A PERSERIS copay assistance program will be available to eligible patients. Eligible patients may pay as little as $5 each month. The INSUPPORT Copay Assistance Program is valid only for patients with private insurance who are prescribed PERSERIS for on-label use.
How do I enroll a patient in the copay assistance program for perseris?
Note that for patients enrolled in "Benefit Coverage Information", INSUPPORT® will automatically determine eligibility and enroll an eligible patient in the Copay Assistance Program for PERSERIS. You may enroll an eligible patient online by going to the INSUPPORT® Portal located at www.insupportportal.com.
What is the drug perseris used to treat?
PERSERIS® (risperidone) for extended-release injectable suspension, for subcutaneous use: Medical Affairs Product Fact Sheet Indications and Usage 1 PERSERIS is indicated for the treatment of schizophrenia in adults. Important Safety Information
How much does perseris cost for extended-release suspension?
Some of your patients may be eligible for savings on PERSERIS® (risperidone) for extended-release injectable suspension. Eligible patients may pay as little as $5 per injection of PERSERIS. Restrictions apply. The Program benefit is valid for the out-of-pocket cost for PERSERIS only.
How long does it take for perseris to work?
In a clinical study, patients taking PERSERIS showed significant symptom improvement by 8 weeks. In a clinical study, patients taking PERSERIS showed significant symptom improvement by 8 weeks. Why PERSERIS? PERSERIS is a long-acting form of risperidone and is clinically shown to reduce the symptoms of schizophrenia in adults.
How do you give a Perseris?
Your dose of PERSERIS will be given by an injection under the skin in your abdominal area. Your healthcare provider may pinch a little bit of your skin in order to give you your injection. You may feel a small bump at the spot where the medication is given.
What are the side effects of Perseris?
Some of the most common side effects of PERSERIS include weight gain; constipation; drowsiness; pain in arms, legs, back, or muscles; restlessness; feeling excessive worry or nervousness; and pain or redness at the injection site.
What is Perseris used for?
PERSERIS® (per-SAIR-iss) (risperidone) for extended-release injectable suspension, for subcutaneous use, is a prescription medicine used to treat schizophrenia in adults. Do not receive PERSERIS if you are allergic to risperidone, paliperidone, or any of its components.
When was Perseris released?
Development timeline for PerserisDateArticleJul 27, 2018Approval FDA Approves Perseris (risperidone) for Extended-Release Injectable Suspension for the Treatment of Schizophrenia in AdultsJul 30, 2018
What is the half life of Perseris?
The terminal half-life of RSQM following one injection is between nine and 11 days, and of 9HR it is between eight and nine days.
What are long acting injectable antipsychotics?
These antipsychotic drugs come in a long-lasting form:Aripiprazole (Abilify Maintena)Aripiprazole lauroxil (Aristada)Fluphenazine (Prolixin)Haloperidol (Haldol)Olanzapine pamoate (Zyprexa Relprevv)Paliperidone (Invega Sustenna, Invega Trinza)Risperidone (Risperdal Consta)
How often is Perseris given?
Initiate PERSERIS at a dose of 90 mg or 120 mg once monthly by subcutaneous injection. Do not administer more than one dose (90 mg or 120 mg total) per month.
Does Perseris need to be refrigerated?
Store in refrigerator at 2° to 8°C (36° to 46°F). Allow PERSERIS kit to come to room temperature, 20°C to 25°C (68°F to 77°F), for at least 15 minutes prior to mixing. PERSERIS may be stored in its unopened original packaging at room temperature, 20°C to 25°C (68°F to 77°F), for up to 7 days prior to administration.
How do you administer risperidone Depot?
RISPERDAL CONSTA should be administered every two weeks by deep intramuscular deltoid or gluteal injection using the enclosed appropriate safety needle. For deltoid administration, use the 1-inch needle alternating injections between the two arms.
Is Perseris FDA approved?
FDA approves Perseris for extended-release injectable suspension to treat schizophrenia in adults.
Who manufactures Perseris?
About Indivior Indivior is a global specialty pharmaceutical company with a 20-year legacy of leadership in patient advocacy and health policy while providing education on evidence-based treatment models that have revolutionized modern addiction treatment.
How strong is risperidone?
Your doctor may change your dose depending on how well risperidone works for you. If you have problems with your kidneys or liver your doctor may ask you to take a lower dose and increase your dose very slowly. Standard tablets come as 0.25mg, 0.5mg, 1mg, 2mg, 3mg, 4mg and 6mg strength tablets.
How often does Sublocade release?
SUBLOCADE comes in 2 doses: 300 mg and 100 mg. You'll receive a dose once a month (with at least 26 days between doses). Your treatment provider will start with 300 mg to help the medication reach an effective level in your body.
What is the difference between Aristada and Aristada initio?
ARISTADA INITIO is intended for single administration in contrast to ARISTADA which is administered monthly, every 6 weeks, or every 8 weeks. Do not substitute ARISTADA INITIO for ARISTADA because of differing pharmacokinetic profiles.
What are the side effects of risperidone?
Side EffectsAggressive behavior.agitation.anxiety.changes in vision, including blurred vision.difficulty concentrating.difficulty speaking or swallowing.inability to move the eyes.increase in amount of urine.More items...•
What are subcutaneous injections?
Subcutaneous (SQ or Sub-Q) injection means the injection is given in the fatty tissue, just under the skin. A SQ injection is the best way to give yourself certain medicines, including: Insulin.
How much does Perseris cost?
Perseris Prices. The cost for Perseris subcutaneous powder for injection, extended release 90 mg is around $1,978 for a supply of 1 powder for injections, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans.
How much does a free drug card save?
The free Drugs.com Discount Card works like a coupon and can save you up to 80% or more off the cost of prescription medicines, over-the-counter drugs and pet prescriptions.
What is the dosage of Perseris?from drugs.com
Perseris (risperidone) for extended-release injectable suspension, for subcutaneous use is, when fully mixed a viscous suspension that, varies from white to yellow-green and is available in dosage strengths of 90 mg and 120 mg.
How long before Perseris is used?from drugs.com
When initiation of fluoxetine or paroxetine is considered, patients may be placed on the lowest dose (90 mg) of Perseris between 2- to 4-weeks before the planned start of fluoxetine or paroxetine therapy to adjust for the expected increase in plasma concentrations of risperidone.
Why PERSERIS?from perseris.com
In clinical trials, PERSERIS was shown to reduce the symptoms of schizophrenia in adults. Can PERSERIS help you? Get questions to ask your healthcare provider and discover the possibilities below:
What are the symptoms of Perseris?from drugs.com
Advise breastfeeding women using Perseris to monitor infants for somnolence, failure to thrive, jitteriness, and extrapyramidal symptoms (tremors and abnormal muscle movements) and to seek medical care if they notice these signs [see Use in Specific Populations ( 8.2 )].
What is the affinity of risperidone?from drugs.com
Pharmacodynamics. Risperidone is a monoaminergic antagonist with high affinity (Ki of 0.12 to 7.3 nM) for the serotonin Type 2 (5HT 2 ), dopamine Type 2 (D 2 ), α 1 and α 2 adrenergic, and H 1 histaminergic receptors.
What are the metabolic changes associated with antipsychotics?from drugs.com
These metabolic changes include hyperglycemia, dyslipidemia, and body weight gain. While all of the drugs in the class have been shown to produce some metabolic changes, each drug has its own specific risk profile.
Does fluoxetine affect risperidone?from drugs.com
Fluoxetine (20 mg once daily) and paroxetine (20 mg once daily), potent CYP2D6 inhibitors, have been shown to increase the plasma concentration of risperidone by 2.5- to 2.8-fold and 3- to 9-fold, respectively. Fluoxetine did not affect the plasma concentration of 9-hydroxyrisperidone. Paroxetine lowered the concentration of 9-hydroxyrisperidone by about 10%. The effects of discontinuation of concomitant fluoxetine or paroxetine therapy on the pharmacokinetics of risperidone and 9-hydroxyrisperidone have not been studied.
What should a patient with atypical APs be monitored for?
Any patient treated with atypical APs, including PERSERIS, should be monitored for symptoms of hyperglycemia including polydipsia, polyuria, polyphagia, and weakness. Patients who develop symptoms of hyperglycemia during treatment with atypical APs, including PERSERIS, should undergo FBG testing.
What are the metabolic changes associated with APs?
Hyperglycemia and Diabetes Mellitus (DM), in some cases extreme and associated with ketoacidosis or hyperosmolar coma or death, have been reported in patients treated with APs, including risperidone.
Does risperidone cause neutropenia?
Leukopenia, Neutropenia, and Agranulocytosis have been reported with antipsychotic agents, including risperidone. In patients with a history of a clinically significant low white blood count (WBC) or a drug-induced leukopenia/neutropenia, perform a complete blood count frequently during the first few months of therapy. Consider discontinuation at the first sign of a clinically significant decline in WBC in the absence of other causative factors. Monitor patients with clinically significant neutropenia for fever or other symptoms/signs of infection and treat promptly if such symptoms/signs occur. Discontinue PERSERIS in patients with severe neutropenia (absolute neutrophil count <1000/mm 3) and follow WBC until recovery.
Can risperidone cause seizures?
Seizures have been observed in risperidone studies in adults with schizophrenia. PERSERIS should be used cautiously in patients with a history of seizures or other conditions that potentially lower the seizure threshold.
Does carbamazepine decrease risperidone?
Carbamazepine and other strong CYP3A4 inducers decrease risperidone plasma concentration.
Is dyslipidemia atypical?
Dyslipidemia has been observed in patients treated with atypical APs.
Does risperidone cause prolactin elevation?
Hyperprolactinemia: Risperidone elevates prolactin levels, and the elevation persists during chronic administration. Risperidone is associated with higher levels of prolactin elevation than other antipsychotic agents. Hyperprolactinemia may inhibit reproductive function in female and male patients.
Can you get copay assistance with Medicare?
Patients with government insurance are not eligible for the Copay Assistance Program, including, but not limited to, Medicare, Medicaid, Medigap, VA, DoD, TRICARE, CHAMPVA, or any other federally or state-funded government-assisted program. Other restrictions apply.
Does Insupport provide copay ID?
INSUPPORT® will provide the enrolling healthcare provider with the patient's Copay Member ID for submission of copay claims to INSUPPORT®, as well as copay claim submission instructions (this information is provided immediately if using web enrollment). A Copay Member ID card will be provided to the patient in his/her welcome letter upon enrollment in the program.
What are the metabolic changes associated with antipsychotics?
These metabolic changes include hyperglycemia, dyslipidemia, and body weight gain. While all of the drugs in the class have been shown to produce some metabolic changes, each drug has its own specific risk profile.
What receptors does risperidone target?
Risperidone is a monoaminergic antagonist with high affinity (Ki of 0.12 to 7.3 nM) for the serotonin Type 2 (5HT2) , dopamine Type 2 (D2) , α1 and α2 adrenergic, and H1 histaminergic receptors . Risperidone showed low to moderate affinity (Ki of 47 to 253 nM) for the serotonin 5HT1C, 5HT1D, and 5HT1A receptors, weak affinity (Ki of 620 to 800 nM) for the dopamine D1 and haloperidol-sensitive sigma site, and no affinity (when tested at concentrations > 10-5 M) for cholinergic muscarinic or β1 and β2 adrenergic receptors.
Does risperidone affect AUC?
Repeated doses of oral risperidone (4 mg once daily) did not affect the pre-dose or average plasma concentrations and exposure (AUC) of valproate (1000 mg/day in three divided doses) compared to placebo (n = 21). However, there was a 20% increase in valproate peak plasma concentration (Cmax) after concomitant administration of oral risperidone.
Does carbamazepine affect risperidone?
Carbamazepine co-administration with oral risperidone decreased the steady-state plasma concentrations of risperidone and 9-hydroxyrisperidone by about 50%. Plasma concentrations of carbamazepine did not appear to be affected. Co-administration of other known CYP3A4 enzyme inducers (e.g., phenytoin, rifampin, and phenobarbital) with risperidone may cause similar decreases in the combined plasma concentrations of risperidone and 9-hydroxyrisperidone, which could lead to decreased efficacy of
Can risperidone cause seizures?
Seizures have been observed during pre-marketing studies of risperidone in adult patients with schizophrenia. PERSERIS should be used cautiously in patients with a history of seizures or other conditions that potentially lower the seizure threshold.
Is leukopenia a risk factor for risperidone?
Agranulocytosis has also been reported. Possible risk factors for leukopenia/neutropenia include pre-existing low white blood cell count (WBC) and a history of drug-induced leukopenia/neutropenia. Patients with a history of a clinically significant low WBC or a drug-induced leukopenia/neutropenia should have their complete blood count (CBC) monitored frequently during the first few months of therapy and discontinuation of PERSERIS should be considered at the first sign of a clinically significant decline in WBC in the absence of other causative factors.
Does risperidone elevate prolactin?
As with other drugs that antagonize dopamine D2 receptors, risperidone elevates prolactin levels and the elevation persists during chronic administration. Risperidone is associated with higher levels of prolactin elevation than other antipsychotic agents.
How to avoid Perseris?from drugs.com
Avoid becoming overheated or dehydrated. Drink plenty of fluids, especially in hot weather and during exercise. Avoid driving or hazardous activity until you know how Perseris will affect you. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.
What other drugs will affect Perseris?from drugs.com
Using Perseris with other drugs that make you sleepy or slow your breathing can cause dangerous side effects or death. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.
What is Perseris?from drugs.com
Perseris is an antipsychotic medication. It works by changing the effects of chemicals in the brain.
What should a patient with atypical APs be monitored for?from perserishcp.com
Any patient treated with atypical APs, including PERSERIS, should be monitored for symptoms of hyperglycemia including polydipsia, polyuria, polyphagia, and weakness. Patients who develop symptoms of hyperglycemia during treatment with atypical APs, including PERSERIS, should undergo FBG testing.
Can you change your antipsychotics?from drugs.com
If you already use other antipsychotic medication, you may need to keep using it for a short time. Do not change your dose or dosing schedule without your doctor's advice.
Where is Perseris injected?from drugs.com
Perseris is injected under the skin or into a muscle.
Does carbamazepine decrease risperidone?from perserishcp.com
Carbamazepine and other strong CYP3A4 inducers decrease risperidone plasma concentration.
Why do people stop taking Perseris?
Schizophrenia is a chronic and severe mental disorder that requires ongoing treatment to manage symptoms.2 People with schizophrenia are often unable to perceive their illness, which is a key reason they stop taking their medication.3,4,5 Long-acting injectable antipsychotics, including PERSERIS, provide patients with steady-state plasma concentrations of active drug that remain within a therapeutic range for an extended period.
Can dementia patients die from antipsychotics?
Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death.
Is Perseris an injectable?
Slough, UK and Richmond, VA, 27 February 2019 – Indivior PLC (LON: INDV) today announced the launch of once-monthly PERSERISTM (risperidone) for extended-release injectable suspension in the United States. PERSERIS is approved by the U.S. Food and Drug Administration for the treatment of schizophrenia in adults. PERSERIS delivers its active ingredient, risperidone, in an extended-release delivery system with no loading doses or oral supplementation recommended.
What is Perseris used for?
Uses for Perseris. Risperidone injection is used to treat the symptoms of psychotic (mental) disorders, such as schizophrenia. Risperdal Consta® may be used alone or together with other medicines (eg, lithium or valproate) to treat patients with bipolar disorder.
Can you put belts on Perseris?
Avoid rubbing, massaging, or placing belts or waistbands on the injection site during treatment with Perseris™.
Does risperidone affect the CNS?
Check with your doctor before using this medicine with alcohol or other medicines that affect the central nervous system ( CNS). The use of alcohol or other medicines that affect the CNS with risperidone may worsen the side effects of this medicine, such as dizziness, poor concentration, drowsi ness, unusual dreams, and trouble with sleeping. Some examples of medicines that affect the CNS are antihistamines or medicine for allergies or colds, sedatives, tranquilizers, or sleeping medicines, medicine for depression, medicine for anxiety, prescription pain medicine or narcotics, medicine for attention deficit and hyperactivity disorder, medicine for seizures or barbiturates, muscle relaxants, or anesthetics, including some dental anesthetics.
Is Risperidone safe for elderly?
RisperiDONE is not approved for the treatment of patients with dementia-related psychosis and has not been studied in this population .
Can risperidone be used for dementia?
This may increase the chance of having side effects during treatment. This medicine should not be used for behavioral problems in older adults with dementia. \
Can Zotepine and Zuclopenthixol be used together?
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Can you take Risperidone with dementia?
Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. RisperiDONE is not approved for use in patients with dementia-related psychosis .
Warnings and Precautions
Adverse Reactions
- The most common adverse reactions in a clinical trial (≥ 5% and greater than placebo) were increased weight, constipation, sedation/somnolence, pain in extremity, back pain, akathisia, anxiety, and musculoskeletal pain. The most common injection site reactions (≥ 5%) were injection site pain and erythema. This is not a complete list of potential adverse events. Please s…
Drug Interactions
- Carbamazepine and other strong CYP3A4 inducers decrease risperidone plasma concentration.
- Fluoxetine, paroxetine, and other strong CYP2D6 inhibitors increase risperidone plasma concentration.
- Use with other CNS drugs or alcohol may increase nervous system disorders.
- Carbamazepine and other strong CYP3A4 inducers decrease risperidone plasma concentration.
- Fluoxetine, paroxetine, and other strong CYP2D6 inhibitors increase risperidone plasma concentration.
- Use with other CNS drugs or alcohol may increase nervous system disorders.
- PERSERIS may enhance hypotensive effects of hypotensive agents.
Use in Specific Populations
- Pregnancy: PERSERIS may cause extrapyramidal and/or withdrawal symptoms in neonates with third trimester exposure. Advise patients to notify their healthcare professional if they become or intend to become pregnant during treatment with PERSERIS. Patients exposed to PERSERIS during pregnancy may be registered with the National Pregnancy Registry fo...