What should I know about Stivarga before taking it?
high blood pressure. Your blood pressure should be checked every week for the first 6 weeks of starting STIVARGA. Your blood pressure should be checked regularly and any high blood pressure should be treated while you are receiving STIVARGA. Tell your healthcare provider if you have severe headaches, light-headedness, or changes in your vision
What type of cancer is Stivarga used for?
STIVARGA is indicated for patients with a type of liver cancer called hepatocellular carcinoma in people who have been previously treated with sorafenib. STIVARGA is the first FDA-approved treatment for HCC in 10 years.
How often should I check my blood pressure when taking Stivarga?
Your blood pressure should be checked every week for the first 6 weeks of starting STIVARGA. Your blood pressure should be checked regularly and any high blood pressure should be treated while you are receiving STIVARGA. Tell your healthcare provider if you have severe headaches, light-headedness, or changes in your vision
Does Medicare pay for stivarga?
Do Medicare prescription drug plans cover Stivarga? Yes. 100% of Medicare prescription drug plans cover this drug.
Where can I get stivarga?
3 ways to get STIVARGA® (regorafenib)Specialty pharmacy. provider (SPP) ... Access Services by Bayer™ Access Services by Bayer provides nursing support, financial assistance, and help with taking STIVARGA. ... Doctor's office. You may receive your medicine at a doctor's office if an on-site pharmacy is available.
How successful is stivarga?
Improvement in Overall Survival Patients taking STIVARGA (379) lived a median of 10.6 months compared to those taking placebo (194) who lived a median of 7.8 months. There were 233 deaths out of 379 patients with STIVARGA (62%) vs 140 deaths out of 194 patients with placebo (72%)
Who is the manufacturer of stivarga?
Stivarga (Regorafenib) is an oral multikinase inhibitor developed by Bayer HealthCare for the treatment of metastatic colorectal cancer (mCRC).
Is stivarga a last resort?
The drug regorafenib (Stivarga®) was approved last year as third line treatment for patients with advanced Gastrointestinal Stromal Tumour (GIST).
Does stivarga shrink tumors?
Regorafenib may shrink the cancer or stop it growing for a time. You usually take regorafenib for as long as it is helping you and the side effects aren't too bad.
How long do you live with Stage 4 colon?
Treatment of stage IV colon cancer is mostly palliative and its median survival is reported to be approximately 9 months with best supportive care. With 5-FU/LV, median survival improved to 12 months, and with combination 5-FU/LV plus irinotecan or oxaliplatin it is reported to be between 14 and 19 months.
Is stivarga good?
STIVARGA Is Effective in GIST STIVARGA is an oral multitargeted agent for treatment of GIST that targets angiogenesis, oncogenesis, and the tumor microenvironment. In the GRID study, STIVARGA demonstrated a significant improvement in PFS compared to placebo in GIST patients with 2 or more prior lines of therapy.
Does stivarga make you tired?
STIVARGA may also make you feel tired. If you are feeling tired, try “REST”: Reprioritize daily tasks to do your most important ones when you have the most energy; don't worry about doing less important things if you are tired. Exercise lightly or remain active.
How long has stivarga been around?
Regorafenib demonstrated to increase the overall survival of patients with metastatic colorectal cancer and has been approved by the US FDA on September 27, 2012.
What is the severe and sometimes fatal warning associated with taking stivarga?
WARNING: HEPATOTOXICITY Severe and sometimes fatal hepatotoxicity has been observed in clinical trials.
Does stivarga cause pain?
People in the clinical trials experienced side effects when taking STIVARGA. Side effects with STIVARGA may occur early on in treatment....Most common side effects.stomach-area (abdomen) painvoice change or hoarsenesstiredness, weakness, fatigueincrease in certain liver function testsinfectionweight loss2 more rows
Is regorafenib available on the NHS?
Regorafenib (Stivarga) is available on the NHS. It is a possible treatment for advanced hepatocellular carcinoma (liver cancer) in adults who have had sorafenib and have: a tumour that can't be removed by surgery (unresectable)
What is the cost of regorafenib?
Regorafenib is dosed in 40-mg tablets, and the recommended starting dose is 160 mg. The AWP is $147.26 per 40-mg tablet.
Is STIVARGA targeted therapy?
Regorafenib (Stivarga) is a type of targeted therapy known as a kinase inhibitor.
Is STIVARGA chemotherapy?
Regorafenib is a chemotherapy drug that is a small molecule called a Tyrosine Kinase Inhibitor (TKI) that turns off several proteins that are not functioning properly which help cancer cells to grow and survive.
What is stivarga used for?
STIVARGA is indicated for patients with a type of liver cancer called hepatocellular carcinoma in people who have been previously treated with sorafenib.
How long after stivarga can you breastfeed?
are breast-feeding or plan to breast-feed. It is not known if STIVARGA passes into your breast milk. Do not breastfeed during treatment with STIVARGA and for 2 weeks after your final dose of STIVARGA
Can you die from stiverga?
severe bleeding. STIVARGA can cause bleeding, which can be serious and sometimes lead to death. Tell your healthcare provider if you have any signs of bleeding while taking STIVARGA, including: vomiting blood or if your vomit looks like coffee grounds, pink or brown urine, red or black (looks like tar) stools, coughing up blood or blood clots, menstrual bleeding that is heavier than normal, unusual vaginal bleeding, nose bleeds that happen often, bruising, and lightheadedness
Does stiverga cause diarrhea?
The most common side effects with STIVARGA include pain including stomach-area (abdomen); tiredness, weakness, fatigue; diarrhea (frequent or loose bowel movements); decreased appetite; infection; voice change or hoarseness; increase in certain liver function tests; fever; swelling, pain, and redness of the lining in your mouth, throat, stomach, and bowel (mucositis); and weight loss.
Can you die from taking stivarga?
STIVARGA (regorafenib) can cause liver problems, which can be serious and sometimes lead to death. Your healthcare provider will do blood tests to check your liver function before you start taking STIVARGA and during your treatment with STIVARGA to check for liver problems.
Does stivarga cause infections?
STIVARGA may cause serious side effects, including: Infection. STIVARGA may lead to a higher risk of infections especially of the urinary tract, nose, throat and lung. STIVARGA may lead to a higher risk of fungal infections of the mucous membrane, skin or the body.
What is stivarga used for?from stivarga-us.com
STIVARGA is indicated for patients with a type of liver cancer called hepatocellular carcinoma in people who have been previously treated with sorafenib.
What is hepatotoxicity in STIVARGA?from hcp.nexavar-us.com
Hepatotoxicity: Severe drug-induced liver injury with fatal outcome occurred in STIVARGA-treated patients across all clinical trials. In most cases, liver dysfunction occurred within the first 2 months of therapy and was characterized by a hepatocellular pattern of injury. In hepatocellular carcinoma (HCC), there was no increase in the incidence of fatal hepatic failure as compared to placebo.
What are the most common laboratory abnormalities observed in the Nexavar study?from hcp.nexavar-us.com
In the DTC study, the most common laboratory abnormalities observed in the NEXAVAR arm versus the placebo arm, respectively, were elevated ALT (59% vs. 24%), elevated AST (54% vs. 15%), and hypocalcemia (36% vs. 11%). The relative increase for the following laboratory abnormalities observed in NEXAVAR-treated DTC patients as compared to placebo-treated patients is similar to that observed in the RCC and HCC studies: lipase, amylase, hypokalemia, hypophosphatemia, neutropenia, lymphopenia, anemia, and thrombocytopenia.
How long after stivarga do you need to use contraception?from hcp.stivarga-us.com
Advise females of reproductive potential and males with female partners of reproductive potential to use effective contraception during treatment with STIVARGA and for 2 months after the final dose.
What is the treatment for hepatocellular carcinoma?from hcp.stivarga-us.com
STIVARGA is indicated for the treatment of patients with hepatocellular carcinoma (HCC) who have been previously treated with sorafenib.
How long to wait to take Nexavar after surgery?from hcp.nexavar-us.com
Withhold NEXAVAR for at least 10 days prior to elective surgery. Do not administer for at least 2 weeks following major surgery and until adequate wound healing.
What is Nexavar used for?from hcp.nexavar-us.com
NEXAVAR is indicated for the treatment of patients with advanced renal cell carcinoma (RCC). NEXAVAR is indicated for the treatment of patients with locally recurrent or metastatic, progressive, differentiated thyroid carcinoma (DTC) that is refractory to radioactive iodine treatment.
How long after stivarga can you breastfeed?
are breast-feeding or plan to breast-feed. It is not known if STIVARGA passes into your breast milk. Do not breastfeed during treatment with STIVARGA and for 2 weeks after your final dose of STIVARGA
What is SPP pharmacy?
Specialty pharmacy. provider (SPP) When filing a prescription through an SPP, you will likely receive your medicine through the mail. SPP employees: Work directly with your oncology team and health insurance providers to coordinate your care. Will assist with delivery/payment details and support programs.
What is access services by Bayer?
Access Services by Bayer provides nursing support, financial assistance, and help with taking STIVARGA.
Can stiverga cause a fever?
Infection. STIVARGA may lead to a higher risk of infections especially of the urinary tract, nose, throat and lung. STIVARGA may lead to a higher risk of fungal infections of the mucous membrane, skin or the body. Tell your healthcare provider right away if you get fever, severe cough with or without an increase in mucus (sputum) production, severe sore throat, shortness of breath, burning or pain when urinating, unusual vaginal discharge or irritation, redness, swelling or pain in any part of the body
Can you die from stiverga?
severe bleeding. STIVARGA can cause bleeding, which can be serious and sometimes lead to death. Tell your healthcare provider if you have any signs of bleeding while taking STIVARGA, including: vomiting blood or if your vomit looks like coffee grounds, pink or brown urine, red or black (looks like tar) stools, coughing up blood or blood clots, menstrual bleeding that is heavier than normal, unusual vaginal bleeding, nose bleeds that happen often, bruising, and lightheadedness
Does stiverga cause diarrhea?
The most common side effects with STIVARGA include pain including stomach-area (abdomen); tiredness, weakness, fatigue; diarrhea (frequent or loose bowel movements); decreased appetite; infection; voice change or hoarseness; increase in certain liver function tests; fever; swelling, pain, and redness of the lining in your mouth, throat, stomach, and bowel (mucositis); and weight loss.
Can you die from taking stivarga?
STIVARGA (regorafenib) can cause liver problems, which can be serious and sometimes lead to death. Your healthcare provider will do blood tests to check your liver function before you start taking STIVARGA and during your treatment with STIVARGA to check for liver problems.
What to do if you miss a stivarga?
If you forget to take STIVARGA until the next day, NEVER try to “catch up”—don’t take 2 doses on the same day to make up for a missed dose.
How to keep stivarga from drying out?
Do: Always keep STIVARGA tightly closed in its original bottle as it contains a special drying agent (called a desiccant) to keep your medicine dry. Remove the drying agent to get tablets from the bottle. Always put it back in the bottle after getting your medicine.
What to do if you take more than your prescribed dose?
Call your healthcare provider or go to the nearest emergency room right away if you take more than your prescribed dose by mistake
How much fat is in vicarga?
STIVARGA should be swallowed whole with water and after a low-fat meal. This is a meal that contains less than 600 calories and less than 30% fat. You can decide what time you want to take STIVARGA each day.
How long before surgery can you stop taking vicarga?
have high blood pressure. have heart problems or chest pain. plan to have surgery or have had a recent surgery. You should stop taking STIVARGA at least 2 weeks before planned surgery. are pregnant or plan to become pregnant. STIVARGA can harm your unborn baby.
Can you breastfeed after taking stivarga?
It is not known if STIVARGA passes into your breast milk. Do not breastfeed during treatment with STIVARGA and for 2 weeks after your final dose of STIVARGA. Tell your doctor or nurse about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Can you drink grapefruit juice with stiverga?
You should avoid consuming grapefruit juice and St. John's Wort during treatment with STIVARGA, as these may affect the way the medicine works.
How to contact Buspaf for free medicine?
Provides free medicine for patients who are uninsured or underinsured and meet certain eligibility criteria. Call 1-866 -2BUSPAF (228-7723) to speak with a reimbursement counselor (Monday‐Friday, 8:30 am-6:00 pm ET) Learn More.
What is the number to call for Medicare reimbursement?
Call 1-800-288-8374 to speak with a reimbursement counselor (Monday‐Friday, 9:00 am-6:00 pm ET) Learn More.
How long after stivarga do you need to use contraception?
Advise females of reproductive potential and males with female partners of reproductive potential to use effective contraception during treatment with STIVARGA and for 2 months after the final dose.
How long to withhold vicarga?
Withhold STIVARGA for at least 2 weeks prior to elective surgery. Do not administer for at least 2 weeks following major surgery and until adequate wound healing. The safety of resumption of STIVARGA after resolution of wound healing complications has not been established.
What is access services by Bayer?
Access Services by Bayer is a free support program available to eligible patients who have been prescribed STIVARGA ® (regorafenib). Access Services by Bayer provides patients with information about their therapy, helps them evaluate their financial assistance options, and offers education and support to healthcare professionals.
What is the treatment for hepatocellular carcinoma?
STIVARGA is indicated for the treatment of patients with hepatocellular carcinoma (HCC) who have been previously treated with sorafenib.
Does stivarga cause urinary tract infections?
Infections: STIVARGA caused an increased risk of infections. The overall incidence of infection (Grades 1-5) was higher (32% vs 17%) in 1142 STIVARGA-treated patients as compared to the control arm in randomized placebo-controlled trials. The incidence of grade 3 or greater infections in STIVARGA treated patients was 9%. The most common infections were urinary tract infections (5.7%), nasopharyngitis (4.0%), mucocutaneous and systemic fungal infections (3.3%) and pneumonia (2.6%). Fatal outcomes caused by infection occurred more often in patients treated with STIVARGA (1.0%) as compared to patients receiving placebo (0.3%); the most common fatal infections were respiratory (0.6% vs 0.2%). Withhold STIVARGA for Grade 3 or 4 infections, or worsening infection of any grade. Resume STIVARGA at the same dose following resolution of infection.
Can you stop stivarga?
Interrupt and then reduce or discontinue STIVARGA for hepatotoxicity as manifested by elevated liver function tests or hepatocellular necrosis, depending upon severity and persistence.
Does vicarga cause hemorrhage?
Hemorrhage: STIVARGA caused an increased incidence of hemorrhage. The overall incidence (Grades 1-5) was 18.2% in 1142 patients treated with STIVARGA vs 9.5% with placebo in randomized, placebo-controlled trials. The incidence of grade 3 or greater hemorrhage in patients treated with STIVARGA was 3.0%. The incidence of fatal hemorrhagic events was 0.7%, involving the central nervous system or the respiratory, gastrointestinal, or genitourinary tracts. Permanently discontinue STIVARGA in patients with severe or life-threatening hemorrhage and monitor INR levels more frequently in patients receiving warfarin.
