What is Tafinlar and Mekinist used for?
TAFINLAR and MEKINIST are prescription medicines that can be used in combination to treat a type of lung cancer called non-small cell lung cancer (NSCLC) that has spread to other parts of the body (metastatic NSCLC), and that has a certain type of abnormal “BRAF V600E” gene.
Can you take Tafinlar without Mekinist?
It is important to take TAFINLAR® (dabrafenib) capsules + MEKINIST® (trametinib) tablets exactly as your health care provider tells you.
What is the income requirements for Novartis patient assistance?
To be eligible for NPAF assistance, you must:Household SizeAnnual Household Income Threshold2 People< USD 100 0003 People< USD 125 0004 People< USD 150 000> 5 PeopleAdd USD 25 000 for each additional person1 more row
What is the cost of Tafinlar?
Learn more about this drug here . This is a brand name drug and a generic may be available. The average cost for 120 Capsule(s), 75mg each, is $14,986.80. You can buy Tafinlar at the discounted price of $12,299.26 by using the WebMDRx coupon, a savings of 18%.
How long does TAFINLAR and MEKINIST work?
The median (or midpoint) duration of response for patients who have never been treated was 15.2 months. That means that half of the patients who responded to treatment continued to respond longer than 15.2 months and half responded for less than 15.2 months.
Does MEKINIST need to be refrigerated?
Both medications should be taken at least 1 hour before a meal or 2 hours after a meal. Mekinist must be stored in a refrigerator (or a refrigerated lunch pack if you are traveling) in the original bottle with the lid closely tightly to protect the medication from heat, light, and moisture.
How do you qualify for free eliquis?
You may be eligible for the Free 30-Day Trial Offer for ELIQUIS® (apixaban) if:You have not previously filled a prescription for ELIQUIS;You have a valid 30-day prescription for ELIQUIS;You are being treated with ELIQUIS for an FDA-approved indication that an HCP has planned for more than 35 days of treatment;More items...
How do I get Cosentyx for free?
Get free medication if you're eligible If you have commercial or private insurance and your prescription coverage isn't initially approved, you may get up to 2 years of COSENTYX for free through Covered Until You're Covered† while we work with your healthcare provider to try to secure coverage for COSENTYX.
What is Novartis program?
If you have limited or no insurance coverage, the Novartis Patient Assistance Foundation, Inc. provides medicines at no cost to eligible US patients who are experiencing financial hardship.
What is the generic name for Tafinlar?
Generic name: Dabrafenib Tafinlar is the trade name for the generic chemotherapy drug dabrafenib. In some cases, health care professionals may use the generic name dabrafenib when referring to the trade name Tafinlar. Drug type: Tafinlar is a targeted therapy.
How is Tafinlar administered?
Since TAFINLAR + MEKINIST is an oral melanoma treatment, you'll take it by mouth—at least 1 hour before or at least 2 hours after eating.
Is dabrafenib a chemotherapy?
Dabrafenib is the generic name for the trade name chemotherapy drug Tafinlar. In some cases, health care professionals may use the trade name Tafinlar when referring to the generic drug dabrafenib. Drug type: Dabrafenib is a targeted therapy.
Does reclast have a copay card?
Reclast Coupons, Copay Cards and Rebates Reclast offers may be in the form of a printable coupon, rebate, savings or copay card, trial offer, or free samples. Some offers may be printed right from a website, others require registration, completing a questionnaire, or obtaining a sample from the doctor's office.
How does Xolair co pay assistance work?
You will pay as little as the first $5 for your drug out-of pocket cost and/or as little as $5 for your injection out-of-pocket costs. The final amount you owe may be as little as $5, but may vary depending on your health insurance plan. *EOBs must be submitted within 365 days of the date of service.
How does Entresto copay card work?
Eligible commercially insured patients get each 30-, 60-, or 90-day supply of Entresto® for as little as a $10 co-pay. The program pays the balance of the co-pay per fill, up to a total maximum of $2500 per calendar year. Offer not valid under Medicare, Medicaid, or any other federal or state program.
Who manufactures Ciprodex?
See full prescribing information for CIPRODEX. To report SUSPECTED ADVERSE REACTIONS, contact Novartis Pharmaceuticals Corporation at 1-888-669-6682 or FDA at 1-800-FDA- 1088 or www.fda.gov/medwatch.
What is a tafinar?
TAFINLAR and MEKINIST are prescription medicines that can be used in combination to treat a type of lung cancer called non-small cell lung cancer (NSCLC) that has spread to other parts of the body (metastatic NSCLC), and that has a certain type of abnormal “ BRAF V ... See More
What is a single point of contact for Novartis?
One single point of contact to help guide you through getting access to the Novartis medicine (s) prescribed by your doctor
What is PANO on Novartis?
Our Patient Assistance Now Oncology (PANO) program was created to assist you with accessing your Novartis medicine (s)—from insurance verification to financial assistance—all through a knowledgeable and supportive call center.
Does Novartis offer oncology?
Novartis Oncology is committed to helping you get the Novartis medicine (s) you need. Access to medicine (s) can sometimes be difficult or confusing. PANO offers resources and support designed specifically to help make that process easier.* PANO can offer the following services:
What is tafinar used for?
Indications TAFINLAR, in combination with MEKINIST, is indicated for the treatment of patients with unresectable or metastatic melanoma with BRAF V600E or V600K mutations as detected by an FDA-approved test.
What is a tafenar capsule?
TAFINLAR ® (dabrafenib) capsules, in combination with MEKINIST ® (trametinib) tablets, is indicated for the treatment of patients with unresectable or metastatic melanoma with BRAF V600E or V600K mutations as detected by an FDA-approved test.
How to assess LVEF?
Assess LVEF by echocardiogram or multigated acquisition (MUGA) scan before initiation of the combination, 1 month after initiation, and then at 2- to 3-month intervals while on treatment. Withhold TAFINLAR for symptomatic cardiomyopathy or asymptomatic left ventricular dysfunction of >20% from baseline that is below institutional LLN. Resume TAFINLAR at the same dose level upon recovery of cardiac function to at least the institutional LLN for LVEF and absolute decrease ≤10% compared to baseline. For an asymptomatic absolute decrease in LVEF of 10% or greater from baseline that is below the LLN, withhold MEKINIST for up to 4 weeks. If improved to normal LVEF value, resume at a lower dose. If no improvement to normal LVEF value within 4 weeks, permanently discontinue MEKINIST. For symptomatic cardiomyopathy or an absolute decrease in LVEF of >20% from baseline that is below LLN, permanently discontinue MEKINIST.
How long to wait to resume mekinist?
Withhold MEKINIST if RPED is diagnosed. If resolution of the RPED is documented on repeat ophthalmologic evaluation within 3 weeks, resume MEKINIST at the same or a reduced dose. If no improvement after 3 weeks, resume at a reduced dose or permanently discontinue MEKINIST.
Does tafinar cause malignancies?
Based on its mechanism of action, TAFINLAR may promote the growth and development of malignancies with activation of monomeric G protein (RAS) through mutation or other mechanisms. Across clinical trials of TAFINLAR monotherapy and the combination, noncutaneous malignancies occurred in 1% of patients.
Is tafinar a melanoma drug?
TAFINLAR, in combination with MEKINIST, is indicated for the adjuvant treatment of patients with melanoma with BRAF V600E or V600K mutations, as detected by an FDA-approved test, and involvement of lymph node (s), following complete resection.
How to contact Novartis oncology?
Encourage your patients to find out if they are eligible to enroll in the Novartis Oncology Universal Co-pay Program by visiting Copay.NovartisOncology.com or calling 1-877-577-7756.
Patient Website
Our patient website is a helpful resource for patients taking TAFINLAR + MEKINIST, providing the Medication Guide, information on co-pay assistance, and downloadable support materials. Visit the site at us.tafinlarmekinist.com.
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TAFINLAR, in combination with MEKINIST, is indicated for the treatment of patients with unresectable or metastatic melanoma with BRAF V600E or V600K mutations as detected by an FDA-approved test.
Side Effects
In a multi-drug regimen, each medication has unique side effects. When these medicines are given together, drug-related side effects reported in clinical studies give the best estimate of what to expect. In clinical studies, the most commonly reported dabrafenib + trametinib side effects are shown here.
Monitoring
Labs (blood tests) may be checked before treatment and periodically during treatment until stable.
Questions to Ask Your..
A better understanding of your treatments will allow you to ask more questions of your healthcare team. We then hope that with the answers, you will get better results and have greater satisfaction with your care. Because we know it's not always easy to know what questions to ask, we've tried to make it easy for you!
ChemoExperts Tips
A specific test, approved by FDA, known as the “BRAF V600E mutation,” or “V600K” is recommended before starting dabrafenib therapy to determine whether dabrafenib will likely kill melanoma cells. If the mutation is NOT detected, then the chance of dabrafenib working may be low
Patient Assistance & Co-payment Coverage
Patients under the age of 65 years, or those with private insurance plans: If you have insurance and are looking for patient assistance or copay assistance for Dabrafenib (Tafinlar®) + Trametinib (Mekinist®), we have provided links that may help.
Emotional Wellness
What is Emotional Wellness? Emotional wellness is having a positive outlook balanced with a realistic understanding of current life events. This requires both an awareness and acceptance of your emotions. It is with this knowledge that you can develop a plan to take the necessary actions to positively impact your life.
What is Tafinlar used for?
Tafinlar (dabrafenib) is a member of the multikinase inhibitors drug class and is commonly used for Melanoma - Metastatic, Non-Small Cell Lung Cancer, and Thyroid Cancer.
Does Clozarila have a pharmacy card?
For Focalin XR, Clozaril, and Ritalin LA, Clozarila pharmacy card will be issued. All other medication will be shipped directly to the patient, unless otherwise noted. *Additional products may be available. Please contact the program for a complete product listing. www.pap.novartis.com
Is Tafinlar a generic?
Tafinlar is available as a brand name drug only, a generic version is not yet available. For more information, read about generic Tafinlar availability . This Tafinlar price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies.
How Do Dabrafenib and Trametinib Work Together?
Dabrafenib blocks the activity of a mutated version of a molecule called BRAF. Trametinib blocks the activity of an enzyme molecule called MEK. Both BRAF and MEK are key molecules that help regulate cell growth.
What Are the Goals of Dabrafenib and Trametinib?
The combination of dabrafenib and trametinib targets specific molecules that regulate cancer cell growth , with the goals of :
What molecule does Dabrafenib target?
Dabrafenib targets the V600E-mutated BRAF molecule to block its signaling.
What is the best treatment for advanced melanoma?
Two such drugs, dabrafenib (Tafinlar) and trametinib (Mekinist), shrink tumors and help patients with advanced melanoma live longer. Through clinical trials, cancer researchers have found that combining dabrafenib and trametinib can treat advanced melanoma more effectively than either medication on its own. The combination also produces less ...
What is the largest non-profit funder of melanoma research?
Melanoma Research. The Melanoma Research Alliance is the largest, non-profit funder of melanoma research worldwide. Since 2007, we have directly funded over $123 million in innovative grants to improve prevention, detection, and treatment of melanoma.
When was dabrafenib approved?
In 2014, the FDA approved the use of dabrafenib in combination with trametinib to treat patients who have advanced stages of melanoma:
When did Phase III clinical trials show improved patient outcomes?
Results from two Phase III clinical trials in 2014 showed improved patient outcomes for patients taking dabrafenib and trametinib compared with:
What is a mekinist?
Mekinist (trametinib) is a member of the multikinase inhibitors drug class and is commonly used for Melanoma - Metastatic, Non-Small Cell Lung Cancer, and Thyroid Cancer.
What is a patient assistance program?
Patient assistance programs (PAPs) are usually sponsored by pharmaceutical companies and provide free or discounted medicines to low income or uninsured and under-insured people who meet specific guidelines. Eligibility requirements vary for each program.
Does Clozarila have a pharmacy card?
For Focalin XR, Clozaril, and Ritalin LA, Clozarila pharmacy card will be issued. All other medication will be shipped directly to the patient, unless otherwise noted. *Additional products may be available. Please contact the program for a complete product listing. www.pap.novartis.com
Is Mekinist a generic?
Mekinist is available as a brand name drug only, a generic version is not yet available. For more information, read about generic Mekinist availability . This Mekinist price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies.
