Patient Assistance Programs for Zontivity Patient assistance programs (PAPs) are usually sponsored by pharmaceutical companies and provide free or discounted medicines to low income or uninsured and under-insured people who meet specific guidelines. Eligibility requirements vary for each program.
Full Answer
How much does Zontivity cost?
The cost for Zontivity oral tablet 2.08 mg is around $434 for a supply of 30 tablets, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans.
Who manufactures Zontivity?
ZONTIVITY tablets, 2.08 mg vorapaxar, are yellow, oval-shaped, film-coated tablets with “351” on one side and the Merck logo on the other side.
What is vorapaxar used for?
Vorapaxar is used together with other medications, such as aspirin and clopidogrel (Plavix), to reduce the risk of serious or life-threatening heart or blood vessel problems such as heart attack and stroke in people who have already had a heart attack or have problems with the blood flow in their legs.
Is vorapaxar approved?
FDA Approves ZONTIVITY™ (vorapaxar), First-in-Class PAR-1 Antagonist, for the Reduction of Thrombotic Cardiovascular Events in Patients with a History of Heart Attack or with Peripheral Arterial Disease. driven by an 18 percent relative risk reduction in MI [5.4 percent vs.
What is a PAR-1 antagonist?
PAR-1 antagonists, also known as thrombin-receptor antagonists, prevent the cleavage of the extracellular domain of the PAR-1 receptor by thrombin, without inhibiting other functions of thrombin (such as the coagulation cascade).
What is the mechanism of action of vorapaxar?
Mechanism of action Vorapaxar is a new anti-platelet drug that is part of the PAR-1 antagonist family, a new class of anti-platelet drug. It functions by inhibiting thrombin-related platelet aggregation.
When was vorapaxar approved by the FDA?
Based on the results of the trial, in May 2014, the U.S. Food and Drug Administration (FDA) approved vorapaxar for the reduction of thrombotic cardiovascular events in patients with prior MI or with PAD.
What is the mechanism of action of dipyridamole?
Mechanism of Action Dipyridamole functions predominantly by inhibiting the function of phosphodiesterase and adenosine deaminase. [11] Phosphodiesterase is useful for the conversion of cyclic adenosine monophosphate (cAMP) and cyclic guanine monophosphate (cGMP) to their non-cyclic equivalent.
What is dipyridamole used for?
Dipyridamole is used with other drugs to reduce the risk of blood clots after heart valve replacement. It works by preventing excessive blood clotting.
What is abciximab used for?
Abciximab is used to lessen the chance of heart attack in people who need percutaneous coronary intervention (PCI), a procedure to open blocked arteries of the heart.
Is Integrilin antiplatelet?
Integrilin belongs to a class of drugs called Antiplatelet Agents, Cardiovascular; Glycoprotein IIb/IIIa Inhibitors.
Is cilostazol an anticoagulant?
Cilostazol is classified as an antiplatelet agent because it inhibits the platelet aggregation induced by collagen, 5'-adenosine diphosphate (ADP), epinephrine, and arachidonic acid. Unlike other antiplatelet agents cilostazol not only inhibits platelet function but also improves endothelial cell function.
What is a zontivity offer?
Zontivity offers may be in the form of a printable coupon, rebate, savings card, trial offer, or free samples. Some offers may be printed right from a website, others require registration, completing a questionnaire, or obtaining a sample from the doctor's office.
How much does Zontivity cost?
The cost for Zontivity oral tablet 2.08 mg is around $389 for a supply of 30 tablets, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans.
Can you request samples from Zontivity?
Zontivity FREE Samples: Your healthcare provider may request samples for their practice by creating an online account.
Does Zontivity offer rebates?
Zontivity Co-pay Card Rebate: Eligible commercially insured patients may recevie a rebate for their out-of-pocket cost if their pharmacy was unable to process the Co-pay Card; rebate instructions found on the co-pay card; for additional information contact the program at 844-847-7738.
What is the purpose of the ZONTIVITY antagonist?
ZONTIVITY is a protease-activated receptor-1 (PAR-1) antagonist indicated for the reduction of thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or with peripheral arterial disease (PAD). ZONTIVITY has
Do countries collect sensitive information?
Some countries consider some categories of information particularly sensitive or special. We do not intentionally collect or maintain any sensitive information, including ethnicity, nationality, gender, religious beliefs, political opinions, health or genetic information.
Is zontivism contraindicated in patients with a history of stroke, TIA, or?
CONTRAINDICATIONS: ZONTIVITY is contraindicated in patients with a history of stroke, TIA, or ICH because of an increased risk of ICH in this population. Discontinue ZONTIVITY in patients who experience a stroke, TIA, or ICH. ZONTIVITY is contraindicated in patients with active pathological bleeding such as ICH or peptic ulcer.
Can you use zontivity for TIA?
Do not use ZONTIVITY in patients with a history of stroke, transient ischemic attack (TIA), or intracranial hemorrhage (ICH), or with active pathological bleeding. Antiplatelet agents, including ZONTIVITY, increase the risk of bleeding, including ICH and fatal bleeding.
Is zontivity recommended for severe hepatic impairment?
ZONTIVITY is not recommended in patients with severe hepatic impairment.
Is zontivity contraindicated for peptic ulcers?
ZONTIVITY is contraindicated in patients with active pathological bleeding such as ICH or peptic ulcer.
What is the purpose of zontivity?
ZONTIVITY is a prescription medicine used to treat people who have. had a heart attack or. reduced blood flow in their legs (peripheral arterial disease). ZONTIVITY is used with aspirin and/or clopidogrel to lower your chance of having another serious problem with your heart or blood vessels, such as heart attack, stroke, or death.
How does ZONTIVITY work?
ZONTIVITY, aspirin, and clopidogrel are all a type of medication called antiplatelet therapy.
What does it mean when you vomit after taking Zontivity?
red or black stools (looks like tar) coughing up blood or blood clots. While you take ZONTIVITY and for about 4 weeks after your treatment with ZONTIVITY is stopped: you may bruise and bleed more easily (nose bleeds may be common)
What to tell your doctor before taking Zontivity?
Before you take ZONTIVITY, tell your doctor if you: have had bleeding problems or history of stomach ulcers. have had a stroke or "mini-stroke" (also known as transient ischemic attack or TIA) have had bleeding (hemorrhage) in your brain. have had any recent serious injury or surgery.
Is Zontivity a cardiovascular drug?
cardiovascular risk. ZONTIVITY is used with aspirin, with clopidogrel (Plavix ® ), or with aspirin and clopidogrel to lower your chance of having another serious problem with your heart or blood vessels, such as heart attack, stroke, or death.
Can you take zontivity while breastfeeding?
It is not known if ZONTIVITY will harm your unborn baby. are breastfeeding or plan to breastfeed. It is not known if ZONTIVITY passes into your breast milk. You and your doctor should decide if you will take ZONTIVITY or breastfeed.
Can you die from zontivities?
ZONTIVITY is used to lower your chance of having another serious problem with your heart or blood vessels, but ZONTIVITY ( and similar drugs) can cause bleeding that can be serious and lead to death .
What is a zontivity?from drugs.com
Zontivity ® is indicated for the reduction of thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or with peripheral arterial disease (PAD). Zontivity has been shown to reduce the rate of a combined endpoint of cardiovascular death, MI, stroke, and urgent coronary revascularization (UCR).
When to discontinue zontivity?from drugs.com
Discontinue Zontivity in patients who experience a stroke, TIA, or ICH [see Adverse Reactions (6.1) and Clinical Studies (14)] .
How long does it take for Zontivity to inhibit platelets?from drugs.com
At the recommended dose, Zontivity achieves ≥80% inhibition of TRAP-induced platelet aggregation within one week of initiation of treatment. The duration of platelet inhibition is dose- and concentration-dependent. Inhibition of TRAP-induced platelet aggregation at a level of 50% can be expected at 4 weeks after discontinuation of daily doses of Zontivity 2.08 mg, consistent with the terminal elimination half-life of vorapaxar [see Clinical Pharmacology (12.3)] .
How much vorapaxar is in zontivity?from drugs.com
Zontivity is available for oral use as tablets containing 2.08 mg of vorapaxar, which is equivalent to 2.5 mg of vorapaxar sulfate. Each film-coated tablet of Zontivity contains the following inactive ingredients: lactose monohydrate, microcrystalline cellulose, croscarmellose sodium, povidone, and magnesium stearate.
What is in a zontivity bottle?from drugs.com
The Zontivity bottle contains a desiccant packet to help keep your medicine dry (protect it from moisture). Keep the desiccant packet in the bottle. Do not throw away the desiccant packet.
How is vorapaxar eliminated?from drugs.com
Vorapaxar is eliminated by metabolism via CYP3A4 and CYP2J2. The major active circulating metabolite is M20 (monohydroxy metabolite) and the predominant metabolite identified in excreta is M19 (amine metabolite). The systemic exposure of M20 is ~20% of the exposure to vorapaxar. Excretion.
How old are patients in TRA 2?from drugs.com
In TRA 2°P, in post-MI or PAD patients without a history of stroke or TIA, 33% of patients were ≥65 years of age and 9% were ≥75 years of age. The relative risk of bleeding (Zontivity compared with placebo) was similar across age groups. No overall differences in safety or effectiveness were observed between these patients and younger patients. Zontivity increases the risk of bleeding in proportion to a patient's underlying risk. Because older patients are generally at a higher risk of bleeding, consider patient age before initiating Zontivity [see Adverse Reactions (6.1)] .
Uses for Zontivity
Vorapaxar is used to lower risk of having blood clots in patients with a history of heart attack or with reduced blow flow in their legs.
Before using Zontivity
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Proper use of Zontivity
Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.
Precautions while using Zontivity
It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood tests may be needed to check for unwanted effects.
Zontivity side effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
