How much does interferon gamma cost?
Interferon gamma, used in chronic granulomatous disease, costs about $140 for a 100-microg vial; yearly costs average $21840 per patient.
What is actimmune used for?
ACTIMMUNE® is part of a drug regimen used to treat Chronic Granulomatous Disease, or CGD. CGD is a genetic disorder, usually diagnosed in childhood, that affects some cells of the immune system and the body's ability to fight infections effectively.
How is interferon gamma administered?
ACTIMMUNE® (Interferon gamma-1b) should be administered subcutaneously 3 times weekly. It can be injected by the patient or caregiver after appropriate training by a healthcare professional.
Who makes actimmune?
Visit www.ACTIMMUNE.com to download a copy of the ACTIMMUNE Full Prescribing Information. Horizon Pharma plc is a biopharmaceutical company focused on improving patients' lives by identifying, developing, acquiring and commercializing differentiated and accessible medicines that address unmet medical needs.
What are the symptoms of granulomatous disease?
SymptomsFever.Chest pain when inhaling or exhaling.Swollen and sore lymph glands.A persistent runny nose.Skin irritation that may include a rash, swelling or redness.Swelling and redness in your mouth.More items...•
What is chronic granulomatous?
Chronic granulomatous disease (CGD) is a genetic disorder in which white blood cells called phagocytes are unable to kill certain types of bacteria and fungi. People with CGD are highly susceptible to frequent and sometimes life-threatening bacterial and fungal infections.
How long can you take interferon for?
Interferon treatment for hepatitis C would typically last 24–48 weeks (6–12 months). Interferons caused many long-term side effects partly because of this long treatment time.
What does interferon-gamma do?
Interferon gamma (IFN-γ) is a cytokine critical to both innate and adaptive immunity, and functions as the primary activator of macrophages, in addition to stimulating natural killer cells and neutrophils.
Is interferon-gamma FDA approved?
ACTIMMUNE® (Interferon gamma-1b) is approved by the FDA to delay time to disease progression in patients with severe malignant osteopetrosis (SMO). ACTIMMUNE® is believed to work by changing how some cells in your body work. This includes the cells that help form your bones.
Who makes interferon gamma?
Interferon-gamma is secreted predominantly by activated lymphocytes such as CD4 T helper type 1 (Th1) cells and CD8 cytotoxic T cells (23–26), γδ T cells (27–33), and natural killer (NK) cells (34, 35) and, to a less extent, by natural killer T cells (NKT), B cells (36–39), and professional antigen-presenting cells ( ...
Is gamma interferon the same as QuantiFERON?
QuantiFERON-TB Gold (QFT) is a simple blood test that aids in the detection of Mycobacterium tuberculosis, the bacteria which causes tuberculosis (TB). QFT is an interferon-gamma (IFN-γ) release assay, commonly known as an IGRA, and is a modern alternative to the tuberculin skin test (TST, PPD or Mantoux).
When is interferon gamma released?
Interferon-γ release assays (IGRA) are medical tests used in the diagnosis of some infectious diseases, especially tuberculosis. Interferon-γ (IFN-γ) release assays rely on the fact that T-lymphocytes will release IFN-γ when exposed to specific antigens.
How is interferon gamma released?
tuberculosis. White blood cells from most persons that have been infected with M. tuberculosis will release interferon-gamma (IFN-g) when mixed with antigens (substances that can produce an immune response) derived from M. tuberculosis.
What type of interferon is interferon gamma?
type II interferonIFN-γ, or type II interferon, is a cytokine that is critical for innate and adaptive immunity against viral, some bacterial and protozoan infections. IFN-γ is an important activator of macrophages and inducer of major histocompatibility complex class II molecule expression.
Important Note
The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.
Uses
This medication is a certain type of interferon used to reduce the frequency and severity of serious infections due to a genetic disorder called Chronic Granulomatous Disease (CGD). It is often used along with antibiotics to help prevent these serious infections.
How To Use
Before using, gently swirl the vial solution and check this product visually for particles or discoloration. If either is present, do not use the liquid. Do not shake the vial. Doing so may decrease the effectiveness of the drug. Learn how to prepare and inject the drug and review all instructions in the product package.
Side Effects
Flu-like symptoms (e.g., fever, chills, unusual weakness, muscle aches), headache, nausea, and vomiting may occur. If any of these effects persist or worsen, notify your doctor. Tell your doctor immediately if any of these serious side effects occur: muscle pain, joint pain, redness/swelling/pain at the injection site, stomach/abdominal pain.
Precautions
Tell your doctor your medical history, especially of: heart problems (e.g., arrhythmias, heart failure or disease), seizure disorders, nervous system problems (e.g., tremor, problems walking, chronic dizziness), low blood cell counts (e.g., neutropenia, thrombocytopenia), any allergies (especially to other interferon products).
Drug Interactions
Tell your doctor of all prescription and nonprescription medication you may use, especially: drugs that may suppress your immune system (e.g., cancer chemotherapy, prednisone, cyclosporine). Do not start or stop any medicine without doctor or pharmacist approval.
Overdose
If overdose is suspected, contact your local poison control center or emergency room immediately.
What is actimmune used for?
Actimmune (interferon gamma-1b) is a member of the interferons drug class and is commonly used for Chronic Granulomatous Disease, Cutaneous T-cell Lymphoma, Idiopathic Pulmonary Fibrosis, and others.
What is the FDA approved diagnosis?
FDA-approved diagnosis. Must be a US resident and treated by a US licensed healthcare provider. Co-payment assistance, reimbursement support, and patient assistance programs are available for eligible patients. Please visit www.actimmune.com or call 1-877-305-7704 for more information. Applicable drugs:
What are the side effects of acimune?
The most common adverse experiences occurring with ACTIMMUNE therapy are “flu-like” symptoms such as fever, headache, chills, myalgia, or fatigue, which may decrease in severity as treatment continues, and may be minimized by bedtime administration of ACTIMMUNE.
Does acetaminophen help with fever?
Acetaminophen may be used to prevent or partially alleviate the fever and headache. Isolated cases of acute serious hypersensitivity reactions have been observed in patients receiving ACTIMMUNE. Reversible neutropenia, thrombocytopenia, and elevations of AST and/or ALT have been observed during ACTIMMUNE therapy.
What is the name of the drug that is given to you with a prescription for gamma-1b?
With your prescription of ACTIMMUNE ® (interferon gamma-1b), you and your family have access to Horizon By Your Side, a program that offers a wide range of services at no cost to help you reach your goals for treatment and healthy living.
What is the purpose of aximune?
ACTIMMUNE ® is part of a drug regimen used to treat Chronic Granulomatous Disease , or CGD. CGD is a genetic disorder, usually diagnosed in childhood, that affects some cells of the immune system and the body's ability to fight infections effectively. CGD is often treated (though not cured) with antibiotics, antifungals, and ACTIMMUNE.
Can you take acimune at the same time as a shot?
Avoid taking ACTIMMUNE at the same time as a vaccination.
Can you take acimune if you are allergic to interferon?
Don't use ACTIMMUNE if you are allergic to interferon-gamma, E coli -derived products, or any ingredients contained in the product.
Can actimune cause bone marrow to be reduced?
Bone marrow function may be suppressed with ACTIMMUNE, and decreased production of cells important to the body may occur. This effect, which can be severe, is usually reversible when the drug is discontinued or the dose is reduced.
Can acimune cause rash?
In rare cases, ACTIMMUNE can cause severe allergic reactions and/or rash. If you experience a serious reaction to ACTIMMUNE, discontinue it immediately and contact your doctor or seek medical help.
What is the purpose of aximune?
ACTIMMUNE ® is part of a drug regimen used to treat Chronic Granulomatous Disease , or CGD. CGD is a genetic disorder, usually diagnosed in childhood, that affects some cells of the immune system and the body's ability to fight infections effectively. CGD is often treated (though not cured) with antibiotics, antifungals, and ACTIMMUNE.
Can actimune cause bone marrow to be reduced?
Bone marrow function may be suppressed with ACTIMMUNE, and decreased production of cells important to the body may occur. This effect, which can be severe, is usually reversible when the drug is discontinued or the dose is reduced.
Does acetaminophen help with fever?
Bedtime administration of ACTIMMUNE may help reduce some of these symptoms. Acetaminophen may be helpful in preventing fever and headache.
Can acimune cause rash?
In rare cases, ACTIMMUNE can cause severe allergic reactions and/or rash. If you experience a serious reaction to ACTIMMUNE, discontinue it immediately and contact your doctor or seek medical help.
Can you take acimune with chemotherapy?
Some drugs may interact with ACTIMMUNE to potentially increase the risk of damage to your heart or nervous system, such as certain chemotherapy drugs. Tell your doctor about all other medications you are taking. Avoid taking ACTIMMUNE at the same time as a vaccination.
Can you take acimune if you are allergic to interferon?
Don't use ACTIMMUNE if you are allergic to interferon-gamma, E coli -derived products, or any ingredients contained in the product.
Can you reversibly take acimune?
This effect, which can be severe, is usually reversible when the drug is discontinued or the dose is reduced. Taking ACTIMMUNE may cause reversible changes to your liver function, particularly in patients less than 1 year old.
Contraindications
- InterMune, Inc. was founded in Brisbane, California, 1998. They are a biotechnical company whose primary focus is on creating and commercializing therapies related to pulmonary disease, infectious disease, and cancer. InterMune, Inc.'s entire product line is focused on improving com…
Warnings and Precautions
Drug Interactions
Adverse Reactions
- In patients who develop or have known hypersensitivity to interferon-gamma, E. coliderived products, or any component of the product
Important Note
- ACTIMMUNE should be used with caution in patients with:
- Monitoring:
- Pregnancy, Lactation, and Fertility:
Uses
- Concomitant use of drugs with neurotoxic, hematotoxic, or cardiotoxic effects may increase the toxicity of interferons
- Avoid simultaneous administration of ACTIMMUNE with other heterologous serum protein or immunological preparations (eg, vaccines)
How to Use
- The most common adverse experiences occurring with ACTIMMUNE therapy are “flu-like” symptoms such as fever, headache, chills, myalgia, or fatigue, which may decrease in severity as treatment contin...
- Isolated cases of acute serious hypersensitivity reactions have been observed in patients receiving ACTIMMUNE
- The most common adverse experiences occurring with ACTIMMUNE therapy are “flu-like” symptoms such as fever, headache, chills, myalgia, or fatigue, which may decrease in severity as treatment contin...
- Isolated cases of acute serious hypersensitivity reactions have been observed in patients receiving ACTIMMUNE
- Reversible neutropenia, thrombocytopenia, and elevations of AST and/or ALT have been observed during ACTIMMUNE therapy
- At doses 10 times greater than the weekly recommended dose, ACTIMMUNE may exacerbate pre-existing cardiac conditions, or may cause reversible neurological effects such as decreased mental status, g...
Side Effects
- The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug. INTERFERON GAMMA 1B - INJECTABLE (in-ter-F…
Precautions
- This medication is a certain type of interferon used to reduce the frequency and severity of serious infections due to a genetic disorder called Chronic Granulomatous Disease (CGD). It is often used along with antibiotics to help prevent these serious infections. This medication is also used to slow down the progress of another genetic bone disease...
Drug Interactions
- Before using, gently swirl the vial solution and check this product visually for particles or discoloration. If either is present, do not use the liquid. Do not shake the vial. Doing so may decrease the effectiveness of the drug. Learn how to prepare and inject the drug and review all instructions in the product package. If any of the information is unclear, consult your doctor or p…
Notes
- Flu-like symptoms (e.g., fever, chills, unusual weakness, muscle aches), headache, nausea, and vomiting may occur. If any of these effects persist or worsen, notify your doctor. Tell your doctor immediately if any of these serious side effects occur: muscle pain, joint pain, redness/swelling/pain at the injection site, stomach/abdominal pain. Tell your doctor immediatel…
Storage
- Tell your doctor your medical history, especially of: heart problems (e.g., arrhythmias, heart failure or disease), seizure disorders, nervous system problems (e.g., tremor, problems walking, chronic dizziness), low blood cell counts (e.g., neutropenia, thrombocytopenia), any allergies (especially to other interferon products). This drug is not recommended for use during pregnancy due to the ri…
Medical Alert
- Tell your doctor of all prescription and nonprescription medication you may use, especially: drugs that may suppress your immune system (e.g., cancer chemotherapy, prednisone, cyclosporine). Do not start or stop any medicine without doctor or pharmacist approval.