What should I tell my healthcare provider about Ninlaro?
Tell your healthcare provider if you get new or worsening signs or symptoms of the following during treatment with NINLARO: skin rash and pain (shingles) due to reactivation of the chicken pox virus (herpes zoster) blurred vision or other changes in your vision, dry eye, and pink eye (conjunctivitis)
Is it safe to take Ninlaro for multiple myeloma?
INDICATION AND IMPORTANT SAFETY INFORMATION FOR NINLARO ® (ixazomib) Uses of NINLARO. NINLARO is a prescription medicine used to treat multiple myeloma in combination with the medicines REVLIMID® (lenalidomide) and dexamethasone, in people who have received at least one prior treatment for their multiple myeloma.
What happens if your platelet count is low with Ninlaro?
Low platelet counts (thrombocytopenia) are common with NINLARO and can sometimes be serious. You may need platelet transfusions if your counts are too low. Tell your healthcare provider if you have any signs of low platelet counts, including bleeding and easy bruising. Stomach and intestinal (gastrointestinal) problems.
How long does it take NINLARO to work?
In the NINLARO study, the median time that patients experienced their first response was about 1 month with the NINLARO regimen compared with about 2 months with the placebo regimen (placebo+lenalidomide+dexamethasone). It took longer for some patients to see a response.
How is NINLARO taken?
Administration guidelines for NINLARO® (ixazomib) Take each dose of NINLARO at about the same time of day each week. Take each dose of NINLARO at least 1 hour before or at least 2 hours after food. Swallow NINLARO capsules whole with water. Do not crush, chew, or open the capsule.
What is NINLARO used to treat?
NINLARO is a prescription medicine used to treat multiple myeloma in combination with the medicines REVLIMID® (lenalidomide) and dexamethasone, in people who have received at least one prior treatment for their multiple myeloma.
How long does NINLARO stay in your system?
How long does Ninlaro stay in your system? Each dose of Ninlaro may stay in your system for about 47 days after you take it.
Does NINLARO make you tired?
Thrombotic microangiopathy (TMA). Get medical help right away if you get any of the following signs or symptoms during treatment with NINLARO: fever, bruising, nose bleeds, tiredness, or decreased urination.
Does NINLARO cause weight gain?
blurred vision, dry or red eyes; back pain; fluid retention--swelling in your hands or feet, rapid weight gain; liver problems--upper stomach pain, jaundice (yellowing of the skin or eyes);
What are side effects of NINLARO?
Diarrhea, nausea/vomiting, constipation, dry eyes, blurred vision, or eye redness/itching/discharge may occur. Nausea, vomiting, and diarrhea can be severe. In some cases, your doctor may prescribe medication to prevent or relieve nausea, vomiting, and diarrhea.
What type of drug is NINLARO?
Ninlaro belongs to a class of drugs called proteasome inhibitors. It's a targeted treatment for multiple myeloma. Ninlaro targets (works on) a specific protein inside myeloma cells. It creates a buildup of protein in the myeloma cells, which causes those cells to die.
Is NINLARO FDA approved?
On November 20, 2015, the US Food and Drug Administration (FDA) approved NINLARO(ixazomib) capsules for oral use, in combination with lenalidomide and dexamethasone, for the treatment of patients with multiple myeloma who have received at least one prior therapy.
How long a person can live with multiple myeloma?
83.1% of males survive myeloma for at least one year. This falls to 52.6% surviving for five years or more, as shown by age-standardised net survival for patients diagnosed with myeloma during 2013-2017 in England. [1] Survival for females at one year is 82.1% and falls to 51.8% surviving for at least five years.
Is multiple myeloma always fatal?
While multiple myeloma doesn't yet have a cure and can be fatal, patients' life expectancies vary widely, according to Jens Hillengass, MD, Chief of Myeloma at Roswell Park Comprehensive Cancer Center. “I have seen patients live from several weeks to more than 20 years after being diagnosed,” Dr.
What is the best treatment for multiple myeloma?
Steroids. Corticosteroids help destroy myeloma cells and make chemotherapy more effective. The most common types used to treat myeloma are dexamethasone and prednisolone.
What kind of drug is NINLARO?
Ninlaro belongs to a class of drugs called proteasome inhibitors. It's a targeted treatment for multiple myeloma. Ninlaro targets (works on) a specific protein inside myeloma cells. It creates a buildup of protein in the myeloma cells, which causes those cells to die.
What are side effects of NINLARO?
Diarrhea, nausea/vomiting, constipation, dry eyes, blurred vision, or eye redness/itching/discharge may occur. Nausea, vomiting, and diarrhea can be severe. In some cases, your doctor may prescribe medication to prevent or relieve nausea, vomiting, and diarrhea.
What are the side effects of dexamethasone?
AdvertisementAggression.agitation.anxiety.decrease in the amount of urine.fast, slow, pounding, or irregular heartbeat or pulse.headache.mental depression.mood changes.More items...
What are the side effects of Revlimid?
The most common side effects of REVLIMID include:diarrhea.rash.nausea.constipation.tiredness or weakness.fever.itching.
How to report ninlaro side effects?from ninlaro.com
You may report side effects to FDA at 1-800-FDA-1088. Before taking NINLARO, tell your healthcare provider about all your medical conditions, including if you: Have liver problems.
What is the name of the medication used to treat multiple myeloma?from ninlaro.com
NINLARO is a prescription medicine used to treat multiple myeloma in combination with the medicines REVLIMID® (lenalidomide) and dexamethasone, in people who have received at least one prior treatment for their multiple myeloma.
What are the symptoms of ninlaros?from ninlaro.com
Tell your healthcare provider if you get any new or worsening symptoms including: tingling, numbness, pain, a burning feeling in your feet or hands, or weakness in your arms or legs. Swellingis common with NINLARO and can sometimes be severe.
What is a rash that is causing death?from ninlaro.com
Tell your healthcare provider if you get a new or worsening rash. Thrombotic microangiopathy (TMA). This is a condition involving blood clots and injury to small blood vessels that may cause harm to your kidneys, brain, and other organs, and may lead to death.
What is a SLIM CRAB tear sheet?from ninlarohcp.com
The SLiM CRAB Tear Sheets help educate patients on the signs and symptoms of multiple myeloma and identify some of the lab tests that are used.
How do you know if you have liver problems?from ninlaro.com
Tell your healthcare provider if you get these signs of a liver problem: yellowing of your skin or the whites of your eyes; pain in your right upper-stomach area. Other common side effects have occurred.
Can you breastfeed after taking ninlaro?from ninlaro.com
It is not known if NINLARO passes into breast milk, if it affects an infant who is breastfed, or breast milk production. Do not breastfeed during treatment with NINLARO and for 90 days after your final dose of NINLARO. Taking too much NINLARO (overdose) can cause serious side effects, including death.
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Working With Your Care Team
It's important to have open and honest conversations with your healthcare team. Use these questions to help prepare for your next conversation with your healthcare provider.
IN THEIR WORDS: PATIENT STORIES
Hear from patients as they share their stories about living with multiple myeloma.
How to report ninlaro side effects?
You may report side effects to FDA at 1-800-FDA-1088. Before taking NINLARO, tell your healthcare provider about all your medical conditions, including if you: Have liver problems.
What is Ninlaro used for?
Uses of NINLARO. Ninlaro is a prescription medicine used to treat mutiple myeloma in combination with the medicines REVLIMID® (lenalidomide) and dexamethasone, in people who have received at least one prior treatment for their multiple myeloma.
What is the name of the medication used to treat multiple myeloma?
NINLARO is a prescription medicine used to treat multiple myeloma in combination with the medicines REVLIMID® (lenalidomide) and dexamethasone, in people who have received at least one prior treatment for their multiple myeloma.
What are the symptoms of ninlaros?
Tell your healthcare provider if you get any new or worsening symptoms including: tingling, numbness, pain, a burning feeling in your feet or hands, or weakness in your arms or legs. Swellingis common with NINLARO and can sometimes be severe.
What is a rash that is causing death?
Tell your healthcare provider if you get a new or worsening rash. Thrombotic microangiopathy (TMA). This is a condition involving blood clots and injury to small blood vessels that may cause harm to your kidneys, brain, and other organs, and may lead to death.
How do you know if you have liver problems?
Tell your healthcare provider if you get these signs of a liver problem: yellowing of your skin or the whites of your eyes; pain in your right upper-stomach area. Other common side effects have occurred.
Can you breastfeed after taking ninlaro?
It is not known if NINLARO passes into breast milk, if it affects an infant who is breastfed, or breast milk production. Do not breastfeed during treatment with NINLARO and for 90 days after your final dose of NINLARO. Taking too much NINLARO (overdose) can cause serious side effects, including death.