Paclitaxel prescription assistance is sponsored by Teva to help low-income and uninsured patients get expensive brand-name Paclitaxel either for free or at a large discount. PS Card recommends RX Access for help in the Paclitaxel PAP application process.
Full Answer
Why do I need to take other medications with paclitaxel?
Because severe allergic reactions have occurred in some people taking Paclitaxel, you will be asked to take medications to help prevent a reaction. Your doctor will prescribe the exact regimen.
What is paclitaxel?
Paclitaxel is a member of the mitotic inhibitors drug class and is commonly used for Breast Cancer, Breast Cancer - Adjuvant, Breast Cancer - Metastatic, and others. This paclitaxel price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies.
What should I know before receiving paclitaxel?
The nurse or doctor who gives Paclitaxel must be carefully trained. If you experience pain or notice redness or swelling at the IV site while you are receiving Paclitaxel, alert your health care professional immediately.
What should I do if I have an allergic reaction to paclitaxel?
If you experience pain or notice redness or swelling at the IV site while you are receiving Paclitaxel, alert your health care professional immediately. Because severe allergic reactions have occurred in some people taking Paclitaxel, you will be asked to take medications to help prevent a reaction. Your doctor will prescribe the exact regimen.
What is paclitaxel used for?
Paclitaxel is a member of the mitotic inhibitors drug class and is commonly used for Breast Cancer, Breast Cancer - Adjuvant, Breast Cancer - Metastatic, and others.
How much does a free drug card save?
The free Drugs.com Discount Card works like a coupon and can save you up to 80% or more off the cost of prescription medicines, over-the-counter drugs and pet prescriptions.
Is Paclitaxel valid with insurance?
Prices are for cash paying customers only and are not valid with insurance plans. This paclitaxel price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies.
paclitaxel injection, USP Quick Finder
Pfizer RxPathways connects eligible patients to a range of assistance programs that offer insurance support, co-pay help, and medicines for free or at a savings. Patients and physicians can contact RxPathways at (866) 706-2400 or visit the website for more information on these programs www.pfizerrxpathways.com.
WARNING
Paclitaxel Injection, USP should be administered under the supervision of a physician experienced in the use of cancer chemotherapeutic agents. Appropriate management of complications is possible only when adequate diagnostic and treatment...
INDICATIONS AND USAGE
Paclitaxel Injection, USP is indicated as subsequent therapy for the treatment of advanced carcinoma of the ovary. As first-line therapy, paclitaxel is indicated in combination with cisplatin.
DOSAGE AND ADMINISTRATION
NOTE: Contact of the undiluted concentrate with plasticized PVC equipment or devices used to prepare solutions for infusion is not recommended...
CONTRAINDICATIONS
Paclitaxel Injection, USP is contraindicated in patients who have a history of hypersensitivity reactions to paclitaxel or other drugs formulated in Polyoxyl 35 Castor Oil, NF.
WARNINGS
Anaphylaxis and severe hypersensitivity reactions characterized by dyspnea and hypotension requiring treatment, angioedema, and generalized urticaria have occurred in 2%-4% of patients receiving paclitaxel in...
ADVERSE REACTIONS
Pooled Analysis of Adverse Event Experiences from Single-Agent Studies: Data in the following table are based on the experience of 812 patients (493...
What is paclitaxel used for?from drugs.com
Paclitaxel is a novel antimicrotubule agent that promotes the assembly of microtubules from tubulin dimers and stabilizes microtubules by preventing depolymerization. This stability results in the inhibition of the normal dynamic reorganization of the microtubule network that is essential for vital interphase and mitotic cellular functions. In addition, Paclitaxel induces abnormal arrays or “bundles” of microtubules throughout the cell cycle and multiple asters of microtubules during mitosis.#N#Following intravenous administration of Paclitaxel, Paclitaxel plasma concentrations declined in a biphasic manner. The initial rapid decline represents distribution to the peripheral compartment and elimination of the drug. The later phase is due, in part, to a relatively slow efflux of Paclitaxel from the peripheral compartment.#N#Pharmacokinetic parameters of Paclitaxel following 3- and 24-hour infusions of Paclitaxel at dose levels of 135 and 175 mg/m 2 were determined in a Phase 3 randomized study in ovarian cancer patients and are summarized in the following table.#N#TABLE 1. SUMMARY OF PHARMACOKINETIC PARAMETERS—MEAN VALUES
What is paclitaxel injection?from drugs.com
Paclitaxel Injection, USP is indicated as subsequent therapy for the treatment of advanced carcinoma of the ovary. As first-line therapy, Paclitaxel Injection, USP is indicated in combination with cisplatin.#N#Paclitaxel Injection, USP is indicated for the adjuvant treatment of node-positive breast cancer administered sequentially to standard doxorubicin-containing combination chemotherapy. In the clinical trial, there was an overall favorable effect on disease-free and overall survival in the total population of patients with receptor-positive and receptor-negative tumors, but the benefit has been specifically demonstrated by available data (median follow-up 30 months) only in the patients with estrogen and progesterone receptor-negative tumors ( see CLINICAL STUDIES: Breast Carcinoma ).#N#Paclitaxel Injection, USP is indicated for the treatment of breast cancer after failure of combination chemotherapy for metastatic disease or relapse within 6 months of adjuvant chemotherapy. Prior therapy should have included an anthracycline unless clinically contraindicated.#N#Paclitaxel Injection, USP, in combination with cisplatin, is indicated for the first-line treatment of non-small cell lung cancer in patients who are not candidates for potentially curative surgery and/or radiation therapy.#N#Paclitaxel Injection, USP is indicated for the second-line treatment of AIDS-related Kaposi's sarcoma.
How long is Taxol stable?from drugs.com
Unopened vials of Taxol (paclitaxel) Injection are stable until the date indicated on the package when stored between 20°–25° C (68°–77° F), in the original package. Neither freezing nor refrigeration adversely affects the stability of the product. Upon refrigeration, components in the Taxol vial may precipitate, but will redissolve upon reaching room temperature with little or no agitation. There is no impact on product quality under these circumstances. If the solution remains cloudy or if an insoluble precipitate is noted, the vial should be discarded. Solutions for infusion prepared as recommended are stable at ambient temperature (approximately 25° C) and lighting conditions for up to 27 hours.
How to dispose of anticancer drugs?from drugs.com
1–4 To minimize the risk of dermal exposure, always wear impervious gloves when handling vials containing Taxol Injection. If Taxol solution contacts the skin, wash the skin immediately and thoroughly with soap and water. Following topical exposure, events have included tingling, burning, and redness. If Taxol contacts mucous membranes, the membranes should be flushed thoroughly with water. Upon inhalation, dyspnea, chest pain, burning eyes, sore throat, and nausea have been reported.
How long does it take for Taxol to work?from drugs.com
After failure of initial chemotherapy for metastatic disease or relapse within 6 months of adjuvant chemotherapy, Taxol at a dose of 175 mg/m 2 administered intravenously over 3 hours every 3 weeks has been shown to be effective.
What are the reactions to taxol?from drugs.com
Injection site reactions, including reactions secondary to extravasation, were usually mild and consisted of erythema, tenderness, skin discoloration, or swelling at the injection site. These reactions have been observed more frequently with the 24-hour infusion than with the 3-hour infusion. Recurrence of skin reactions at a site of previous extravasation following administration of Taxol at a different site, ie, “recall,” has been reported.
What is the metabolite of paclitaxel?from drugs.com
In vitro studies with human liver microsomes and tissue slices showed that Paclitaxel was metabolized primarily to 6α-hydroxyPaclitaxel by the cytochrome P450 isozyme CYP2C8; and to 2 minor metabolites, 3'- p -hydroxyPaclitaxel and 6α, 3'- p -dihydroxyPaclitaxel, by CYP3A4.
Where is paclitaxel given?
Paclitaxel is given as an injection or infusion into the vein (intravenous, IV).
What is paclitaxel used for?
What Paclitaxel Is Used For: Treatment of breast, ovarian, lung, bladder, prostate, melanoma, esophageal, as well as other types of solid tumor cancers. It has also been used in Kaposi's sarcoma.
What is the class of paclitaxel?
Different drugs may affect different parts of the body. Paclitaxel belongs to a class of chemotherapy drugs called plant alkaloids. Plant alkaloids are made from plants. The vinca alkaloids are made from the periwinkle plant (catharanthus rosea). The taxanes are made from the bark of the Pacific Yew tree (taxus).
What happens if you take paclitaxel with hives?
Hypersensitivity reaction. Fever, facial flushing, chills, shortness of breath, or hives after Paclitaxel is given (see allergic reaction). The majority of these reactions occur within the first 10 minutes of an infusion.
Why is chemotherapy given in cycles?
The scheduling of chemotherapy is set based on the type of cells, rate at which they divide, and the time at which a given drug is likely to be effective. This is why chemotherapy is typically given in cycles. Chemotherapy is most effective at killing cells that are rapidly dividing.
How long does it take for pain to go away after paclitaxel?
Hair loss. Arthralgias and myalgias , pain in the joints and muscles. (see pain) Usually temporary occurring 2 to 3 days after Paclitaxel, and resolve within a few days.
Can paclitaxel cause tissue damage?
If the medication escapes from the vein it can cause tissue damage. The nurse or doctor who gives Paclitaxel must be carefully trained. If you experience pain or notice redness or swelling at the IV site while you are receiving Paclitaxel, alert your health care professional immediately.
Important Note
The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.
How To Use
This medication is given by continuous infusion into a vein over 24 hours. This is usually given once every three weeks, but the dose may be adjusted based on your progress. It is usually administered in a hospital setting where you can be monitored closely. Medication to prevent side effects is usually given before you receive paclitaxel.
Drug Interactions
Tell your doctor or pharmacist of all prescription and nonprescription medications you may use, especially of: ketoconazole, all anti-cancer medications, St John's wort. Do not start or stop any medicine without doctor or pharmacist approval.
Overdose
If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include tingling of the hands or feet; severe mouth sores, or trouble breathing.
Missed Dose
Discuss the dosing schedule with your doctor. Do not double the dose to catch up.
Storage
Store original vials in the refrigerator. The infusion solution can be stored at 77 degrees F (25 degrees C). Check the expiration date and discard any unused medication after that time.
What is paclitaxel used for?
Paclitaxel is used to treat various types of cancer.
Can you take ketoconazole without a doctor's approval?
Tell your doctor or pharmacist of all prescription and nonprescription medications you may use, especially of: ketoconazole, all anti-cancer medications, St John's wort. Do not start or stop any medicine without doctor or pharmacist approval.
Can you get a rash from paclitaxel?
WARNING: Infrequently, serious (sometimes fatal) allergic reactions have occurred with paclitaxel use. Patients who experience severe allergic reactions must never again use this drug. Seek immediate medical attention if you develop signs of an allergic reaction such as rash, itching, breathing trouble, swelling or dizziness. This medication can lower the body's ability to fight an infection. Notify your doctor promptly if you develop signs of an infection such as fever, chills or persistent sore throat. Blood tests (e.g., white blood cell counts) are recommended during paclitaxel use. This medication must be given in an appropriate setting.
What to do if you have neutropenia with Abraxane?
Monitor for neutropenia, which may be severe and result in infection or sepsis. Perform frequent complete blood cell counts on all patients receiving ABRAXANE
What is the first line of treatment for metastatic adenocarcinoma?
ABRAXANE is indicated for the first-line treatment of patients with metastatic adenocarcinoma of the pancreas, in combination with gemcitabine. Monitor for neutropenia, which may be severe and result in infection or sepsis. Perform frequent complete blood cell counts on all patients receiving ABRAXANE.
Can paclitaxel cause hepatic impairment?
The exposure and toxicity of paclitaxel can be increased in patients with hepatic impairment. Closely monitor patients with hepatic impairment for severe myelosuppression
Is Abraxanepro for US healthcare professionals?
The information contained in this section of www.abraxanepro.com is technical in nature and is intended for US healthcare professionals only.
Can Medicare patients get help?
Patients who are unable to afford their medication (including patients with Medicare, Medicaid, or other government-sponsored insurance) may be able to receive help from independent third-party organizations. ‡
Does insurance pay for Abraxane?
There are programs and organizations that may help pay for ABRAXANE, depending on a patient’s insurance situation.
Is anthracycline contraindicated for lung cancer?
Prior therapy should have included an anthracycline unless clinically contraindicated. ABRAXANE is indicated for the first-line treatment of locally advanced or metastatic non–small cell lung cancer, in combination with carboplatin, in patients who are not candidates for curative surgery or radiation therapy.
What is Celgene Patient Support?
Celgene Patient Support ® is committed to helping patients access ABRAXANE, no matter what their insurance situation. It provides:
What to do if you have neutropenia with Abraxane?
Monitor for neutropenia, which may be severe and result in infection or sepsis. Perform frequent complete blood cell counts on all patients receiving ABRAXANE
What is the first line of treatment for metastatic adenocarcinoma?
ABRAXANE is indicated for the first-line treatment of patients with metastatic adenocarcinoma of the pancreas, in combination with gemcitabine. Monitor for neutropenia, which may be severe and result in infection or sepsis. Perform frequent complete blood cell counts on all patients receiving ABRAXANE.
Is anthracycline contraindicated for lung cancer?
Prior therapy should have included an anthracycline unless clinically contraindicated. ABRAXANE is indicated for the first-line treatment of locally advanced or metastatic non–small cell lung cancer, in combination with carboplatin, in patients who are not candidates for curative surgery or radiation therapy.
Can paclitaxel cause hepatic impairment?
The exposure and toxicity of paclitaxel can be increased in patients with hepatic impairment. Closely monitor patients with hepatic impairment for severe myelosuppression
Is myelosuppression a dose dependent disease?
Severe myelosuppression (primarily neutropenia) is dose-dependent and a dose-limiting toxicity of ABRAXANE. In clinical studies, Grade 3-4 neutropenia occurred in 34% of patients with metastatic breast cancer (MBC), 47% of patients with non–small cell lung cancer (NSCLC), and 38% of patients with pancreatic cancer
Important Note
- The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your …
How to Use
- This medication is given by continuous infusion into a vein over 24 hours. This is usually given once every three weeks, but the dose may be adjusted based on your progress. It is usually administered in a hospital setting where you can be monitored closely. Medication to prevent side effects is usually given before you receive paclitaxel.
Precautions
- Tell your doctor your medical history, especially of: heart disease, liver disease, bone marrow disorders, infections, any allergies you may have. Because this medication can lower your body's ability to fight an infection, avoid touching your eyes or inside your nose without first washing your hands. Use caution with sharp objects like safety razors or nail cutters and avoid activities such …
Drug Interactions
- Tell your doctor or pharmacist of all prescription and nonprescription medications you may use, especially of: ketoconazole, all anti-cancer medications, St John's wort. Do not start or stop any medicine without doctor or pharmacist approval.
Overdose
- If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include tingling of the hands or feet; severe mouth sores, or trouble breathing.
Storage
- Store original vials in the refrigerator. The infusion solution can be stored at 77 degrees F (25 degrees C). Check the expiration date and discard any unused medication after that time.
Medical Alert
- Your condition can cause complications in a medical emergency. For enrollment information call MedicAlert at 1-800-854-1166 (USA), or 1-800-668-1507 (Canada).