Patient Assistance & Copay Programs for Trifluridine ophthalmic Patient assistance programs (PAPs) are usually sponsored by pharmaceutical companies and provide free or discounted medicines and copay programs to low income or uninsured and under-insured people who meet specific guidelines. Eligibility requirements vary for each program.
Full Answer
What is tipiracil/trifluridine?
Lonsurf (tipiracil/trifluridine) is a member of the antineoplastic combinations drug class and is commonly used for Colorectal Cancer and Gastric Cancer. This Lonsurf price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies.
How much does trifluridine cost?
The cost for trifluridine ophthalmic ophthalmic solution 1% is around $199 for a supply of 7.5 milliliters, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans.
What is trifluridine ophthalmic?
Trifluridine ophthalmic is a member of the ophthalmic anti-infectives drug class and is commonly used for Herpetic Keratitis. The cost for trifluridine ophthalmic ophthalmic solution 1% is around $199 for a supply of 7.5 milliliters, depending on the pharmacy you visit.
How much does Lonsurf cost at the pharmacy?
Lonsurf Prices. This Lonsurf price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies. The cost for Lonsurf oral tablet (6.14 mg-15 mg) is around $3,454 for a supply of 20 tablets, depending on the pharmacy you visit.
Is trifluridine Tipiracil chemotherapy?
Introduction: Trifluridine/tipiracil is a novel oral cytotoxic chemotherapy consisting of a thymidine-based nucleoside analog, trifluridine, and a thymidine phosphorylase inhibitor, tipiracil. Trifluridine/tipiracil was approved for the treatment of metastatic colorectal cancer refractory to standard therapies.
How effective is LONSURF?
On average, the time to cancer progression was 2 months for patients on Lonsurf compared to 1.7 months for patients receiving a placebo. Worsening of the disease or death occurred in 88% of patients treated with Lonsurf and 94% of patients who received placebo.
What kind of drug is LONSURF?
Lonsurf is a type of chemotherapy drug. You might have Lonsurf as a treatment for bowel cancer that has spread to other parts of the body.
What are the side effects of LONSURF?
The most common side effects with LONSURF include tiredness (fatigue, weakness), nausea, decreased appetite, diarrhea, vomiting, abdominal pain, and fever. Tell your doctor if you have nausea, vomiting, or diarrhea that is severe or that does not go away.
How long do people live on LONSURF?
In a clinical trial, half of the patients with metastatic stomach cancer treated with LONSURF were still alive at 5.7 months and half of the patients who received placebo were still alive at 3.6 months.
What is the half life of LONSURF?
After the administration of TFD/TPI 35 mg/m2 twice daily, the mean elimination half-lives of TFD and TPI were 1.4 hours and 2.1 hours, respectively, after a single dose. The mean elimination half-lives at steady state of TFD and TPI were 2.1 hours and 2.4 hours, respectively.
Is LONSURF better than stivarga?
These agents were tested in very similar settings, but they have never been compared head-to-head. Stivarga was compared with placebo in a large study and it showed superiority to placebo in all parameters. Lonsurf was also compared with placebo and also showed an improvement in all efficacy parameters.
Is LONSURF a new drug?
Lonsurf (Trifluridine plus Tipiracil): A New Oral Treatment Approved for Patients with Metastatic Colorectal Cancer - PMC. The . gov means it's official.
Do you take LONSURF with food?
LONSURF® (trifluridine and tipiracil) tablets are: A tablet you swallow twice a day with food- the type of food does not matter. A tablet you swallow whole. Do not retake doses of LONSURF that are vomited or missed and continue with the next scheduled dose.
What is LONSURF indicated for?
LONSURF is indicated for the treatment of adult patients with metastatic colorectal cancer previously treated with fluoropyrimidine‑, oxaliplatin‑ and irinotecan‑based chemotherapy, an anti‑VEGF biological therapy, and if RAS wild type, an anti‑EGFR therapy.
Does LONSURF cause shortness of breath?
Lonsurf side effects low red blood cells (anemia) - pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet; or.
Is LONSURF FDA approved?
FDA approves Lonsurf for recurrent, metastatic gastric and gastroesophageal junction adenocarcinoma. On February 22, 2019, the Food and Drug Administration approved trifluridine/ tipiracil tablets (LONSURF, Taiho Pharmaceutical Co., Ltd.)
Do you take LONSURF with food?
LONSURF® (trifluridine and tipiracil) tablets are: A tablet you swallow twice a day with food- the type of food does not matter. A tablet you swallow whole. Do not retake doses of LONSURF that are vomited or missed and continue with the next scheduled dose.
Is LONSURF FDA approved?
FDA approves Lonsurf for recurrent, metastatic gastric and gastroesophageal junction adenocarcinoma. On February 22, 2019, the Food and Drug Administration approved trifluridine/ tipiracil tablets (LONSURF, Taiho Pharmaceutical Co., Ltd.)
Is LONSURF a cytotoxic chemotherapy?
LONSURF is a cytotoxic drug. Follow applicable special handling and disposal procedures. 1 Table 1 shows the calculated initial daily dose based on body surface area (BSA). A maximum of 3 dose reductions are permitted.
Can stivarga shrink tumors?
Regorafenib may shrink the cancer or stop it growing for a time. You usually take regorafenib for as long as it is helping you and the side effects aren't too bad.
How much does trifluridine cost?
The cost for trifluridine ophthalmic ophthalmic solution 1% is around $166 for a supply of 7.5 milliliters, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans.
How much does a free drug card save?
The free Drugs.com Discount Card works like a coupon and can save you up to 80% or more off the cost of prescription medicines, over-the-counter drugs and pet prescriptions.
What is a lonsuf?
LONSURF is indicated for the treatment of adult patients with metastatic gastric or gastroesophageal junction adenocarcinoma previously treated with at least two prior lines of chemotherapy that included a fluoropyrimidine, a platinum, either a taxane or irinotecan, and if appropriate, HER2/neu‑targetedtherapy.
What is the molar ratio of Lonsurf?
LONSURF®(trifluridine and tipiracil) tablets consist of a thymidine‑based nucleoside analog, trifluridine, and the thymidine phosphorylase inhibitor, tipiracil, at a molar ratio 1:0.5 (weight ratio, 1:0.471). Inclusion of tipiracil increases trifluridine exposure by inhibiting its metabolism by thymidine phosphorylase.
Which type of cancer has more pulmonary emboli?
Pulmonary emboli occurred more frequently in LONSURF‑treated patients compared to placebo: in mCRC (2% vs 0%) and in metastatic gastric cancer and GEJ (3% vs 2%).
Can you breastfeed with lonsufrf?
Because of the potential for serious adverse reactions in breast‑fed infants, advise women not to breastfeed during treatment with LONSURF and for 1 day following the final dose.
Can lonsurf harm the fetus?
Embryo‑Fetal Toxicity:LONSURF can cause fetal harm when administered to a pregnant woman. Advise pregnant women of the potential risk to the fetus. Advise females of reproductive potential to use effective contraception during treatment and for at least 6 months after the final dose.
Does trifluridine interfere with DNA?
Following uptake into cancer cells, trifluridine, in its triphosphate form (FTD‑TP), is incorporated into the DNA, interferes with DNA function, and inhibits cell proliferation. No enzyme has been identified for the dephosphorylation of FTD‑TP, which may explain its incorporation into DNA.
Is a medicaid prescription offer valid?
Offer not valid for prescriptions reimbursed under Medicaid, a Medicare drug benefit plan, Tricare, or other federal or state programs (such as medical assistance programs). If the patient is eligible for drug benefits under any such program, this offer is not valid and the patient cannot use this offer.
What is a lonsurf?
Lonsurf (tipiracil/trifluridine) is a member of the antineoplastic combinations drug class and is commonly used for Colorectal Cancer, and Gastric Cancer.
How much does a free drug card save?
The free Drugs.com Discount Card works like a coupon and can save you up to 80% or more off the cost of prescription medicines, over-the-counter drugs and pet prescriptions.
Why is oral tablet important?
Oral Tablet. Important: When there is a range of pricing, consumers should normally expect to pay the lower price. However, due to stock shortages and other unknown variables we cannot provide any guarantee. Important: When there is a range of pricing, consumers should normally expect to pay the lower price.
Is Lonsurf a generic?
Lonsurf is available as a brand name drug only, a generic version is not yet available. For more information, read about generic Lonsurf availability . This Lonsurf price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies.
What happens if you take lonsuf?
LONSURF can cause a decrease in your white blood cells, red blood cells, and platelets. Low white blood cells can make you more likely to get serious infections that could lead to death. Your healthcare provider should do blood tests before you receive LONSURF, at day 15 during treatment with LONSURF, and as needed to check your blood cell counts. Your healthcare provider may lower your dose of LONSURF or stop LONSURF if you have low white blood cell or platelet counts
What is the name of the cancer that spreads to other parts of the body?
a kind of stomach cancer called gastric cancer including cancer of the gastroesophageal junction that has spread to other parts of the body and who have been previously treated or cannot receive certain chemotherapy medications.
What are the symptoms of a lonsuf?
Tell your healthcare provider right away if you get any of the following signs and symptoms of infection during treatment with LONSURF: fever, chills, or body aches.
Can you get pregnant with lonsufr?
Are pregnant or plan to become pregnant. LONSURF can harm your unborn baby. Females who can become pregnant: Your healthcare provider will verify your pregnancy status before you start treatment with LONSURF. You should use effective birth control during and 6 months after the last dose of treatment with LONSURF.
Is lonsurf safe for children?
a kind of stomach cancer called gastric cancer including cancer of the gastroesophageal junction that has spread to other parts of the body and who have been previously treated or cannot receive certain chemotherapy medications. It is not known if LONSURF is safe and effective in children.
Does lonsufra have side effects?
Tell your doctor if you have nausea, vomiting, or diarrhea that is severe or that does not go away. These are not all of the possible side effects of LONSURF.
Is a medicaid prescription offer valid?
Offer not valid for prescriptions reimbursed under Medicaid, a Medicare drug benefit plan, Tricare, or other federal or state programs (such as medical assistance programs). If the patient is eligible for drug benefits under any such program, this offer is not valid and the patient cannot use this offer.
What is 1% trifluridine?from rxlist.com
VIROPTIC Ophthalmic Solution, 1% (trifluridine ophthalmic solution) is indicated for the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis due to herpes simplex virus, types 1 and 2.
How long does trifluridine last?from drugs.com
Once your condition improves, you may need to keep using the medication 4 times daily for another 7 days. Follow your doctor's dosing instructions very carefully. You may need eye exams to help your doctor determine how long to treat you with trifluridine.
What is trifluridine (Viroptic)?from goodrx.com
Trifluridine (Viroptic) is an antiviral medication. It stops the herpes virus from making DNA and replicating (copying itself).
What are the side effects of trifluridine (Viroptic)?from goodrx.com
With any medication, there are risks and benefits. Even if the medication is working, you may experience some unwanted side effects.
Does trifluridine penetrate the aqueous humor?from rxlist.com
Decreased corneal integrity or stromal or uveal inflammation may enhance the penetration of triflu ridine into the aqueous humor. Unlike the results of ocular penetration of trifluridine in vitro, 5-carboxy-2'- deoxyuridine was not found in detectable concentrations within the aqueous humor of the human eye.
Is viroptic cheaper than trifluridine?from goodrx.com
Trifluridine (Viroptic) is available as a generic medication and may be significantly cheaper compared to the brand version. Unless there is a specific reason you need the brand, the generic medication will be a better value. For even more savings, use a GoodRx coupon and pay just a fraction of the retail price.
Is trifluridine excreted in milk?from rxlist.com
It is unlikely that trifluridine is excreted in human milk after ophthalmic instillation of VIROPTIC because of the relatively small dosage (≤5 mg/day), its dilution in body fluids and its extremely short half-life (approximately 12 minutes).
What is a lonsuf?
LONSURF is indicated for the treatment of adult patients with metastatic gastric or gastroesophageal junction adenocarcinoma previously treated with at least two prior lines of chemotherapy that included a fluoropyrimidine, a platinum, either a taxane or irinotecan, and if appropriate, HER2/neu‑targeted therapy.
Which type of cancer has more pulmonary emboli?
Pulmonary emboli occurred more frequently in LONSURF‑treated patients compared to placebo: in mCRC (2% vs 0%) and in metastatic gastric cancer and GEJ (3% vs 2%).
Can you breastfeed with lonsufrf?
There are no data to assess the effects of LONSURF or its metabolites on the breast‑fed infant or the effects on milk production. Because of the potential for serious adverse reactions in breast‑fed infants, advise women not to breastfeed during treatment with LONSURF and for 1 day following the final dose.
What is a caregiver brochure?
Caregiver BrochureProvides an overview of LONSURF and how it is taken, useful tips that may help manage common side effects, and strategies to help caregivers take care of themselves and their loved one
What is a lonsuf?
LONSURF is indicated for the treatment of adult patients with metastatic gastric or gastroesophageal junction adenocarcinoma previously treated with at least two prior lines of chemotherapy that included a fluoropyrimidine, a platinum, either a taxane or irinotecan, and if appropriate, HER2/neu‑targetedtherapy.
What is the molar ratio of Lonsurf?
LONSURF®(trifluridine and tipiracil) tablets consist of a thymidine‑based nucleoside analog, trifluridine, and the thymidine phosphorylase inhibitor, tipiracil, at a molar ratio 1:0.5 (weight ratio, 1:0.471). Inclusion of tipiracil increases trifluridine exposure by inhibiting its metabolism by thymidine phosphorylase.
Which type of cancer has more pulmonary emboli?
Pulmonary emboli occurred more frequently in LONSURF‑treated patients compared to placebo: in mCRC (2% vs 0%) and in metastatic gastric cancer and GEJ (3% vs 2%).
What is a treatment calendar?
Treatment CalendarAllows patients to track their dosing habits and record side effects or questions
Can you breastfeed with lonsufrf?
Because of the potential for serious adverse reactions in breast‑fed infants, advise women not to breastfeed during treatment with LONSURF and for 1 day following the final dose.
Can lonsurf harm the fetus?
Embryo‑Fetal Toxicity:LONSURF can cause fetal harm when administered to a pregnant woman. Advise pregnant women of the potential risk to the fetus. Advise females of reproductive potential to use effective contraception during treatment and for at least 6 months after the final dose.
Important Note
- The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your …
How to Use
- Use this medication in the eye(s) as directed. To avoid a reoccurrence of infection, finish the prescribed treatment, even if the eye looks normal. Do not continue using this for longer than prescribed. Apply eye drops to the affected eye(s) as follows: Wash hands first. To avoid contamination, be careful not to touch the dropper tip or let it touch your eye or any other surfac…
Side Effects
- This medication may temporarily sting or burn your eyes when first applied. If the irritation continues or becomes bothersome or the condition for which this was prescribed does not improve within seven days, inform your doctor. Vision may be temporarily unstable for a few minutes after applying this. Use caution if driving or performing duties requiring clear vision. Unli…
Drug Interactions
- Tell your doctor of any nonprescription or prescription medication you use, especially of: other eye medications. Do not start or stop any medicine without doctor or pharmacist approval.
Overdose
- If overdose is suspected, contact your local poison control center or emergency room immediately. This medicine may be harmful if swallowed.
Missed Dose
- If you miss a dose, use it as soon as remembered; do not use it if it is near the time for the next dose, instead, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up.
Storage
- Tightly replace cap after each use. Store in the refrigerator between 36 and 46 degrees F (2 to 8 degrees C). Discard this if the solution is not clear or colorless.
Warnings and Precautions
- Severe Myelosuppression: LONSURF caused severe and life‑threatening myelosuppression (Grade 3‑4) consisting of neutropenia (38%), anemia (18%), thrombocytopenia (5%), and febrile neutropenia (3%). Two patients (0.2%) died due to neutropenic infection. A total of 12% of LONSURF‑treated patients received granulocyte‑colony stimulating factors. Obtain complete blo…
Use in Specific Populations
- Lactation:It is not known whether LONSURF or its metabolites are present in human milk. There are no data to assess the effects of LONSURF or its metabolites on the breast‑fed infant or the effects on milk production. Because of the potential for serious adverse reactions in breast‑fed infants, advise women not to breastfeed during treatment with LONSURF and for 1 day followin…
Adverse Reactions
- Most Common Adverse Drug Reactions in Patients Treated With LONSURF (≥5%):The most common adverse drug reactions in LONSURF‑treated patients vs placebo‑treated patients with mCRC, respectively, were asthenia/fatigue (52% vs 35%), nausea (48% vs 24%), decreased appetite (39% vs 29%), diarrhea (32% vs 12%), vomiting (28% vs 14%), infections (27% vs 1...