 months after the last dose of NEXAVAR. For males with female partners who are able to become pregnant: Use effective birth control (contraception) during your treatment with NEXAVAR and for 3 months after the last dose of NEXAVAR.
What does Nexavar test for?
Your healthcare provider may do tests during your treatment with NEXAVAR to check the levels of potassium, magnesium, and calcium in your blood, and check the electrical activity of your heart with an electrocardiogram ( ECG). Tell your healthcare provider right away if you feel faint, lightheaded, dizzy or feel your heart beating irregularly ...
How long before surgery can you stop Nexavar?
Tell your healthcare provider if you plan to have any surgery before starting or during treatment with NEXAVAR. You should stop taking NEXAVAR at least 10 days before planned surgery. Your healthcare provider should tell you when you may start taking NEXAVAR again after surgery.
Does Nexavar cause fertility problems?
NEXAVAR may cause fertility problems in males. This may affect your ability to father a child. Talk to your healthcare provider if this is a concern for you.
Is Nexavar safe for children?
a type of kidney cancer called renal cell carcinoma (RCC) a type of thyroid cancer called differentiated thyroid carcinoma (DTC) that can no longer be treated with radioactive iodine and is progressing. It is not known if NEXAVAR is safe and effective in children. See More.
How long after Nexavar can you breastfeed?
Do not breastfeed during treatment with NEXAVAR and for 2 weeks after receiving the last dose of NEXAVAR. Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Where to report side effects of prescription drugs?
You are encouraged to report negative side effects or quality complaints of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
Does Nexavar cause fertility problems?
NEXAVAR may cause fertility problems in males. This may affect your ability to father a child. Talk to your healthcare provider if this is a concern for you.
Can Nexavar harm a baby?
NEXAVAR may harm your unborn baby. Tell your healthcare provider right away if you become pregnant during treatment with NEXAVAR. For females who are able to become pregnant: Your healthcare provider should do a pregnancy test before you start treatment with NEXAVAR.
Does Nexavar help with wound healing?
risk of wound healing problems. Wounds may not heal properly during NEXAVAR treatment. Tell your healthcare provider if you plan to have any surgery before starting or during treatment with NEXAVAR.
Can you take Nexavar if you are allergic to sorafenib?
Do not take NEXAVAR if you: are allergic to sorafenib or any of the other ingredients in NEXAVAR. have squamous cell lung cancer and receive carboplatin and paclitaxel.
Does Bayer require prior authorization?
Some insurance plans require patients to obtain approval for coverage before starting therapy (known as Prior Authorization), which can take time and delay the start of therapy. Access Services by Bayer may be able to provide temporary assistance for patients to start therapy right away while waiting for their Prior Authorization approval.
What is Nexavar used for?
NEXAVAR is indicated for the treatment of patients with advanced renal cell carcinoma (RCC). NEXAVAR is indicated for the treatment of patients with locally recurrent or metastatic, progressive, differentiated thyroid carcinoma (DTC) that is refractory to radioactive iodine treatment.
What is the incidence of ischemia in a nexavar group?
Cardiovascular Events: In the SHARP (HCC) study, the incidence of cardiac ischemia/infarction was 2.7% in NEXAVAR-treated patients compared with 1.3% for placebo-treated group. In the TARGET (RCC) study, the incidence of cardiac ischemia/infarction was higher in the NEXAVAR-treated group (2.9%) compared with the placebo-treated group (0.4%). In the DECISION (DTC) study, the incidence of cardiac ischemia/infarction was 1.9% in the NEXAVAR-treated group compared with 0% in the placebo-treated group. Patients with unstable coronary artery disease or recent myocardial infarction were excluded from this study. Consider temporary or permanent discontinuation of NEXAVAR in patients who develop cardiovascular events.
What are the most common laboratory abnormalities observed in the Nexavar study?
In the DTC study, the most common laboratory abnormalities observed in the NEXAVAR arm versus the placebo arm, respectively, were elevated ALT (59% vs. 24%), elevated AST (54% vs. 15%), and hypocalcemia (36% vs. 11%). The relative increase for the following laboratory abnormalities observed in NEXAVAR-treated DTC patients as compared to placebo-treated patients is similar to that observed in the RCC and HCC studies: lipase, amylase, hypokalemia, hypophosphatemia, neutropenia, lymphopenia, anemia, and thrombocytopenia.
What is the treatment for hepatocellular carcinoma?
STIVARGA is indicated for the treatment of patients with hepatocellular carcinoma (HCC) who have been previously treated with sorafenib.
How long after Nexavar can you breastfeed?
Lactation: Because of the potential for serious adverse reactions in a breastfed child from NEXAVAR, advise lactating women not to breastfeed during treatment with NEXAVAR and for 2 weeks after the last dose.
How long to wait to take Nexavar after surgery?
Withhold NEXAVAR for at least 10 days prior to elective surgery. Do not administer for at least 2 weeks following major surgery and until adequate wound healing.
What is hepatotoxicity in STIVARGA?
Hepatotoxicity: Severe drug-induced liver injury with fatal outcome occurred in STIVARGA-treated patients across all clinical trials. In most cases, liver dysfunction occurred within the first 2 months of therapy and was characterized by a hepatocellular pattern of injury. In hepatocellular carcinoma (HCC), there was no increase in the incidence of fatal hepatic failure as compared to placebo.
What is Nexavar used for?
NEXAVAR is indicated for the treatment of patients with advanced renal cell carcinoma (RCC). NEXAVAR is indicated for the treatment of patients with locally recurrent or metastatic, progressive, differentiated thyroid carcinoma (DTC) that is refractory to radioactive iodine treatment.
What is the incidence of ischemia in a nexavar group?
Cardiovascular Events: In the SHARP (HCC) study, the incidence of cardiac ischemia/infarction was 2.7% in NEXAVAR-treated patients compared with 1.3% for placebo-treated group. In the TARGET (RCC) study, the incidence of cardiac ischemia/infarction was higher in the NEXAVAR-treated group (2.9%) compared with the placebo-treated group (0.4%). In the DECISION (DTC) study, the incidence of cardiac ischemia/infarction was 1.9% in the NEXAVAR-treated group compared with 0% in the placebo-treated group. Patients with unstable coronary artery disease or recent myocardial infarction were excluded from this study. Consider temporary or permanent discontinuation of NEXAVAR in patients who develop cardiovascular events.
What are the most common laboratory abnormalities observed in the Nexavar study?
In the DTC study, the most common laboratory abnormalities observed in the NEXAVAR arm versus the placebo arm, respectively, were elevated ALT (59% vs. 24%), elevated AST (54% vs. 15%), and hypocalcemia (36% vs. 11%). The relative increase for the following laboratory abnormalities observed in NEXAVAR-treated DTC patients as compared to placebo-treated patients is similar to that observed in the RCC and HCC studies: lipase, amylase, hypokalemia, hypophosphatemia, neutropenia, lymphopenia, anemia, and thrombocytopenia.
What is the treatment for hepatocellular carcinoma?
STIVARGA is indicated for the treatment of patients with hepatocellular carcinoma (HCC) who have been previously treated with sorafenib.
How long after Nexavar can you breastfeed?
Lactation: Because of the potential for serious adverse reactions in a breastfed child from NEXAVAR, advise lactating women not to breastfeed during treatment with NEXAVAR and for 2 weeks after the last dose.
How long to wait to take Nexavar after surgery?
Withhold NEXAVAR for at least 10 days prior to elective surgery. Do not administer for at least 2 weeks following major surgery and until adequate wound healing.
What is access services by Bayer?
Access Services by Bayer ™ is a free support program available to eligible patients who have been prescribed NEXAVAR ® (sorafenib). Access Services by Bayer provides patients with information about their therapy, helps them evaluate their financial assistance options, and offers education and support to health care professionals.
What is Nexavar used for?
NEXAVAR is a prescription medicine used to treat: a type of liver cancer called hepatocellular carcinoma (HCC) that cannot be removed by surgery. a type of kidney cancer called renal cell carcinoma (RCC) a type of thyroid cancer called differentiated thyroid carcinoma (DTC) that can no longer be treated with radioactive iodine and is progressing. ...
Where to report a negative side effect of Nexavar?
You are encouraged to report negative side effects or quality complaints of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088. For important risk and use information about NEXAVAR, please see the full Prescribing Information.
How long after nexavar is used?
Use effective birth control (contraception) during your treatment with NEXAVAR and for 6 months after the last dose of NEXAVAR. For males with female partners who are able to become pregnant: Use effective birth control (contraception) during your treatment with NEXAVAR and for 3 months after the last dose of NEXAVAR.
How to know if Nexavar is working?
Your healthcare provider will do blood tests to check your liver function regularly during your treatment with NEXAVAR. Tell your healthcare provider right away if you develop any of the following symptoms: yellowing of your skin or the whites of your eyes. dark “tea-colored” urine.
Can Nexavar cause bleeding?
increased risk of bleeding. Bleeding is a common side effect of NEXAVAR that can be serious and can lead to death. Tell your healthcare provider right away if you have any signs of bleeding during treatment with NEXAVAR:
Does Nexavar cause fertility problems?
NEXAVAR may cause fertility problems in males. This may affect your ability to father a child. Talk to your healthcare provider if this is a concern for you.
Can Nexavar harm a baby?
are pregnant or plan to become pregnant. NEXAVAR may harm your unborn baby. Tell your healthcare provider right away if you become pregnant during treatment with NEXAVAR.
What if I need a prior authorization for my medication?
If your insurer requires a prior authorization (PA), the PA must be approved before you can enroll in the Oncology $0 Co-Pay Program. In the meantime, contact Access Services by Bayer to see if you are eligible for temporary assistance so that you can start your therapy right away.
What if I am already enrolled in Access Services by Bayer?
The Oncology $0 Co-Pay Program is for commercially insured patients who have never been enrolled in the Access Services by Bayer Commercial Co-Pay Assistance Program. If you are currently enrolled in the income-based tiered program, you will remain on this program until your enrollment expires. When your annual enrollment expires, you will then be eligible for the Oncology $0 Co-Pay Program.
Can Nexavar cause bleeding?
increased risk of bleeding. Bleeding is a common side effect of NEXAVAR that can be serious and can lead to death. Tell your healthcare provider right away if you have any signs of bleeding during treatment with NEXAVAR:
Does Nexavar cause fertility problems?
NEXAVAR may cause fertility problems in males. This may affect your ability to father a child. Talk to your healthcare provider if this is a concern for you.
Does Nexavar help with wound healing?
risk of wound healing problems. Wounds may not heal properly during NEXAVAR treatment. Tell your healthcare provider if you plan to have any surgery before starting or during treatment with NEXAVAR.
Where to report side effects of prescription drugs?
You are encouraged to report negative side effects or quality complaints of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
Do you need a pregnancy test before taking Nexavar?
Your healthcare provider should do a pregnancy test before you start treatment with NEXAVAR.
