How do you find Vumerity?
To get started, call 1-800-456-2255 Monday-Friday from 8:30 AM to 8 PM ET. We're here for you throughout your time on VUMERITY, from treatment education to financial assistance. Get one-on-one phone support, access to resources, and helpful information throughout your time on VUMERITY.
Is there a generic for Vumerity?
There is currently no generic form of Vumerity. A generic drug is an exact copy of the active drug in a brand-name medication. Brand-name medications usually cost more than generics. Tecfidera is a brand-name drug that contains the active drug dimethyl fumarate.
Can you just stop taking Vumerity?
You may get infections more easily while you are taking VUMERITY. Any infection that you already have may get worse. Infections could be serious and sometimes life-threatening. If you have a serious infection, your doctor may recommend that you stop taking VUMERITY until you recover.
Does dimethyl fumarate have copay assistance?
Dimethyl Fumarate (dimethyl fumarate - generic equivalent of Tecfidera) No patient assistance program available at this time.
Does Vumerity cause hair loss?
Studies of Vumerity did not report hair loss as a side effect.
Does Vumerity weaken the immune system?
Serious infections Vumerity (diroximel fumarate) can put you at higher risk for serious opportunistic infections (OIs) because it weakens your immune system. OIs are infections that typically don't cause serious problems, but can result in more frequent or more severe illness for people with weakened immune systems.
Can you live with MS without medication?
A small number of people with MS have only mild disease and do well without treatment. But many get worse over time. Medicines can reduce the severity of attacks of relapsing-remitting MS and how often you have them.
Does MS stop progressing at certain age?
Secondary progressive MS (SPMS) is considered the long-term outcome of RMS, but more than 30% of people with MS continue to have RMS at an advanced age. Only 3.4% of people with MS are diagnosed with RMS after age 50, considered late-onset MS, and only 1% are diagnosed after the age 60, considered very late-onset MS.
Can you drink while on Vumerity?
If you're taking VUMERITY, you do not have to stop drinking alcohol altogether. But you should not drink alcohol at the same time you take your VUMERITY pills. That's because drinking alcohol at the same time you take your VUMERITY pills could reduce the amount of the active ingredient that your body absorbs.
How do people afford MS medication?
There are some national foundations that provide help for people with MS. They include NeedyMeds, The Patient Access Network Foundation and Chronic Disease Fund. Social Security Disability Insurance is available for people who are unable to work, but are entitled to receive disability benefits.
Do MS patients pay for prescriptions?
MS is not in itself a medical condition for which you are automatically exempt from paying charges. Prescriptions are free if, at the time the prescription was dispensed, you: are under 16.
How do you get MS meds without insurance?
Use the NeedyMeds site or call 1-800-503-6897 to find all available programs for a medication (brand-name or generic) or condition. Access to the site is free and requires no registration. MS Navigator Tip: In some cases, drug discount cards can help to lower out-of-pocket costs at the pharmacy.
Are Vumerity and Tecfidera the same?
Vumerity is similar to Tecfidera but has a distinct chemical structure that has been shown to be better tolerated, with fewer reported gastrointestinal side effects than Tecfidera. Once in the body, Vumerity rapidly converts to the same active ingredient as Tecfidera.
How long has Vumerity been on the market?
Development timeline for VumerityDateArticleOct 30, 2019Approval FDA Approves Vumerity (diroximel fumarate) for Multiple SclerosisJul 30, 2019Diroximel Fumarate Demonstrated Significantly Improved Gastrointestinal Tolerability Profile Compared to Dimethyl Fumarate in Patients with Multiple Sclerosis3 more rows•Jan 6, 2020
What is the generic name for Tecfidera?
Dimethyl fumarate (Tecfidera) is an oral medication, taken every 12 hours, for the treatment of relapsing forms of MS.
How long does it take for Vumerity to start working?
Vumerity (diroximel fumarate) is a delayed-release capsule used to treat relapsing forms of the autoimmune disorder multiple sclerosis. It is thought to have an effect as early as 24 weeks after patients start taking it.
How much does a free drug card save?
The free Drugs.com Discount Card works like a coupon and can save you up to 80% or more off the cost of prescription medicines, over-the-counter drugs and pet prescriptions.
What is the drug class of virerity?
Vumerity (diroximel fumarate) is a member of the selective immunosuppressants drug class and is commonly used for Multiple Sclerosis.
What is a vimerity offer?
Vumerity offers may be in the form of a printable coupon, rebate, savings card, trial offer, or free samples. Some offers may be printed right from a website, others require registration, completing a questionnaire, or obtaining a sample from the doctor's office.
When there is a range of pricing, should consumers expect to pay the lower price?
Important: When there is a range of pricing, consumers should normally expect to pay the lower price. However, due to stock shortages and other unknown variables we cannot provide any guarantee.
Is vivacity a generic drug?
Vumerity is available as a brand name drug only, a generic version is not yet available. For more information, read about generic Vumerity availability .
CONTRAINDICATIONS
With known hypersensitivity to diroximel fumarate, dimethyl fumarate, or to any of the excipients of VUMERITY. Reactions may include anaphylaxis and angioedema
ADVERSE REACTIONS
The most common adverse reactions (incidence ≥10% and ≥2% more than placebo) for dimethyl fumarate (which has the same active metabolite as VUMERITY) were flushing, abdominal pain, diarrhea, and nausea
USE IN SPECIFIC POPULATIONS
No dosage adjustment is necessary in patients with mild renal impairment. Because of an increase in the exposure of a major metabolite, use of VUMERITY is not recommended in patients with moderate or severe renal impairment
What is PML in MS?
Progressive multifocal leukoencephalopathy (PML) has occurred in patients with MS treated with dimethyl fumarate (which has the same active metabolite as VUMERITY). PML is an opportunistic viral infection of the brain caused by the JC virus (JCV) that typically only occurs in patients who are immunocompromised, and that usually leads to death or severe disability. A fatal case of PML occurred in a patient who received dimethyl fumarate for 4 years while enrolled in a clinical trial. During the clinical trial, the patient experienced prolonged lymphopenia (lymphocyte counts predominantly <0.5 × 109/L for 3.5 years) while taking dimethyl fumarate [see Warnings and Precautions (5.4)]. The patient had no other identified systemic medical conditions resulting in compromised immune system function and had not previously been treated with natalizumab, which has a known association with PML. The patient was also not taking any immunosuppressive or immunomodulatory medications concomitantly. PML has also occurred in patients taking dimethyl fumarate in the postmarketing setting in the presence of lymphopenia (<0.9 × 109/L). While the role of lymphopenia in these cases is uncertain, the PML cases have occurred predominantly in patients with lymphocyte counts <0.8×109/L persisting for more than 6 months.
How to contact Biogen Copay?
Biogen Copay Program(call 1-800-456-2255 for eligibility guidelines). In addition, with both signatures Biogen will have access to your patient’s prescription status should you or your patient need assistance.
How many mg of diroximel fumarate is in a capsule?
VUMERITY is available as delayed-release capsules for oral administration, containing 231 mg of diroximel fumarate. The 231 mg capsules have a white cap and a white body, printed with “DRF 231 mg” in black ink on the body. VUMERITY is available as follows:
What is the apparent volume of distribution of MMF?
The apparent volume of distribution for MMF is between 72 L and 83 L in healthy subjects after administration of VUMERITY. Human plasma protein binding of MMF is 27-45% and independent of concentration.
Does diroximel fumarate affect fertility?
No adverse effects on fertility were observed following oral administration of diroximel fumarate to male rats (0, 40, 120, or 400 mg/kg/day) prior to and during mating with untreated females and, in a separate study, to female rats (0, 40, 120, or 450 mg/kg/day) prior to and during mating with untreated males and continuing to Gestation Day (GD) 7. At the highest doses tested, plasma exposures (AUC) for MMF were approximately 7-9 times that in humans at the RHD. Plasma levels of HES were not quantitated.
Is diroximel fumarate safe for pregnant women?
There are no adequate data on the developmental risk associated with the use of VUMERITY or dimethyl fumarate (which has the same active metabolite as VUMERITY) in pregnant women. In animal studies, administration of diroximel fumarate during pregnancy or throughout pregnancy and lactation resulted in adverse effects on embryofetal and offspring development (increased incidences of skeletal abnormalities, increased mortality, decreased body weights, neurobehavioral impairment) at clinically relevant drug exposures [see Data]. In the U.S. general population, the estimated background risk of major birth defects and miscarriage in clinically recognized pregnancies is 2-4% and 15-20%, respectively. The background risk of major birth defects and miscarriage for the indicated population is unknown. Data Animal Data Oral administration of diroximel fumarate (0, 40, 100, or 400 mg/kg/day) to pregnant rats throughout organogenesis resulted in a decrease in fetal body weight and an increase in fetal skeletal variations at the highest dose tested, which was associated with maternal toxicity. Plasma exposures (AUC) for MMF and HES (the major circulating drug-related compound in humans) at the no-effect dose (100 mg/kg/day) for adverse effects on embryofetal development were approximately 2 times those in humans at the recommended human dose (RHD) of 924 mg/day.
Is dimethyl fumarate contraindicated?
VUMER ITY is contraindicated in patients currently taking dimethyl fumarate, which is also metabolized to monomethyl fumarate. VUMERITY may be initiated the day following discontinuation of dimethyl fumarate [see Contraindications (4)].
