What is interferon gamma-1b?
ACTIMMUNE® (Interferon gamma-1b) helps lower the risk of serious infection* in people with chronic granulomatous disease (CGD). Interested in learning more about ACTIMMUNE? CGD Nurse Advocates can help you better understand CGD and how ACTIMMUNE may help.
What is Actimmune®?
ACTIMMUNE® (Interferon gamma-1b) helps lower the risk of serious infection* in people with chronic granulomatous disease (CGD). Interested in learning more about ACTIMMUNE?
How do I contact Actimmune® support team?
Reach out to us Monday – Friday from 8 AM to 8 PM ET at 1-833-346-9243. At ACTIMMUNE.com, you can learn more about the signs and symptoms of chronic granulomatous disease (CGD). You can find information on how ACTIMMUNE ® helps protect against serious infections and hear from patients and caregivers about living with CGD and taking ACTIMMUNE ®.
How much does Actimmune subcutaneous solution cost?
The cost for Actimmune subcutaneous solution (2000000 intl units/0.5 mL) is around $63,546 for a supply of 6 milliliters, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans.
Who provides Actimmune patient assistance?
Where is InterMune located?
How much does interferon gamma cost?
Interferon gamma, used in chronic granulomatous disease, costs about $140 for a 100-microg vial; yearly costs average $21840 per patient.
What is interferon gamma used for?
Interferon gamma-1b injection is used to lower the frequency and severity of serious infections caused by chronic granulomatous disease (CGD). It is also used to slow down the progression of severe, malignant osteopetrosis (SMO).
How is interferon gamma administered?
ACTIMMUNE® (Interferon gamma-1b) should be administered subcutaneously 3 times weekly. It can be injected by the patient or caregiver after appropriate training by a healthcare professional.
How long can you take interferon for?
Interferon treatment for hepatitis C would typically last 24–48 weeks (6–12 months). Interferons caused many long-term side effects partly because of this long treatment time.
Is interferon gamma FDA approved?
ACTIMMUNE® (Interferon gamma-1b) is approved by the FDA to delay time to disease progression in patients with severe malignant osteopetrosis (SMO). ACTIMMUNE® is believed to work by changing how some cells in your body work. This includes the cells that help form your bones.
What increases interferon-gamma?
High Interferon-Gamma LPS can be elevated by bacterial infections, a “leaky gut”, or other health conditions. Nitric oxide also increases interferon-gamma levels [4].
What triggers interferon-gamma release?
IFN‐γ is primarily secreted by activated T cells and natural killer (NK) cells, and can promote macrophage activation, mediate antiviral and antibacterial immunity, enhance antigen presentation, orchestrate activation of the innate immune system, coordinate lymphocyte–endothelium interaction, regulate Th1/Th2 balance, ...
Is IFN-gamma inflammatory?
Abstract. IFN-gamma has long been recognized as a signature proinflammatory cytokine that plays a central role in inflammation and autoimmune disease. There is now emerging evidence indicating that IFN-gamma possesses unexpected properties as a master regulator of immune responses and inflammation.
What is the role of interferon?
Interferons were first described as an antiviral factor that interferes with viral replication in mammalian cells (10). They are secreted from infected cells and activate innate immune response that promotes not only cytokine production but also natural killer cell functions and antigen presentation (11, 12).
What does high interferon-gamma mean?
Elevated IFN-gamma levels are commonly associated with: Increased severity of heart disease, as seen in a study on 104 people with coronary heart disease and type 2 diabetes [22] Amyotrophic lateral sclerosis (ALS) disease progression, as seen in a study on 52 people [23] Lupus, as seen in a study on 64 people [24]
What type of interferon is interferon-gamma?
type II interferonIFN-γ, or type II interferon, is a cytokine that is critical for innate and adaptive immunity against viral, some bacterial and protozoan infections. IFN-γ is an important activator of macrophages and inducer of major histocompatibility complex class II molecule expression.
Is IFN-gamma inflammatory?
Abstract. IFN-gamma has long been recognized as a signature proinflammatory cytokine that plays a central role in inflammation and autoimmune disease. There is now emerging evidence indicating that IFN-gamma possesses unexpected properties as a master regulator of immune responses and inflammation.
Important Note
The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.
Uses
This medication is a certain type of interferon used to reduce the frequency and severity of serious infections due to a genetic disorder called Chronic Granulomatous Disease (CGD). It is often used along with antibiotics to help prevent these serious infections.
How To Use
Before using, gently swirl the vial solution and check this product visually for particles or discoloration. If either is present, do not use the liquid. Do not shake the vial. Doing so may decrease the effectiveness of the drug. Learn how to prepare and inject the drug and review all instructions in the product package.
Side Effects
Flu-like symptoms (e.g., fever, chills, unusual weakness, muscle aches), headache, nausea, and vomiting may occur. If any of these effects persist or worsen, notify your doctor. Tell your doctor immediately if any of these serious side effects occur: muscle pain, joint pain, redness/swelling/pain at the injection site, stomach/abdominal pain.
Precautions
Tell your doctor your medical history, especially of: heart problems (e.g., arrhythmias, heart failure or disease), seizure disorders, nervous system problems (e.g., tremor, problems walking, chronic dizziness), low blood cell counts (e.g., neutropenia, thrombocytopenia), any allergies (especially to other interferon products).
Drug Interactions
Tell your doctor of all prescription and nonprescription medication you may use, especially: drugs that may suppress your immune system (e.g., cancer chemotherapy, prednisone, cyclosporine). Do not start or stop any medicine without doctor or pharmacist approval.
Overdose
If overdose is suspected, contact your local poison control center or emergency room immediately.
Important Safety Information
ACTIMMUNE® is part of a drug regimen used to treat Chronic Granulomatous Disease, or CGD. CGD is a genetic disorder, usually diagnosed in childhood, that affects some cells of the immune system and the body’s ability to fight infections effectively. CGD is often treated (though not cured) with antibiotics, antifungals, and ACTIMMUNE.
Important Safety Information
ACTIMMUNE® is part of a drug regimen used to treat Chronic Granulomatous Disease, or CGD. CGD is a genetic disorder, usually diagnosed in childhood, that affects some cells of the immune system and the body’s ability to fight infections effectively. CGD is often treated (though not cured) with antibiotics, antifungals, and ACTIMMUNE.
CONTRAINDICATIONS
In patients who develop or have known hypersensitivity to interferon-gamma, E. coli derived products, or any component of the product
WARNINGS AND PRECAUTIONS
Pre-existing cardiac conditions, including ischemia, congestive heart failure, or arrhythmia
DRUG INTERACTIONS
Concomitant use of drugs with neurotoxic, hematotoxic, or cardiotoxic effects may increase the toxicity of interferons
ADVERSE REACTIONS
The most common adverse experiences occurring with ACTIMMUNE therapy are “flu-like” symptoms such as fever, headache, chills, myalgia, or fatigue, which may decrease in severity as treatment continues, and may be minimized by bedtime administration of ACTIMMUNE. Acetaminophen may be used to prevent or partially alleviate the fever and headache
What is actimmune used for?
Actimmune (interferon gamma-1b) is a member of the interferons drug class and is commonly used for Chronic Granulomatous Disease, Cutaneous T-cell Lymphoma, Idiopathic Pulmonary Fibrosis, and others.
What is the FDA approved diagnosis?
FDA-approved diagnosis. Must be a US resident and treated by a US licensed healthcare provider. Co-payment assistance, reimbursement support, and patient assistance programs are available for eligible patients. Please visit www.actimmune.com or call 1-877-305-7704 for more information. Applicable drugs:
Understanding Health Plans and Making the Right Choice for You
Learn how health plan providers determine coverage, what the two main types of health plans in the United States are, and what to consider when choosing a plan.
The Insurance Approval Process
Learn how health plan providers review requests for coverage and what to do when requests are denied.
The Assistance Fund
The Assistance Fund is an independent charitable patient assistance organization that provides support for adults and children with rare and chronic diseases. The organization may help provide families with financial and travel assistance.
Good Days
Good Days works to improve the health and quality of life of patients with chronic disease, cancer, or other life-altering conditions. The organization may help provide families with financial and travel assistance.
National Organization for Rare Disorders (NORD)
NORD is a patient advocacy organization dedicated to people with rare diseases and the groups that help them. NORD provides patients and families with advocacy information, assistance programs, and connections to patient organizations.
Important Safety Information
ACTIMMUNE® is part of a drug regimen used to treat Chronic Granulomatous Disease, or CGD. CGD is a genetic disorder, usually diagnosed in childhood, that affects some cells of the immune system and the body’s ability to fight infections effectively. CGD is often treated (though not cured) with antibiotics, antifungals, and ACTIMMUNE.
Important Safety Information
ACTIMMUNE® is part of a drug regimen used to treat Chronic Granulomatous Disease, or CGD. CGD is a genetic disorder, usually diagnosed in childhood, that affects some cells of the immune system and the body’s ability to fight infections effectively. CGD is often treated (though not cured) with antibiotics, antifungals, and ACTIMMUNE.
What are the side effects of acimune?
The most common adverse experiences occurring with ACTIMMUNE therapy are “flu-like” symptoms such as fever, headache, chills, myalgia, or fatigue, which may decrease in severity as treatment continues, and may be minimized by bedtime administration of ACTIMMUNE.
Does acetaminophen help with fever?
Acetaminophen may be used to prevent or partially alleviate the fever and headache. Isolated cases of acute serious hypersensitivity reactions have been observed in patients receiving ACTIMMUNE. Reversible neutropenia, thrombocytopenia, and elevations of AST and/or ALT have been observed during ACTIMMUNE therapy.
What is the name of the drug that is given to you with a prescription for gamma-1b?
With your prescription of ACTIMMUNE ® (interferon gamma-1b), you and your family have access to Horizon By Your Side, a program that offers a wide range of services at no cost to help you reach your goals for treatment and healthy living.
What is the purpose of aximune?
ACTIMMUNE ® is part of a drug regimen used to treat Chronic Granulomatous Disease , or CGD. CGD is a genetic disorder, usually diagnosed in childhood, that affects some cells of the immune system and the body's ability to fight infections effectively. CGD is often treated (though not cured) with antibiotics, antifungals, and ACTIMMUNE.
Can you take acimune at the same time as a shot?
Avoid taking ACTIMMUNE at the same time as a vaccination.
Can you take acimune if you are allergic to interferon?
Don't use ACTIMMUNE if you are allergic to interferon-gamma, E coli -derived products, or any ingredients contained in the product.
Can actimune cause bone marrow to be reduced?
Bone marrow function may be suppressed with ACTIMMUNE, and decreased production of cells important to the body may occur. This effect, which can be severe, is usually reversible when the drug is discontinued or the dose is reduced.
Can acimune cause rash?
In rare cases, ACTIMMUNE can cause severe allergic reactions and/or rash. If you experience a serious reaction to ACTIMMUNE, discontinue it immediately and contact your doctor or seek medical help.
How to get more information about Actimmune?
To receive farther information about Actimmune and its effects, talk to your doctor.
What is actimmune used for?
Actimmune is an injectable medication that is used to prevent serious infections caused by Chronic Granulomatous Disease (CGD).
Is Prescription Hope An Actimmune Coupon Card, Generic, Or Insurance Product?
Prescription Hope is not an Actimmune coupon card or insurance policy. Our program is also not an Actimmune Generic. Prescription Hope is a national advocacy program that works with any coverage you may already have. Although Prescription Hope is not an Actimmune coupon, individuals looking for an Actimmune coupon can find more savings through Prescription Hope!
Can Prescription Hope Get My Actimmune If I Have Health Insurance Coverage?
Because Prescription Hope is not a health insurance plan, our program works alongside any coverage you may currently have to obtain your Actimmune medication at an affordable price. Our national advocacy program does not have medication tiers, copays, or deductibles.
Is there a generic version of Actimmune?
There is currently not a generic version of Actimmune available in the United States. Please note: Fraudulent online pharmacies may try to sell you an illegal Actimmune generic medication. Do not purchase medications from these pharmacies as they could be harmful. Ask your doctor for advice when it comes to purchasing your medications.
Do I Qualify For Actimmune Patient Assistance With Prescription Hope?
Prescription Hope works with thousands of Americans every month, obtaining prescription medications on their behalf for the set price of $50.00 per month per medication.
What is the CGD nurse advocate number?
CGD Nurse Advocates do not provide individual patient care or medical advice. Reach out to us Monday – Friday from 8 AM to 8 PM ET at 1-833-346-9243.
Does acetaminophen help with fever?
Bedtime administration of ACTIMMUNE may help reduce some of these symptoms. Acetaminophen may be helpful in preventing fever and headache.
Who provides Actimmune patient assistance?
Actimmune Patient Assistance Program is provided by InterMune, Inc.. They offer a 90 day supply of Actimmune at a reduced cost to those who are eligible for the program. Eligibility is based off of the following requirements:
Where is InterMune located?
InterMune, Inc. was founded in Brisbane, California, 1998. They are a biotechnical company whose primary focus is on creating and commercializing therapies related to pulmonary disease, infectious disease, and cancer. InterMune, Inc.'s entire product line is focused on improving comfort in patients while they receive their treatments.
Important Note
- InterMune, Inc. was founded in Brisbane, California, 1998. They are a biotechnical company whose primary focus is on creating and commercializing therapies related to pulmonary disease, infectious disease, and cancer. InterMune, Inc.'s entire product line is focused on improving com…
Uses
How to Use
Side Effects
Precautions
- This medication is a certain type of interferon used to reduce the frequency and severity of serious infections due to a genetic disorder called Chronic Granulomatous Disease (CGD). It is often used along with antibiotics to help prevent these serious infections. This medication is also used to slow down the progress of another genetic bone disease...
Drug Interactions
- Before using, gently swirl the vial solution and check this product visually for particles or discoloration. If either is present, do not use the liquid. Do not shake the vial. Doing so may decrease the effectiveness of the drug. Learn how to prepare and inject the drug and review all instructions in the product package. If any of the information is unclear, consult your doctor or p…
Notes
- Flu-like symptoms (e.g., fever, chills, unusual weakness, muscle aches), headache, nausea, and vomiting may occur. If any of these effects persist or worsen, notify your doctor. Tell your doctor immediately if any of these serious side effects occur: muscle pain, joint pain, redness/swelling/pain at the injection site, stomach/abdominal pain. Tell your doctor immediatel…
Storage
- Tell your doctor your medical history, especially of: heart problems (e.g., arrhythmias, heart failure or disease), seizure disorders, nervous system problems (e.g., tremor, problems walking, chronic dizziness), low blood cell counts (e.g., neutropenia, thrombocytopenia), any allergies (especially to other interferon products). This drug is not recommended for use during pregnancy due to the ri…
Medical Alert
- Tell your doctor of all prescription and nonprescription medication you may use, especially: drugs that may suppress your immune system (e.g., cancer chemotherapy, prednisone, cyclosporine). Do not start or stop any medicine without doctor or pharmacist approval.
Contraindications
- Do not share this medication with others. Laboratory and/or medical tests (e.g., blood counts, liver and kidney function) will be performed to monitor your progress and/or possible side effects.
Warnings and Precautions
- Store in the refrigerator between 36 and 46 degrees F (2 and 8 degrees C) away from light and moisture. Do not freeze. Do not leave vials out of the refrigerator for greater than 12 hours. Discard any unused portion of the vial or any vials left out of the refrigerator for greater than 12 hours.
Drug Interactions
- Your condition can cause complications in a medical emergency. For enrollment information call MedicAlert at 1-800-854-1166 (USA), or 1-800-668-1507 (Canada).
Adverse Reactions
- In patients who develop or have known hypersensitivity to interferon-gamma, E. coliderived products, or any component of the product