What is Xofigo therapy?
Xofigo® (radium Ra 223 dichloride) injection is used to treat prostate cancer that no longer responds to hormonal or surgical treatment that lowers testosterone. It is for men whose prostate cancer has spread to the bone with symptoms but not to other parts of the body.
Who can administer Xofigo?
Xofigo is an alpha particle-emitting therapy that is administered by a nuclear medicine specialist or a radiation oncologist in a designated clinical setting.
Is Xofigo FDA approved?
The U.S. Food and Drug Administration today approved Xofigo (radium Ra 223 dichloride) to treat men with symptomatic late-stage (metastatic) castration-resistant prostate cancer that has spread to bones but not to other organs.
What are the side effects of Xofigo?
The most common side effects of Xofigo include:Nausea.Diarrhea.Vomiting.Swelling of the arms or legs (peripheral edema)Low blood cell counts.
How long does it take for Xofigo to work?
After you have an injection of Xofigo, the drug is quickly absorbed from your bloodstream into your bones. It starts working in your bones within the first 10–15 minutes after you have an injection.
How is Xofigo given?
Xofigo is given as an intravenous (IV) injection. An IV injection is when medication is put into your vein through an IV line.
How long does radium-223 stay in the body?
Most of the 223Ra in feces and urine is eliminated in the first two days, and after four days there is very little 223Ra in feces and urine, or circulating in the blood.
When was Xofigo approved by FDA?
On May 15, 2013, the U.S. Food and Drug Administration (FDA) approved radium Ra 223 dichloride (Xofigo Injection, Bayer HealthCare Pharmaceuticals Inc.) for the treatment of patients with castration-resistant prostate cancer, symptomatic bone metastases, and no known visceral metastatic disease.
How is radium-223 administered?
You have radium 223 as an injection into a vein. Usually this is through a thin short tube (cannula) which is put into a vein in your arm or hand each time you have treatment. The injection takes around a minute. You normally have the injection every 4 weeks.
What is the success rate for radiation therapy?
“In fact, based on the literature reviewed, it appears that external-beam radiation therapy is a superior treatment in some cases. “When patients are treated with modern external-beam radiation therapy, the overall cure rate was 93.3% with a metastasis-free survival rate at 5 years of 96.9%.
Is Xofigo covered by Medicare?
Xofigo is covered by most health insurance plans, including Medicare.
Does Provenge lower PSA?
PROVENGE works differently from other cancer treatments, such as chemotherapy or hormone therapy. Unlike these treatments, PROVENGE may not lower your PSA level. The goal of PROVENGE treatment is not to lower PSA level, it is to extend life.
Did the FDA approve radium?
Abstract. On May 15, 2013, the U.S. Food and Drug Administration (FDA) approved radium Ra 223 dichloride (Ra-223; Xofigo injection; Bayer HealthCare Pharmaceuticals Inc.) for the treatment of patients with castration-resistant prostate cancer (CRPC), symptomatic bone metastases, and no known visceral metastatic disease ...
What is the drug Orgovyx?
Orgovyx is an orally administered treatment that works by blocking the pituitary gland from making hormones called luteinizing hormone and follicle-stimulating hormone, thereby reducing the amount of testosterone the testicles are able to make.
What PSMA 617?
Lu-PSMA-617 is an investigational PSMA-targeted radioligand therapy for metastatic castration-resistant prostate cancer. It is a type of precision cancer treatment combining a targeting compound (ligand) with a therapeutic radioisotope (a radioactive particle)11-13.
Is Ra 223 a beta emitter?
Although radium-223 and its decay products also emit beta and gamma radiation, over 95% of the decay energy is in the form of alpha radiation.