Precautions
Pitolisant is used to treat excessive daytime sleepiness or cataplexy (sudden loss of muscle strength) in adults with narcolepsy. Pitolisant may also be used for purposes not listed in this medication guide. You should not use pitolisant if you have severe liver disease. You should not use pitolisant if you are allergic to it, or if you have:
What is Pitolisant used to treat?
Pitolisant can cause a serious heart problem. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV. Other drugs may affect pitolisant, including prescription and over-the-counter medicines, vitamins, and herbal products.
What are the side effects of Pitolisant?
Pitolisant is in a class of medications called H 3 blockers. It works by changing the amounts of certain natural substances in the area of the brain that controls sleep and wakefulness.
What class of drug is intramuscular Pitolisant?
How much does Wakix cost per month?
Wakix Coupon & Prices - Cost $49 per month.
Is pitolisant a controlled substance?
by Drugs.com No, Wakix (pitolisant) is not a controlled substance. In August 2019, Wakix was the first treatment approved for narcolepsy that was NOT classified as a controlled substance. It works by increasing the synthesis and release of histamine, a wake-promoting neurotransmitter in the brain.
How do you get prescribed Wakix?
Prescribing WAKIXComplete the WAKIX Prescription Referral Form. The diagnosis (ICD-10) codes for narcolepsy are included on the prescription referral form: G47. ... Fax the completed form to WAKIX for You at 1-855-635-8520.WAKIX for You will contact your patient directly to help him or her get started with WAKIX.
How is pitolisant administered?
The recommended dosage range for WAKIX is 17.8 mg to 35.6 mg administered orally once daily in the morning upon wakening.
What is pitolisant used for?
Pitolisant is used to treat cataplexy (weak or paralyzed muscles) or excessive daytime sleepiness (EDS) in patients with narcolepsy. Narcolepsy is an uncontrollable desire for sleep or a sudden attack of deep sleep.
Who should not take Wakix?
The safety and effectiveness of WAKIX have not been established in patients less than 18 years of age. WAKIX is extensively metabolized by the liver. WAKIX is contraindicated in patients with severe hepatic impairment. Dosage adjustment is required in patients with moderate hepatic impairment.
How fast does Wakix work?
It's important to know that WAKIX may take some time to work, and for some patients, it may take up to 8 weeks to achieve a response.
Can you take Wakix and Adderall together?
Interactions between your drugs No interactions were found between Adderall and Wakix.
Is there a generic for Wakix?
Wakix is not available in a generic form. A generic drug is an exact copy of the active drug in a brand-name medication.
When should I take pitolisant?
How should this medicine be used? Pitolisant comes as a tablet to take by mouth. It is usually taken once a day with or without food as soon as you wake up in the morning. Take pitolisant at the same time every day.
How does pitolisant promote wakefulness?
Pitolisant is a first-in-class agent utilizing histamine to improve wakefulness by acting as an antagonist/inverse agonist of the presynaptic histamine 3 receptor. This review summarizes the clinical efficacy, safety and tolerability of pitolisant in treating the symptoms of narcolepsy.
What is the mechanism of action of pitolisant?
Mechanism of Action Wakix is a selective histamine 3 (H₃) receptor antagonist/inverse agonist. The mechanism of action of Wakix is unclear; however, its efficacy could be mediated through its activity at H₃ receptors, thereby increasing the synthesis and release of histamine, a wake promoting neurotransmitter.
Is Solriamfetol a controlled substance?
As such, DEA hereby schedules solriamfetol as a controlled substance under the CSA. The CSA outlines the findings required to place a drug or other substance in any particular schedule (I, II, III, IV, or V). 21 U.S.C. 812(b).
Is Armodafinil a controlled substance?
Armodafinil is a federally controlled substance (C-IV) because it can be abused or lead to dependence. Keep armodafinil in a safe place to prevent misuse and abuse. Selling or giving away armodafinil may harm others, and is against the law.
Is pitolisant FDA approved?
Harmony Biosciences announced on Oct. 13, 2020, that the U.S. Food and Drug Administration has approved Wakix (pitolisant) for the treatment of cataplexy in adult patients with narcolepsy. The FDA previously approved Wakix for the treatment of excessive daytime sleepiness in adult patients with narcolepsy.
What is the brand name for pitolisant?
Pitolisant, sold under the brand name Wakix among others, is a medication for the treatment of excessive daytime sleepiness in adults with narcolepsy. It is a histamine 3 (H3) receptor antagonist/inverse agonist.
How should I take pitolisant?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
What is Pitolisant used for?
Pitolisant is used to treat excessive daytime sleepiness or cataplexy (sudden loss of muscle strength) in adults with narcolepsy. Pitolisant may also be used for purposes not listed in this medication guide.
What should I avoid while taking pitolisant?
Follow your doctor's instructions about any restrictions on food, beverages, or activity .
What other drugs will affect pitolisant?
When you start or stop taking pitolisant, your doctor may need to adjust the doses of any other medicines you take on a regular basis.
How long after birth control can you use pitolisant?
Keep using birth control for at least 21 days after your last dose of pitolisant. Pitolisant is not approved for use by anyone younger than 18 years old.
Can you take pitolisant if you have liver disease?
You should not use pitolisant if you have severe liver disease.
Can Pitolisant cause heart problems?
Pitolisant can cause a serious heart problem. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV.
Why is Pitolisant prescribed?
Why is this medication prescribed? Expand Section. Pitolisant is used to treat excessive daytime sleepiness caused by narcolepsy (a condition that causes excessive daytime sleepiness) and to treat cataplexy (episodes of muscle weakness that begin suddenly and last for a short time) in adults with narcolepsy.
What to do if you are allergic to pitolisant?
Before taking pitolisant, tell your doctor and pharmacist if you are allergic to pitolisant, any other medications, or any of the ingredients in pitolisant tablets. Ask your pharmacist for a list of the ingredients. tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, ...
How long after stopping pitolisant can you take birth control?
Use another form of birth control while taking pitolisant and for 21 days after you stop taking it. Talk to your doctor about types of birth control that will work for you during and after your treatment with pitolisant. tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding.
How long does it take for pitolisant to work?
Pitolisant may decrease your sleepiness, but it will not cure your sleep disorder. It may take 8 weeks or longer before you feel the full benefit of pitolisant. Continue to take pitolisant even if you feel well-rested. Do not stop taking pitolisant without talking to your doctor.
How to dispose of unneeded medication?
However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website ( http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.
What is the phone number to call for poison control?
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.
Can you change the time of day you take pitolisant?
Do not change the time of day that you take pitolisant without talking to your doctor. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take pitolisant exactly as directed.
What is a pitolisant used for?from goodrx.com
PITOLISANT is used to treat excessive sleepiness or cataplexy in patients with narcolepsy. Cataplexy causes a sudden muscle weakness due to a strong emotional response. Compare histamine-3 Antagonists/Inverse agonists. Prescription Settings.
What are some stimulants for narcolepsy?from medicalnewstoday.com
Examples of stimulants approved for treating narcolepsy include modafinil ( Provigil) and armodafinil (Nuvigil). Wakix is a histamine-3 blocker, and it acts in a different way than stimulant medications.
What is pitolisant used for?from en.wikipedia.org
Pitolisant is used in adults for the treatment of excessive daytime sleepiness in people with narcolepsy, with or without cataplexy. Narcolepsy is a sleep problem that is characterized by an irresistible urge to sleep and disturbed nighttime sleep, while cataplexy refers to attacks of severe muscle weakness that cause a person to collapse.
When was Pitolisant approved?from en.wikipedia.org
Pitolisant was approved by the U.S. Food and Drug Administration (FDA) in August 2019. It was granted orphan drug designation for the treatment of narcolepsy, fast track designation for the treatment of excessive daytime sleepiness (EDS) and cataplexy in people with narcolepsy, and breakthrough therapy designation for the treatment ...
What should I avoid while taking pitolisant?from drugs.com
Follow your doctor's instructions about any restrictions on food, beverages, or activity .
What other drugs will affect pitolisant?from drugs.com
When you start or stop taking pitolisant, your doctor may need to adjust the doses of any other medicines you take on a regular basis.
What is the Epworth Sleepiness Scale?from en.wikipedia.org
To measure the daytime sleepiness, the investigators used a scale called the Epworth Sleepiness Scale (ESS). The ESS asks participants to rate the likelihood that they would fall asleep while doing eight daily activities (such as sitting and reading or watching television).
What to keep on a prescription list?from medlineplus.gov
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
How to dispose of unneeded medication?from medlineplus.gov
However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website ( http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.
