How is prolixin decanoate administered?
To begin therapy with Prolixin Decanoate the following regimens are suggested: For most patients, a dose of 12.5 to 25 mg (0.5 to 1 mL) may be given to initiate therapy. The onset of action generally appears between 24 and 72 hours after injection and the effects of the drug on psychotic symptoms becomes significant within 48 to 96 hours.
What are the contraindications for prolixin decanoate?
Prolixin Decanoate (Fluphenazine Decanoate Injection) is contraindicated in comatose or severely depressed states. The presence of blood dyscrasia or liver damage precludes the use of fluphenazine decanoate. Fluphenazine decanoate is not intended for use in children under 12 years of age.
How much fluphenazine decanoate is in Prolixin?
Prolixin Decanoate is available for intramuscular or subcutaneous administration, providing 25 mg fluphenazine decanoate per mL in a sesame oil vehicle with 1.2% (w/v) benzyl alcohol as a preservative. At the time of manufacture, the air in the vials is replaced by nitrogen. Prolixin Decanoate - Clinical Pharmacology
Is there a generic version of prolixin decanoate?
If generic versions of this product have been approved by the FDA, there may be generic equivalents available. Prolixin Decanoate is the decanoate ester of a trifluoromethyl phenothiazine derivative. It is a highly potent behavior modifier with a markedly extended duration of effect.
How much does a prolixin injection cost?
The cost for fluphenazine oral tablet 10 mg is around $97 for a supply of 50, depending on the pharmacy you visit....Injectable Solution.QuantityPer unitPrice5 milliliters$15.73$78.66
How much does fluphenazine cost without insurance?
How much does Fluphenazine Decanoate cost without insurance? Patients can usually expect to pay $202.84 for Fluphenazine Decanoate.
How do you administer prolixin?
How to use Prolixin Decanoate Solution. This medication is given by injection into a muscle (intramuscularly-IM) or beneath the skin (subcutaneously-subQ) by a nurse or doctor. This medication is usually injected every 4-6 weeks, or as directed by your doctor.
How long does prolixin injection last?
Your healthcare provider will administer these injections. The medication effects last for approximately 2-3 weeks. Fluphenazine liquid suspension should be measured with a dosing spoon or oral syringe, which you can get from your pharmacy.
What is the brand name for fluphenazine?
Fluphenazine is a phenothiazine, also called a neuroleptic, used to treat symptoms of a certain type of mental/mood condition (schizophrenia). Fluphenazine is available under the following different brand names: Modecate, Modecate Concentrate, Moditen, Prolixin (discontinued brand), and RhoFluphenazine.
What are prolixin side effects?
Drowsiness, lethargy, dizziness, lightheadedness, nausea, loss of appetite, sweating, dry mouth, blurred vision, headache, and constipation may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.
Why was prolixin discontinued?
The manufacturer discontinued the drug due to a shortage of ingredients, but it is still licensed for use.
What drug class is prolixin?
Prolixin belongs to a class of drugs called Antipsychotics, 1st Generation; Antipsychotics, Phenothiazine.
How does fluphenazine make you feel?
you should know that fluphenazine may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position.
How long does it take for prolixin to leave your system?
Fluphenazine has a half-life of about 100 hours. So, it will take approximately four days for fluphenazine to get wholly washed out from your system.
Does prolixin cause weight gain?
Side effects include: Extrapyramidal reactions (e.g., pseudo-parkinsonism, dystonia, dyskinesia, akathisia, oculogyric crises, opisthotonos, hyperreflexia), drowsiness, lethargy, weight gain.
Is prescription cost per item?
Prescriptions cost £8.60 per item. If you need a repeat prescription, Prescription Prepayment Certificates (PPC) are available.
How much does 800 mg ibuprofen cost?
The average retail price for 30 tablets of 800 milligrams (mg) generic ibuprofen is $13.39, but a bottle of ibuprofen can cost anywhere from $2 to $31 depending on the type of pill, the brand, dosage, quantity, and where you buy it.
What is an expensive antibiotic?
The cephalosporins are among the most expensive antibiotics in use today; thus, use of these expensive agents must be justified by lower toxicity, greater efficacy, or both in comparison with drugs of more reasonable cost.
How do Goodrx cards work?
It's similar to using a coupon at a grocery store. Simply print the coupon and bring it with you to the pharmacy when you pick up your prescription. The pharmacist will enter the numbers on the coupon into their system to find the discount.
Important Note
The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.
Uses
This medication is used to treat symptoms of certain types of mental or emotional conditions.
How To Use
Take with food or milk if stomach upset occurs unless directed otherwise by your doctor. This medication must be taken as prescribed. Do not stop taking this drug suddenly without consulting your doctor. Some conditions may worsen if the medication is suddenly stopped.
Side Effects
Constipation, drowsiness, vision changes or dry mouth may occur. If any of these effects persist or worsen, notify your doctor.
Precautions
Tell your doctor your medical history, especially of: very high or very low blood pressure, liver or heart disease, Reye's syndrome, alcohol or drug dependencies, nervous system problems, blood disorders, allergies (especially drug allergies). Use caution performing tasks that require alertness, such as driving or using machinery.
Drug Interactions
Inform your doctor about all the medications you use (both prescription and nonprescription), especially of: anti-depressant/anti-anxiety drugs, sparfloxacin, grepafloxacin, guanethidine, guanadrel, metrizamide, cabergoline, lithium, narcotic pain medications (e.g., codeine), drugs used to aid sleep, drowsiness-causing antihistamines (e.g., diphenhydramine), other drugs that make you drowsy.
Overdose
If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include restlessness, muscle spasms, tremors, twitching, deep sleep or loss of consciousness, and seizures.
Important Note
The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.
Uses
This medication is used to treat symptoms of certain types of mental or emotional conditions.
How To Use
Take with food or milk if stomach upset occurs unless directed otherwise by your doctor. Measure carefully and dilute (mix) with 4 ounces (120ml) or more of water, milk, juice or non-caffeinated carbonated drink. Do not dilute with coffee, tea, colas or apple juice as the drug may lose its effectiveness. Take immediately after diluting.
Side Effects
Constipation, drowsiness, vision changes, or dry mouth may occur. If any of these effects persist or worsen, notify your doctor.
Precautions
Tell your doctor your medical history especially: very high or very low blood pressure, liver or heart disease, Reye's syndrome, alcohol or drug dependencies, nervous system problems, blood disorders, any allergies (especially any drug allergies). Use caution performing tasks that require alertness, such as driving or using machinery.
Drug Interactions
Tell your doctor or pharmacist of all prescription and nonprescription drugs you may use, especially: other anti-depressant/anti-anxiety drugs, sparfloxacin, grepafloxacin, guanethidine, guanadrel, metrizamide, cabergoline, lithium.
Overdose
If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include restlessness, muscle spasms, tremors, twitching, deep sleep or loss of consciousness, and seizures.
What is a decanoate injection?
Prolixin Decanoate (Fluphenazine Decanoate Injection) is a long-acting parenteral antipsychotic drug intended for use in the management of patients requiring prolonged parenteral neuroleptic therapy ( e.g., chronic schizophrenics).
How old is too old to take fluphenazine decanoate?
Fluphenazine decanoate is not intended for use in children under 12 years of age.
How much fluphenazine is equivalent to 25 mg?
No precise formula can be given to convert to use of Prolixin Decanoate; however, a controlled multicentered study,* in patients receiving oral doses from 5 to 60 mg fluphenazine hydrochloride daily, showed that 20 mg fluphenazine hydrochloride daily was equivalent to 25 mg (1 mL) Prolixin Decanoate every three weeks.
Does fluphenazine decanoate affect the central nervous system?
Most often these extrapyramidal symptoms are reversible; however, they may be persistent (see below). The frequency of such reactions is related in part to chemical structure: one can expect a higher incidence with fluphenazine decanoate than with less potent piperazine derivatives or with straight-chain phenothiazines such as chlorpromazine. With any given phenothiazine derivative, the incidence and severity of such reactions depend more on individual patient sensitivity than on other factors, but dosage level and patient age are also determinants.
Is fluphenazine decanoate safe for dermatoses?
Because of the possibility of cross-sensitivity, fluphenazine decanoate should be used cautiously in patients who have developed cho lestatic jaundice, dermatoses, or other allergic reactions to phenothiazine derivatives.
Is phenothiazine a hypnotic?
Phenothiazines are contraindicated in patients with suspected or established subcortical brain damage. Phenothiazine compounds should not be used in patients receiving large doses of hypnotics. Prolixin Decanoate (Fluphenazine Decanoate Injection) is contraindicated in comatose or severely depressed states.
Is fluphenazine decanoate the same as fluphenazine hydrochloride?
The basic effects of fluphenazine decanoate appear to be no different from those of fluphenazine hydrochloride, with the exception of duration of action. The esterification of fluphenazine markedly prolongs the drug’s duration of effect without unduly attenuating its beneficial action.
What to do if you miss a fluphenazine injection?
Do not double your next dose or take more than what is prescribed. If you miss a dose of fluphenazine long-acting injection, see your healthcare provider to receive your dose as soon as possible.
How long does it take for pain to go away after fluphenazine decanoate?
Patients receiving fluphenazine decanoate long-acting injection may notice some pain at the site of the injection. This pain should resolve after a few days.
What Is The Most Important Information I Should Know About Fluphenazine?
Schizophrenia requires long-term treatment. Do not stop taking fluphenazine, even when you feel better.
How Should I Take Fluphenazine?
Fluphenazine is usually taken once or twice daily with or without food.
What Happens If I Miss a Dose of Fluphenazine?
Do not double your next dose or take more than what is prescribed. If you miss a dose of fluphenazine long-acting injection, see your healthcare provider to receive your dose as soon as possible.
What Are Possible Side Effects Of Fluphenazine?
Rapid heartbeat, constipation, blurry vision, dry mouth, drop in blood pressure upon standing, feeling drowsy, dizzy, or restless
How Long Does It Take For Fluphenazine To Work?
If you take the fluphenazine long-acting injection, it will take a few days before fluphenazine is fully absorbed and at an adequate level to begin treating your symptoms. After starting fluphenazine long-acting injection for the first time, or re-starting after a time of no medication, your provider may also have you take fluphenazine tablets for a few days.
What is Medicare Part D Extra Help?
Medicare Part D Extra Help — Low-Income Subsidy. Medicare patients who have limited income and resources may qualify for "extra help" to pay for prescription drugs.
How to contact JJPAF?
To see if you might qualify for assistance, please contact a JJPAF program specialist at 800-652-6227 ( Monday–Friday, 9:00 AM to 6:00 PM ET) or visit the foundation website at JJPAF.org . The following programs are not affiliated with Janssen.
What is fluphenazine used for?
Fluphenazine is a member of the phenothiazine antipsychotics drug class and is commonly used for Psychosis.
Does fluphenazine have a coupon?
Fluphenazine Coupons and Rebates. Fluphenazine offers may be in the form of a printable coupon, rebate, savings card, trial offer, or free samples. Some offers may be printed right from a website, others require registration, completing a questionnaire, or obtaining a sample from the doctor's office.
Is fluphenazine a cash payment?
Prices are for cash paying customers only and are not valid with insurance plans. This fluphenazine price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies.
Important Note
- The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your …
How to Use
- This medication is injected into a muscle (IM) or under the skin (SQ). This medication must be used as prescribed. Do not stop using this drug suddenly without consulting your doctor. Some conditions may worsen if the medication is suddenly stopped. It may take up to two weeks for the full benefit of this drug to take effect.
Precautions
- Tell your doctor your medical history, especially of: very high or very low blood pressure, liver or heart disease, Reye's syndrome, alcohol or drug dependencies, nervous system problems, blood disorders, allergies (especially drug allergies). Use caution performing tasks that require alertness such as driving or using machinery. Use of alcohol can cause extreme drowsiness. Avoid alcoho…
Drug Interactions
- Inform your doctor about all the medications you use (both prescription and nonprescription), especially of: other anti-depressant/anti-anxiety drugs, sparfloxacin, grepafloxacin, guanethidine, guanadrel, metrizamide, cabergoline, lithium, narcotic pain medication (e.g., codeine), drugs used to aid sleep, drowsiness-causing antihistamines (e.g., diphenhydramine), other drugs that make …
Overdose
- If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include, restlessness, confusion, excitement, weakness, fatigue, fainting, dizziness, rapid or irregular heartbeat, small pupil size, tremors, difficulty in swallowing or breathing, excessive drowsiness, very low body temperature, or seizures.
Missed Dose
- If you miss a dose and use 1 dose daily: use as soon as remembered unless it is almost time for the next dose. In that case, skip the missed dose and resume your usual schedule. If you use more than 1 dose daily: use as soon as possible if it is within an hour or so of the missed dose. If not remembered within an hour, skip the missed dose and resume your usual dosing schedule. …
Storage
- Store at room temperature away from sunlight and moisture. Do not store in the bathroom. Do not freeze.
Medical Alert
- Your condition can cause complications in a medical emergency. For enrollment information call MedicAlert at 1-800-854-1166 (USA), or 1-800-668-1507 (Canada).
Important Note
- The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug. FLUPHENAZINE - ORAL (flew-FEN-uh-zeen) COM…
How to Use
- Take with food or milk if stomach upset occurs unless directed otherwise by your doctor. This medication must be taken as prescribed. Do not stop taking this drug suddenly without consulting your doctor. Some conditions may worsen if the medication is suddenly stopped. It may take up to two weeks for the full benefit of this medication to take effect.
Side Effects
- Constipation, drowsiness, vision changes or dry mouth may occur. If any of these effects persist or worsen, notify your doctor. Unlikely to occur but report promptly: restlessness, muscle stiffness, weakness, difficulty speaking, loss of balance, mask- like facial expression, trembling or shaking, dizziness, lip smacking or other uncontrollable mov...
Precautions
- Tell your doctor your medical history, especially of: very high or very low blood pressure, liver or heart disease, Reye's syndrome, alcohol or drug dependencies, nervous system problems, blood disorders, allergies (especially drug allergies). Use caution performing tasks that require alertness, such as driving or using machinery. Use of alcohol can cause extreme drowsiness. Av…
Drug Interactions
- Inform your doctor about all the medications you use (both prescription and nonprescription), especially of: anti-depressant/anti-anxiety drugs, sparfloxacin, grepafloxacin, guanethidine, guanadrel, metrizamide, cabergoline, lithium, narcotic pain medications (e.g., codeine), drugs used to aid sleep, drowsiness-causing antihistamines (e.g., diphenhydramine), other drugs that make …
Overdose
- If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include restlessness, muscle spasms, tremors, twitching, deep sleep or loss of consciousness, and seizures.
Missed Dose
- If you miss a dose and take 1 dose daily: take as soon as remembered unless it is almost time for the next dose. In that case, skip the missed dose and resume your usual schedule. If you take more than 1 dose daily: take as soon as possible if it is within an hour or so of the missed dose. If not remembered within an hour, skip the missed dose and resume your usual dosing schedule. …
Storage
- Store at room temperature away from sunlight and moisture. Do not store in the bathroom. Do not freeze. Keep tightly closed.
Medical Alert
- Your condition can cause complications in a medical emergency. For enrollment information call MedicAlert at 1-800-854-1166 (USA), or 1-800-668-1507 (Canada).
Important Note
- The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug. FLUPHENAZINE CONCENTRATE - ORAL (flew-FE…
How to Use
- Take with food or milk if stomach upset occurs unless directed otherwise by your doctor. Measure carefully and dilute (mix) with 4 ounces (120ml) or more of water, milk, juice or non-caffeinated carbonated drink. Do not dilute with coffee, tea, colas or apple juice as the drug may lose its effectiveness. Take immediately after diluting. Do not dilu...
Side Effects
- Constipation, drowsiness, vision changes, or dry mouth may occur. If any of these effects persist or worsen, notify your doctor. Unlikely to occur but report promptly: restlessness, muscle stiffness, weakness, difficulty speaking, loss of balance, mask- like facial expression, trembling or shaking, dizziness, lip smacking or other uncontrollable movements, difficulty urinating, skin ras…
Precautions
- Tell your doctor your medical history especially: very high or very low blood pressure, liver or heart disease, Reye's syndrome, alcohol or drug dependencies, nervous system problems, blood disorders, any allergies (especially any drug allergies). Use caution performing tasks that require alertness, such as driving or using machinery. Use of alcohol can cause extreme drowsiness. Av…
Drug Interactions
- Tell your doctor or pharmacist of all prescription and nonprescription drugs you may use, especially: other anti-depressant/anti-anxiety drugs, sparfloxacin, grepafloxacin, guanethidine, guanadrel, metrizamide, cabergoline, lithium. Tell your doctor if you are taking drugs that cause drowsiness such as: medicine for sleep, sedatives, tranquilizers, anti- anxiety drugs (e.g., diazep…
Overdose
- If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include restlessness, muscle spasms, tremors, twitching, deep sleep or loss of consciousness, and seizures.
Notes
- It is important you be monitored. Keep all doctor appointments. Do not share this medication with others.
Missed Dose
- If you miss a dose and take 1 dose daily: take as soon as remembered unless it is almost time for the next dose. In that case, skip the missed dose and resume your usual schedule. If you take more than 1 dose daily: take as soon as possible if it is within an hour or so of the missed dose. If not remembered within an hour, skip the missed dose and resume your usual dosing schedule. …
Storage
- Store at room temperature away from sunlight and moisture. Do not store in the bathroom. Do not freeze. Keep tightly closed.
Medical Alert
- Your condition can cause complications in a medical emergency. For enrollment information call MedicAlert at 1-800-854-1166 (USA), or 1-800-668-1507 (Canada).
Prolixin Decanoate Description
- Prolixin Decanoate is the decanoate ester of a trifluoromethyl phenothiazine derivative. It is a highly potent behavior modifier with a markedly extended duration of effect. Prolixin Decanoate is available for intramuscular or subcutaneous administration, providing 25 mg fluphenazine decanoate per mL in a sesame oil vehicle with 1.2% (w/v) benzyl a...
Prolixin Decanoate - Clinical Pharmacology
- The basic effects of fluphenazine decanoate appear to be no different from those of fluphenazine hydrochloride, with the exception of duration of action. The esterification of fluphenazine markedly prolongs the drug’s duration of effect without unduly attenuating its beneficial action. Prolixin Decanoate has activity at all levels of the central nervous system as well as on multiple …
Indications and Usage For Prolixin Decanoate
- Prolixin Decanoate (Fluphenazine Decanoate Injection) is a long-acting parenteral antipsychotic drug intended for use in the management of patients requiring prolonged parenteral neuroleptic therapy (e.g., chronic schizophrenics). Prolixin Decanoate has not been shown effective in the management of behavioral complications in patients with mental retardation.
Contraindications
- Phenothiazines are contraindicated in patients with suspected or established subcortical brain damage. Phenothiazine compounds should not be used in patients receiving large doses of hypnotics. Prolixin Decanoate (Fluphenazine Decanoate Injection) is contraindicated in comatose or severely depressed states. The presence of blood dyscrasia or liver damage precludes the us…
Warnings
- Tardive Dyskinesia
Tardive dyskinesia, a syndrome consisting of potentially irreversible, involuntary, dyskinetic movements may develop in patients treated with neuroleptic (antipsychotic) drugs. Although the prevalence of the syndrome appears to be highest among the elderly, especially elderly women, i… - Neuroleptic Malignant Syndrome
A potentially fatal symptom complex sometimes referred to as Neuroleptic Malignant Syndrome (NMS) has been reported in association with antipsychotic drugs. Clinical manifestations of NMS are hyperpyrexia, muscle rigidity, altered mental status and evidence of autonomic instability (irr…
Precautions
- General
Because of the possibility of cross-sensitivity, fluphenazine decanoate should be used cautiously in patients who have developed cholestatic jaundice, dermatoses, or other allergic reactions to phenothiazine derivatives. Psychotic patients on large doses of a phenothiazine drug who are un… - Information for Patients
Given the likelihood that a substantial proportion of patients exposed chronically to neuroleptics will develop tardive dyskinesia, it is advised that all patients in whom chronic use is contemplated be given, if possible, full information about this risk. The decision to inform patients and/or their …
Adverse Reactions
- Central Nervous System:The side effects most frequently reported with phenothiazine compounds are extrapyramidal symptoms including pseudoparkinsonism, dystonia, dyskinesia, akathisia, oculogyric crises, opisthotonos, and hyperreflexia. Muscle rigidity sometimes accompanied by hyperthermia has been reported following use of fluphenazine decanoate. Mos…
Prolixin Decanoate Dosage and Administration
- Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Prolixin Decanoate (Fluphenazine Decanoate Injection) may be given intramuscularly or subcutaneously. A dry syringe and needle of at least 21 gauge should be used. Use of a wet needle or syringe may cause the solution to beco…