Patient Assistance Programs for Mexiletine Patient assistance programs (PAPs) are usually sponsored by pharmaceutical companies and provide free or discounted medicines to low income or uninsured and under-insured people who meet specific guidelines. Eligibility requirements vary for each program.
Full Answer
How much does mexiletine cost?
Mexiletine is a member of the group I antiarrhythmics drug class and is commonly used for Arrhythmia, Diabetic Peripheral Neuropathy, Myotonia Congenita, and others. The cost for mexiletine oral capsule 150 mg is around $79 for a supply of 100 capsules, depending on the pharmacy you visit.
What is mexiletine used for?
Mexiletine is an oral medication that blocks sodium channels in cardiac myocytes and nerve cells. In cardiac myocytes, mexiletine affects phase 0 of the cardiac myocyte action potential, inhibiting the inward sodium current, and its mechanism of action can be generalized across all Class 1B antiarrhythmics.
Is mexiletine covered by Medicare?
Medicare plans typically list mexiletine in Tier 2 of their formulary. Tier 2 means that this drug is a “non-preferred generic”. It will be expensive and there may be cheaper drugs that work in a similar fashion.
How many milligrams of mexiletine should I take?
Standard drug regimens include 150 to 200 mg 2 to 3 times a day. Mexiletine is predominantly metabolized by the liver with an elimination half-life of 9 to 12 hours.
Is mexiletine covered by Medicare?
Yes. 74% of Medicare prescription drug plans cover this drug.
Does Teva have a patient assistance program?
Teva's commitment to patients provides certain Teva medications at no cost to patients in the United States who meet certain insurance and income criteria. Please click here to review the list of medications available through the Teva Cares Foundation Patient Assistance Program (PAP), or call 877-237-4881.
Why was mexiletine discontinued?
However, mexiletine treatment had to be discontinued permanently in 8 of 92 patients (9%) because of intolerable side effects. We conclude that the added efficacy and possible improved arrhythmia-free survival associated with combining mexiletine with a class Ia agent should be further investigated.
What is Pfizer Assistance Program?
Pfizer RxPathways® patients in need get access to their Pfizer medicines. Today, Pfizer RxPathways® connects eligible U.S. patients to a range of Pfizer assistance programs that provide insurance support, co-pay help, and medicines for free or at a savings.
Does Viatris have a patient assistance program?
The Viatris Patient Assistance Program provides certain medicines for free to patients with demonstrated financial need. Viatris is committed to helping patients get the treatments they need, when and where they need them.
Is there a patient assistance program for Adderall?
Government Programs for ADHD Prescription Assistance Call 1-800-333-4114 to find out if you qualify.
Is there an alternative to mexiletine?
Tocainide--an alternative to mexiletine.
Does mexiletine cause weight gain?
Mexiletine is approved for the treatment of ventricular arrhythmias, which are life-threatening abnormal heart rhythms. Does mexiletine cause weight gain? Weight gain is not a typical side effect of mexiletine.
Does mexiletine cause insomnia?
It is generally used in 100–300 mg doses three times a day, with a maximum recommended dose of 1200 mg/day. Neurological side effects are common, but are usually limited to headache, insomnia, tremors, dizziness, and fatigue, and seizures have been occasionally reported.
What is Xelsource?
Psoriatic Arthritis. • XELJANZ/XELJANZ XR (tofacitinib) is indicated for the treatment of adult patients with active psoriatic arthritis who have had an inadequate response or intolerance to methotrexate or other disease-modifying antirheumatic drugs (DMARDs).
What is Pfizer enCompass?
Pfizer enCompass offers various services to patients including reimbursement support for insured patients; co-pay assistance for eligible commercially insured patients who cannot afford their co-pays, co-insurances, or deductibles; and a free medicine patient assistance program for eligible uninsured or underinsured ...
Which Pfizer blood pressure medication is being recalled?
The drugs in the Pfizer recall include certain batches of Accupril (quinapril hydrochloride) tablets and Accuretic (quinapril hydrochloride plus hydrochlorothiazide) tablets distributed by Pfizer, as well as two related generic formulations distributed by Greenstone.
Does Ajovy have a patient assistance program?
Co-payment assistance, reimbursement support, and patient assistance programs are available for eligible patients.
Is there a copay card for generic Truvada?
Gilead offers a patient assistance program for low-income people without insurance and a co-pay card to cover out-of-pocket costs for those with private insurance. Teva announced that it will also offer a co-pay card for its generic Truvada that will cover $600 worth of out-of-pocket costs for a month's supply.
What are the symptoms of overdose?
Symptoms of overdose may include dizziness, drowsiness, nausea, low blood pressure, slow pulse, tingling in fingers or toes, seizures, and loss of consciousness.
What are the symptoms of a syringe in the ears?
Nausea, vomiting, heartburn, dizziness, tremor, changes in vision, nervousness, confusion, headache, fatigue, depression, changes in sleep habits, numbness or tingling especially of the hands or feet, ringing in the ears may occur. If any of these symptoms persist or worsen, notify your doctor. Inform your doctor if you develop: chest pain, rapid heartbeat, general weakness, yellowing of the eyes or skin, fever or sore throat. In the unlikely event you have an allergic reaction to this drug, seek immediate medical attention. Symptoms of an allergic reaction include: rash, itching, swelling, dizziness, breathing trouble. If you notice other effects not listed above, contact your doctor or pharmacist.
How many Americans can't afford medication?
There are over 100 million Americans that either can‚t afford their medication or are struggling to afford their medication. We aim to help each and every American in that situation.
What are the symptoms of an allergic reaction to a sulfate based sulfate answer?
Symptoms of an allergic reaction include: rash, itching, swelling, dizziness, breathing trouble. If you notice other effects not listed above, contact your doctor or pharmacist.
Can you take Mexiletine while pregnant?
Tell your doctor your medical history, especially: congestive heart failure, low blood pressure, liver disease, history of seizures, any allergies- especially allergies to amide- type anesthetics (e.g., lidocaine, tocainamide) or other drugs. Mexiletine should be used only when clearly needed during pregnancy.
Can you smoke rifampin?
Smoking can decrease the effects of this drug. Do not start or stop any medicine without doctor or pharmacist approval.
What is mexiletine used for?
Mexiletine is a primary amine in the form of (1-(2', 6'-dimethylphenoxy) 2 amino propane and has close structural properties to lidocaine.[1] Mexiletine is largely used to suppress ventricular arrhythmias and has a role in peripheral neuropathy and chronic pain, although the use for either is limited and seldom given its extensive side effect ...
What is the class of mexiletine?
Mexiletine is a class 1B antiarrhythmic agent. [10] Mexiletine is a sodium channel blocker and further classified as a Class 1B antiarrhythmic in the Vaughan-Williams classification scheme of antiarrhythmic drugs. Mexiletine is an oral medication that blocks sodium channels in cardiac myocytes and nerve cells.
What is the use dependence of class 1 antiarrhythmics?
Furthermore, most Class 1 antiarrhythmics exhibit a property called "use dependence." Use dependence is so named relative to the state of the channel that is being affected. Class 1 antiarrhythmic drugs block sodium channels best when these channels are in use, specifically when the sodium channel is in an open or inactive state. Cardiac myocyte sodium channels occur more often in these states at faster heart rates, allowing more of the drug to bind at these higher rates.[12] Mexiletine exhibits use dependence by rapidly unbinding when the myocytes re-polarize and no longer remain in the depolarized state or when the sodium channels are in a resting state (not in use). During faster heart rates, the duration between depolarized states becomes reduced, decreasing the time to allow the drug to unbind and increasing the time sodium channels spend in an open or inactive state, which leads to more drug bound to sodium channels, and thus having a greater effect. There is more time between subsequent cardiac myocyte action potentials at slower heart rates, allowing more of the drug to unbind as the sodium channels spend more time in the resting state. Fundamentally, use dependence means more binding at faster heart rates, and its clinical relevance is that tachycardia can be dangerous as there is an increased risk of adverse effects and toxicity at these faster rates. [12]
How to manage mexiletine toxicity?
Management of mexiletine toxicity is by symptomatic treatment. Without question, discontinue mexiletine when toxicity presents. Depending on the severity of the toxicity, patients may require invasive therapy to clear the drug, such as hemodialysis or hemoperfusion. Denaro published a paper in 1989 stating that such interventions may play a role, in addition to extracorporeal circulatory assistance where available.[20] Regardless, patients are supported until toxic drug effects subside.
How long does mexiletine stay in your system?
Gastrointestinal symptoms are highly variable but can include xerostomia, nausea/vomiting, and diarrhea. Mexiletine has a half-life of 10 to 12 hours and is metabolized by the liver with small amounts, about 10% of the administered dose, of excretion in the urine.
What is Vaughan Williams EM?
Vaughan Williams EM. A classification of antiarrhythmic actions reassessed after a decade of new drugs. J Clin Pharmacol. 1984 Apr;24(4):129-47. [PubMed: 6144698]
When was mexiletine approved?
Mexiletine has been approved for use since 1969 .[1] In 2012, Catalano et al. published a paper stating the MHM can be synthesized. Additionally, they published toxicopharmacological properties on MHM and compared it to the parent compound, mexiletine, in the in vitrosetting.
What is this medicine?
MEXILETINE (mex IL e teen) is an antiarrhythmic agent. This medicine is used to treat irregular heart rhythm and can slow rapid heartbeats. It can help your heart to return to and maintain a normal rhythm. Because of the side effects caused by this medicine, it is usually used for heartbeat problems that may be life-threatening.
How should I use this medicine?
Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. It is recommended that you take this medicine with food or an antacid. Take your doses at regular intervals. Do not take your medicine more often than directed. Do not stop taking except on the advice of your doctor or health care professional.
What if I miss a dose?
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
What should I watch for while using this medicine?
Your condition will be monitored closely when you first begin therapy. Often, this drug is first started in a hospital or other monitored health care setting. Once you are on maintenance therapy, visit your doctor or health care provider for regular checks on your progress.
What side effects may I notice from receiving this medicine?
Side effects that you should report to your doctor or health care professional as soon as possible:
Important Note
The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.
Uses
This medication is used to treat irregular heart rhythms (arrhythmias) and maintain a normal heart rate.
How To Use
This medication should be taken with food, milk or an antacid to prevent stomach upset. Take this medication with a full glass (8 oz or 240 ml) of water unless your doctor directs you otherwise. Do not lie down for 30 minutes after taking this medication. This medication works best when there is a constant level of the drug in your body.
Side Effects
Nausea, vomiting, heartburn, dizziness, tremor, changes in vision, nervousness, confusion, headache, fatigue, depression, changes in sleep habits, numbness or tingling especially of the hands or feet, ringing in the ears may occur. If any of these symptoms persist or worsen, notify your doctor.
Precautions
Tell your doctor your medical history, especially: congestive heart failure, low blood pressure, liver disease, history of seizures, any allergies- especially allergies to amide- type anesthetics (e.g., lidocaine, tocainamide) or other drugs. Mexiletine should be used only when clearly needed during pregnancy.
Drug Interactions
Tell your doctor of all medications you may use (both prescription and nonprescription), especially: rifampin, theophylline, caffeine, phenytoin, metoclopramide, sodium bicarbonate, potassium citrate, ammonium chloride. Smoking can decrease the effects of this drug. Do not start or stop any medicine without doctor or pharmacist approval.
Overdose
If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include dizziness, drowsiness, nausea, low blood pressure, slow pulse, tingling in fingers or toes, seizures, and loss of consciousness.
Ways to Save on Mexiletine
Here are some ways that may lower the cost of your mexiletine prescription.
Mexiletine Medicare Prescription Drug Plans Formulary Information & Restrictions
Medicare prescription drug plans typically list mexiletine on Tier 2 of their formulary. Generally, the higher the tier, the more you have to pay for the medication. Most plans have 5 tiers.
Important Note
- The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug. MEXILETINE - ORAL (mex-ILL-ih-teen) COMMON …
Uses
- This medication is used to treat irregular heart rhythms (arrhythmias) and maintain a normal heart rate.
How to Use
- This medication should be taken with food, milk or an antacid to prevent stomach upset. Take this medication with a full glass (8 oz or 240 ml) of water unless your doctor directs you otherwise. Do not lie down for 30 minutes after taking this medication. This medication works best when there is a constant level of the drug in your body. To do this...
Side Effects
- Nausea, vomiting, heartburn, dizziness, tremor, changes in vision, nervousness, confusion, headache, fatigue, depression, changes in sleep habits, numbness or tingling especially of the hands or feet, ringing in the ears may occur. If any of these symptoms persist or worsen, notify your doctor. Inform your doctor if you develop: chest pain, rapid heartbeat, general weakness, ye…
Precautions
- Tell your doctor your medical history, especially: congestive heart failure, low blood pressure, liver disease, history of seizures, any allergies- especially allergies to amide- type anesthetics (e.g., lidocaine, tocainamide) or other drugs. Mexiletine should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. Mexiletine is excreted into breast mi…
Drug Interactions
- Tell your doctor of all medications you may use (both prescription and nonprescription), especially: rifampin, theophylline, caffeine, phenytoin, metoclopramide, sodium bicarbonate, potassium citrate, ammonium chloride. Smoking can decrease the effects of this drug. Do not start or stop any medicine without doctor or pharmacist approval.
Overdose
- If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include dizziness, drowsiness, nausea, low blood pressure, slow pulse, tingling in fingers or toes, seizures, and loss of consciousness.
Notes
- Your doctor may want you to check your pulse rate every day while you take this medication. Learn how to monitor your pulse.
Missed Dose
- Take any missed dose as soon as possible but not if it is almost time for the next dose. If it is time for the next dose, skip the missed dose and resume your regular schedule. Do not double the dose to catch up.
Medical Alert
- Your condition can cause complications in a medical emergency. For enrollment information call MedicAlert at 1-800-854-1166 (USA), or 1-800-668-1507 (Canada).