What is the cost of Nexavar?
The cost for Nexavar oral tablet 200 mg is around $24,033 for a supply of 120 tablets, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans. This Nexavar price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies.
When should I stop taking Nexavar?
risk of wound healing problems. Tell your healthcare provider if you plan to have any surgery before starting or during treatment with NEXAVAR. You should stop taking NEXAVAR at least 10 days before planned surgery. Your healthcare provider should tell you when you may start taking NEXAVAR again after surgery.
What is the generic of Nexavar?
Sorafenib is used to treat kidney, liver, and thyroid cancer. It works by slowing or stopping the growth of cancer cells.
Where can I get sorafenib?
NEXAVAR tablets are available by prescription only and distributed through your healthcare professional (HCP), as well as different types of pharmacies: a network of specialty pharmacy providers (SPPs) and dispensing pharmacies. Your insurance company may require you to fill your prescription through an SPP.
How long can you live with sorafenib?
Median overall survival was 26.1 months with overall 6- and 12-month survival rates of 92.1 and 85%, respectively. Median time to radiological progression was 8 months. The progression-free rate was 64.3%. Fatigue, skin disorders and diarrhea were the most frequent grade 3-4 side effects.
Is Nexavar a chemotherapy?
What Is Nexavar? Nexavar (sorafenib) is a cancer (chemotherapeutic) medication used to treat a type of kidney cancer called advanced renal cell carcinoma. Nexavar is also used to treat liver cancer.
Does Nexavar cause hair loss?
These are less common side effects for patients receiving Nexavar, when compared with those receiving placebo: High blood pressure (particularly in first 6 weeks of treatment) Hair loss (thinning or patchy hair loss) Nausea.
How effective is Nexavar?
The patients administered with Nexavar showed a 41% reduction in the risk of progression or death when compared to placebo-treated patients. The median PFS was 10.8 months in patients treated with Nexavar, compared to 5.8 months in patients receiving placebo.
What happens when you stop taking sorafenib?
Our results showed that the side effects of sorafenib, such as HFSR, diarrhea and hypertension, resolved after the discontinuation of sorafenib. Weight loss and alopecia also improved gradually.
Can Nexavar shrink tumors?
Sorafenib (Nexavar; Bayer) shrinks desmoid tumors in one third of patients, according to a recent clinical trial thatcould lead to the first drug approval for the disease (N Engl J Med 2018;379:2417–28).
When should I take sorafenib?
Sorafenib comes as a tablet to take by mouth. It is usually taken twice a day. Sorafenib is taken without food, 1 hour before or 2 hours after a meal. Take sorafenib at around the same times every day.
How do you take Nexavar?
Swallow Nexavar tablets with a glass of water, either without food or with a low-fat or moderate fat meal. Do not take this medicine with high fat meals, as this may make Nexavar less effective. If you intend to have a high fat meal, take the tablets at least 1 hour before or 2 hours after the meal.
What happens when you stop taking sorafenib?
Our results showed that the side effects of sorafenib, such as HFSR, diarrhea and hypertension, resolved after the discontinuation of sorafenib. Weight loss and alopecia also improved gradually.
How effective is Nexavar?
The patients administered with Nexavar showed a 41% reduction in the risk of progression or death when compared to placebo-treated patients. The median PFS was 10.8 months in patients treated with Nexavar, compared to 5.8 months in patients receiving placebo.
Can Nexavar shrink tumors?
Sorafenib (Nexavar; Bayer) shrinks desmoid tumors in one third of patients, according to a recent clinical trial thatcould lead to the first drug approval for the disease (N Engl J Med 2018;379:2417–28).
Does Nexavar cause hair loss?
These are less common side effects for patients receiving Nexavar, when compared with those receiving placebo: High blood pressure (particularly in first 6 weeks of treatment) Hair loss (thinning or patchy hair loss) Nausea.
What is Nexavar used for?
Nexavar has been approved by the FDA for treatment of advanced kidney cancer. Nexavar is administered in tablet form.
Does Bayer offer Nexavar?
Nexavar REACH Program, a patient assistance program provided by Bayer HealthCare Pharmaceuticals, offers Nexavar at no cost to those who are eligible for the program. Eligibility is based off of the following requirements:
How to know if Nexavar is working?
Your healthcare provider will do blood tests to check your liver function regularly during your treatment with NEXAVAR. Tell your healthcare provider right away if you develop any of the following symptoms: yellowing of your skin or the whites of your eyes. dark “tea-colored” urine.
Where to report a negative side effect of Nexavar?
You are encouraged to report negative side effects or quality complaints of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088. For important risk and use information about NEXAVAR, please see the full Prescribing Information.
How long after nexavar is used?
Use effective birth control (contraception) during your treatment with NEXAVAR and for 6 months after the last dose of NEXAVAR. For males with female partners who are able to become pregnant: Use effective birth control (contraception) during your treatment with NEXAVAR and for 3 months after the last dose of NEXAVAR.
What does Nexavar test for?
Your healthcare provider may do tests during your treatment with NEXAVAR to check the levels of potassium, magnesium, and calcium in your blood, and check the electrical activity of your heart with an electrocardiogram ( ECG). Tell your healthcare provider right away if you feel faint, lightheaded, dizzy or feel your heart beating irregularly ...
How long before surgery can you stop Nexavar?
Tell your healthcare provider if you plan to have any surgery before starting or during treatment with NEXAVAR. You should stop taking NEXAVAR at least 10 days before planned surgery. Your healthcare provider should tell you when you may start taking NEXAVAR again after surgery.
Does Nexavar cause fertility problems?
NEXAVAR may cause fertility problems in males. This may affect your ability to father a child. Talk to your healthcare provider if this is a concern for you.
Is Nexavar safe for children?
a type of kidney cancer called renal cell carcinoma (RCC) a type of thyroid cancer called differentiated thyroid carcinoma (DTC) that can no longer be treated with radioactive iodine and is progressing. It is not known if NEXAVAR is safe and effective in children. See More.
What is Nexavar used for?
NEXAVAR is indicated for the treatment of patients with advanced renal cell carcinoma (RCC). NEXAVAR is indicated for the treatment of patients with locally recurrent or metastatic, progressive, differentiated thyroid carcinoma (DTC) that is refractory to radioactive iodine treatment.
What is the incidence of ischemia in a nexavar group?
Cardiovascular Events: In the SHARP (HCC) study, the incidence of cardiac ischemia/infarction was 2.7% in NEXAVAR-treated patients compared with 1.3% for placebo-treated group. In the TARGET (RCC) study, the incidence of cardiac ischemia/infarction was higher in the NEXAVAR-treated group (2.9%) compared with the placebo-treated group (0.4%). In the DECISION (DTC) study, the incidence of cardiac ischemia/infarction was 1.9% in the NEXAVAR-treated group compared with 0% in the placebo-treated group. Patients with unstable coronary artery disease or recent myocardial infarction were excluded from this study. Consider temporary or permanent discontinuation of NEXAVAR in patients who develop cardiovascular events.
What are the most common laboratory abnormalities observed in the Nexavar study?
In the DTC study, the most common laboratory abnormalities observed in the NEXAVAR arm versus the placebo arm, respectively, were elevated ALT (59% vs. 24%), elevated AST (54% vs. 15%), and hypocalcemia (36% vs. 11%). The relative increase for the following laboratory abnormalities observed in NEXAVAR-treated DTC patients as compared to placebo-treated patients is similar to that observed in the RCC and HCC studies: lipase, amylase, hypokalemia, hypophosphatemia, neutropenia, lymphopenia, anemia, and thrombocytopenia.
What is the treatment for hepatocellular carcinoma?
STIVARGA is indicated for the treatment of patients with hepatocellular carcinoma (HCC) who have been previously treated with sorafenib.
How long after Nexavar can you breastfeed?
Lactation: Because of the potential for serious adverse reactions in a breastfed child from NEXAVAR, advise lactating women not to breastfeed during treatment with NEXAVAR and for 2 weeks after the last dose.
How long to wait to take Nexavar after surgery?
Withhold NEXAVAR for at least 10 days prior to elective surgery. Do not administer for at least 2 weeks following major surgery and until adequate wound healing.
What is access services by Bayer?
Access Services by Bayer ™ is a free support program available to eligible patients who have been prescribed NEXAVAR ® (sorafenib). Access Services by Bayer provides patients with information about their therapy, helps them evaluate their financial assistance options, and offers education and support to health care professionals.
What is Nexavar used for?
NEXAVAR is indicated for the treatment of patients with advanced renal cell carcinoma (RCC). NEXAVAR is indicated for the treatment of patients with locally recurrent or metastatic, progressive, differentiated thyroid carcinoma (DTC) that is refractory to radioactive iodine treatment.
What is the incidence of ischemia in a nexavar group?
Cardiovascular Events: In the SHARP (HCC) study, the incidence of cardiac ischemia/infarction was 2.7% in NEXAVAR-treated patients compared with 1.3% for placebo-treated group. In the TARGET (RCC) study, the incidence of cardiac ischemia/infarction was higher in the NEXAVAR-treated group (2.9%) compared with the placebo-treated group (0.4%). In the DECISION (DTC) study, the incidence of cardiac ischemia/infarction was 1.9% in the NEXAVAR-treated group compared with 0% in the placebo-treated group. Patients with unstable coronary artery disease or recent myocardial infarction were excluded from this study. Consider temporary or permanent discontinuation of NEXAVAR in patients who develop cardiovascular events.
What are the most common laboratory abnormalities observed in the Nexavar study?
In the DTC study, the most common laboratory abnormalities observed in the NEXAVAR arm versus the placebo arm, respectively, were elevated ALT (59% vs. 24%), elevated AST (54% vs. 15%), and hypocalcemia (36% vs. 11%). The relative increase for the following laboratory abnormalities observed in NEXAVAR-treated DTC patients as compared to placebo-treated patients is similar to that observed in the RCC and HCC studies: lipase, amylase, hypokalemia, hypophosphatemia, neutropenia, lymphopenia, anemia, and thrombocytopenia.
What is the treatment for hepatocellular carcinoma?
STIVARGA is indicated for the treatment of patients with hepatocellular carcinoma (HCC) who have been previously treated with sorafenib.
How long after Nexavar can you breastfeed?
Lactation: Because of the potential for serious adverse reactions in a breastfed child from NEXAVAR, advise lactating women not to breastfeed during treatment with NEXAVAR and for 2 weeks after the last dose.
How long to wait to take Nexavar after surgery?
Withhold NEXAVAR for at least 10 days prior to elective surgery. Do not administer for at least 2 weeks following major surgery and until adequate wound healing.
What is hepatotoxicity in STIVARGA?
Hepatotoxicity: Severe drug-induced liver injury with fatal outcome occurred in STIVARGA-treated patients across all clinical trials. In most cases, liver dysfunction occurred within the first 2 months of therapy and was characterized by a hepatocellular pattern of injury. In hepatocellular carcinoma (HCC), there was no increase in the incidence of fatal hepatic failure as compared to placebo.
What is Nexavar used for?
Nexavar (sorafenib) is a member of the multikinase inhibitors drug class and is commonly used for Hepatic Tumor, Hepatocellular Carcinoma, Renal Cell Carcinoma, and others.
How much does Nexavar cost?
The cost for Nexavar oral tablet 200 mg is around $21,683 for a supply of 120 tablets, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans.
How much does a free drug card save?
The free Drugs.com Discount Card works like a coupon and can save you up to 80% or more off the cost of prescription medicines, over-the-counter drugs and pet prescriptions.
Is Nexavar a generic?
Nexavar is available as a brand name drug only, a generic version is not yet available. For more information, read about generic Nexavar availability . This Nexavar price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies.
