Full Answer
How should I take Nexavar?
Take NEXAVAR exactly as your healthcare provider tells you to take it. The recommended daily dose of NEXAVAR is 2 tablets taken 2 times a day (for a total of 4 tablets each day). Your healthcare professional may change your dose during treatment or stop treatment for some time if you have side effects.
Will Nexavar Cure my Cancer?
NEXAVAR will not cure your cancer, but it has been shown to slow or temporarily stop the growth or spread of certain cancer cells. This is called stable disease. Progressive disease is cancer that is growing or spreading. In clinical studies, stable disease was the most common response to NEXAVAR.
Is Nexavar safe for children?
NEXAVAR is an oral anticancer medication available only by prescription. NEXAVAR has not been studied in children.
What are the side effects of Nexavar?
NEXAVAR may cause liver problems that may lead to liver failure and death. Your healthcare provider will do blood tests to check your liver function regularly during your treatment with NEXAVAR. Tell your healthcare provider right away if you develop any of the following symptoms: change in thyroid hormone levels.
What is the cost of Nexavar?
The cost for Nexavar oral tablet 200 mg is around $24,033 for a supply of 120 tablets, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans. This Nexavar price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies.
When should I stop taking Nexavar?
risk of wound healing problems. Tell your healthcare provider if you plan to have any surgery before starting or during treatment with NEXAVAR. You should stop taking NEXAVAR at least 10 days before planned surgery. Your healthcare provider should tell you when you may start taking NEXAVAR again after surgery.
What is the generic of Nexavar?
Sorafenib is used to treat kidney, liver, and thyroid cancer. It works by slowing or stopping the growth of cancer cells.
Where can I get sorafenib?
NEXAVAR tablets are available by prescription only and distributed through your healthcare professional (HCP), as well as different types of pharmacies: a network of specialty pharmacy providers (SPPs) and dispensing pharmacies. Your insurance company may require you to fill your prescription through an SPP.
How long can you live with sorafenib?
Median overall survival was 26.1 months with overall 6- and 12-month survival rates of 92.1 and 85%, respectively. Median time to radiological progression was 8 months. The progression-free rate was 64.3%. Fatigue, skin disorders and diarrhea were the most frequent grade 3-4 side effects.
Is Nexavar chemo?
Nexavar (sorafenib) is a cancer (chemotherapeutic) medication used to treat a type of kidney cancer called advanced renal cell carcinoma. Nexavar is also used to treat liver cancer.
Does Nexavar cause hair loss?
These are less common side effects for patients receiving Nexavar, when compared with those receiving placebo: High blood pressure (particularly in first 6 weeks of treatment) Hair loss (thinning or patchy hair loss) Nausea.
How effective is Nexavar?
The patients administered with Nexavar showed a 41% reduction in the risk of progression or death when compared to placebo-treated patients. The median PFS was 10.8 months in patients treated with Nexavar, compared to 5.8 months in patients receiving placebo.
What happens when you stop taking sorafenib?
Our results showed that the side effects of sorafenib, such as HFSR, diarrhea and hypertension, resolved after the discontinuation of sorafenib. Weight loss and alopecia also improved gradually.
Can Nexavar shrink tumors?
Sorafenib (Nexavar; Bayer) shrinks desmoid tumors in one third of patients, according to a recent clinical trial thatcould lead to the first drug approval for the disease (N Engl J Med 2018;379:2417–28).
What are the side effects of sorafenib?
Side EffectsBleeding gums.blistering, peeling, redness, or swelling of the palms of the hands or bottoms of the feet.bloating of the abdomen or stomach.blood in the urine or stools.clay-colored stools.coughing up blood.difficulty with breathing or swallowing.increased menstrual flow or vaginal bleeding.More items...•
When should I take sorafenib?
Sorafenib comes as a tablet to take by mouth. It is usually taken twice a day. Sorafenib is taken without food, 1 hour before or 2 hours after a meal. Take sorafenib at around the same times every day.
What happens when you stop taking sorafenib?
Our results showed that the side effects of sorafenib, such as HFSR, diarrhea and hypertension, resolved after the discontinuation of sorafenib. Weight loss and alopecia also improved gradually.
How effective is Nexavar?
The patients administered with Nexavar showed a 41% reduction in the risk of progression or death when compared to placebo-treated patients. The median PFS was 10.8 months in patients treated with Nexavar, compared to 5.8 months in patients receiving placebo.
Can Nexavar shrink tumors?
Sorafenib (Nexavar; Bayer) shrinks desmoid tumors in one third of patients, according to a recent clinical trial thatcould lead to the first drug approval for the disease (N Engl J Med 2018;379:2417–28).
Does Nexavar cause hair loss?
These are less common side effects for patients receiving Nexavar, when compared with those receiving placebo: High blood pressure (particularly in first 6 weeks of treatment) Hair loss (thinning or patchy hair loss) Nausea.
How long after Nexavar can you breastfeed?
Do not breastfeed during treatment with NEXAVAR and for 2 weeks after receiving the last dose of NEXAVAR. Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Where to report side effects of prescription drugs?
You are encouraged to report negative side effects or quality complaints of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
Does Nexavar cause fertility problems?
NEXAVAR may cause fertility problems in males. This may affect your ability to father a child. Talk to your healthcare provider if this is a concern for you.
Can Nexavar harm a baby?
NEXAVAR may harm your unborn baby. Tell your healthcare provider right away if you become pregnant during treatment with NEXAVAR. For females who are able to become pregnant: Your healthcare provider should do a pregnancy test before you start treatment with NEXAVAR.
Does Nexavar help with wound healing?
risk of wound healing problems. Wounds may not heal properly during NEXAVAR treatment. Tell your healthcare provider if you plan to have any surgery before starting or during treatment with NEXAVAR.
Can you take Nexavar if you are allergic to sorafenib?
Do not take NEXAVAR if you: are allergic to sorafenib or any of the other ingredients in NEXAVAR. have squamous cell lung cancer and receive carboplatin and paclitaxel.
Does Bayer require prior authorization?
Some insurance plans require patients to obtain approval for coverage before starting therapy (known as Prior Authorization), which can take time and delay the start of therapy. Access Services by Bayer may be able to provide temporary assistance for patients to start therapy right away while waiting for their Prior Authorization approval.
What does Nexavar test for?
Your healthcare provider may do tests during your treatment with NEXAVAR to check the levels of potassium, magnesium, and calcium in your blood, and check the electrical activity of your heart with an electrocardiogram ( ECG). Tell your healthcare provider right away if you feel faint, lightheaded, dizzy or feel your heart beating irregularly ...
Where to report a negative side effect of Nexavar?
You are encouraged to report negative side effects or quality complaints of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088. For important risk and use information about NEXAVAR, please see the full Prescribing Information.
How long after nexavar is used?
Use effective birth control (contraception) during your treatment with NEXAVAR and for 6 months after the last dose of NEXAVAR. For males with female partners who are able to become pregnant: Use effective birth control (contraception) during your treatment with NEXAVAR and for 3 months after the last dose of NEXAVAR.
How to know if Nexavar is working?
Your healthcare provider will do blood tests to check your liver function regularly during your treatment with NEXAVAR. Tell your healthcare provider right away if you develop any of the following symptoms: yellowing of your skin or the whites of your eyes. dark “tea-colored” urine.
How long before surgery can you stop Nexavar?
Tell your healthcare provider if you plan to have any surgery before starting or during treatment with NEXAVAR. You should stop taking NEXAVAR at least 10 days before planned surgery. Your healthcare provider should tell you when you may start taking NEXAVAR again after surgery.
Does Nexavar cause fertility problems?
NEXAVAR may cause fertility problems in males. This may affect your ability to father a child. Talk to your healthcare provider if this is a concern for you.
Is Nexavar safe for children?
a type of kidney cancer called renal cell carcinoma (RCC) a type of thyroid cancer called differentiated thyroid carcinoma (DTC) that can no longer be treated with radioactive iodine and is progressing. It is not known if NEXAVAR is safe and effective in children. See More.
What is Nexavar used for?
NEXAVAR is indicated for the treatment of patients with advanced renal cell carcinoma (RCC). NEXAVAR is indicated for the treatment of patients with locally recurrent or metastatic, progressive, differentiated thyroid carcinoma (DTC) that is refractory to radioactive iodine treatment.
What is the incidence of ischemia in a nexavar group?
Cardiovascular Events: In the SHARP (HCC) study, the incidence of cardiac ischemia/infarction was 2.7% in NEXAVAR-treated patients compared with 1.3% for placebo-treated group. In the TARGET (RCC) study, the incidence of cardiac ischemia/infarction was higher in the NEXAVAR-treated group (2.9%) compared with the placebo-treated group (0.4%). In the DECISION (DTC) study, the incidence of cardiac ischemia/infarction was 1.9% in the NEXAVAR-treated group compared with 0% in the placebo-treated group. Patients with unstable coronary artery disease or recent myocardial infarction were excluded from this study. Consider temporary or permanent discontinuation of NEXAVAR in patients who develop cardiovascular events.
What are the most common laboratory abnormalities observed in the Nexavar study?
In the DTC study, the most common laboratory abnormalities observed in the NEXAVAR arm versus the placebo arm, respectively, were elevated ALT (59% vs. 24%), elevated AST (54% vs. 15%), and hypocalcemia (36% vs. 11%). The relative increase for the following laboratory abnormalities observed in NEXAVAR-treated DTC patients as compared to placebo-treated patients is similar to that observed in the RCC and HCC studies: lipase, amylase, hypokalemia, hypophosphatemia, neutropenia, lymphopenia, anemia, and thrombocytopenia.
What is the treatment for hepatocellular carcinoma?
STIVARGA is indicated for the treatment of patients with hepatocellular carcinoma (HCC) who have been previously treated with sorafenib.
How long after Nexavar can you breastfeed?
Lactation: Because of the potential for serious adverse reactions in a breastfed child from NEXAVAR, advise lactating women not to breastfeed during treatment with NEXAVAR and for 2 weeks after the last dose.
How long to wait to take Nexavar after surgery?
Withhold NEXAVAR for at least 10 days prior to elective surgery. Do not administer for at least 2 weeks following major surgery and until adequate wound healing.
What is hepatotoxicity in STIVARGA?
Hepatotoxicity: Severe drug-induced liver injury with fatal outcome occurred in STIVARGA-treated patients across all clinical trials. In most cases, liver dysfunction occurred within the first 2 months of therapy and was characterized by a hepatocellular pattern of injury. In hepatocellular carcinoma (HCC), there was no increase in the incidence of fatal hepatic failure as compared to placebo.
How should I take NEXAVAR?
Take NEXAVAR exactly as your healthcare provider tells you to take it. The recommended daily dose of NEXAVAR is 2 tablets taken 2 times a day (for a total of 4 tablets each day). Your healthcare professional may change your dose during treatment or stop treatment for some time if you have side effects. Take NEXAVAR without food (at least 1 hour before or 2 hours after a meal). If you miss a dose of NEXAVAR, skip the missed dose, and take your next dose at your regular time. Do not double your dose of NEXAVAR. If you take too much NEXAVAR, call your doctor or go to the nearest hospital emergency room right away.
What to do if you miss Nexavar?
If you miss a dose of NEXAVAR, skip the missed dose, and take your next dose at your regular time. Do not double your dose of NEXAVAR. If you take too much NEXAVAR, call your doctor or go to the nearest hospital emergency room right away.
How long after nexavar is used?
Use effective birth control (contraception) during your treatment with NEXAVAR and for 6 months after the last dose of NEXAVAR. For males with female partners who are able to become pregnant: Use effective birth control (contraception) during your treatment with NEXAVAR and for 3 months after the last dose of NEXAVAR.
How to know if Nexavar is working?
Your healthcare provider will do blood tests to check your liver function regularly during your treatment with NEXAVAR. Tell your healthcare provider right away if you develop any of the following symptoms: yellowing of your skin or the whites of your eyes. dark “tea-colored” urine.
How long after meal can you take Nexavar?
Take NEXAVAR without food (at least 1 hour before or 2 hours after a meal). If you miss a dose of NEXAVAR, skip the missed dose, and take your next dose at your regular time.
Is Nexavar safe for children?
a type of kidney cancer called renal cell carcinoma (RCC) a type of thyroid cancer called differentiated thyroid carcinoma (DTC) that can no longer be treated with radioactive iodine and is progressing. It is not known if NEXAVAR is safe and effective in children. See More.
Does Nexavar affect your body?
It is important to remember that therapies like NEXAVAR may affect some of your body's normal cells as well, so tell your healthcare team as soon as you notice any side effects.
How to report Nexavar side effects?
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Nexavar holder?
A holder for your NEXAVAR tablets, which can help you organize your doses throughout the week
Can Nexavar cause bleeding?
increased risk of bleeding. Bleeding is a common side effect of NEXAVAR that can be serious and can lead to death. Tell your healthcare provider right away if you have any signs of bleeding during treatment with NEXAVAR:
Does Nexavar cause fertility problems?
NEXAVAR may cause fertility problems in males. This may affect your ability to father a child. Talk to your healthcare provider if this is a concern for you.
Can Nexavar harm a baby?
are pregnant or plan to become pregnant. NEXAVAR may harm your unborn baby. Tell your healthcare provider right away if you become pregnant during treatment with NEXAVAR.
Does Nexavar help with wound healing?
risk of wound healing problems. Wounds may not heal properly during NEXAVAR treatment. Tell your healthcare provider if you plan to have any surgery before starting or during treatment with NEXAVAR.
Can you change your thyroid hormone with Nexavar?
change in thyroid hormone levels. If you have differentiated thyroid cancer, you can have changes in your thyroid hormone levels during treatment with NEXAVAR. Your healthcare provider may need to change your dose of thyroid medicine during treatment with NEXAVAR. Your healthcare provider should check your thyroid hormone levels every month during treatment with NEXAVAR.
What is Nexavar used for?
Nexavar has been approved by the FDA for treatment of advanced kidney cancer. Nexavar is administered in tablet form.
Does Bayer offer Nexavar?
Nexavar REACH Program, a patient assistance program provided by Bayer HealthCare Pharmaceuticals, offers Nexavar at no cost to those who are eligible for the program. Eligibility is based off of the following requirements:
What is Nexavar used for?
NEXAVAR is indicated for the treatment of patients with advanced renal cell carcinoma (RCC). NEXAVAR is indicated for the treatment of patients with locally recurrent or metastatic, progressive, differentiated thyroid carcinoma (DTC) that is refractory to radioactive iodine treatment.
What is the incidence of ischemia in a nexavar group?
Cardiovascular Events: In the SHARP (HCC) study, the incidence of cardiac ischemia/infarction was 2.7% in NEXAVAR-treated patients compared with 1.3% for placebo-treated group. In the TARGET (RCC) study, the incidence of cardiac ischemia/infarction was higher in the NEXAVAR-treated group (2.9%) compared with the placebo-treated group (0.4%). In the DECISION (DTC) study, the incidence of cardiac ischemia/infarction was 1.9% in the NEXAVAR-treated group compared with 0% in the placebo-treated group. Patients with unstable coronary artery disease or recent myocardial infarction were excluded from this study. Consider temporary or permanent discontinuation of NEXAVAR in patients who develop cardiovascular events.
What are the most common laboratory abnormalities observed in the Nexavar study?
In the DTC study, the most common laboratory abnormalities observed in the NEXAVAR arm versus the placebo arm, respectively, were elevated ALT (59% vs. 24%), elevated AST (54% vs. 15%), and hypocalcemia (36% vs. 11%). The relative increase for the following laboratory abnormalities observed in NEXAVAR-treated DTC patients as compared to placebo-treated patients is similar to that observed in the RCC and HCC studies: lipase, amylase, hypokalemia, hypophosphatemia, neutropenia, lymphopenia, anemia, and thrombocytopenia.
What is the treatment for hepatocellular carcinoma?
STIVARGA is indicated for the treatment of patients with hepatocellular carcinoma (HCC) who have been previously treated with sorafenib.
How long after Nexavar can you breastfeed?
Lactation: Because of the potential for serious adverse reactions in a breastfed child from NEXAVAR, advise lactating women not to breastfeed during treatment with NEXAVAR and for 2 weeks after the last dose.
How long to wait to take Nexavar after surgery?
Withhold NEXAVAR for at least 10 days prior to elective surgery. Do not administer for at least 2 weeks following major surgery and until adequate wound healing.
What is access services by Bayer?
Access Services by Bayer ™ is a free support program available to eligible patients who have been prescribed NEXAVAR ® (sorafenib). Access Services by Bayer provides patients with information about their therapy, helps them evaluate their financial assistance options, and offers education and support to health care professionals.
What is Nexavar used for?
NEXAVAR is a prescription medicine used to treat: a type of liver cancer called hepatocellular carcinoma (HCC) that cannot be removed by surgery. a type of kidney cancer called renal cell carcinoma (RCC) a type of thyroid cancer called differentiated thyroid carcinoma (DTC) that can no longer be treated with radioactive iodine and is progressing.
Where to report a negative side effect of Nexavar?
You are encouraged to report negative side effects or quality complaints of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088. For important risk and use information about NEXAVAR, please see the full Prescribing Information.
How long after nexavar is used?
Use effective birth control (contraception) during your treatment with NEXAVAR and for 6 months after the last dose of NEXAVAR. For males with female partners who are able to become pregnant: Use effective birth control (contraception) during your treatment with NEXAVAR and for 3 months after the last dose of NEXAVAR.
How to know if Nexavar is working?
Your healthcare provider will do blood tests to check your liver function regularly during your treatment with NEXAVAR. Tell your healthcare provider right away if you develop any of the following symptoms: yellowing of your skin or the whites of your eyes. dark “tea-colored” urine.
Does Nexavar cause fertility problems?
NEXAVAR may cause fertility problems in males. This may affect your ability to father a child. Talk to your healthcare provider if this is a concern for you.
Can Nexavar harm a baby?
are pregnant or plan to become pregnant. NEXAVAR may harm your unborn baby. Tell your healthcare provider right away if you become pregnant during treatment with NEXAVAR.
Can you take Nexavar if you are allergic to sorafenib?
Do not take NEXAVAR if you: are allergic to sorafenib or any of the other ingredients in NEXAVAR. have squamous cell lung cancer and receive carboplatin and paclitaxel.
