Precautions
Interferon gamma-1b is made from human proteins. Interferons help the body fight viral infections. Interferon gamma-1b is used to prevent serious infections in people with a condition called chronic granulomatous disease. Interferon gamma-1b is also used to slow the progression of a bone disorder called malignant osteopetrosis.
What is interferon gamma-1b used for?
Interferon gamma-1b side effects. Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
What are the side effects of interferon gamma-1b?
Store interferon gamma-1b in the refrigerator, do not freeze. You may take the medicine out of the refrigerator and allow it to reach room temperature before injecting your dose. Do not leave the medicine at room temperature for longer than 12 hours. Throw the medicine if it has been at room temperature for more than 12 hours.
Does interferon gamma-1b need to be refrigerated?
Drinking alcohol with interferon gamma-1b can cause side effects. This medicine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
What happens if you drink alcohol while taking interferon gamma-1b?
What is interferon gamma-1b?
How to report Interferon gamma-1b side effects?
What other drugs will affect interferon gamma-1b?
How long can you keep interferon gamma-1b in the refrigerator?
How old do you have to be to take interferon?
What are the side effects of Interferon?
Does interferon affect kidney function?
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How much does interferon gamma cost?
Interferon gamma, used in chronic granulomatous disease, costs about $140 for a 100-microg vial; yearly costs average $21840 per patient.
What is interferon gamma used for?
Interferon gamma-1b injection is used to lower the frequency and severity of serious infections caused by chronic granulomatous disease (CGD). It is also used to slow down the progression of severe, malignant osteopetrosis (SMO).
How is interferon gamma administered?
ACTIMMUNE® (Interferon gamma-1b) should be administered subcutaneously 3 times weekly. It can be injected by the patient or caregiver after appropriate training by a healthcare professional.
Who makes actimmune?
Visit www.ACTIMMUNE.com to download a copy of the ACTIMMUNE Full Prescribing Information. Horizon Pharma plc is a biopharmaceutical company focused on improving patients' lives by identifying, developing, acquiring and commercializing differentiated and accessible medicines that address unmet medical needs.
How long can you take interferon for?
Interferon treatment for hepatitis C would typically last 24–48 weeks (6–12 months). Interferons caused many long-term side effects partly because of this long treatment time.
Is interferon gamma FDA approved?
ACTIMMUNE® (Interferon gamma-1b) is approved by the FDA to delay time to disease progression in patients with severe malignant osteopetrosis (SMO). ACTIMMUNE® is believed to work by changing how some cells in your body work. This includes the cells that help form your bones.
What increases interferon-gamma?
High Interferon-Gamma LPS can be elevated by bacterial infections, a “leaky gut”, or other health conditions. Nitric oxide also increases interferon-gamma levels [4].
What triggers interferon-gamma release?
IFN‐γ is primarily secreted by activated T cells and natural killer (NK) cells, and can promote macrophage activation, mediate antiviral and antibacterial immunity, enhance antigen presentation, orchestrate activation of the innate immune system, coordinate lymphocyte–endothelium interaction, regulate Th1/Th2 balance, ...
Is IFN-gamma inflammatory?
Abstract. IFN-gamma has long been recognized as a signature proinflammatory cytokine that plays a central role in inflammation and autoimmune disease. There is now emerging evidence indicating that IFN-gamma possesses unexpected properties as a master regulator of immune responses and inflammation.
What is chronic granulomatous?
Chronic granulomatous disease (CGD) is a genetic disorder in which white blood cells called phagocytes are unable to kill certain types of bacteria and fungi. People with CGD are highly susceptible to frequent and sometimes life-threatening bacterial and fungal infections.
What is a granulomatous?
Overview. Chronic granulomatous (gran-u-LOM-uh-tus) disease (CGD) is an inherited disorder that occurs when a type of white blood cell (phagocyte) that usually helps your body fight infections doesn't work properly. As a result, the phagocytes can't protect your body from bacterial and fungal infections.
Who makes interferon gamma?
Interferon-gamma is secreted predominantly by activated lymphocytes such as CD4 T helper type 1 (Th1) cells and CD8 cytotoxic T cells (23–26), γδ T cells (27–33), and natural killer (NK) cells (34, 35) and, to a less extent, by natural killer T cells (NKT), B cells (36–39), and professional antigen-presenting cells ( ...
What is the role of interferon?
Interferons were first described as an antiviral factor that interferes with viral replication in mammalian cells (10). They are secreted from infected cells and activate innate immune response that promotes not only cytokine production but also natural killer cell functions and antigen presentation (11, 12).
What does high interferon gamma mean?
Elevated IFN-gamma levels are commonly associated with: Increased severity of heart disease, as seen in a study on 104 people with coronary heart disease and type 2 diabetes [22] Amyotrophic lateral sclerosis (ALS) disease progression, as seen in a study on 52 people [23] Lupus, as seen in a study on 64 people [24]
What is human interferon gamma?
Human interferon gamma is a cytokine belonging to a diverse group of interferons which have a crucial immunological function against mycobacteria and a wide variety of viral infections.
What type of interferon is interferon gamma?
type II interferonIFN-γ, or type II interferon, is a cytokine that is critical for innate and adaptive immunity against viral, some bacterial and protozoan infections. IFN-γ is an important activator of macrophages and inducer of major histocompatibility complex class II molecule expression.
Chronic granulomatous disease - Symptoms and causes
Overview. Chronic granulomatous (gran-u-LOM-uh-tus) disease (CGD) is an inherited disorder that occurs when a type of white blood cell (phagocyte) that usually helps your body fight infections doesn't work properly.
Interferon Gamma-1b Injection: MedlinePlus Drug Information
Before receiving interferon gamma-1b injection, tell your doctor and pharmacist if you are allergic to interferon gamma-1b injection, products made from the E. colibacteria, any other medications, or any of the other ingredients in interferon gamma-1b injection.Ask your pharmacist for a list of the ingredients.
What is actimmune used for?
Actimmune (interferon gamma-1b) is a member of the interferons drug class and is commonly used for Chronic Granulomatous Disease, Cutaneous T-cell Lymphoma, Idiopathic Pulmonary Fibrosis, and others.
What is the FDA approved diagnosis?
FDA-approved diagnosis. Must be a US resident and treated by a US licensed healthcare provider. Co-payment assistance, reimbursement support, and patient assistance programs are available for eligible patients. Please visit www.actimmune.com or call 1-877-305-7704 for more information. Applicable drugs:
What is interferon gamma-1b?
Interferon gamma-1b is made from human proteins. Interferons help the body fight viral infections.
How to report Interferon gamma-1b side effects?
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Interferon gamma-1b side effects (more detail)
What other drugs will affect interferon gamma-1b?
Other drugs may interact with interferon gamma-1b, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
How long can you keep interferon gamma-1b in the refrigerator?
Do not leave the medicine at room temperature for longer than 12 hours.
How old do you have to be to take interferon?
Interferon gamma-1b is not approved for use by anyone younger than 1 year old.
What are the side effects of Interferon?
Interferon gamma-1b side effects. Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: confusion, hallucinations; a seizure (convulsions);
Does interferon affect kidney function?
While using interferon gamma-1b, you may need frequent blood tests. Your kidney function may also need to be checked. Tell your doctor if you have any changes in height or weight. Interferon gamma-1b doses are based on body surface area (height and weight), and any changes may affect your dose.
