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Why choose Grifols?
Since Grifols was founded, our ongoing innovation has helped shape industry standards in the plasma industry. The efforts of every member of the Grifols team enable us to achieve our mission of improving people's health and well-being.
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This modal can be closed by pressing the Escape key or activating the close button. Grifols is a global company that since 1909 has enhanced the health and well-being of people around the world.
What is the history of the Grifols group?
We trace our roots back to 1909 when Dr. Josep Antoni Grifols i Roig founded the laboratory Instituto Central de Análisis Clínicos, Bacteriológicos y Químicos in Barcelona.
What is Grifols?
What is the Grifols mission?
What is a hemophilia award?
About this website
Home | Plasma
Right now, we are in the process of uniting some of the best plasma donation centers in the industry under our Grifols network. These plasma centers are located all over the nation and include: Biomat USA, Talecris Plasma Resources, IBBI, PlasmaCare, and GCAM.
Germany - Grifols.com
Grifols Deutschland GmbH. Grifols Deutschland was established in 1997. Based in Frankfurt, we manage the Bioscience sales in Germany, and Diagnostic sales in the German, Austrian and Swiss (DACH) markets.
Home | CSL Vifor
Vifor Pharma is committed to improving the lives of patients around the world with the development of innovative pharmaceutical products. Our passion, values and ethics will continue to drive our approach to research and development activity as we continue to work closely with experts in all areas of medicine to develop new medicines and optimizing our current products for patients in need.
BioLife Plasma Services
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What is Grifols?
Grifols is a global company that since 1909 has enhanced the health and well-being of people around the world. Our four divisions - Bioscience, Diagnostic, Hospital, and Bio Supplies - develop, produce, and market innovative solutions and services in more than 100 countries. Commitment to Society. Our mission is to improve ...
What is the Grifols mission?
The efforts of every member of the Grifols team enable us to achieve our mission of improving people's health and well-being.
What is a hemophilia award?
A periodic award focused on encouraging healthcare providers, hemophilia treatment centers, as well as hemophilia societies to submit proposals that would contribute to improving the care of hemophilia patients and enhancing their quality of life.
What is the function of the Fab portion of IgG?from ncbi.nlm.nih.gov
Major functions of the Fab portion of IgG are neutralization of infective pathogens (by interfering with pathogen attachment to host cell receptor or by targeting various steps in their lifecycle) and non-specific opsonization by binding to the surface of microorganisms leading to phagocytosis. [19]
What is the function of IgG-Fc?from ncbi.nlm.nih.gov
IgG-Fc binds to various FcgRs, which are expressed on almost all the immune cell types and can be either activatory or inhibitory in function. IgG-FcgR interaction results in pleiotropic functional consequences, including the activation or inhibition of effector immune response, expansion of regulatory T cell population (inhibits overt immune response), modulation of FcgR expression on B cells and immune cells, phagocytosis, antibody-dependent cellular cytotoxicity (ADCC), immune cell differentiation and maturation, apoptosis regulation, expression of proinflammatory mediators, modulation of the antigen-presenting cell and dendritic cell functions. [20] [21] [22]
How does IVIG work?from ncbi.nlm.nih.gov
In humoral immunodeficiencies, IVIG primarily acts by substituting for the lack of IgG and confers passive immunity by neutralizing bacterial toxins and viruses through the Fab portion. They also help activate the complement cascade at low doses by specific interaction with pathogens , a function that reverses in high doses to complement inactivation by non-specific interactions. [23] Polyvalent IVIG products with a higher number of donors would contain a much larger spectrum of specificities and would be more efficient in immune replacement therapies. [24] The effects of replacement dose IVIG in PIs are observable well beyond the half-life of IgG administered, suggesting the induction of active immunity. [25] This is exemplified by the activation of cellular immunity; for example, IVIG modulates T cell immunity in PIs and increases CD4 counts in CVID, induces B cell immunoglobulin production in CVID patients, and induces dendritic cell (DC) maturation. [26] [27] [28]
What is IVIG in medicine?from ncbi.nlm.nih.gov
Intravenous immunoglobulin (IVIG) is a concentrate of the pooled immunoglobulins derived from 1000 to 100000 healthy donors depending upon the manufacturer . Immunoglobulins play a pivotal role in humoral adaptive immunity; ergo, IVIG reflects a collective exposure of the donor population to their environment and can be expected to contain an antibody repertoire of multiple specificities against a broad spectrum of infectious agents (bacterial, viral, and others), self-antigens and anti-idiotype antibodies.
How is IVIG administered?from ncbi.nlm.nih.gov
The most common means of administration is as a single intramuscular dose after the suspected exposure to a particular pathogen, and the earlier it is administered after exposure, the better the outcome. In addition to the intramuscular route, some of these immune sera are given as IVIG therapy. They may also be administered in a multi-dose regimen; for example, 750 mg/kg of respiratory syncytial virus (RSV) IVIG is given every month to infants in RSV season. The dosage can also increase in cases of immunocompromised and immunosuppressed patients. [18]
What is the role of IgG autoantibodies in inflammation?from ncbi.nlm.nih.gov
Autoimmunity is essentially an overt immune response against the body’s own tissues, and IgG autoantibodies are considered the main players in most conditions. Self-antigen is recognized by Fab fragment of IgG autoantibody, and Fc fragment relays this signal to Fc-gamma-receptors (FcgRs) on various immune cells. [21] IgG autoantibodies cause inflammation by interacting with FcgRs, neonatal FcR (FcRn), and complement proteins. [29] [30] [31] Autoantibodies disrupt a myriad of functions, including cellular lysis (as in ITP), triggering micro thrombosis, ADCC, complement-dependent cytotoxicity, uncontrolled neutrophil activation, stimulation of hormonal receptor (Graves disease), receptor blockade of neural transmission (MG), induction of inflammation (rheumatoid arthritis) and altered cell signaling. [32]
Why are IVIG products not recommended for post transplantation?from ncbi.nlm.nih.gov
Hyperosmolar IVIG products are not for post-transplantation patients due to the risk of renal failure and osmotic nephropathy.
What is Grifols?
Grifols is a global company that since 1909 has enhanced the health and well-being of people around the world. Our four divisions - Bioscience, Diagnostic, Hospital, and Bio Supplies - develop, produce, and market innovative solutions and services in more than 100 countries. Commitment to Society. Our mission is to improve ...
What is the Grifols mission?
The efforts of every member of the Grifols team enable us to achieve our mission of improving people's health and well-being.
What is a hemophilia award?
A periodic award focused on encouraging healthcare providers, hemophilia treatment centers, as well as hemophilia societies to submit proposals that would contribute to improving the care of hemophilia patients and enhancing their quality of life.
