Who should receive Erbitux®?
ERBITUX ® is approved for the treatment of certain patients who have colorectal cancer that has spread to other parts of the body. Only patients whose tumors are KRAS wild-type (which means they have a KRAS mutation-negative gene), and whose tumors have a protein called epidermal growth factor receptor (EGFR), should receive ERBITUX.
Does Erbitux cause hypomagnesemia?
ERBITUX can cause hypomagnesemia. Hypomagnesemia occurred in 55% of 365 patients receiving ERBITUX in study CA225-025 and two other clinical trials in patients with colorectal cancer (CRC) or head and neck cancer, including Grades 3 and 4 in 6% to 17%.
What is Erbitux (cetuximab)?
Erbitux (cetuximab) is a member of the EGFR inhibitors drug class and is commonly used for Colorectal Cancer, Head and Neck Cancer, and Squamous Cell Carcinoma. The cost for Erbitux intravenous solution (2 mg/mL) is around $719 for a supply of 50 milliliters, depending on the pharmacy you visit.
How much does Erbitux cost for colon cancer?
Erbitux (cetuximab) is a member of the EGFR inhibitors drug class and is commonly used for Colorectal Cancer, Head and Neck Cancer, and Squamous Cell Carcinoma. The cost for Erbitux intravenous solution (2 mg/mL) is around $719 for a supply of 50 milliliters, depending on the pharmacy you visit.
Does Eli Lilly have a patient assistance program?
Lilly Cares® Foundation Patient Assistance Program (Lilly Cares) is a nonprofit charitable organization that provides prescribed Lilly medications for free for up to 12 months to qualifying U.S. patients.
Who manufactures Erbitux?
"Bristol-Myers Squibb is incredibly proud to have built Erbitux into a major brand and an important therapy for so many patients with certain colorectal and head and neck cancers," said Murdo Gordon , head of worldwide markets, Bristol-Myers Squibb .
What cancer is Erbitux used for?
Cetuximab is a type of targeted cancer drug. It is also known by its brand name Erbitux. You might have it as a treatment for advanced bowel cancer and head and neck cancers that start in the mouth and throat.
Is Erbitux chemo?
ERBITUX with platinum-based chemotherapy and fluorouracil (CT) was shown to help some people live longer compared to CT alone. Half the patients on ERBITUX with CT were still alive at 10.1 months, compared to 7.4 months with CT alone (median overall survival).
How long does Erbitux stay in your system?
Erbitux can have long-lasting effects on your body. You may need medical tests for at least 8 weeks after your last dose.
How successful is cetuximab?
Cetuximab also has activity as monotherapy in patients with recurrent and/or metastatic SCCHN who had failed platinum-based chemotherapy,. with a 12.6% response rate, disease control rate of 46%, and median response duration of ~ 6 months.
Can Erbitux cure cancer?
Erbitux Offers 'cure' Potential To 3 Out Of 4 Advanced Colon Cancer Patients - But Conditions Apply. Researchers have narrowed down the conditions in metastatic colorectal cancer (mCRC) where treatment with the targeted biologic therapy Erbitux (cetuximab) is most likely to succeed.
Does Erbitux cause hair loss?
ERBITUX may cause hair changes. Hair changes during EGFR treatment may: Make the eyelashes grow very fast and become very long and bother your eyes. Cause fast growth to eyebrows.
How do you know if cetuximab is working?
Treatment with cetuximab may cause changes in the way your liver works. This will return to normal when the treatment finishes. You're very unlikely to notice any problems, but your doctor or nurse will take regular blood samples to check your liver is working properly. You will have regular blood tests to check this.
Can cetuximab shrink Tumours?
In this study, the side effects and severity of adverse reactions seen with the cetuximab product used were consistent with other studies of US patients receiving ERBITUX for mCRC. Shrinkage of combined tumor size was ≥50%.
Does ERBITUX cause neuropathy?
You may lose some feeling or have tingling or burning in your hands and/or feet. This is called peripheral neuropathy. This may increase with continued treatment.
How often is ERBITUX given?
HOW TO USE: Cetuximab is given by injection into a vein as directed by your doctor, usually once every week or every 2 weeks by a healthcare professional. Another drug (such as diphenhydramine) may be given before you receive cetuximab to lessen the chance of certain side effects.
Is Erbitux generic?
Cetuximab is the generic name for the trade name drug Erbitux®. In some cases, health care professionals may use the trade name Erbitux® or other name C225 when referring to the generic drug name Cetuximab. Drug type: Cetuximab is an anti-cancer ("anti-neoplastic") targeted therapy.
Is there a biosimilar for cetuximab?
AbbVie (previously Allergan) in collaboration with Amgen, is developing a biosimilar of cetuximab (ABP 494), an anti-epidermal growth factor receptor (anti-EGFr) monoclonal antibody, for the treatment of cancer. Preclinical development in colorectal cancer, and head and neck cancer is underway in the US.
How long has cetuximab been around?
Cetuximab was approved by the US Food and Drug Administration (FDA) in March 2006, for use in combination with radiation therapy for treating squamous cell carcinoma of the head and neck (SCCHN) or as a single agent in patients who have had prior platinum-based therapy.
Is cetuximab FDA approved?
On April 6, 2021, FDA approved a new dosage regimen of 500 mg/m² as a 120 minute intravenous infusion every two weeks for cetuximab (brand name Erbitux) for patients with K-Ras wild-type, EGFR-expressing colorectal cancer or squamous cell carcinoma of the head and neck.
What are the side effects of erbitux?
The most common side effects (all grades of severity) in patients with colorectal cancer that has spread to other parts of the body whose tumors had a protein called Epidermal Growth Factor Receptor (EGFR) treated with ERBITUX and irinotecan were: acne-like rash, feeling weakness or discomfort, diarrhea, and nausea.
How much does ERBITUX affect blood flow?
2% of patients in the ERBITUX plus radiation and cisplatin treatment arm experienced decreased blood flow to the heart, compared to 0.9% in the radiation therapy and cisplatin alone treatment arm
How long after erbitux can you get pregnant?
Because ERBITUX can harm an unborn baby, you should use contraception and not become pregnant during treatment with ERBITUX and for at least 2 months after your last dose of ERBITUX. If you become pregnant during your treatment or within 2 months after your last dose, discuss this with your doctor.
How long after erbitux is it safe to wear sunscreen?
Sun exposure may worsen these effects. Patients taking ERBITUX should wear sunscreen and hats to limit sun exposure during treatment and for 2 months after the last dose of ERBITUX
How long should you monitor electrolytes after ERBITUX?
Your doctor or nurse should periodically monitor your blood electrolyte levels during and for at least 8 weeks after treatment with ERBITUX, and administer intravenous replacement as needed
Is Erbitux a combination drug?
ERBITUX is approved in combination with encorafenib, for the treatment of adult patients with colorectal cancer that has spread to other parts of the body. Only patients whose tumors are BRAF V600E mutant (which means they have a BRAF V600E mutation-positive gene) and their condition has progressed from a previous treatment should receive ERBITUX with encorafenib. An FDA-approved test is used to determine if tumors have these particular traits.
Is Erbitux approved for colorectal cancer?
ERBITUX is not approved to treat colorectal cancer in patients whose tumors have mutations in genes called RAS (often called " RAS mutant"), or in patients for whom the mutational status of the RAS genes is not known.
What is ERBITUX approved for?
ERBITUX is approved for the treatment of certain patients who have colorectal cancer that has spread to other parts of the body. Only patients whose tumors are KRAS wild-type (which means they have a KRAS mutation-negative gene), and whose tumors have a protein called epidermal growth factor receptor (EGFR), should receive ERBITUX.
What are the side effects of erbitux?
The most common side effects (all grades of severity) in patients with colorectal cancer that has spread to other parts of the body whose tumors had a protein called Epidermal Growth Factor Receptor (EGFR) treated with ERBITUX and irinotecan were: acne-like rash, feeling weakness or discomfort, diarrhea, and nausea.
How much does ERBITUX affect blood flow?
2% of patients in the ERBITUX plus radiation and cisplatin treatment arm experienced decreased blood flow to the heart, compared to 0.9% in the radiation therapy and cisplatin alone treatment arm
How long after erbitux is it safe to wear sunscreen?
Sun exposure may worsen these effects. Patients taking ERBITUX should wear sunscreen and hats to limit sun exposure during treatment and for 2 months after the last dose of ERBITUX
How to tell if you have a heart attack from an infusion?
Symptoms can include trouble with breathing (including tightening of the airways, wheezing, or hoarseness), low blood pressure, shock, loss of consciousness, and/or heart attack. Report these signs and symptoms of infusion reactions, as well as fever, and/or chills to your doctor or nurse.
Does erbitux cause low magnesium levels?
ERBITUX when given by itself and in combination with other cancer drugs can cause low levels of magnesium, calcium and potassium.
Does erbitux cause hair loss?
ERBITUX can cause skin problems including an acne-like rash, skin drying and cracking, infections (including infections of the blood, skin, eyes, and lips), swelling of the base of the nails or loss of the nails, inflammation of the eye or eyelid, decreased vision and abnormal hair growth. These symptoms were seen in several clinical trials for colorectal cancer and head and neck cancer with ERBITUX.
What is erbitux used for?
Erbitux (cetuximab) is a member of the EGFR inhibitors drug class and is commonly used for Colorectal Cancer, Head and Neck Cancer, and Squamous Cell Carcinoma.
How much does a free drug card save?
The free Drugs.com Discount Card works like a coupon and can save you up to 80% or more off the cost of prescription medicines, over-the-counter drugs and pet prescriptions.
Is Erbitux valid with insurance?
Prices are for cash paying customers only and are not valid with insurance plans. This Erbitux price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies.
How much does ERBITUX affect blood flow?
2% of patients in the ERBITUX plus radiation and cisplatin treatment arm experienced decreased blood flow to the heart, compared to 0.9% in the radiation therapy and cisplatin alone treatment arm
How long after erbitux can you get pregnant?
Because ERBITUX can harm an unborn baby, you should use contraception and not become pregnant during treatment with ERBITUX and for at least 2 months after your last dose of ERBITUX. If you become pregnant during your treatment or within 2 months after your last dose, discuss this with your doctor.
How long after erbitux is it safe to wear sunscreen?
Sun exposure may worsen these effects. Patients taking ERBITUX should wear sunscreen and hats to limit sun exposure during treatment and for 2 months after the last dose of ERBITUX
How long should you monitor electrolytes after ERBITUX?
Your doctor or nurse should periodically monitor your blood electrolyte levels during and for at least 8 weeks after treatment with ERBITUX, and administer intravenous replacement as needed
Is Erbitux a combination drug?
ERBITUX is approved in combination with encorafenib, for the treatment of adult patients with colorectal cancer that has spread to other parts of the body. Only patients whose tumors are BRAF V600E mutant (which means they have a BRAF V600E mutation-positive gene) and their condition has progressed from a previous treatment should receive ERBITUX with encorafenib. An FDA-approved test is used to determine if tumors have these particular traits.
Is Erbitux approved for colorectal cancer?
ERBITUX is not approved to treat colorectal cancer in patients whose tumors have mutations in genes called RAS (often called " RAS mutant"), or in patients for whom the mutational status of the RAS genes is not known.
How to tell if you have a heart attack from an infusion?
Symptoms can include trouble with breathing (including tightening of the airways, wheezing, or hoarseness), low blood pressure, shock, loss of consciousness, and/or heart attack. Report these signs and symptoms of infusion reactions, as well as fever, and/or chills to your doctor or nurse.
