Precautions
What is ponatinib? Ponatinib is a cancer medicine that interferes with the growth of some cancer cells. Ponatinibis used in adults to treat a type of blood cancer called chronic myeloid leukemia (CML), or Philadelphia chromosome positive acute lymphoblastic leukemia (ALL).
What is ponatinib used to treat?
Iclusig (ponatinib) is a member of the BCR-ABL tyrosine kinase inhibitors drug class and is commonly used for Acute Lymphoblastic Leukemia, and Chronic Myelogenous Leukemia. The cost for Iclusig oral tablet 10 mg is around $18,711 for a supply of 30 tablets, depending on the pharmacy you visit.
What is Iclusig (ponatinib)?
The program is for commercially insured patients only. Many programs are available from federal and state governments, non-profits, manufacturers, and other organizations to help you get the drugs you need at a reduced cost. Eligibility is often based on income, insurance or Medicare status, and other factors.
Who is eligible for the drug incentive program?
What is ponatinib used for?
What should I avoid while taking ponatinib?
How long after ponatinib is it safe to give birth?
How long before surgery can you stop ponatinib?
Can you share ponatinib with children?
Can you take ponatinib if you are allergic to it?
Can ponatinib cause heart problems?
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About this website
Ponatinib (ICLUSIG) Chemotherapy Drug Information
(poe NA ti nib) Generic Name: Ponatinib . Trade Name: ICLUSIG® . Ponatinib is the generic name for the trade drug ICLUSIG®. In some cases, health care professionals may use the trade name ICLUSIG® when referring to the generic drug name ponatinib.
Ponatinib - Wikipedia
Ponatinib (trade name Iclusig / aɪ ˈ k l uː s ɪ ɡ / eye-KLOO-sig, previously AP24534) is an oral drug developed by ARIAD Pharmaceuticals for the treatment of chronic myeloid leukemia (CML) and Philadelphia chromosome–positive (Ph+) acute lymphoblastic leukemia (ALL). It is a multi-targeted tyrosine-kinase inhibitor. Some forms of CML, those that have the T315I mutation, are resistant to ...
Ponatinib | Cancer information | Cancer Research UK
Ponatinib (Iclusig) Ponatinib (Iclusig) Ponatinib is a type of targeted cancer drug.It is also called Iclusig. It is a treatment for some types of chronic myeloid leukaemia (CML) and acute lymphoblastic leukaemia (ALL).
Ponatinib: A Review of Efficacy and Safety - PubMed
Ponatinib is a third generation kinase inhibitor designed to overcome the gatekeeper T315I mutation. In different trials this drug showed inhibitory activity against native BCR-ABL1 kinase and several ABL1 mutations. For this reason, ponatinib is currently indicated for the treatment of chronic myel …
Ponatinib (Iclusig®) | Macmillan Cancer Support
Ponatinib (Iclusig ®) can be used to treat some types of leukaemia, such as chronic myeloid leukaemia (CML).It is best to read this information with our general information about targeted therapies and the type of leukaemia you have.. Ponatinib belongs to a group of targeted therapy drugs known as tyrosine kinase inhibitors (TKIs).
Ponatinib (marketed as Iclusig) Informaton | FDA
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What is ponatinib used for?
Ponatinib is a cancer medicine that interferes with the growth of some cancer cells.
What should I avoid while taking ponatinib?
Grapefruit may interact with ponatinib and lead to unwanted side effects. Avoid the use of grapefruit products.
How long after ponatinib is it safe to give birth?
Ponatinib may harm an unborn baby. Use effective birth control to prevent pregnancy while you are using ponatinib and for at least 3 weeks after your last dose.
How long before surgery can you stop ponatinib?
If you need surgery, tell the surgeon ahead of time that you are using ponatinib. You may need to stop using the medicine at least 1 week before a surgery.
Can you share ponatinib with children?
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use ponatinib only for the indication prescribed.
Can you take ponatinib if you are allergic to it?
You should not use ponatinib if you are allergic to it.
Can ponatinib cause heart problems?
Ponatinib may cause heart or blood vessel problems that could lead to heart attack, stroke, or death.
What are the side effects of ponatinib?
Potential severe side effects include abdominal pain, pancreatitis, blood vessel narrowing, or vision problems. Dose reductions are required in 55% of patients and roughly 2 out of 3 patients have to interrupt ponatinib therapy due to side effects or low blood cell counts.
How often can you take ponatinib?
Usual starting dose for patients with liver problems, which is lowered to decrease risk of side effects: Ponatinib 30 mg oral tablet by mouth once Daily, every day. Currently, ponatinib is dispensed by a single pharmacy known as Biologics Pharmacy via the Ariad Pass program. Once it is received, it is taken at home.
How long does it take for CML to go away after taking ponatinib?
Ponatinib is not commonly given with the goal of cure, but all signs of the CML may become undetectable after taking ponatinib for one or more years. Tap along the timeline to move to different parts of the audio file.
What is specialty pharmacy?
A specialty pharmacy is one that manages the handling and services for drugs used by patients with rare or chronic diseases and disorders. Typically, this pharmacy possesses special accreditation (a type of certification) allowing it to dispense rare and expensive medications.
Can you take pain medication before a biopsy?
You may request sedative medications prior to the procedure if you have anxiety. You should arrange to have someone drive you home if you take anxiety medications or receive pain medications prior to the procedure. You may have discomfort around the biopsy area and experience soreness for a few days afterwards.
Can you miss ponatinib?
It is important that you do not miss doses, unless your doctor specifically says that this is okay. Missing doses may prevent you from achieving a remission and increase the risk of ponatinib no longer working. Note: Individual doses may vary based upon your Doctor's recommendation, or drug availability. listen.
Does ponatinib help with CML?
However, ponatinib works on most mutations found in Chronic Myeloid Leukemia (CML) cells. Ponatinib is taken to reduce symptoms from CML or prevent them from ever occurring. Ponatinib is not a cure, and is usually taken for many years to prevent CML from progressing to more aggressive phases.
Who is Prescription Hope?
Prescription Hope is a nationally recognized prescription medication access program, headquartered in Columbus, Ohio. Prescription Hope offers access to over 1,500 brand-name medications through patient assistance programs. All you pay is a set service fee of $50 for each medication per month.
Do I Qualify For Iclusig Patient Assistance With Prescription Hope?
Prescription Hope works with thousands of Americans every month, obtaining prescription medications on their behalf for the set price of $50.00 per month per medication.
Is Prescription Hope An Iclusig Coupon Card, Generic, Or Insurance Product?
Prescription Hope is not an Iclusig coupon card or insurance policy. Our program is also not an Iclusig Generic. Prescription Hope is a national advocacy program that works with any coverage you may already have.
Can Prescription Hope Get My Iclusig If I Have Health Insurance Coverage?
Because Prescription Hope is not a health insurance plan, our program works alongside any coverage you may currently have to obtain your Iclusig medication at an affordable price. Our national advocacy program does not have medication tiers, copays, or deductibles.
Iclusig: Prescribed As Part Of A Treatment For Leukemia
Iclusig is a medication that targets proteins in cancer cells and stops the cancer cell from growing. It is used to treat certain types of leukemia.
Can Prescription Hope Help Me Obtain My Other Medications?
According to the Centers for Disease Control, nearly one in five Americans regularly takes three prescription medications. Our advocates work on your behalf to obtain all your medications for the set price of $50.00 per month for each medication. Prescription Hope works directly with over 180 U.S.
What is a review of ponatinib?
Ponatinib: A Review of Efficacy and Safety
When was Ponatinib suspended?
Ponatinib was temporarily suspended in 2013 for the occurrence of cardiovascular thrombotic events. Since then, different investigators analyzed baseline characteristics of patient candidates for ponatinib, especially cardiovascular profile, in order to describe general management recommendations in this setting.
Is ponatinib a CML drug?
For this reason, ponatinib is currently indicated for the treatment of chronic myeloid leukaemia (CML) in every phase of disease resistant and/or intolerant to dasatinib and nilotinib and for whom imatinib is not indicated anymore or for patients with T315I mutation.
Resources
This information may help you and your care partner better understand ICLUSIG.
Glossary
Accelerated phase CML: The second phase of CML progression, when the number of blast cells has increased.
What is ponatinib used for?from dir.indiamart.com
Ponatinib is used to treat chronic myeloid leukemia (CML) or Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ ALL) after other medicines did not work well. Leukemia is a type of cancer where the body makes abnormal white blood cells
What to tell your healthcare provider before taking Iclusig?from iclusig.com
Before you take ICLUSIG, tell your healthcare provider about all of your medical conditions, including if you: have a history of blood clots in your blood vessels (arteries or veins) have heart problems , including heart failure, irregular heartbeats, and QT prolongation. have diabetes. have a history of high cholesterol.
Does ponatinib affect fertility?from iclusig.com
Ponatinib may impair fertility in females , and it is not known if these effects are reversible.
What is ponatinib used for?from dir.indiamart.com
Ponatinib is used to treat chronic myeloid leukemia (CML) or Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ ALL) after other medicines did not work well. Leukemia is a type of cancer where the body makes abnormal white blood cells
What is the Iclusig Takeda rebate?from drugs.com
Iclusig Takeda Oncology Co-pay Assistance Program Rebate: If a commercially insured patient is unable to take advantage of the assistance program at their local pharmacy they may be eligible for a rebate ; for additional information contact the program at 844-817-6468.
What is ponatinib used for?
Ponatinib is a cancer medicine that interferes with the growth of some cancer cells.
What should I avoid while taking ponatinib?
Grapefruit may interact with ponatinib and lead to unwanted side effects. Avoid the use of grapefruit products.
How long after ponatinib is it safe to give birth?
Ponatinib may harm an unborn baby. Use effective birth control to prevent pregnancy while you are using ponatinib and for at least 3 weeks after your last dose.
How long before surgery can you stop ponatinib?
If you need surgery, tell the surgeon ahead of time that you are using ponatinib. You may need to stop using the medicine at least 1 week before a surgery.
Can you share ponatinib with children?
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use ponatinib only for the indication prescribed.
Can you take ponatinib if you are allergic to it?
You should not use ponatinib if you are allergic to it.
Can ponatinib cause heart problems?
Ponatinib may cause heart or blood vessel problems that could lead to heart attack, stroke, or death.
