Does Medicare pay for STIVARGA?
Do Medicare prescription drug plans cover Stivarga? Yes. 100% of Medicare prescription drug plans cover this drug.
What is the severe and sometimes fatal warning associated with taking STIVARGA?
WARNING: HEPATOTOXICITY Severe and sometimes fatal hepatotoxicity has been observed in clinical trials. Monitor hepatic function prior to and during treatment.
How successful is STIVARGA?
Improvement in Overall Survival Patients taking STIVARGA (379) lived a median of 10.6 months compared to those taking placebo (194) who lived a median of 7.8 months. There were 233 deaths out of 379 patients with STIVARGA (62%) vs 140 deaths out of 194 patients with placebo (72%)
Where can I get STIVARGA?
3 ways to get STIVARGA® (regorafenib)Specialty pharmacy. provider (SPP) ... Access Services by Bayer™ Access Services by Bayer provides nursing support, financial assistance, and help with taking STIVARGA. ... Doctor's office. You may receive your medicine at a doctor's office if an on-site pharmacy is available.
Is STIVARGA a last resort?
The drug regorafenib (Stivarga®) was approved last year as third line treatment for patients with advanced Gastrointestinal Stromal Tumour (GIST).
Does STIVARGA cause pain?
People in the clinical trials experienced side effects when taking STIVARGA. Side effects with STIVARGA may occur early on in treatment....Most common side effects.stomach-area (abdomen) painvoice change or hoarsenesstiredness, weakness, fatigueincrease in certain liver function testsinfectionweight loss2 more rows
Does stivarga shrink tumors?
Regorafenib may shrink the cancer or stop it growing for a time. You usually take regorafenib for as long as it is helping you and the side effects aren't too bad.
Is stivarga good?
STIVARGA Is Effective in GIST STIVARGA is an oral multitargeted agent for treatment of GIST that targets angiogenesis, oncogenesis, and the tumor microenvironment. In the GRID study, STIVARGA demonstrated a significant improvement in PFS compared to placebo in GIST patients with 2 or more prior lines of therapy.
Does stivarga cause hair loss?
Weight loss. A change in voice (often described by patients as hoarseness)...Laboratory Test Abnormalities.Side effects reported in phase III trial of regorafenib vs. placeboRegorafenib (n=131)Any grade (all severities)Placebo (n=66)Any gradeAlopecia (hair loss)24%2%Rash, maculopapular18%3%Nausea16%9%10 more rows•Dec 14, 2012
Is STIVARGA chemotherapy?
Stivarga® is the trade name for the generic chemotherapy drug regorafenib. In some cases, health care professionals may use the generic name regorafenib when referring to the trade name Stivarga®. Drug type: Stivarga® is a targeted therapy.
Is STIVARGA an immunotherapy?
Nivolumab is an immunotherapy drug encouraging the body's own immune system to attack cancer cells. Both drugs have been approved, but not for how they are being used as combination therapy in this study. Brand name of regorafenib is Stivarga; brand name of nivolumab is Opdivo.
How is STIVARGA taken?
STIVARGA should be swallowed whole with water and after a low-fat meal. This is a meal that contains less than 600 calories and less than 30% fat. You can decide what time you want to take STIVARGA each day. You may prefer to take it with breakfast, dinner, or a midday meal.
What are the side effects of regorafenib?
Side EffectsBleeding gums.bloody or cloudy urine.cough or hoarseness.coughing up blood.difficult, burning, or painful urination.difficulty with breathing or swallowing.fever or chills.frequent urge to urinate.More items...•
Does STIVARGA shrink tumors?
Regorafenib may shrink the cancer or stop it growing for a time. You usually take regorafenib for as long as it is helping you and the side effects aren't too bad.
What class of drug is STIVARGA?
Stivarga belongs to a class of drugs called Antineoplastics, Tyrosine Kinase Inhibitor; Antineoplastics, Angiogenesis Inhibitor. It is not known if Stivarga is safe and effective in children.
Is STIVARGA chemotherapy?
Stivarga® is the trade name for the generic chemotherapy drug regorafenib. In some cases, health care professionals may use the generic name regorafenib when referring to the trade name Stivarga®. Drug type: Stivarga® is a targeted therapy.
How long to wait to give stivarga after surgery?
Therefore, STIVARGA has the potential to adversely affect wound healing. Withhold STIVARGA for at least 2 weeks prior to elective surgery. Do not administer for at least 2 weeks following major surgery and until adequate wound healing.
How long after stivarga can you breastfeed?
Nursing Mothers: Because of the potential for serious adverse reactions in breastfed infants from STIVARGA, do not breastfeed during treatment with STIVARGA and for 2 weeks after the final dose.
How long after stivarga do you need to use contraception?
Advise females of reproductive potential and males with female partners of reproductive potential to use effective contraception during treatment with STIVARGA and for 2 months after the final dose.
What is a RPLS?
Reversible Posterior Leukoencephalopathy Syndrome (RPLS): Reversible posterior leukoencephalopathy syndrome (RPLS), a syndrome of subcortical vasogenic edema diagnosed by characteristics finding on MRI , occurred in one of 4800 STIVARGA-treated patients across all clinical trials. Perform an evaluation for RPLS in any patient presenting with seizures, severe headache, visual disturbances, confusion, or altered mental function. Discontinue STIVARGA in patients who develop RPLS.
What is the treatment for hepatocellular carcinoma?
STIVARGA is indicated for the treatment of patients with hepatocellular carcinoma (HCC) who have been previously treated with sorafenib.
What is the treatment for a metastatic colorectal cancer?
STIVARGA is indicated for the treatment of patients with metastatic colorectal cancer (CRC) who have been previously treated with fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapy, an anti-VEGF therapy, and , if RAS wild-type, an anti-EGFR therapy.
How to report Bayer products?
You are encouraged to report side effects or quality complaints of products to the FDA by visiting www.fda.gov/medwatch or calling 1-800-FDA-1088. For Bayer products, you can report these directly to Bayer by clicking here.
How long after stivarga can you breastfeed?
are breast-feeding or plan to breast-feed. It is not known if STIVARGA passes into your breast milk. Do not breastfeed during treatment with STIVARGA and for 2 weeks after your final dose of STIVARGA
What is the best medicine for colon cancer?
STIVARGA (regorafenib) is a prescription medicine used to treat people with: 1 colon or rectal cancer that has spread to other parts of the body and for which they have received previous treatment with certain chemotherapy medicines 2 a rare stomach, bowel, or esophagus cancer called GIST (gastrointestinal stromal tumor) that cannot be treated with surgery or that has spread to other parts of the body and for which they have received previous treatment with certain medicines 3 a type of liver cancer called hepatocellular carcinoma (HCC) in people who have been previously treated with sorafenib
What is it called when you feel like you're passing out?
a condition called reversible posterior leukoencephalopathy syndrome (RPLS). Call your healthcare provider right away if you get severe headaches, seizure, confusion, change in vision, or problems thinking.
What is the skin problem called when you have a rash on your foot?
a skin problem called hand-foot skin reaction and severe skin rash. Hand-foot skin reactions are common and sometimes can be severe.
How to contact Bayer for access services?
Simply call 1-800-288-8374 to speak to a specially trained Access Services by Bayer counselor.
What is the name of the cancer that has spread to other parts of the body?
STIVARGA (regorafenib) is a prescription medicine used to treat people with: colon or rectal cancer that has spread to other parts of the body and for which they have received previous treatment with certain chemotherapy medicines. a rare stomach, bowel, or esophagus cancer called GIST (gastrointestinal stromal tumor) that cannot be treated ...
Does stivarga cause infections?
STIVARGA may cause serious side effects, including: Infection. STIVARGA may lead to a higher risk of infections especially of the urinary tract, nose, throat and lung. STIVARGA may lead to a higher risk of fungal infections of the mucous membrane, skin or the body.
How long after stivarga can you breastfeed?
are breast-feeding or plan to breast-feed. It is not known if STIVARGA passes into your breast milk. Do not breastfeed during treatment with STIVARGA and for 2 weeks after your final dose of STIVARGA
What is the skin problem called when you have a rash on your foot?
a skin problem called hand-foot skin reaction and severe skin rash. Hand-foot skin reactions are common and sometimes can be severe.
What is the name of the cancer that has spread to other parts of the body?
STIVARGA (regorafenib) is a prescription medicine used to treat people with: colon or rectal cancer that has spread to other parts of the body and for which they have received previous treatment with certain chemotherapy medicines. a rare stomach, bowel, or esophagus cancer called GIST (gastrointestinal stromal tumor) that cannot be treated ...
What is SPP pharmacy?
Specialty pharmacy. provider (SPP) When filing a prescription through an SPP, you will likely receive your medicine through the mail. SPP employees: Work directly with your oncology team and health insurance providers to coordinate your care. Will assist with delivery/payment details and support programs.
What is access services by Bayer?
Access Services by Bayer provides nursing support, financial assistance, and help with taking STIVARGA.
Does stivarga cause infections?
STIVARGA may cause serious side effects, including: Infection. STIVARGA may lead to a higher risk of infections especially of the urinary tract, nose, throat and lung. STIVARGA may lead to a higher risk of fungal infections of the mucous membrane, skin or the body.
What is the rarest cancer in the stomach?
a rare stomach, bowel, or esophagus cancer called GIST (gastrointestinal stromal tumor) that cannot be treated with surgery or that has spread to other parts of the body and for which they have received previous treatment with certain medicines. a type of liver cancer called hepatocellular carcinoma ...
What is stivarga used for?
Stivarga (regorafenib) is a member of the multikinase inhibitors drug class and is commonly used for Colorectal Cancer, Gastrointestinal Stromal Tumor, and Hepatocellular Carcinoma.
How much does Stivarga cost?
The cost for Stivarga oral tablet 40 mg is around $19,581 for a supply of 84, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans.
How much does a free drug card save?
The free Drugs.com Discount Card works like a coupon and can save you up to 80% or more off the cost of prescription medicines, over-the-counter drugs and pet prescriptions.
When there is a range of pricing, should consumers expect to pay the lower price?
Important: When there is a range of pricing, consumers should normally expect to pay the lower price. However, due to stock shortages and other unknown variables we cannot provide any guarantee.
How long after stivarga do you need to use contraception?
Advise females of reproductive potential and males with female partners of reproductive potential to use effective contraception during treatment with STIVARGA and for 2 months after the final dose.
What is access services by Bayer?
Access Services by Bayer is a free support program available to eligible patients who have been prescribed STIVARGA ® (regorafenib). Access Services by Bayer provides patients with information about their therapy, helps them evaluate their financial assistance options, and offers education and support to healthcare professionals.
What is the treatment for hepatocellular carcinoma?
STIVARGA is indicated for the treatment of patients with hepatocellular carcinoma (HCC) who have been previously treated with sorafenib.
What is a RPLS?
Reversible Posterior Leukoencephalopathy Syndrome (RPLS): Reversible posterior leukoencephalopathy syndrome (RPLS), a syndrome of subcortical vasogenic edema diagnosed by characteristics finding on MRI , occurred in one of 4800 STIVARGA-treated patients across all clinical trials. Perform an evaluation for RPLS in any patient presenting with seizures, severe headache, visual disturbances, confusion, or altered mental function. Discontinue STIVARGA in patients who develop RPLS.
What is the treatment for a metastatic colorectal cancer?
STIVARGA is indicated for the treatment of patients with metastatic colorectal cancer (CRC) who have been previously treated with fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapy, an anti-VEGF therapy, and , if RAS wild-type, an anti-EGFR therapy.
How long to withhold vicarga?
Withhold STIVARGA for at least 2 weeks prior to elective surgery. Do not administer for at least 2 weeks following major surgery and until adequate wound healing. The safety of resumption of STIVARGA after resolution of wound healing complications has not been established.
Does stiverga cause hypertension?
Hypertension: Hypertensive crisis occurred in 0.2% in STIVARGA-treated patients and in none of the patients in placebo arm across all randomized, placebo-controlled trials. STIVARGA caused an increased incidence of hypertension (30% vs 8% in mCRC, 59% vs 27% in GIST, and 31% vs 6% in HCC). The onset of hypertension occurred during the first cycle of treatment in most patients who developed hypertension (67% in randomized, placebo controlled trials). Do not initiate STIVARGA until blood pressure is adequately controlled. Monitor blood pressure weekly for the first 6 weeks of treatment and then every cycle, or more frequently, as clinically indicated. Temporarily or permanently withhold STIVARGA for severe or uncontrolled hypertension.
How long after stivarga can you breastfeed?
Nursing Mothers: Because of the potential for serious adverse reactions in breastfed infants from STIVARGA, do not breastfeed during treatment with STIVARGA and for 2 weeks after the final dose.
How long after stivarga do you need to use contraception?
Advise females of reproductive potential and males with female partners of reproductive potential to use effective contraception during treatment with STIVARGA and for 2 months after the final dose.
What is a RPLS?
Reversible Posterior Leukoencephalopathy Syndrome (RPLS): Reversible posterior leukoencephalopathy syndrome (RPLS), a syndrome of subcortical vasogenic edema diagnosed by characteristics finding on MRI , occurred in one of 4800 STIVARGA-treated patients across all clinical trials. Perform an evaluation for RPLS in any patient presenting with seizures, severe headache, visual disturbances, confusion, or altered mental function. Discontinue STIVARGA in patients who develop RPLS.
What is the treatment for hepatocellular carcinoma?
STIVARGA is indicated for the treatment of patients with hepatocellular carcinoma (HCC) who have been previously treated with sorafenib.
What is stiverga used for?
STIVARGA is indicated for the treatment of patients with locally advanced, unresectable or metastatic gastrointestinal stromal tumor (GIST) who have been previously treated with imatinib mesylate and sunitinib malate. STIVARGA is indicated for the treatment of patients with hepatocellular carcinoma ...
How long to withhold vicarga?
Withhold STIVARGA for at least 2 weeks prior to elective surgery. Do not administer for at least 2 weeks following major surgery and until adequate wound healing. The safety of resumption of STIVARGA after resolution of wound healing complications has not been established.
What is the treatment for a metastatic colorectal cancer?
STIVARGA is indicated for the treatment of patients with metastatic colorectal cancer (CRC) who have been previously treated with fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapy, an anti-VEGF therapy, and , if RAS wild-type, an anti-EGFR therapy.
How long after stivarga can you breastfeed?
Nursing Mothers: Because of the potential for serious adverse reactions in breastfed infants from STIVARGA, do not breastfeed during treatment with STIVARGA and for 2 weeks after the final dose.
How long after stivarga do you need to use contraception?
Advise females of reproductive potential and males with female partners of reproductive potential to use effective contraception during treatment with STIVARGA and for 2 months after the final dose.
What is a RPLS?
Reversible Posterior Leukoencephalopathy Syndrome (RPLS): Reversible posterior leukoencephalopathy syndrome (RPLS), a syndrome of subcortical vasogenic edema diagnosed by characteristics finding on MRI , occurred in one of 4800 STIVARGA-treated patients across all clinical trials. Perform an evaluation for RPLS in any patient presenting with seizures, severe headache, visual disturbances, confusion, or altered mental function. Discontinue STIVARGA in patients who develop RPLS.
What is the treatment for hepatocellular carcinoma?
STIVARGA is indicated for the treatment of patients with hepatocellular carcinoma (HCC) who have been previously treated with sorafenib.
How long to withhold vicarga?
Withhold STIVARGA for at least 2 weeks prior to elective surgery. Do not administer for at least 2 weeks following major surgery and until adequate wound healing. The safety of resumption of STIVARGA after resolution of wound healing complications has not been established.
What is vicarga used for?
STIVARGA is indicated for the treatment of patients with metastatic colorectal cancer (CRC) who have been previously treated with fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapy, an anti-VEGF therapy , and, if RAS wild-type, an anti- EGFR therapy. STIVARGA is indicated for the treatment of patients with locally advanced, ...
Does stiverga cause hypertension?
Hypertension: Hypertensive crisis occurred in 0.2% in STIVARGA-treated patients and in none of the patients in placebo arm across all randomized, placebo-controlled trials. STIVARGA caused an increased incidence of hypertension (30% vs 8% in mCRC, 59% vs 27% in GIST, and 31% vs 6% in HCC). The onset of hypertension occurred during the first cycle of treatment in most patients who developed hypertension (67% in randomized, placebo controlled trials). Do not initiate STIVARGA until blood pressure is adequately controlled. Monitor blood pressure weekly for the first 6 weeks of treatment and then every cycle, or more frequently, as clinically indicated. Temporarily or permanently withhold STIVARGA for severe or uncontrolled hypertension.
