Full Answer
What is pegloticase used for?
Pegloticase injection is used to treat chronic gout in adult patients who have already been treated with other medicines that did not work well. Gout is a condition that is caused by too much uric acid in the blood (hyperuricemia). Pegloticase injection works by causing less uric acid to be produced by the body.
How much does KRYSTEXXA cost?
As a guide, Krystexxa intravenous solution (8 mg/mL) typically costs $26,000 for 1 milliliter.
What is the mechanism of action of pegloticase?
Pegloticase is a pegylated, recombinant uricase (urate-oxidase), created by a genetically altered variant of Escherichia coli that exerts its mechanism of action by catalyzing uric acid to the water-soluble purine metabolite allantoin.
Does Medicare cover KRYSTEXXA?
Blue Medicare Medical Policies Krystexxa is considered medically necessary for the treatment of adult patients with chronic gout when specified medical criteria and guidelines are met. Added HCPCS code J2507 to Billing/Coding section.
What is the new drug for gout?
The U.S. Food and Drug Administration today approved Krystexxa (pegloticase) to treat the painful condition known as gout in adults who do not respond to or who cannot tolerate conventional therapy.
How long is KRYSTEXXA infusion?
KRYSTEXXA should be infused slowly over no less than 120 minutes. In the event of an infusion reaction, the infusion should be slowed, or stopped and restarted at a slower rate.
Can you take nsaids with pegloticase?
Prophylaxis with a non-steroidal anti-inflammatory drug (NSAID) or colchicine is recommended starting at least 1 week before initiation of pegloticase therapy and lasting at least 6 months, unless medically contraindicated or not tolerated.
Does pegloticase increase urine levels of uric acid?
In clinical trials, pegloticase lowered uric acid levels to as low as 1 mg/dL (or less) within 24 hours. Pegloticase is a drug you take to manage your gout and prevent flares, but it will not treat a gout flare or its symptoms.
Can you take pegloticase with allopurinol?
allopurinol pegloticase Using pegloticase together with allopurinol is not recommended. Treatment with pegloticase requires monitoring of uric acid levels in the blood to reduce the risk of side effects such as allergic and infusion reactions, and allopurinol can interfere with the monitoring.
What are the side effects of KRYSTEXXA?
Common side effects of Krystexxa include:nausea.vomiting.sore throat.runny or stuffy nose.new gout flares.constipation.easy bruising, and.hives.
Who can prescribe KRYSTEXXA?
These allergic reactions can be life-threatening and usually happen within 2 hours of the infusion. KRYSTEXXA should be given to you by a doctor or nurse in a healthcare setting where serious allergic reactions can be treated.
Is KRYSTEXXA FDA approved?
"KRYSTEXXA is the first-ever and only treatment approved by the FDA for adult patients who suffer with chronic gout that is refractory to conventional therapy," said Paul Hamelin R.Ph., President of Savient Pharmaceuticals.
What are the side effects of KRYSTEXXA?
Common side effects of Krystexxa include:nausea.vomiting.sore throat.runny or stuffy nose.new gout flares.constipation.easy bruising, and.hives.
Do gouty tophi go away?
Tophi are diagnostic for chronic tophaceous gout. Tophi can be found around joints, in the olecranon bursa, or at the pinna of the ear. With treatment, tophi can be dissolved and will completely disappear over time.
What is KRYSTEXXA made of?
KRYSTEXXA (pegloticase) is a uric acid specific enzyme which is a PEGylated product that consists of recombinant modified mammalian urate oxidase (uricase) produced by a genetically modified strain of Escherichia coli.
Is there a shot to prevent gout?
Pegloticase injection is in a class of medications called PEGylated uric acid specific enzymes. It works by decreasing the amount of uric acid in the body. Pegloticase injection is used to prevent gout attacks but not to treat them once they occur.
What to talk to doctor before taking G6PD?
Before you receive treatment, talk to your doctor about your medical history including if you have heart problems, high blood pressure, or G6PD deficiency.
How much does prescription hope cost?
Prescription Hope works with thousands of Americans every month, obtaining prescription medications on their behalf for the set price of $50.00 per month per medication.The income guidelines to qualify for Prescription Hope are as follows; An individual earning up to or around $30,000 per year.
How to contact Vimovo?from horizontherapeutics.com
For more information about VIMOVO, call 1-855-881-3093 or visit the website for additional details including Full Prescribing Information and Boxed Warning.
How to contact Duexis?from horizontherapeutics.com
For more information about DUEXIS, call 1-855-250-6335 or visit the website for additional details including Full Prescribing Information and Boxed Warning.
How to contact Procysbi?from horizontherapeutics.com
If you have been prescribed PROCYSBI and are interested in the Horizon By Your Side program, you can call 1-855-888-4004. Learn more about PROCYSBI ® (cysteamine bitartrate) delayed-release capsules and delayed-release oral granules including full prescribing information.
COMMON PRIOR AUTHORIZATION CRITERIA
Although requirements vary by plan, below are the common criteria that may be requested for KRYSTEXXA.
SOLUBILITY OF URIC ACID: LOWERING s UA LEVEL IS NECESSARY TO BEGIN DEPLETION OF URATE BURDEN 2-8
An sUA level of 6 mg/dL is not low enough for many patients with gout. 2,3
REIMBURSEMENT FORMS & DOWNLOADS
Choose one of two convenient options to initiate and submit the Patient Enrollment Form (PEF).
Downloadable Patient Enrollment Form
Once your patient is enrolled in the program, you will receive a comprehensive summary of your patient’s benefits.
Patient Support
Check in with your patients prior to each infusion and send appointment reminders
Access to KRYSTEXXA
KRYSTEXXA makes it easy to help patients start treatment with payor forms and reimbursement codes.
Starting KRYSTEXXA
There are several steps that will help prepare patients for infusion and ensure proper administration of KRYSTEXXA.
What to talk to doctor before taking G6PD?from prescriptionhope.com
Before you receive treatment, talk to your doctor about your medical history including if you have heart problems, high blood pressure, or G6PD deficiency.
Does Febuxostat lower urate levels?from findanyanswer.com
Febuxostat, like allopurinol, is a xanthine oxidase inhibitor that can lower urate levels in patients with gout and thus prevent acute attacks. It has become the usual first alternative for allopurinol-intolerant patients with gout.
Your partner throughout treatment
Fill out the form below and a Gout Nurse Advocate will be in touch within 2 business days to confirm your eligibility for a Patient Access Liaison (PAL). Once you’re enrolled in Horizon By Your Side, you will receive a welcome call from your PAL. After that, you can call, text, or email them whenever you need non-medical assistance.
USE AND IMPORTANT SAFETY INFORMATION
KRYSTEXXA ® (pegloticase) is a prescription medicine used in adults to help reduce the signs and symptoms of gout that are not controlled by other treatments.
