Financial Assistance
- Copay assistance program – Help with your copay if you're an eligible patient who receives PANHEMATIN infusions in an outpatient care setting.
- Patient Assistance Program (PAP) – Assistance with accessing PANHEMATIN if you are an eligible patient who doesn't have insurance or are underinsured.
- Additional referrals – Help with referrals to outside assistance sources when available.
Full Answer
How much Panhematin should I take for a heart attack?
Three to four mg/kg of Panhematin ® given once daily for four days early in an attack produces a highly beneficial effect in most patients. Commonly noted are decreases in pulse rate, blood pressure, abdominal pain, as well as decreased levels of urinary porphobilinogen (PBG).
How is Panhematin ® administered?
Panhematin ® should be infused into a large peripheral vein. A large central line or port may be used, if available. Doctors administer Panhematin ® to correct heme deficiency in the liver and repress production of porphyrin precursors. Panhematin ® almost always normalizes porphyrin and porphyrin precursor values.
Does Panhematin ® produce phlebitis?
Panhematin ® is less likely to produce phlebitis if it is mixed with human albumin before it is given.
What is Panhematin ® from Recordati Rare Diseases?
Panhematin ® from Recordati Rare Diseases in Lebanon New Jersey, is a lyophilized form of alkaline heme that has to be reconstituted immediately prior to administration. Panhematin ® should be infused into a large peripheral vein.
How does Hemin treat porphyria?
Hemin and intravenous glucose act by repressing δ-aminolevulinic acid synthase, the initial and rate-limiting enzyme for heme synthesis in the liver. However, hemin leads to more rapid resolution of symptoms and, to a greater extent than glucose, suppresses the overproduction of porphyrin precursors.
Why is Hematin given in porphyria?
Hematin suppressed the chemical signs of porphyria in all patients and the symptoms in those with acute attacks. The clinical response to hematin occurred uniformly on the third or fourth day of treatment, suggesting that a stereotypic response to this form of therapy can be defined.
What is intermittent porphyria?
Summary. Acute intermittent porphyria (AIP) is a rare metabolic disorder that is characterized by partial deficiency of the enzyme hydroxymethylbilane synthase (also known as porphobilinogen deaminase). This enzyme deficiency can result in the accumulation of porphyrin precursors in the body.
Is Hemin available in India?
Treatment with hemin is the most effective treatment for porphyria attacks,, but is also not readily available in India.
What is the meaning of hematin?
Medical Definition of hematin 1 : a brownish black or bluish black derivative C34H33N4O5Fe of oxidized heme containing iron with a valence of three also : any of several similar compounds. 2 : heme.
What is Panhematin used for?
PANHEMATIN® is a hemin for injection prescription medication used to relieve repeated attacks of acute intermittent porphyria related to the menstrual cycle in affected women, after initial carbohydrate therapy is known or suspected to be inadequate.
Is porphyria a disability?
People who have been diagnosed with Porphyria can experience a range of uncomfortable or even debilitating symptoms, and in some cases, getting the Social Security disability benefits that they need can be the best opportunity to continue to take care of themselves when they can't go to work.
What does porphyria pain feel like?
The most commonly reported debilitating symptoms are diffuse severe pain affecting the abdomen, back, or limbs; other common attack signs and symptoms include nausea and vomiting, constipation, hypertension, motor weakness, insomnia, or anxiety [1–3, 5].
Can porphyria cause mental illness?
Abstract. Acute intermittent porphyria mimics a variety of commonly occurring disorders and thus poses a diagnostic quagmire. Psychiatric manifestations include hysteria, anxiety, depression, phobias, psychosis, organic disorders, agitation, delirium, and altered consciousness ranging from somnolence to coma.
What is a Hemin infusion?
Hemin injection is used to reduce the repeated attacks of porphyria (blood disorder) in some women during their menstrual periods after other treatments (eg, carbohydrate therapy) did not work. This medicine is to be given only by or under the direct supervision of your doctor.
What is the difference between hemin and hematin?
Hemin is protoporphyrin IX containing a ferric iron (Fe3+) ion with a coordinating chloride ligand. Chemically, hemin differs from the related heme-compound hematin chiefly in that the coordinating ion is a chloride ion in hemin, whereas the coordinating ion is a hydroxide ion in hematin.
What is acid Haematin?
Black to brown amorphous to microcrystalline granules are encountered in histologic sections prepared from tissues fixed in formalin having a low pH. This pigment is produced by acid acting upon hemoglobin and is known as formalin pigment or acid hematin.
How is hematin produced?
During the catabolism of hemoglobin (Hb) in the plasmodial digestive vacuole (DV) to supply the malaria parasites with extracellular nutrients, free heme or Fe(II)-protoporphyrin-lX that is toxic to the parasite is released and gets oxidized to form hematin.
Is hematin in the blood?
Hematin (Panhematin, Ovation Pharmaceuticals, Deerfield, Ill) contains alkaline heme from processed human red blood cells. It is a lyophilized powder that is best reconstituted in albumin to form a stable solution and minimize thrombophlebitis and anticoagulation.
Resources for Your Patients
These resources may help your patients get access to the medication and information they need.
Resources for your patients to help them prepare for AIP attacks
Living with AIP can be challenging, but having a plan in place will allow your patients to focus on getting the care they need when they have an AIP attack.
Resources for education and support
Whether your patients are newly diagnosed or have been living with AIP for some time, they are likely to have many questions and concerns. The resources below are appropriate for your practice as well as your patients.
What is the Panhematin patient support number?
Panhematin Patient Support Copay Assistance Program: Eligible patients may receive financial assistance when they receive their infusions in an outpatient setting; for more information contact the program at 866-209-7604.
What is panhematin used for?
Panhematin (hemin) is a member of the miscellaneous uncategorized agents drug class and is commonly used for Porphyria.
Program Details
PatientAssistance.com is glad to present this offer finding to you. You will find the program details located through the offer link below.
How To Use
Simply print this page and bring to your local pharmacy. If you have any issues please have the pharmacist call 1-800-577-6484.
How to contact Panhematin?
For medical information questions (for healthcare professionals only) regarding Panhematin ® , please call 1-888-575-8344. For safety or adverse event related questions, please call 1-888-575-8344. If your physician would like to speak to a Porphyria expert who has expertise in using Panhematin ® , the American Porphyria Foundation (APF) will gladly provide that information. Call us at 301-347-7166.
What is the APF number for panhematin?
Call us at 301-347-7166.
How long does panhematin last?
Three to four mg/kg of Panhematin ® given once daily for four days early in an attack produces a highly beneficial effect in most patients. Commonly noted are decreases in pulse rate, blood pressure, abdominal pain, as well as decreased levels of urinary porphobilinogen (PBG). These effects can occur within a day.
Where is Panhematin from?
Panhematin ® from Recordati Rare Diseases in Lebanon New Jersey, is a lyophilized form of alkaline heme that has to be reconstituted immediately prior to administration. Panhematin ® should be infused into a large peripheral vein. A large central line or port may be used, if available.
When was panhematin first used?
Although there have been no controlled studies, the results since the first report in 1971 are impressive enough to advocate the early use of Panhematin ® for Porphyria attacks. When Panhematin ® is given late in an attack, less benefit may occur.
Does panhematin cause phlebitis?
Panhematin ® may also produce superficial thrombophlebitis, especially if infused into a small vein. Panhematin ® is less likely to produce phlebitis if it is mixed with human albumin before it is given. Before Panhematin ® is used, it should be clear that the patient indeed suffers from one of the acute Porphyrias (Acute Intermittent Porphyria (AIP), Hereditary Coproporphyria (HCP), Variegate Porphyria (VP), or ALAD Deficient Porphyria (ADP)) and that the patient's symptoms are due to an acute attack. Panhematin ® therapy may not be indicated unless the diagnosis of acute Porphyria is proven by a marked increase in urine PBG.
Can panhematin be used for porphyria?
Today, physicians experienced in treating patients with attacks of Porphy ria recommend early use of Panhematin ® rather than waiting to see if glucose alone will be of decisive help. However, not every patient who experiences an attack of Porphyria needs Panhematin ® since mild attacks may well respond to glucose alone.
Can NiceRx help me get Panhematin cheaper if I have insurance?
Without insurance, Panhematin costs will vary depending on where you buy the medication as prices will vary by retailer. As a guide, Panhematin intravenous powder for injection 350 mg will cost around $8,900 for 1 powder for injection.
What doses of Panhematin are available?
Panhematin is available as a sterile, lyophilized powder for reconstitution for injection, in the following doses: 350 mg hemin, 240 mg sodium carbonate, and 335 mg of sorbitol. When mixed with Sterile Water for Injection, each 48 mL provides the equivalent of approximately 336 mg hematin (7 mg/mL).
Panhematin side effects
The most common side effects of Panhematin in clinical trials include:
Panhematin generic
Panhematin is the trademark brand name for hemin for injection manufactured by Recordati Rare Diseases Inc. A generic version of hemin for injection is not available. Generic drugs are generally cheaper than brand-name drugs, but you can still find Panhematin savings through NiceRx.
