TAVALISSE TOGETHER is a program for adult patients with chronic immune thrombocytopenia (ITP) who are taking or are interested in taking TAVALISSE. This program partners with patients throughout their treatment journey, helping them to become successful with their ITP treatment and achieve their goals.
Full Answer
Is Tavalisse covered by Medicare?
Medicare prescription drug plans typically list Tavalisse on Tier 5 of their formulary. Generally, the higher the tier, the more you have to pay for the medication.
What is Tavalisse used for?
TAVALISSE is a prescription medication used to treat adults with low platelet counts due to chronic immune thrombocytopenia (ITP) when a prior treatment for ITP has not worked well enough.
How much is Tavalisse?
The cost for Tavalisse oral tablet 100 mg is around $13,720 for a supply of 60 tablets, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans.
Is Tavalisse a specialty drug?
TAVALISSE™ is a limited distribution medication that is available from select specialty pharmacies.
How long does it take Tavalisse to work?
In clinical studies, TAVALISSE has been shown to raise platelet counts over time. Many patients who had a positive response with TAVALISSE saw an increase in their platelet counts at their first check-in (approximately 2 weeks).
Is ITP chronic?
ITP can be acute (short-term) or chronic (long-term). Acute ITP often lasts less than 6 months. It mainly occurs in children — both boys and girls — and is the most common type of ITP. Chronic ITP lasts 6 months or longer and mostly affects adults.
Who makes Tavalisse?
Rigel's first FDA approved product is TAVALISSE® (fostamatinib disodium hexahydrate), which is the only oral spleen tyrosine kinase (SYK) inhibitor for the treatment of adult patients with chronic immune thrombocytopenia (ITP) who have had an insufficient response to a previous treatment.
When was Tavalisse approved by the FDA?
On April 17, 2018, the Food and Drug Administration approved fostamatinib disodium hexahydrate tablets (TAVALISSE, Rigel Pharmaceuticals, Inc.) for the treatment of thrombocytopenia in adult patients with chronic immune thrombocytopenia (ITP) who have had an insufficient response to a previous treatment.
What is fostamatinib used for?
Fostamatinib is used to treat thrombocytopenia (less than normal number of platelets) in adults with chronic immune thrombocytopenia (ITP; an ongoing condition that may cause unusual bruising or bleeding due to an abnormally low number of platelets in the blood) who were not helped with another treatment.
Is fostamatinib FDA approved?
On April 17, 2018, the US Food and Drug Administration (FDA) approved fostamatinib disodium hexahydrate (Tavalisse; Rigel Pharmaceuticals), an oral spleen tyrosine kinase (SYK) inhibitor, for the treatment of adults with chronic ITP who had an insufficient response to previous treatment.
What is Nplate injection?
What is Nplate®? Nplate® is a treatment for low platelet counts in adults and children with immune thrombocytopenia (ITP) when other treatments or medicines have not worked well enough.
What is tavalise used for?
TAVALISSE (fostamatinib disodium hexahydrate) tablets is indicated for the treatment of thrombocytopenia in adult patients with chronic immune thrombocytopenia (ITP) who have had an insufficient response to a previous treatment.
What are the adverse reactions to TAVALISSE?
Serious adverse drug reactions in the ITP double-blind studies were febrile neutropenia, diarrhea, pneumonia, and hypertensive crisis, which occurred in 1% of TAVALISSE patients. In addition, severe adverse reactions occurred including dyspnea and hypertension (both 2%), neutropenia, arthralgia, chest pain, diarrhea, dizziness, nephrolithiasis, pain in extremity, toothache, syncope, and hypoxia (all 1%).
How severe is diarrhea in tavalis?
If diarrhea becomes severe (>Grade 3), interrupt, reduce dose or discontinue TAVALISSE.
Does tavalise increase BCRP?
Concomitant use of TAVALISSE may increase concentrations of BCRP substrate drugs (eg, rosuvastatin) and P-Glycoprotein (P-gp) substrate drugs (eg, digoxin), which may require a dose reduction of the BCRP and P-gp substrate drug.
Can tavalise cause hypertension?
Hypertension can occur with TAVALISSE treatment. Patients with pre-existing hypertension may be more susceptible to the hypertensive effects. Monitor blood pressure every 2 weeks until stable, then monthly, and adjust or initiate antihypertensive therapy for blood pressure control maintenance during therapy. If increased blood pressure persists, TAVALISSE interruption, reduction, or discontinuation may be required.
Does tavalasse cause neutropenia?
Neutropenia occurred in 6% of patients treated with TAVALISSE; febrile neutropenia occurred in 1% of patients. Monitor the ANC monthly and for infection during treatment. Manage toxicity with TAVALISSE interruption, reduction, or discontinuation.
Can tavalise harm a fetus?
TAVALISSE can cause fetal harm when administered to pregnant women. Advise pregnant women the potential risk to a fetus. Advise females of reproductive potential to use effective contraception during treatment and for at least 1 month after the last dose. Verify pregnancy status prior to initiating TAVALISSE. It is unknown if TAVALISSE or its metabolite is present in human milk. Because of the potential for serious adverse reactions in a breastfed child, advise a lactating woman not to breastfeed during TAVALISSE treatment and for at least 1 month after the last dose.
What is TAVALISSE TOGETHER?
TAVALISSE TOGETHER builds upon the information you may be sharing with your patients. The more patients know about ITP, what to expect with treatment, and how to get the most out of conversations with their healthcare team, the better prepared they’ll be to stay on track.
What is a tavalasse?
TAVALISSE TOGETHER is a program for adult patients with chronic immune thrombocytopenia (ITP) who are taking or are interested in taking TAVALISSE. This program partners with patients throughout their treatment journey, helping them to become successful with their ITP treatment and achieve their goals.
How old do you have to be to qualify for ITP?
. They have been diagnosed with low platelet counts due to chronic immune thrombocytopenia (ITP) when a prior treatment for ITP has not worked well enough. They are 18 years of age or older. They have a commercial insurance plan.
Is talavisse taken together?
Whether your patients are just getting started or they’re already taking TAVALISSE, TAVALISSE TOGETHER is here to help them fit their ITP treatment seamlessly into daily life.
What is TAVALISSE treatment?
TARGETED TREATMENT. TAVALISSE directly targets an enzyme in your body called spleen tyrosine kinase (SYK). SYK is an important part of the chain of events that causes the immune system to destroy platelets in ITP.
What happens when you have an ITP?
For example, when your body forms a scab, or clot, over an injury, platelets are the first cells on the scene to begin the healing process. People with ITP have lower amounts of platelets in their blood, which makes it harder for blood clots to form. 4. ITP can lead to major bleeding and other complications .
Can tavalassis cause a decrease in white blood cells?
Decreases in your white blood cell count are common with TAVALISSE and can be severe. This may increase your risk for infection, including serious infections. Your healthcare provider will regularly do blood tests to check your white blood cell counts.
Does tavalise cause high blood pressure?
TAVALISSE can cause serious side effects including: • High blood pressure (hypertension). New or worsening high blood pressure is common in people treated with TAVALISSE and can be severe. Your healthcare provider will check your blood pressure regularly during treatment with TAVALISSE.
Can tavalise harm a baby?
•are pregnant or plan to become pregnant. TAVALISSE can harm your unborn baby.
Can you get diarrhea from tavalasse?
IMPORTANT SAFETY INFORMATION . •Diarrhea. Diarrhea is common in people treated with TAVALISSE and can be severe. Tell your healthcare provider if you get diarrhea during treatment with TAVALISSE. Your healthcare provider may recommend changes in your diet, drinking more water, or medicine to limit these symptoms.
Can tavalasse cause liver problems?
Changes in liver function blood tests are common with TAVALISSE. Liver problems may occur and can be severe. Your healthcare provider will regularly do blood tests to check how well your liver is working during treatment with TAVALISSE. IMPORTANT SAFETY INFORMATION . •Diarrhea.
