What is vonvendi used to treat?
Indication: VONVENDI [von Willebrand factor (recombinant)] is used in adults (age 18 years and older) diagnosed with von Willebrand disease to: treat and control bleeding episodes and prevent excessive bleeding during and after surgery. vonvendi [von Willebrand factor (Recombinant)]
When should I take vonvendi?
VONVENDI is used in adults (age 18 years and older) diagnosed with von Willebrand disease to: reduce the number of bleeding episodes when used regularly (prophylaxis) in adults with severe Type 3 von Willebrand disease receiving on-demand therapy Who should not use VONVENDI? Are allergic to any ingredients in VONVENDI.
How much does vonvendi cost?
The cost for Vonvendi intravenous powder for injection recombinant is around $12 for a supply of 1 powder for injection, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans.
What is a von Willebrand factor replacement therapy?
VONVENDI is the only recombinant von Willebrand factor (VWF) replacement therapy, and the first and only treatment to reduce the frequency of bleeding episodes for severe Type 3 VWD approved by the FDA for routine prophylactic use.
What is VONVENDI used for?
treat VWD. VONVENDI® is used to treat bleeds in adults with von Willebrand disease (VWD), an inherited bleeding disorder that makes it difficult to form blood clots. VONVENDI is the first and only recombinant treatment for VWD, meaning it's made without using human blood.
How is VONVENDI administered?
VONVENDI is formulated as a sterile, non-pyrogenic, white to off-white powder for intravenous injection after reconstitution. VONVENDI in a single-use vial contains nominally 650 or 1300 IU VWF:RCo.
What is rVWF?
VONVENDI [von Willebrand factor (recombinant)] is a recombinant von Willebrand factor (rVWF) indicated for use in adults (age 18 and older) diagnosed with von Willebrand disease (VWD) for: On-demand treatment and control of bleeding episodes. Perioperative management of bleeding.
What is recombinant von Willebrand factor?
Von Willebrand factor recombinant injection is used to treat and control serious bleeding episodes in patients with a bleeding problem called von Willebrand disease (VWD). Von Willebrand factor is normally produced in the body and it helps you form blood clots.
How long does Humate P last?
Before reconstitution, HUMATE-P can be safely stored at room temperature (25°C [77°F]) for up to 36 months. (After reconstitution, HUMATE-P should be used within 3 hours.)
What foods to avoid if you have hemophilia?
In addition, limit your intake of the following:large glasses of juice.soft drinks, energy drinks, and sweetened tea.heavy gravies and sauces.butter, shortening, or lard.full-fat dairy products.candy.foods containing trans fats, including fried. foods and baked goods (pastries, pizza, pie, cookies, and crackers)
Is von Willebrand disease a disability?
The condition is medically equal to a condition in the Listing of Impairments. If someone can prove that his or her von Willebrand disease is medically equal to any listing in the Listing of Impairments then that person may qualify for Social Security disability.
Can von Willebrand disease get worse?
The disease can range from mild to severe. It is mild in most people. It can stay the same or get better or worse as you get older.
What factor is used in vonendi?
Your first dose of VONVENDI for each bleeding episode may be administered with a recombinant factor VIII as instructed by your healthcare provider.
Can you use vivendi if you are allergic to mice?
You should not use VONVENDI if you: Are allergic to any ingredients in VONVENDI. Are allergic to mice or hamsters. Tell your healthcare provider if you are pregnant or breastfeeding because VONVENDI may not be right for you.
Can you share a bleeding disorder with someone with von Willebrand disease?
Find a treatment specifically created for von Willebrand disease (VWD) bleeding episodes 1. As an adult living with VWD, you may share a bleeding disorder with others, but you also may have your own Deciding Factor —something that drives you to ask your healthcare provider about finding a treatment that's right for you.
Can VWD change your life?
VWD can change your life, and no one knows that experience better than the people who face it every day.
Can you get a rash from a vonendi?
You can have an allergic reaction to VONVENDI. Call your healthcare provider right away and stop treatment if you get a rash or hives, itching, tightness of the throat, chest pain or tightness, difficulty breathing, lightheadedness, dizziness, nausea or fainting.
Can you take inhibitors of von Willebrand?
If you form inhibitors, it may stop VONVENDI or factor VIII from working properly. Consult with your healthcare provider to make sure you are carefully monitored with blood tests for the development of inhibitors to von Willebrand factor or factor VIII.
How much is Vonvendi powder?
The cost for Vonvendi intravenous powder for injection recombinant is around $12 for a supply of 1 powder for injection, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans.
How much does a free drug card save?
The free Drugs.com Discount Card works like a coupon and can save you up to 80% or more off the cost of prescription medicines, over-the-counter drugs and pet prescriptions.
How is Vonvendi given?from drugs.com
Vonvendi is injected into a vein through an IV. You may be shown how to use an IV at home. Do not give yourself this medicine if you do not understand how to use the injection and properly dispose of needles, IV tubing, and other items used.
When was Vonvendi approved?from pubmed.ncbi.nlm.nih.gov
A recombinant VWF (vonicog alfa, Vonvendi™; manufactured by Baxalta, now part of Shire) was approved by the U.S. Food and Drug Administration (FDA) in December 2015. This review will survey the literature based on a MEDLINE review on the safety, efficacy and pharmacokinetics of Vonvendi.
What other drugs will affect Vonvendi?from drugs.com
Other drugs may interact with von Willebrand factor, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
What is vovidendi used for?from vonvendi.com
Your healthcare provider may prescribe VONVENDI for two different uses: on-demand treatment of bleeds and to prevent excessive bleeding during and after surgery. 1
What factor is used in vonendi?from vonvendi.com
Your first dose of VONVENDI for each bleeding episode may be administered with a recombinant factor VIII as instructed by your healthcare provider.
What is von Willebrand factor?from drugs.com
In VWD patients, von Willebrand factor (recombinant) acts to promote hemostasis by mediating platelet adhesion to damaged vascular subendothelial matrix (e.g., collagen) and platelet aggregation, and as a carrier protein for factor VIII2, protecting it from rapid proteolysis. The adhesive activity of VWF depends on the size of its multimers, with large multimers being the most effective in supporting interactions with collagen and platelet receptors. The factor VIII binding capacity and affinity to von Willebrand factor (recombinant) is comparable to that of VWF present in plasma and platelets, allowing for von Willebrand factor (recombinant) to reduce factor VIII clearance.
Can you take inhibitors of von Willebrand?from vonvendi.com
If you form inhibitors, it may stop VONVENDI or factor VIII from working properly. Consult with your healthcare provider to make sure you are carefully monitored with blood tests for the development of inhibitors to von Willebrand factor or factor VIII.
How does Vonvendi work?
In VWD patients, Vonvendi acts 1) to promote hemostasis by mediating platelet adhesion to damaged vascular sub-endothelial matrix (e.g. collagen) and platelet aggregation, and 2) as a carrier protein for factor VIII, protecting it from rapid proteolysis.
What are the most common adverse reactions to Vonvendi?
The most common adverse reactions observed in ≥2% of subjects in clinical trials with Vonvendi (n=80) were generalized pruritus, vomiting, nausea, dizziness and vertigo.
What is Vonvendi recombinant?
Vonvendi [von Willebrand factor (recombinant)] is a recombinant von Willebrand factor (rVWF) indicated for use in adults (age 18 and older) diagnose d with von Willebrand disease ( VWD) for:
How long before surgery can you take Vonvendi?
A preoperative dose of Vonvendi may be administered 12 to 24 hours prior to surgery to allow the endogenous factor VIII levels to increase to at least 30 IU/dL (minor surgery) or 60 IU/dL (major surgery) before the loading dose (1 hour preoperative dose) of rVWF, with or without recombinant factor VIII, is administered.
What is a Vonvendi swfi?
Vonvendi is packaged with Sterile Water for Injection (sWFI), one Mix2Vial reconstitution device, one full prescribing physician insert, and one patient insert.
What are the proteins present in the final container product other than rVWF?
Proteins present in the final container product other than rVWF are trace quantities of mouse immunoglobulin (IgG, from the immunoaffinity purification), host cell (i.e., CHO) protein, rFurin (used to further process rVWF), and recombin ant factor VIII (rFVIII).
How to draw air from Vonvendi?
Draw air into an empty, sterile disposable plastic syringe. The amount of air should equal the amount of reconstituted Vonvendi to be withdrawn from the vial.
How is Vonvendi given?from drugs.com
Vonvendi is injected into a vein through an IV. You may be shown how to use an IV at home. Do not give yourself this medicine if you do not understand how to use the injection and properly dispose of needles, IV tubing, and other items used.
What other drugs will affect Vonvendi?from drugs.com
Other drugs may interact with von Willebrand factor, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
What is vovidendi used for?from vonvendi.com
Your healthcare provider may prescribe VONVENDI for two different uses: on-demand treatment of bleeds and to prevent excessive bleeding during and after surgery. 1
What factor is used in vonendi?from vonvendi.com
Your first dose of VONVENDI for each bleeding episode may be administered with a recombinant factor VIII as instructed by your healthcare provider.
Can you take inhibitors of von Willebrand?from vonvendi.com
If you form inhibitors, it may stop VONVENDI or factor VIII from working properly. Consult with your healthcare provider to make sure you are carefully monitored with blood tests for the development of inhibitors to von Willebrand factor or factor VIII.
Can VWD change your life?from vonvendi.com
VWD can change your life, and no one knows that experience better than the people who face it every day.
Can Vonvendi cause bleeding?from drugs.com
A lack of von Willebrand factor can cause uncontrolled bleeding. Vonvendi is used to control bleeding episodes in adults with von Willebrand disease. Vonvendi may also be used for purposes not listed in this medication guide.
