What is a vyxeos?
How to contact Jazz Pharmaceuticals?
How to report side effects of Jazz Pharmaceuticals?
Can vyxeos cause anaphylaxis?
Can vyxeos cause copper overload?
Can you give a patient vyxeos?
Is it important to feel supported while receiving secondary acute myeloid leukemia treatment?
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About this website
Can Vyxeos be given outpatient?
VYXEOS can be administered in an outpatient setting for appropriate patients.
What does Vyxeos treat?
VYXEOS is indicated for the treatment of newly-diagnosed therapy-related acute myeloid leukemia (t‑AML) or AML with myelodysplasia-related changes (AML-MRC) in adults and pediatric patients 1 year and older.
How much is Vyxeos?
The cost for Vyxeos intravenous powder for injection (100 mg-44 mg) is around $9,750 for a supply of 1 powder for injection, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans.
How is Vyxeos administered?
VYXEOS (vix-e-ose) is administered as an intravenous (IV) infusion using a central IV line or peripherally inserted central catheter. VYXEOS is given in phases known as induction and consolidation.
How effective is Vyxeos?
12 months following initiation of treatment, 41.5% of patients treated with Vyxeos were still alive, compared with only 27.6% of patients treated with 7+3. 24 months following initiation of treatment, 31.1% of patients treated with Vyxeos were still alive, compared with only 12.3% treated with 7+3.
How often is Vyxeos given?
A second induction cycle may be administered 2 to 5 weeks after the first in patients who do not achieve remission with the first induction cycle, if there was no unacceptable toxicity with Vyxeos. The first consolidation cycle is usually administered 5 to 8 weeks after the start of the last induction.
Why was Mylotarg removed from the market?
Mylotarg was voluntarily withdrawn from the market after subsequent confirmatory trials failed to verify clinical benefit and demonstrated safety concerns, including a high number of early deaths.
Which cell cycle is most affected by cytarabine?
The sugar moiety of cytarabine hinders the rotation of the molecule within the DNA. The DNA replication ceases, specifically during the S phase of the cell cycle, making it a specific drug for rapidly dividing cells, such as those seen in cancer.
What chemo is purple?
Mitoxantrone is a type of chemotherapy. You might have it as a treatment for: breast cancer that has spread.
What is Rylaze?
RYLAZE is indicated as a component of a multi-agent chemotherapeutic regimen given by intramuscular injection for the treatment of acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma (LBL) in adult and pediatric patients 1 month or older who have developed hypersensitivity to E. coli-derived asparaginase.
Is flag Ida chemotherapy?
FLAG-Ida is a combination chemotherapy regimen made up of fludarabine, high dose cytarabine (Ara-C0), idarubicin and granulocyte-colony stimulating factor (G-CSF) used in the treatment of acute myeloid leukaemia (AML).
What is a vyxeos?
WHAT IS VYXEOS? VYXEOS is an intravenous (IV) chemotherapy used for the treatment of certain types of newly-diagnosed acute myeloid leukemia (AML) in adults and pediatric patients 1 year and older , including patients whose AML is related to previously received chemotherapy or radiation therapy (also called therapy-related AML, ...
How to contact Jazz Pharmaceuticals?
To contact Jazz Pharmaceuticals Customer Service, please call 1-800-833-3533. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
How to report side effects of Jazz Pharmaceuticals?
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088. You may also report side effects to Jazz Pharmaceuticals at 1-800-520-5568. Please see full Prescribing Information, including BOXED Warning, and discuss with your doctor. Contact Us.
Can vyxeos cause anaphylaxis?
VYXEOS may cause allergic reactions including anaphylaxis. Seek immediate medical attention if you develop signs and symptoms of anaphylaxis such as: trouble breathing. severe itching. skin rash or hives. swelling of the face, lips, mouth, or tongue.
Can vyxeos cause copper overload?
VYXEOS contains copper and may cause copper overload in patients with Wilson’s disease or other copper-processing disorders. VYXEOS can damage the skin if it leaks out of the vein. Tell your doctor right away if you experience symptoms of burning, stinging, or blisters and skin sores at the injection site.
Can you give a patient vyxeos?
VYXEOS should not be given to patients who have a history of serious allergic reaction to daunorubicin, cytarabine, or any of its ingredients.
Is it important to feel supported while receiving secondary acute myeloid leukemia treatment?
It’s important to feel supported every step of the way while receiving secondary acute myeloid leukemia (sAML) treatment. The resources below may help answer questions you may have about treatment, financial reimbursement, and support groups for those in the AML community.
What is vyxeos used for?
Vyxeos (cytarabine liposomal/daunorubicin liposomal) is a member of the antineoplastic combinations drug class and is commonly used for Acute Myeloid Leukemia.
Is Vyxeos valid with insurance?
Prices are for cash paying customers only and are not valid with insurance plans. This Vyxeos price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies.
What is a vyxeos?
WHAT IS VYXEOS? VYXEOS is an intravenous (IV) chemotherapy used for the treatment of certain types of newly-diagnosed acute myeloid leukemia (AML) in adults and pediatric patients 1 year and older , including patients whose AML is related to previously received chemotherapy or radiation therapy (also called therapy-related AML, ...
How long after vyxeos is it safe to use contraception?
Females and males of reproductive potential should use effective contraception during treatment and for 6 months following the last dose of VYXEOS. The most common side effects were bleeding events, fever, rash, swelling, nausea, sores in the mouth or throat, diarrhea, constipation, muscle pain, tiredness, stomach pain, difficulty breathing, ...
How to contact Jazz Pharmaceuticals?
To contact Jazz Pharmaceuticals Customer Service, please call 1-800-833-3533. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
How to report side effects of Jazz Pharmaceuticals?
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088. You may also report side effects to Jazz Pharmaceuticals at 1-800-520-5568. Please see full Prescribing Information, including BOXED Warning, and discuss with your doctor. Contact Us.
Can a vyxeos injection cause blisters?
VYXEOS can damage the skin if it leaks out of the vein. Tell your doctor right away if you experience symptoms of burning, stinging, or blisters and skin sores at the injection site.
Can you give a patient vyxeos?
VYXEOS should not be given to patients who have a history of serious allergic reaction to daunorubicin, cytarabine, or any of its ingredients.
Can you use vyxeos with cytarabine?
VYXEOS has different dosage recommendations from other medications that contain daunorubicin and/or cytarabine. Do not substitute VYXEOS for other daunorubicin and/or cytarabine-containing products.
1. How it works
Vyxeos is a combination chemotherapy medicine that contains two commonly used drugs for AML, daunorubicin, and cytarabine in a 1:5 molar ratio, that may be given to treat acute myeloid leukemia.
2. Upsides
Vyxeos may be used to treat adults with acute myeloid leukemia (AML) caused by previous chemotherapy treatment or AML with myelodysplasia-related changes (AML-MRC).
3. Downsides
If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include:
4. Bottom Line
Vyxeos is a combination chemotherapy medicine that contains two commonly used drugs for AML, daunorubicin, and cytarabine encapsulated in liposomes, which are fat-like coatings that allow more active drug to reach the bone marrow cells and help to reduce the harmful effects of daunorubicin and cytarabine on healthy tissue.
6. Response and effectiveness
Vyxeos was compared to a standard combination of cytarabine and daunorubicin (7+3) in patients 60 to 75 years with newly diagnosed t-AML or AML-MRC. The median survival was 9.6months in the Vyxeos group and 5.9 months in the 7+3 group. The Complete Remission rate was 38% in the Vyxeos group and 26% in the &+3 group.
7. Interactions
Medicines that interact with Vyxeos may either decrease its effect, affect how long it works for, increase side effects, or have less of an effect when taken with Vyxeos. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does.
Further information
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Vyxeos only for the indication prescribed.
What is a vyxeos?
WHAT IS VYXEOS? VYXEOS is an intravenous (IV) chemotherapy used for the treatment of certain types of newly-diagnosed acute myeloid leukemia (AML) in adults and pediatric patients 1 year and older , including patients whose AML is related to previously received chemotherapy or radiation therapy (also called therapy-related AML, ...
How to contact Jazz Pharmaceuticals?
To contact Jazz Pharmaceuticals Customer Service, please call 1-800-833-3533. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
How to report side effects of Jazz Pharmaceuticals?
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088. You may also report side effects to Jazz Pharmaceuticals at 1-800-520-5568. Please see full Prescribing Information, including BOXED Warning, and discuss with your doctor. Contact Us.
Can vyxeos cause anaphylaxis?
VYXEOS may cause allergic reactions including anaphylaxis. Seek immediate medical attention if you develop signs and symptoms of anaphylaxis such as: trouble breathing. severe itching. skin rash or hives. swelling of the face, lips, mouth, or tongue.
Can vyxeos cause copper overload?
VYXEOS contains copper and may cause copper overload in patients with Wilson’s disease or other copper-processing disorders. VYXEOS can damage the skin if it leaks out of the vein. Tell your doctor right away if you experience symptoms of burning, stinging, or blisters and skin sores at the injection site.
Can you give a patient vyxeos?
VYXEOS should not be given to patients who have a history of serious allergic reaction to daunorubicin, cytarabine, or any of its ingredients.
Is it important to feel supported while receiving secondary acute myeloid leukemia treatment?
It’s important to feel supported every step of the way while receiving secondary acute myeloid leukemia (sAML) treatment. The resources below may help answer questions you may have about treatment, financial reimbursement, and support groups for those in the AML community.
