Patient Assistance & Copay Programs for Toposar Patient assistance programs (PAPs) are usually sponsored by pharmaceutical companies and provide free or discounted medicines and copay programs to low income or uninsured and under-insured people who meet specific guidelines. Eligibility requirements vary for each program.
Full Answer
Can toposar be given parenterally?
TOPOSAR should not be given by rapid intravenous injection. Parenteral drug products should be inspected visually for particulate matter and discoloration (see DESCRIPTION section) prior to administration whenever solution and container permit. Stability: Unopened vials of TOPOSAR are stable for 24 months at room temperature (25°C).
How much does toposar cost?
The cost for Toposar intravenous solution (20 mg/mL) is around $14 for a supply of 5 milliliters, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans.
What is the maximum dose of toposar for lung cancer?
In small cell lung cancer, the Toposar Injection dose in combination with other approved chemotherapeutic drugs ranges from 35 mg/m2/day for 4 days to 50 mg/m2/day for 5 days. For recommended dosing adjustments in patients with renal impairment see PRECAUTIONS section.
How should toposar (etoposide) be administered?
Toposar (etoposide injection) should be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents. Severe myelosuppression with resulting infection or bleeding may occur.
What is VP-16?
Is toposar a chemo drug?
About this website
What does Patient Assist mean?
Patient assistance programs (PAPs) help people with no health insurance and those who are underinsured afford medications. These programs are managed by pharmaceutical companies, nonprofits, and government agencies. PAPs may cover the full cost of medications or provide a discount.
Does Allergan have a patient assistance program?
The Allergan Patient Assistance Program (PAP) provides Allergan medicines at no cost to eligible patients. If the patient qualifies, up to a twelve-month eligibility for the requested medication(s) or device(s) is approved for shipment to the patient's licensed prescriber for dispensing.
Who is myAbbVie assist?
myAbbVie Assist. We believe that people who need our medicines should be able to get them. That's why myAbbVie Assist provides free AbbVie medicine to qualifying patients. If you have any questions, visit the FAQs or call us at 1-800-222-6885.
HIGHLIGHTS OF PRESCRIBING INFORMATION ...
FULL PRESCRIBING INFORMATION 1 INDICATIONS AND USAGE 1.1 Refractory Testicular Tumors ETOPOPHOS is indicated, in combination with other chemotherapeutic drugs, for treatment of
Package leaflet: Information for the patient - National Institutes of ...
Package leaflet: Information for the patient VEPESID™ 50 mg and 100 mg capsules, soft Etoposide Read all of this leaflet carefully before you start taking this medicine because it contains important
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2 . FULL PRESCRIBING INFORMATION. WARNING: NEPHROTOXICITY, PERIPHERAL NEUROPATHY, NAUSEA AND VOMITING and MYELOSUPPRESSION. • Nephrotoxicity: cisplatin for injection can cause severe renal toxicity, including
Reference ID: 4101905 - Food and Drug Administration
FULL PRESCRIBING INFORMATION . 1 . INDICATIONS AND USAGE 1.1 . Refractory Testicular Tumors . ETOPOPHOS is indicated, in combination with other chemotherapeutic drugs, for treatment of
ETOPOSIDE INJECTION USP THERAPEUTIC CLASSIFICATION CAUTION ... - Novartis
Etoposide Injection USP Page 2 of 13 In a limited number of children, etoposide administered in a dose of 200-250 mg/m2 produced a peak serum concentration between 17 and 88 mcg/mL and showed a terminal half-life (T½ß) of 5.7 ± 1.3 hours.
Toposar (etoposide)
If you’re struggling to pay for your Toposar medication, we may be able to help. Through NiceRx, you can receive Toposar for just $49 per month.* NiceRx works directly with your healthcare provider to help you enroll in the Toposar patient assistance program.
Your monthly Toposar cost savings if eligible
You can receive your Toposar prescription for just $49 per month, every month. This flat fee covers the full cost of your Toposar medicine, regardless of retail price.
Am I eligible for the Toposar patient assistance program?
If you meet the eligibility criteria, you could receive your Toposar medication without paying the full retail price. At NiceRx, we review each Toposar assistance program application individually. The factors considered by most programs are:
How do I apply for the Toposar patient assistance program?
NiceRx makes it as simple as possible to apply for the Toposar patient assistance program. Start by completing our enrollment application, and tell us about any medications you’re taking, including Toposar. You will need to provide details about your healthcare provider, insurance, and your household income.
Can NiceRx help me get Toposar if I have insurance?
We may be able to help you if you have insurance but your insurance company won’t pay for your medication, you have high copay or co insurance responsibility or you don’t have insurance.
What is VP-16?
TOPOSAR (etoposide injection, USP) (also commonly known as VP-16) is a semisynthetic derivative ofpodophyllotoxin used in the treatment of certain neoplastic diseases. It is 4’-demethylepipodophyllo-toxin 9-[4,6-0-(R)-ethylidene-b-D-glucopyranoside]. It is very soluble in methanol and chloroform, slightlysoluble in ethanol and sparingly soluble in water and ether. It is made more miscible with water by meansof organic solvents. It has a molecular weight of 588.58 and a molecular formula of C29H32O13.TOPOSAR is available for intravenous use as a 20 mg/mL solution in 100 mg (5mL), 200 mg (10mL) and500 mg (25mL) sterile, multiple dose vials. The pH of the clear yellow solution is 3 to 4. Each mL contains20 mg etoposide, 2 mg citric acid, 30 mg benzyl alcohol, 80 mg polysorbate 80/tween 80, 650 mg poly-ethylene glycol 300, and 30.5% (v/v) alcohol.
Is toposar a chemo drug?
General: In all instances where the use of TOPOSAR is considered for chemotherapy, the physician mustevaluate the need and usefulness of the drug against the risk of adverse reactions. Most such adversereactions are reversible if detected early. If severe reactions occur, the drug should be reduced in dosageor discontinued and appropriate corrective measures should be taken according to the clinical judgmentof the physician. Reinstitution of TOPOSAR therapy should be carried out with caution, and with ade-quate consideration of the further need for the drug and alertness as to possible recurrence of toxicity.Laboratory Tests:Periodic complete blood counts should be done during the course of TOPOSAR treat-ment. They should be performed prior to therapy and at appropriate intervals during and after therapy.At least one determination should be done prior to each dose of TOPOSAR.
What is PAP in Novo Nordisk?
The Novo Nordisk Patient Assistance Program (PAP) is based on our commitment to people living with diabetes. The Patient Assistance Program provides medication at no cost to those who qualify.
Where to mail Novo Nordisk application?
Fax the completed application and proof of income to 1-866-441-4190, or mail them to Novo Nordisk Inc., PO Box 370, Somerville, NJ 08876. Faxes must be sent from your health care provider’s office. Please allow up to 10 business days for processing.
Can Novo Nordisk cancel a program?
Novo Nordisk reserves the right to modify or cancel this program at any time without notice.
Is it important to dispose of Novo Nordisk?
It's important to properly dispose of your used Novo Nordisk products.
Does Novo Nordisk offer diabetes medicine?
Patients who are approved for the PAP may qualify to receive free diabetes medicine from Novo Nordisk. There is no registration charge or monthly fee for participating.
What is toposar injection?
Toposar (etoposide injection) in combination therapy with other approved chemotherapeutic agents in patients with refractory testicular tumors who have already received appropriate surgical, chemotherapeutic, and radiotherapeutic therapy .
How many ml of toposar is in a 100 mg solution?
Toposar (etoposide injection USP) is available for intravenous use as a sterile 20 mg/mL solution in 100 mg (5 mL), 500 mg (25 mL), or 1 g (50 mL) sterile, multiple dose vials. The pH of the clear, yellow liquid is 3.0 to 4.0.
How much etoposide is cleared?
The mean renal clearance of etoposide is 7 to 10 mL/min/m 2 or about 35% of the total body clearance over a dose range of 80 to 600 mg/m 2. Etoposide, therefore, is cleared by both renal and nonrenal processes, i.e., metabolism and biliary excretion. The effect of renal disease on plasma etoposide clearance is not known.
What is etoposide used for?
Etoposide injection and/or capsules in combination with other approved chemotherapeutic agents as first line treatment in patients with small cell lung cancer.
What is the mean volume of etoposide?
The mean volumes of distribution at steady state fall in the range of 18 to 29 liters or 7 to 17 L/m 2. Etoposide enters the CSF poorly. Although it is detectable in CSF and intracerebral tumors, the concentrations are lower than in extracerebral tumors and in plasma. Etoposide concentrations are higher in normal lung than in lung metastases and are similar in primary tumors and normal tissues of the myometrium. In vitro, etoposide is highly protein bound (97%) to human plasma proteins. An inverse relationship between plasma albumin levels and etoposide renal clearance is found in children. In a study determining the effect of other therapeutic agents on the in vitro binding of carbon-14 labeled etoposide to human serum proteins, only phenylbutazone, sodium salicylate, and aspirin displaced protein-bound etoposide at concentrations achieved in vivo.
What is VP-16?
Toposar ® (etoposide injection USP) (also commonly known as VP-16) is a semisynthetic derivative of podophyllotoxin used in the treatment of certain neoplastic diseases. It is 4'-demethylepipodophyllotoxin 9- [4,6-0- (R)-ethylidene-β-D-glucopyranoside]. It is very soluble in methanol and chloroform, slightly soluble in ethanol, ...
When should you do a complete blood count for toposar?
Periodic complete blood counts should be done during the course of Toposar treatment. They should be performed prior to each cycle of therapy and at appropriate intervals during and after therapy. At least one determination should be done prior to each dose of Toposar.
What should subsequent toposar dosing be based on?
Subsequent Toposar dosing should be based on patient tolerance and clinical effect.
What is toposar injection?
Toposar (etoposide injection) in combination therapy with other approved chemotherapeutic agents in patients with refractory testicular tumors who have already received appropriate surgical, chemotherapeutic, and radiotherapeutic therapy .
What is etoposide used for?
Etoposide injection and/or capsules in combination with other approved chemotherapeutic agents as first line treatment in patients with small cell lung cancer.
How many ml of toposar is in a 100 mg solution?
Toposar (etoposide injection USP) is available for intravenous use as a sterile 20 mg/mL solution in 100 mg (5 mL), 500 mg (25 mL), or 1 g (50 mL) sterile, multiple dose vials. The pH of the clear, yellow liquid is 3.0 to 4.0.
How much does cyclosporin A increase etoposide?
High-dose cyclosporin A resulting in concentrations above 2000 ng/mL administered with oral etoposide has led to an 80% increase in etoposide exposure with a 38% decrease in total body clearance of etoposide compared to etoposide alone.
What is the mean volume of etoposide?
The mean volumes of distribution at steady state fall in the range of 18 to 29 liters or 7 to 17 L/m 2. Etoposide enters the CSF poorly. Although it is detectable in CSF and intracerebral tumors, the concentrations are lower than in extracerebral tumors and in plasma. Etoposide concentrations are higher in normal lung than in lung metastases and are similar in primary tumors and normal tissues of the myometrium. In vitro, etoposide is highly protein bound (97%) to human plasma proteins. An inverse relationship between plasma albumin levels and etoposide renal clearance is found in children. In a study determining the effect of other therapeutic agents on the in vitro binding of carbon-14 labeled etoposide to human serum proteins, only phenylbutazone, sodium salicylate, and aspirin displaced protein-bound etoposide at concentrations achieved in vivo.
What is VP-16?
Toposar ® (etoposide injection USP) (also commonly known as VP-16) is a semisynthetic derivative of podophyllotoxin used in the treatment of certain neoplastic diseases. It is 4'-demethylepipodophyllotoxin 9- [4,6-0- (R)-ethylidene-β-D-glucopyranoside]. It is very soluble in methanol and chloroform, slightly soluble in ethanol, and sparingly soluble in water and ether. It is made more miscible with water by means of organic solvents.
What is VP-16?
TOPOSAR (etoposide injection, USP) (also commonly known as VP-16) is a semisynthetic derivative ofpodophyllotoxin used in the treatment of certain neoplastic diseases. It is 4’-demethylepipodophyllo-toxin 9-[4,6-0-(R)-ethylidene-b-D-glucopyranoside]. It is very soluble in methanol and chloroform, slightlysoluble in ethanol and sparingly soluble in water and ether. It is made more miscible with water by meansof organic solvents. It has a molecular weight of 588.58 and a molecular formula of C29H32O13.TOPOSAR is available for intravenous use as a 20 mg/mL solution in 100 mg (5mL), 200 mg (10mL) and500 mg (25mL) sterile, multiple dose vials. The pH of the clear yellow solution is 3 to 4. Each mL contains20 mg etoposide, 2 mg citric acid, 30 mg benzyl alcohol, 80 mg polysorbate 80/tween 80, 650 mg poly-ethylene glycol 300, and 30.5% (v/v) alcohol.
Is toposar a chemo drug?
General: In all instances where the use of TOPOSAR is considered for chemotherapy, the physician mustevaluate the need and usefulness of the drug against the risk of adverse reactions. Most such adversereactions are reversible if detected early. If severe reactions occur, the drug should be reduced in dosageor discontinued and appropriate corrective measures should be taken according to the clinical judgmentof the physician. Reinstitution of TOPOSAR therapy should be carried out with caution, and with ade-quate consideration of the further need for the drug and alertness as to possible recurrence of toxicity.Laboratory Tests:Periodic complete blood counts should be done during the course of TOPOSAR treat-ment. They should be performed prior to therapy and at appropriate intervals during and after therapy.At least one determination should be done prior to each dose of TOPOSAR.